Michael W Donnino

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, W CC 2, MA, 02215, USA Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA
    BMJ 348:g3028. 2014
  2. pmc APACHE II scoring to predict outcome in post-cardiac arrest
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Resuscitation 84:651-6. 2013
  3. pmc Performance of SAPS II and SAPS III scores in post-cardiac arrest
    J D Salciccioli
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Minerva Anestesiol 78:1341-7. 2012
  4. pmc A pilot study examining the severity and outcome of the post-cardiac arrest syndrome: a comparative analysis of two geographically distinct hospitals
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 126:1478-83. 2012
  5. pmc Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects
    Howard A Smithline
    Department of Emergency Medicine, Tufts University School of Medicine and Baystate Medical Center, Springfield, MA, USA
    BMC Clin Pharmacol 12:4. 2012
  6. doi request reprint The development and implementation of cardiac arrest centers
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, WCC2, Boston, MA 02215, United States
    Resuscitation 82:974-8. 2011
  7. doi request reprint Statin therapy is associated with decreased mortality in patients with infection
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Acad Emerg Med 16:230-4. 2009
  8. pmc Coronary artery bypass graft surgery depletes plasma thiamine levels
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nutrition 26:133-6. 2010
  9. doi request reprint Thiamine deficiency in critically ill patients with sepsis
    Michael W Donnino
    Department of Emergency Medicine and Internal Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Crit Care 25:576-81. 2010
  10. pmc Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, West Clinical Center 2, Boston, MA 02215, USA
    Crit Care 15:R189. 2011

