Anette Duensing

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Biology of gastrointestinal stromal tumors: KIT mutations and beyond
    Anette Duensing
    Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Cancer Invest 22:106-16. 2004
  2. ncbi Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
    Anette Duensing
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Oncogene 23:3999-4006. 2004
  3. ncbi Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs)
    Anette Duensing
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 64:5127-31. 2004
  4. ncbi KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications
    Fabiola Medeiros
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 28:889-94. 2004
  5. pmc Daughter centriole elongation is controlled by proteolysis
    Nina Korzeniewski
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Biol Cell 21:3942-51. 2010
  6. ncbi Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred
    Frederick P Li
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 23:2735-43. 2005
  7. pmc Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms
    Anette Duensing
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Virology 372:157-64. 2008
  8. pmc p21(Waf1/Cip1) deficiency stimulates centriole overduplication
    Anette Duensing
    Department of Pathology, Molecular Virology Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cell Cycle 5:2899-902. 2006
  9. pmc A role of the mitotic spindle checkpoint in the cellular response to DNA replication stress
    Anette Duensing
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Cell Biochem 99:759-69. 2006
  10. ncbi PDGFRA activating mutations in gastrointestinal stromal tumors
    Michael C Heinrich
    Department of Medicine, Department of Pathology, Oregon Health and Science University Cancer Institute and Portland VA Medical Center, Portland, OR 97201, USA
    Science 299:708-10. 2003

Detail Information

Publications12

  1. ncbi Biology of gastrointestinal stromal tumors: KIT mutations and beyond
    Anette Duensing
    Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Cancer Invest 22:106-16. 2004
    ..This review focuses on the biological and molecular genetic principles of GISTs, and particularly the role of mutant KIT as a therapeutic target...
  2. ncbi Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
    Anette Duensing
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Oncogene 23:3999-4006. 2004
    ....
  3. ncbi Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs)
    Anette Duensing
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 64:5127-31. 2004
    ..PKCtheta is strongly activated in most GISTs and hence may serve, along with KIT/PDGFRA, as a novel therapeutic target...
  4. ncbi KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications
    Fabiola Medeiros
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 28:889-94. 2004
    ..Notably, some KIT-negative GISTs contain imatinib-sensitive KIT or PDGFRA mutations; therefore, patients with KIT-negative GISTs should not, a priori, be denied imatinib therapy...
  5. pmc Daughter centriole elongation is controlled by proteolysis
    Nina Korzeniewski
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Biol Cell 21:3942-51. 2010
    ..They also highlight the complexity of daughter centriole length control and provide a framework for future studies to dissect the molecular details of this process...
  6. ncbi Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred
    Frederick P Li
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 23:2735-43. 2005
    ..A tumor from the proband was analyzed to compare features with sporadic GISTs...
  7. pmc Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms
    Anette Duensing
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Virology 372:157-64. 2008
    ....
  8. pmc p21(Waf1/Cip1) deficiency stimulates centriole overduplication
    Anette Duensing
    Department of Pathology, Molecular Virology Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cell Cycle 5:2899-902. 2006
    ....
  9. pmc A role of the mitotic spindle checkpoint in the cellular response to DNA replication stress
    Anette Duensing
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Cell Biochem 99:759-69. 2006
    ..These findings imply that the mitotic spindle checkpoint may act in concert with DNA damage and cell-cycle checkpoints as an early anti-tumor barrier and provide a possible explanation for its frequent relaxation in human cancer...
  10. ncbi PDGFRA activating mutations in gastrointestinal stromal tumors
    Michael C Heinrich
    Department of Medicine, Department of Pathology, Oregon Health and Science University Cancer Institute and Portland VA Medical Center, Portland, OR 97201, USA
    Science 299:708-10. 2003
    ..Thus, KIT and PDGFRA mutations appear to be alternative and mutually exclusive oncogenic mechanisms in GISTs...
  11. ncbi Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors
    Brian P Rubin
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Lab Invest 86:981-6. 2006
    ..This paper focuses on what is known about mechanisms of resistance in the treatment of solid tumors by small molecule kinase inhibitors...
  12. ncbi Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate
    Ying Liu
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA
    Cancer Res 67:2685-92. 2007
    ..Our results underscore the importance of H2AX as a human tumor suppressor protein, provide mechanistic insights into imatinib-induced tumor cell apoptosis and establish H2AX as a novel target in cancer therapy...