Research Topics
Genomes and GenesSpecies | W DrieverSummaryAffiliation: Harvard University Country: USA Publications
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Publications
A genetic screen for mutations affecting embryogenesis in zebrafishW Driever
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:37-46. 1996..This screen demonstrates that mutations affecting a variety of developmental processes can be efficiently recovered from zebrafish...- Mutations affecting development of the zebrafish retinaJ Malicki
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:263-73. 1996.... - Mutations affecting development of the notochord in zebrafishD L Stemple
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:117-28. 1996.... - Mutations affecting development of the zebrafish earJ Malicki
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:275-83. 1996..Analysis of mutations presented here will strengthen our understanding of vertebrate ear morphogenesis and provide novel entry points to its genetic analysis... - The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tailA F Schier
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
Development 124:327-42. 1997..These results reveal a redundant function of oep and ntl in mesoderm formation. Our data suggest that both oep and ntl act in the blastoderm margin to specify mesendodermal cell fates... - Mutations affecting the development of the embryonic zebrafish brainA F Schier
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:165-78. 1996..The identified loci establish the genetic foundation for a further analysis of the development of the zebrafish embryonic brain... - Early development of the zebrafish pronephros and analysis of mutations affecting pronephric functionI A Drummond
Renal Unit, Massachusetts General Hospital, Charlestown MA 02129, USA
Development 125:4655-67. 1998..These studies reveal the similarity of normal pronephric development to kidney organogenesis in all vertebrates and allow for a genetic dissection of genes needed to establish the earliest renal function... - Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafishL Solnica-Krezel
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:67-80. 1996..These mutations provide an approach to understanding the genetic control of gastrulation in vertebrates... - Mutations affecting neural survival in the zebrafish Danio rerioS Abdelilah
Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
Development 123:217-27. 1996..The mutations presented here might provide a genetic framework to aid in the understanding of the etiology of degenerative and physiological disorders within the CNS and the activation of inappropriate programmed cell death... - Zebrafish narrowminded suggests a genetic link between formation of neural crest and primary sensory neuronsK B Artinger
Cardiovascular Research Center, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
Development 126:3969-79. 1999..We discuss the implications of these findings for the possibility that RB sensory neurons and neural crest cells share a common evolutionary origin... - Mutations affecting development of zebrafish digestive organsM Pack
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:321-8. 1996..These gastrointestinal mutations may be informative with regard to patterning and crucial lineage decisions during organogenesis, and may be relevant to diabetes, congenital dysmorphogenesis and disorders of cell proliferation... - Pattern formation in janus-mutant zebrafish embryosS Abdelilah
Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
Dev Biol 184:70-84. 1997..As assessed by the presence of the most ventral cell type, blood, ventral specification within a dorsal half-blastoderm is not suppressed... - Hematopoietic mutations in the zebrafishB M Weinstein
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:303-9. 1996..Some cause defects in precursor generation, others defects in differentiation, and others an increase in cellular photosensitivity... - Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryoD Y Stainier
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:285-92. 1996..The mutations identified in this screen point to discrete and critical steps in the formation and function of the heart and vasculature... - A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphismsE W Knapik
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Development 123:451-60. 1996.... - oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheetJ Malicki
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Bldg 149, Charlestown, MA 02129, USA
Development 126:1235-46. 1999..These cell-cell interactions may play a critical role in the patterning events that lead to differentiation of distinct neuronal laminae in the vertebrate retina... - Gridlock, a localized heritable vascular patterning defect in the zebrafishB M Weinstein
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Nat Med 1:1143-7. 1995..The grl defect resembles coarctation of the aorta, a human congenital cardiovascular malformation of unknown aetiology, in the location of the lesion and its consequences and in the mutants' dependence on collateral vessels for survival... - A microsatellite genetic linkage map for zebrafish (Danio rerio)E W Knapik
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
Nat Genet 18:338-43. 1998..These markers will provide an initial infrastructure for the positional cloning of the nearly 600 zebrafish genes identified as crucial to vertebrate development,and will become the anchor for the physical map of the zebrafish genome... - Implications for dorsoventral axis determination from the zebrafish mutation janusS Abdelilah
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129