Collaborators

Detail Information

Publications44

  1. pmc Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, W CC 2, MA, 02215, USA Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA
    BMJ 348:g3028. 2014
    ..To determine if earlier administration of epinephrine (adrenaline) in patients with non-shockable cardiac arrest rhythms is associated with increased return of spontaneous circulation, survival, and neurologically intact survival...
  2. pmc APACHE II scoring to predict outcome in post-cardiac arrest
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Resuscitation 84:651-6. 2013
    ..The goal of the current investigation was to assess the Acute Physiology and Chronic Health Evaluation II score in post-cardiac arrest...
  3. pmc Performance of SAPS II and SAPS III scores in post-cardiac arrest
    J D Salciccioli
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Minerva Anestesiol 78:1341-7. 2012
    ..Our objective was to determine if SAPS II and SAPS III scores predict outcomes in post-cardiac arrest patients...
  4. pmc A pilot study examining the severity and outcome of the post-cardiac arrest syndrome: a comparative analysis of two geographically distinct hospitals
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 126:1478-83. 2012
    ..We tested whether hospital-independent factors would account for the difference in outcome between 2 geographically distinct hospitals...
  5. pmc Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects
    Howard A Smithline
    Department of Emergency Medicine, Tufts University School of Medicine and Baystate Medical Center, Springfield, MA, USA
    BMC Clin Pharmacol 12:4. 2012
    ..The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects...
  6. doi request reprint The development and implementation of cardiac arrest centers
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, WCC2, Boston, MA 02215, United States
    Resuscitation 82:974-8. 2011
    ..This paper may assist other potential clinical sites that are considering or actively developing cardiac arrest centers of their own...
  7. doi request reprint Statin therapy is associated with decreased mortality in patients with infection
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Acad Emerg Med 16:230-4. 2009
    ..The objective was to investigate the association between statin therapy and mortality in emergency department (ED) patients with suspected infection...
  8. pmc Coronary artery bypass graft surgery depletes plasma thiamine levels
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nutrition 26:133-6. 2010
    ..The stress of surgery and critical disease depletes electrolytes, minerals, and essential biochemical substrates. We hypothesized that critical illness (represented by major surgery) would result in decreased thiamine levels over time...
  9. doi request reprint Thiamine deficiency in critically ill patients with sepsis
    Michael W Donnino
    Department of Emergency Medicine and Internal Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Crit Care 25:576-81. 2010
    ..The objective of the study was to determine the prevalence of absolute thiamine deficiency (TD) in critically ill patients with sepsis and to examine the association between thiamine levels and lactic acidosis...
  10. pmc Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, West Clinical Center 2, Boston, MA 02215, USA
    Crit Care 15:R189. 2011
    ..Moreover, statin therapy may decrease CoQ10 levels, but whether this occurs acutely remains unknown. We measured CoQ10 levels in septic shock patients enrolled in a randomized trial of simvastatin versus placebo...
  11. ncbi request reprint Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Emerg Med 50:715-21. 2007
    ..Further, physician knowledge of this disease is vital because the failure to diagnose results in severe neurologic morbidity and possible mortality, but the treatment is safe and effective...
  12. ncbi request reprint Inadequate blood volume collected for culture: a survey of health care professionals
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Hospital, One Deaconess Road, Boston, MA 02215, USA
    Mayo Clin Proc 82:1069-72. 2007
    ..Because volume remains the most important determinant for the optimal yield of organisms, these findings raise an important quality assurance issue...
  13. ncbi request reprint Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients
    Michael W Donnino
    Beth Israel Deaconess Medical Center, Department of Emergency Medicine, One Deaconess Road, CC2 Boston, MA, United States
    Resuscitation 75:229-34. 2007
    ..We investigated whether early, high lactate clearance was associated with reduced mortality in post-cardiac arrest patients...
  14. ncbi request reprint Distinctive acid-base pattern in Wernicke's encephalopathy
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Emerg Med 50:722-5. 2007
    ..Observation of this acid-base disturbance should prompt clinicians to consider thiamine deficiency disorders as a possible cause...
  15. ncbi request reprint Determining disease severity in severe sepsis and septic shock
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Road, West CC2, Boston, MA 02215, USA
    Intern Emerg Med 1:219-20. 2006
  16. pmc Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients
    Michael N Cocchi
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States
    Resuscitation 83:991-5. 2012
    ..Therapeutic options are limited. Previous data suggest a benefit of coenzyme Q(10) (CoQ(10)) in post-arrest patients. We hypothesized that plasma CoQ(10) levels would be low after CA and associated with poorer outcomes...
  17. ncbi request reprint Performance of severity of illness scoring systems in emergency department patients with infection
    Michael D Howell
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 14:709-14. 2007
    ....
  18. ncbi request reprint The rapid shallow breathing index as a predictor of failure of noninvasive ventilation for patients with acute respiratory failure
    Katherine M Berg
    Department of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215 USA
    Respir Care 57:1548-54. 2012
    ..The rapid shallow breathing index (RSBI) is a validated tool for predicting readiness for extubation. We evaluated the ability of the RSBI to predict failure of NIV and mortality in ARF...
  19. pmc Etiology and therapeutic approach to elevated lactate levels
    Lars W Andersen
    Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    Mayo Clin Proc 88:1127-40. 2013
    ..The review ends with some general recommendations on the management of patients with elevated lactate levels. ..
  20. doi request reprint Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients
    David W Callaway
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Trauma 66:1040-4. 2009
    ..No study has defined the role of these markers in the triage and management of the normotensive injured elderly patient...
  21. doi request reprint International validation of the out-of-hospital cardiac arrest score in the United States
    Sabina Hunziker
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Crit Care Med 39:1670-4. 2011
    ..The aim of this study is to externally validate this score in an independent patient population in the United States...
