A E Doyle

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Familial links between attention deficit hyperactivity disorder, conduct disorder, and bipolar disorder
    Alysa E Doyle
    Massachusetts General Hospital, 15 Parkman Street, ACC 725, Boston, MA 02114, USA
    Curr Psychiatry Rep 4:146-52. 2002
  2. ncbi request reprint Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neuropsychol 27:79-105. 2005
  3. ncbi request reprint Executive functions in attention-deficit/hyperactivity disorder
    Alysa E Doyle
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:21-6. 2006
  4. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
  5. pmc Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
    Sherif Karama
    Department of Psychiatry, McGill University, Montreal, Canada
    BMC Psychiatry 8:45. 2008
  6. ncbi request reprint Diagnostic efficiency of neuropsychological test scores for discriminating boys with and without attention deficit-hyperactivity disorder
    A E Doyle
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 68:477-88. 2000
  7. ncbi request reprint Neuropsychological functioning in relatives of girls with and without ADHD
    Alysa E Doyle
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1121-32. 2005
  8. ncbi request reprint Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?
    Alysa E Doyle
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Child Psychol Psychiatry 46:774-803. 2005
  9. ncbi request reprint Attention-deficit/hyperactivity disorder endophenotypes
    Alysa E Doyle
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 57:1324-35. 2005
  10. pmc Neurocognitive impairment in unaffected siblings of youth with bipolar disorder
    A E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Child Psychiatry Service, 55 Fruit Street, Boston, MA 02114, USA
    Psychol Med 39:1253-63. 2009

Detail Information

Publications50

  1. ncbi request reprint Familial links between attention deficit hyperactivity disorder, conduct disorder, and bipolar disorder
    Alysa E Doyle
    Massachusetts General Hospital, 15 Parkman Street, ACC 725, Boston, MA 02114, USA
    Curr Psychiatry Rep 4:146-52. 2002
    ..The current article reviews evidence suggesting that parsing ADHD subjects based on comorbidity with conduct and bipolar disorders may yield familial subtypes that are suitable for genetic analyses...
  2. ncbi request reprint Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neuropsychol 27:79-105. 2005
    ..These findings suggest that executive dysfunctions are correlates of ADHD regardless of gender and age, at least through the late teen years...
  3. ncbi request reprint Executive functions in attention-deficit/hyperactivity disorder
    Alysa E Doyle
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:21-6. 2006
    ..To examine the association between weaknesses in executive functions and attention-deficit/hyperactivity disorder (ADHD)...
  4. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
    ..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
  5. pmc Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
    Sherif Karama
    Department of Psychiatry, McGill University, Montreal, Canada
    BMC Psychiatry 8:45. 2008
    ..Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder...
  6. ncbi request reprint Diagnostic efficiency of neuropsychological test scores for discriminating boys with and without attention deficit-hyperactivity disorder
    A E Doyle
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 68:477-88. 2000
    ..The prognostic implications of variable neuropsychological deficits in children with ADHD require further investigation...
  7. ncbi request reprint Neuropsychological functioning in relatives of girls with and without ADHD
    Alysa E Doyle
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1121-32. 2005
    ..A limited number of studies have examined neuropsychological functioning in the family members of ADHD youth, and none have focused exclusively on relatives of females...
  8. ncbi request reprint Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?
    Alysa E Doyle
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Child Psychol Psychiatry 46:774-803. 2005
    ..Thus far, potential endophenotypes for ADHD have not been systematically studied...
  9. ncbi request reprint Attention-deficit/hyperactivity disorder endophenotypes
    Alysa E Doyle
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 57:1324-35. 2005
    ..We conclude that these endophenotypes will not be a quick fix for the field but offer potential if careful consideration is given to issues of heterogeneity, measurement and statistical power...
  10. pmc Neurocognitive impairment in unaffected siblings of youth with bipolar disorder
    A E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Child Psychiatry Service, 55 Fruit Street, Boston, MA 02114, USA
    Psychol Med 39:1253-63. 2009
    ..The current study investigated whether these neurocognitive impairments index the familial risk underlying the diagnosis...
  11. ncbi request reprint Neuropsychological functioning in youth with bipolar disorder
    Alysa E Doyle
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 58:540-8. 2005
    ..We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD...
  12. ncbi request reprint Further evidence of association between two NET single-nucleotide polymorphisms with ADHD
    J W Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Psychiatry 13:624-30. 2008
    ..This is the first time that identical alleles of NET from different studies were implicated, and thus our report provides further evidence that the NET gene is involved in the etiology of ADHD...
