Research Topics
Species | D M DorfmanSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The leukocyte semaphorin CD100 is expressed in most T-cell, but few B-cell, non-Hodgkin's lymphomasD M Dorfman
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 153:255-62. 1998..Absence of expression of CD100 by neoplastic follicular center B cells is a common feature in follicular lymphomas, but expression of CD100 by T cells is maintained in T-cell lymphoproliferative disorders...
Immunohistochemical staining for bcl-2 and mcl-1 in intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE) and cervical thymic carcinomaD M Dorfman
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Mod Pathol 11:989-94. 1998..We conclude that dual immunoreactivity for bcl-2 and mcl-1 is a feature of malignant neoplasms with thymic differentiation in general, both within the thymus and at ectopic sites...
Treatment of established tumor is associated with ICAM-1 upregulation and reversed by CD8 depletion in a tumor necrosis factor-alpha gene transfected mouse mammary tumorY L Matory
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Pathobiology 67:186-95. 1999..In vivo (Balb/c mice) tumor growth inhibition, treatment of established tumor and the effects of ICAM-1 and CD4+ and CD8+ T cells were evaluated...
Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasmsM W Datta
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Appl Immunohistochem Mol Morphol 8:210-5. 2000..Based on these findings, CD74 and MHC class II are useful markers for the classification of thymic epithelial neoplasms...
Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiationK T Hall
Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 93:11780-5. 1996..Thus, these results suggest that semaphorins as exemplified by CD100 also play a functional role in the immune system...
The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemiaD Jones
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Blood 95:627-32. 2000..Coexpression of CXCR3 and its ligand, Mig, may be an important functional interaction in B-CLL, as well as a useful diagnostic marker for the differential diagnosis of small cell lymphomas. (Blood. 2000;95:627-632)..
T cells mediate treatment of six-day-old cytokine-gene-transfected mouse mammary tumorY L Matory
Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Pathobiology 67:3-11. 1999..Tumor infiltrating lymphocytes or cells from draining lymph nodes demonstrated tumor-specific in vitro cytotoxicity. Immunohistochemical studies revealed T cell infiltrates in transfected tumors...
Inflammatory pseudotumor of lymph node and spleen: an entity biologically distinct from inflammatory myofibroblastic tumorJ L Kutok
Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA
Hum Pathol 32:1382-7. 2001..The absence of ALK kinase as detected by immunohistochemical studies in IPT of the lymph node and spleen suggests that this entity is biologically distinct from the histologically similar IMT...
Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cellsD M Dorfman
Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115
J Biol Chem 267:1279-85. 1992..We propose that GATA-2 is the GATA-binding protein required for PPET-1 gene expression in endothelial cells...