Nature 370:468-71. 1994..These findings support the notion that the establishment of the dorsoventral axis and the first cleavage planes are determined by separate mechanisms in the zebrafish embryo... - Green fluorescent protein marks skeletal muscle in murine cell lines and zebrafishJ B Moss
Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown 02129, USA
Gene 173:89-98. 1996..Transgenic fish continued to express high levels of gfp in skeletal muscle at 1.5 months, demonstrating that GFP is an effective marker of muscle cells in vivo... - Axis-inducing activities and cell fates of the zebrafish organizerL Saude
Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Development 127:3407-17. 2000..We conclude that the deep tissue included in our transplants is important for proper head formation... - Homeodomain position 54 specifies transcriptional versus translational control by BicoidD Niessing
Abteilung Molekulare Entwicklungsbiologie, Max Planck Institute für biopsysikalische Chemie, Gottingen, Germany
Mol Cell 5:395-401. 2000..Replacement of arginine 54, within this motif, alters the RNA but not the DNA binding properties of the HD. Corresponding BCD mutants fail to repress cad mRNA translation, whereas the transcriptional target genes are still activated... - Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neuronsS Guo
Department of Neuroscience, Genentech, Inc, 1 DNA Way, South San Francisco, California, 94080, USA
Dev Biol 208:473-87. 1999..They further reveal an underlying universal mechanism for the control of CA cell fates, which involve combinatorial usage of regulatory genes... - The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formationH M Pogoda
Abteilung für Entwicklungsbiologie, Biologie I, Universitat Freiburg, Hauptstrasse1, D 79104 Freiburg, Germany
Curr Biol 10:1041-9. 2000..The forkhead transcription factor FoxH1 (also known as Fast1) is a component of the Nodal signaling pathway. Although different roles have been suggested for FoxH1, its specific function during development is still unclear... - The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structuresK Fekany
Department of Molecular Biology, Vanderbilt University, Box 1820, Station B, Nashville, TN 37235, USA
Development 126:1427-38. 1999.... - Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafishF Marlow
Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
Dev Biol 203:382-99. 1998..Furthermore, tri and kny have overlapping functions in establishing proper alignment of the anterior neural plate and midline cells expressing shh and twhh genes when the partitioning of the eye primordium takes place... - spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizerH G Belting
, , Hauptstrasse 1, D-79104 Freiburg, Germany
Development 128:4165-76. 2001..Thus, expression of pou2 does not depend on fgf8 and pax2.1. Our data suggest that pou2 is required for the establishment of the normal expression domains of wnt1 and pax2.1 in the MHB primordium... - Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryoJ Holzschuh
Department of Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104, Freiburg, Germany
Mech Dev 101:237-43. 2001..Neurons expressing th but not dat are adrenergic or noradrenergic, and are found in the locus coeruleus, the medulla, the likely analog of the carotid body, and precursors of the enteric and sympathetic nervous system... - Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive isletF Biemar
Institut für Biologie I, Abt Entwicklungsbiologie, Universitat Freiburg, Hauptstrasse 1, Freiburg, D 79104, Germany
Dev Biol 230:189-203. 2001..We discuss our findings on zebrafish pancreatogenesis in the light of evolution of the pancreas in chordates... - Cloning and expression of the TALE superclass homeobox Meis2 gene during zebrafish embryonic developmentF Biemar
, Institut de Chimie, , , B-4000 (Sart Tilman, Liege, Belgium
Mech Dev 109:427-31. 2001..Expression was also detected in the isthmus, along the spinal cord and in the lateral mesoderm. As development proceeds, meis2 is also expressed in the developing retina, pharyngeal arches, and in the vicinity of the gut tube... - The role of the homeodomain protein Bozozok in zebrafish axis formationL Solnica-Krezel
Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
Int J Dev Biol 45:299-310. 2001..Notably, Bozozok appears to function by repressing transcription of target genes such as swr (bmp2b) gene, and as such is the earliest acting repressor that the nascent dorsal axis is using to antagonize ventral influences... - Rescue of bicoid mutant Drosophila embryos by bicoid fusion proteins containing heterologous activating sequencesW Driever
Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, FRG
Nature 342:149-54. 1989.... - The bicoid protein determines position in the Drosophila embryo in a concentration-dependent mannerW Driever
Max Planck Institut für Entwicklungsbiologie Abteilung III Genetik, Tubingen, Federal Republic of Germany
Cell 54:95-104. 1988..The bcd protein thus has the properties of a morphogen that autonomously determines positions in the anterior half of the embryo... - A gradient of bicoid protein in Drosophila embryosW Driever
Max Planck Institut fur Entwicklungsbiologie, Abteilung III Genetik, Tubingen, Federal Republic of Germany
Cell 54:83-93. 1988..The gradient is probably generated by diffusion from the local mRNA source and dispersed degradation... - The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryoW Driever
Max Planck Institut fur Entwicklungsbiologie, Abteilung III Genetik, Tubingen, FRG
Nature 337:138-43. 1989..By binding upstream of the segmentation gene hunchback the bicoid protein controls its transcription, thereby translating maternal pattern-generating information into differential activation of zygotic gene expression... - Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafishE Zecchin
Dipartimento di Biologia, Universita di Padova, Via U Bassi 58 B, 35131 Padova, Italy
Dev Biol 301:192-204. 2007....