  13. ncbi request reprint Learning disabilities and executive dysfunction in boys with attention-deficit/hyperactivity disorder
    L J Seidman
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    Neuropsychology 15:544-56. 2001
    ..These data indicate that comorbid LD, especially arithmetic disability, significantly increases the severity of executive function impairment in ADHD...
  14. ncbi request reprint Stability of executive function deficits into young adult years: a prospective longitudinal follow-up study of grown up males with ADHD
    J Biederman
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Acta Psychiatr Scand 116:129-36. 2007
    ..Although individuals with attention deficit-hyperactivity disorder (ADHD) commonly exhibit deficits in executive functions that greatly increase the morbidity of the disorder, all available information on the subject is cross sectional...
  15. ncbi request reprint Separating attention deficit hyperactivity disorder and learning disabilities in girls: a familial risk analysis
    A E Doyle
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 158:1666-72. 2001
    ....
  16. ncbi request reprint Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder
    J W Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:781-90. 2007
    ..We further suggest that co-morbidity with MDD may enhance detection of the association between SNAP-25 and ADHD...
  17. ncbi request reprint A family study of psychiatric comorbidity in girls and boys with attention-deficit/hyperactivity disorder
    S V Faraone
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
    Biol Psychiatry 50:586-92. 2001
    ..Although this is consistent with prior work suggesting more similarities than differences in the nature of psychiatric comorbidity in ADHD boys and girls, we cannot make strong conclusions, owing to the possibility of cohort effects...
  18. ncbi request reprint Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder
    J Lasky-Su
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Ann Hum Genet 71:648-59. 2007
    ..Although definitive conclusions await independent replication, these results suggest that a variant in DRD5 may affect age at onset for ADHD...
  19. ncbi request reprint Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1150-6. 2008
    ..The main goal of this study was to evaluate the impact of stimulant medication on executive function deficits in a group of adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD; DSM-III-R criteria)...
  20. pmc Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
    ..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies...
  21. ncbi request reprint Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder
    S V Faraone
    Pediatric Psychopharmacology Unit, Child Psychiatric Services, Massachusetts General Hospital, Boston 02114, USA
    Am J Psychiatry 158:1052-7. 2001
    ..Although several studies have shown an association between ADHD and the 7-repeat allele of the dopamine D(4) receptor gene (DRD4), several studies have not. Thus, the status of the ADHD-DRD4 association is uncertain...
  22. ncbi request reprint Long-term stability of the Child Behavior Checklist in a clinical sample of youth with attention deficit hyperactivity disorder
    J Biederman
    Harvard Medical School, Massachusetts General Hospital and McLean Hospital, Boston, MA, USA
    J Clin Child Psychol 30:492-502. 2001
    ..These results support the informativeness of the CBCL as a useful measure of longitudinal course in clinical samples of youth with ADHD...
  23. doi request reprint A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008
    ..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology...
  24. doi request reprint Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms
    Michael C Monuteaux
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 48:757-64. 2009
    ..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD...
  25. ncbi request reprint Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter gene
    Jessica Lasky-Su
    Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, and Pediatric psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    Addict Behav 31:1088-99. 2006
    ..To determine whether SNPs within the dopamine transporter gene (DAT) are associated with quantitative phenotypes generated from drug frequency variables in an ADHD sample...
  26. pmc Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
    ..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD...
  27. ncbi request reprint Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
    Am J Psychiatry 163:1730-8. 2006
    ..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)...
  28. pmc Are cognitive deficits in attention deficit/hyperactivity disorder related to the course of the disorder? A prospective controlled follow-up study of grown up boys with persistent and remitting course
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology, Boston, MA, USA
    Psychiatry Res 170:177-82. 2009
    ..More work is needed to help define the implications of these deficits in individuals with a remitting course of ADHD...
  29. ncbi request reprint Educational and occupational underattainment in adults with attention-deficit/hyperactivity disorder: a controlled study
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1217-22. 2008
    ..This study evaluated subjects to determine whether the educational and occupational deficits associated with ADHD are what would be expected given their intellectual abilities or lower than expected given their intellectual abilities...
  30. ncbi request reprint Can bipolar disorder-specific neuropsychological impairments in children be identified?
    Aude Henin
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Consult Clin Psychol 75:210-20. 2007
    ..Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder...
