D Allan Drummond

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Protein evolution: innovative chaps
    D Allan Drummond
    FAS Center for Systems Biology Northwest Building, Rm 431, 52 Oxford St, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 19:R740-2. 2009
  2. pmc Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
    D Allan Drummond
    FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 134:341-52. 2008
  3. pmc Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
    Kerry A Geiler-Samerotte
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:680-5. 2011
  4. pmc The evolutionary consequences of erroneous protein synthesis
    D Allan Drummond
    FAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Nat Rev Genet 10:715-24. 2009
  5. pmc Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme
    Deepa Agashe
    Department of Organismic and Evolutionary Biology, Biological Laboratories, Harvard University, MA, USA
    Mol Biol Evol 30:549-60. 2013
  6. pmc Why highly expressed proteins evolve slowly
    D Allan Drummond
    Program in Computation and Neural Systems and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 4100, USA
    Proc Natl Acad Sci U S A 102:14338-43. 2005
  7. pmc Population genetics of translational robustness
    Claus O Wilke
    Section of Integrative Biology and Center for Computational Biology and Bioinformatics, University of Texas, Austin 78712, USA
    Genetics 173:473-81. 2006
  8. ncbi request reprint Structural determinants of the rate of protein evolution in yeast
    Jesse D Bloom
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA
    Mol Biol Evol 23:1751-61. 2006
  9. doi request reprint Contact density affects protein evolutionary rate from bacteria to animals
    Tong Zhou
    Center for Computational Biology and Bioinformatics, Section of Integrative Biology, University of Texas at Austin, Austin, TX 78731, USA
    J Mol Evol 66:395-404. 2008
  10. ncbi request reprint A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
    Yougen Li
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Biotechnol 25:1051-6. 2007

Collaborators

Detail Information

Publications14

  1. doi request reprint Protein evolution: innovative chaps
    D Allan Drummond
    FAS Center for Systems Biology Northwest Building, Rm 431, 52 Oxford St, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 19:R740-2. 2009
    ..Mutations in proteins allow functional innovation, but can be critically destabilizing. Recent work shows how chaperonins can rescue innovative mutants, with implications for protein engineering and adaptive evolution...
  2. pmc Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
    D Allan Drummond
    FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 134:341-52. 2008
    ....
  3. pmc Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
    Kerry A Geiler-Samerotte
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:680-5. 2011
    ....
  4. pmc The evolutionary consequences of erroneous protein synthesis
    D Allan Drummond
    FAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Nat Rev Genet 10:715-24. 2009
    ..Evolutionary responses to errors fall into two broad categories: adaptations that minimize errors and their attendant costs and adaptations that exploit errors for the organism's benefit...
  5. pmc Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme
    Deepa Agashe
    Department of Organismic and Evolutionary Biology, Biological Laboratories, Harvard University, MA, USA
    Mol Biol Evol 30:549-60. 2013
    ..Together, our data support the idea that, although a particular set of codons are favored on average across a genome, in an individual gene selection can either act for or against codons depending on their local context...
  6. pmc Why highly expressed proteins evolve slowly
    D Allan Drummond
    Program in Computation and Neural Systems and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 4100, USA
    Proc Natl Acad Sci U S A 102:14338-43. 2005
    ..Our results suggest that proteins evolve at rates largely unrelated to their functions and can explain why highly expressed proteins evolve slowly across the tree of life...
  7. pmc Population genetics of translational robustness
    Claus O Wilke
    Section of Integrative Biology and Center for Computational Biology and Bioinformatics, University of Texas, Austin 78712, USA
    Genetics 173:473-81. 2006
    ..Here, we study a simple theoretical model of translational robustness that allows us to gain analytic insight into how this paradoxical behavior arises...
  8. ncbi request reprint Structural determinants of the rate of protein evolution in yeast
    Jesse D Bloom
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA
    Mol Biol Evol 23:1751-61. 2006
    ..Our results provide evidence that protein structure plays an important role in shaping the rate of sequence evolution and provide evidence to support recent theoretical advances linking structural designability to contact density...
  9. doi request reprint Contact density affects protein evolutionary rate from bacteria to animals
    Tong Zhou
    Center for Computational Biology and Bioinformatics, Section of Integrative Biology, University of Texas at Austin, Austin, TX 78731, USA
    J Mol Evol 66:395-404. 2008
    ..Our study provides evidence that contact density can increase evolutionary rates, and that it acts similarly on the level of entire proteins and of individual protein domains...
  10. ncbi request reprint A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
    Yougen Li
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Biotechnol 25:1051-6. 2007
    ..Among the novel functions they exhibit is the ability to produce drug metabolites. This chimeric P450 family provides a unique ensemble for biotechnological applications and for studying sequence-stability-function relationships...
  11. ncbi request reprint A single determinant dominates the rate of yeast protein evolution
    D Allan Drummond
    Program in Computation and Neural Systems, California Institute of Technology, Pasadena, USA
    Mol Biol Evol 23:327-37. 2006
    ..Our results support the hypothesis that translational selection governs the rate of synonymous and protein sequence evolution in yeast...
  12. pmc Predicting the tolerance of proteins to random amino acid substitution
    Claus O Wilke
    Keck Graduate Institute of Applied Life Sciences, Claremont, California, USA
    Biophys J 89:3714-20. 2005
    ..We test the accuracy of all approximations against our simulation results, and find good overall agreement between the approximations and the simulation measurements...
  13. pmc On the conservative nature of intragenic recombination
    D Allan Drummond
    Program in Computation and Neural Systems, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 102:5380-5. 2005
    ....
  14. pmc Thermodynamic prediction of protein neutrality
    Jesse D Bloom
    Division of Chemistry and Chemical Engineering 210 41, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 102:606-11. 2005
    ..Our work unifies observations about the clustering of functional proteins in sequence space, and provides a basis for interpreting the response of proteins to substitutions in protein engineering applications...