  31. ncbi request reprint Genetic influences on attention deficit hyperactivity disorder
    S V Faraone
    Harvard Institute of Psychiatry, Epidemiology, and Genetics, Department of Psychiatry, Massachusetts Hospital Center, Harvard University, 750 Washington Street, Suite 255, South Easton, MA 02375, USA
    Curr Psychiatry Rep 2:143-6. 2000
    ..In addition, because ADHD appears to be genetically heterogeneous, more work is needed to delineate genetically homogeneous subtypes and describe the range of expression of their underlying genotypes...
  32. ncbi request reprint The nature and heritability of attention-deficit/hyperactivity disorder
    S V Faraone
    Clinical and Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, USA
    Child Adolesc Psychiatr Clin N Am 10:299-316, viii-ix. 2001
    ..Moreover, the effectiveness of stimulants, along with animal models of hyperactivity, point to catecholamine dysregulation as at least one source of ADHD brain dysfunction...
  33. ncbi request reprint Diagnostic threshold for conduct disorder in girls and boys
    Alysa E Doyle
    Clinical and Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, ACC 725, 15 Parkman Street, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 191:379-86. 2003
    ..The current results support the possibility that differential rates of CD reflect actual differences in rates of antisocial behavior across gender...
  34. ncbi request reprint Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 59:460-7. 2006
    ..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported...
  35. pmc Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder
    Ariel B Brown
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010
    ..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
  36. doi request reprint Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescence
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Dev Neuropsychol 33:44-61. 2008
    ..These findings document the stability of EFDs in girls with ADHD from childhood into adolescence...
  37. ncbi request reprint Discordance between psychometric testing and questionnaire-based definitions of executive function deficits in individuals with ADHD
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Boston, MA 02114, USA
    J Atten Disord 12:92-102. 2008
    ....
  38. ncbi request reprint Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in children
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Consult Clin Psychol 72:757-66. 2004
    ..Children and adolescents with ADHD and EFDs were found to be at high risk for significant impairments in academic functioning. These results support screening children with ADHD for EFDs to prevent academic failure...
  39. ncbi request reprint Neuropsychological functioning in girls with attention-deficit/hyperactivity disorder with and without learning disabilities
    Larry J Seidman
    Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropsychology 20:166-77. 2006
    ..These results extend to females the previously documented association of LDs with neuropsychological functioning in males with ADHD...
  40. pmc Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21
    Alysa E Doyle
    Psychiatric and Neurodevelopmental Genetics Unit, Harvard Medical School, Center for Human Genetics Research at Massachusetts General Hospital, Boston MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 49:378-87. 2010
    ....
  41. ncbi request reprint Investigation of parent-of-origin effects in ADHD candidate genes
    Jang Woo Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:776-80. 2007
    ..Thus, we conclude that a substantial parent-of-origin effect is unlikely for these leading ADHD candidate genes...
  42. ncbi request reprint Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHD
    Joseph Biederman
    Pediatric Psychopharmacology and Adult ADHD Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:240-6. 2007
    ..Scores on the CBS above the 50th percentile identify adults with ADHD at significantly higher risk for functional morbidity beyond that conferred by the diagnosis of ADHD alone...
  43. pmc Utility of an abbreviated questionnaire to identify individuals with ADHD at risk for functional impairments
    Joseph Biederman
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Res 42:304-10. 2008
    ....
  44. doi request reprint Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13
    Alysa E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1399-411. 2008
    ..Overall, these data support the utility of neurocognitive traits as ADHD endophenotypes, but also highlight their limited genetic overlap with the disorder...
  45. ncbi request reprint New developments in the treatment of ADHD
    Joseph Biederman
    Dept of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 67:148-59. 2006
  46. ncbi request reprint Association between DRD4 gene and performance of children with ADHD in a test of sustained attention
    Christian Kieling
    Department of Psychiatry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre 90035 003, RS, Brazil
    Biol Psychiatry 60:1163-5. 2006
    ..The adoption of neuropsychological tests as endophenotypic measures can provide an increased sensitivity to specific dimensions of attention-deficit/hyperactivity disorder (ADHD)...
  47. ncbi request reprint Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Psychiatry 57:1336-46. 2005
    ..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...
  48. ncbi request reprint Molecular genetics of attention-deficit/hyperactivity disorder
    Stephen V Faraone
    Medical Genetics Research Center and Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Biol Psychiatry 57:1313-23. 2005
    ....
  49. ncbi request reprint Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals
    Jessica Lasky-Su
    Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 147:100-6. 2008
    ..This analysis adds to previous findings by suggesting that variants at these loci may be specifically associated with inattentive symptoms...
  50. ncbi request reprint Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes?
    Joel T Nigg
    Department of Psychology, Michigan State University, East Lansing, Michigan 48824, USA
    Biol Psychiatry 57:1224-30. 2005
    ....