  22. pmc Prevalence and significance of lactic acidosis in diabetic ketoacidosis
    Kristin Cox
    Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA 02215, USA
    J Crit Care 27:132-7. 2012
    ..The objective of this study was to determine the prevalence of lactic acidosis in DKA and its association with intensive care unit (ICU) length of stay (LOS) and mortality...
  23. pmc Prevalence and characteristics of nonlactate and lactate expressors in septic shock
    Andrea Freyer Dugas
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Crit Care 27:344-50. 2012
    ..The study's objective was to determine the proportion and patient characteristics of patients in vasopressor-dependent septic shock who presented without lactatemia...
  24. doi request reprint Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection
    Todd A Seigel
    Department of Emergency Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Emerg Med 42:254-9. 2012
    ..The presence of systemic inflammatory response criteria aids in recognition of infection, although the reliability of these markers is variable...
  25. ncbi request reprint Initial lactate and lactate change in post-cardiac arrest: a multicenter validation study*
    Michael W Donnino
    1Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 2Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 3Research Center for Emergency Medicine, Aarhus University, Aarhus, Denmark 4Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 5Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA 6Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 7Department of Anesthesia Critical Care, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
    Crit Care Med 42:1804-11. 2014
    ..This association has not been validated in a prospective multicenter study. The objective of the current study was to determine the association between percent lactate change and outcomes in post-cardiac arrest patients...
  26. pmc Continuous neuromuscular blockade is associated with decreased mortality in post-cardiac arrest patients
    Justin D Salciccioli
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States
    Resuscitation 84:1728-33. 2013
    ..Our objective was to determine whether neuromuscular blockade is associated with improved outcomes after out-of-hospital cardiac arrest...
  27. pmc Sublingual microcirculation is impaired in post-cardiac arrest patients
    Yasser G Omar
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States
    Resuscitation 84:1717-22. 2013
    ..We also assessed the association between microcirculatory dysfunction and inflammatory markers in the post-cardiac arrest state...
  28. doi request reprint Predictors of bacteremia in emergency department patients with suspected infection
    Maureen Chase
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Emerg Med 30:1691-7. 2012
    ..The goal of this study is to identify clinical variables associated with bacteremia. Such data could provide a rational basis for blood culture testing in emergency department (ED) patients with suspected infection...
  29. doi request reprint Neurologic recovery after therapeutic hypothermia in patients with post-cardiac arrest myoclonus
    Jason M Lucas
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States
    Resuscitation 83:265-9. 2012
    ..The concept that early myoclonus heralds a uniformly poor prognosis may need to be reconsidered in the era of post-cardiac arrest mild therapeutic hypothermia...
  30. pmc Neurologic outcome in comatose patients resuscitated from out-of-hospital cardiac arrest with prolonged downtime and treated with therapeutic hypothermia
    Won Young Kim
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States Department of Emergency Medicine, Ulsan University College of Medicine, Asan Medical Center, Seoul, Republic of Korea
    Resuscitation 85:1042-6. 2014
    ..The aim of this study was to determine the rate of good neurologic outcome based on the duration of resuscitation efforts in OHCA patients treated with TH...
  31. ncbi request reprint The utility of head computed tomography in the emergency department evaluation of syncope
    Nikhil Goyal
    Department of Emergency Medicine, Henry Ford Hospital, 2799 W Grand Blvd, CFP 2, Detroit, MI 48226, USA
    Intern Emerg Med 1:148-50. 2006
    ..We undertook the following investigation to determine whether HCT aids in the diagnostic investigation of syncope...
  32. ncbi request reprint Relative adrenal insufficiency in post-cardiac arrest shock is under-recognized
    Joseph B Miller
    Henry Ford Hospital, Department of Emergency Medicine, 2799 West Grand Boulevard, Detroit, MI 48202, United States
    Resuscitation 76:221-5. 2008
    ..We sought to investigate current clinical practice pertaining to the evaluation for relative adrenal insufficiency in post-cardiac arrest shock...
  33. pmc The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis
    Ari Moskowitz
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA Electronic address
    J Crit Care 29:182.e5-8. 2014
    ..In the present study, we hypothesize that thiamine deficiency is associated with elevated lactate in patients with DKA...
  34. doi request reprint ED patients with vertigo: can we identify clinical factors associated with acute stroke?
    Maureen Chase
    Beth Israel Deaconess Medical Center, Department of Emergency Medicine, One Deaconess Road, West, Clinical Center 2, Boston, MA 02215, USA
    Am J Emerg Med 30:587-91. 2012
    ..Misdiagnosis of acute stroke may result in significant morbidity and mortality. Magnetic resonance imaging (MRI) is superior to computer tomography (CT) for diagnosis of acute stroke but is costly with limited availability...
  35. ncbi request reprint The role of cranial computed tomography in the immediate post-cardiac arrest period
    Michael N Cocchi
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Intern Emerg Med 5:533-8. 2010
    ..8% of patients had clinically significant abnormalities identified. The exact role of neuroimaging in this population is still in evolution, and further prospective evaluation is warranted...
  36. ncbi request reprint Prevalence of elevated troponin I in end-stage renal disease patients receiving hemodialysis
    Michael W Donnino
    Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA
    Acad Emerg Med 11:979-81. 2004
    ..The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis...
  37. doi request reprint Cannabinoid hyperemesis: a case series
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Emerg Med 40:e63-6. 2011
    ..Traditionally, cannabinoids have been used recreationally or as antiemetics; however, recent reports suggest that chronic abuse can result in the paradoxical effect of a cyclic vomiting syndrome, termed cannabinoid hyperemesis...
  38. ncbi request reprint Critical care and emergency medicine
    Emanuel P Rivers
    Department of Emergency Medicine, Henry Ford Hospital, Case Western Reserve University, Detroit, Michigan, USA
    Curr Opin Crit Care 8:600-6. 2002
    ....
  39. doi request reprint Rapid rewarming of hypothermic patient using arctic sun device
    Michael N Cocchi
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Intensive Care Med 27:128-30. 2012
    ..Clinicians may wish to consider the use of these devices when attempting to warm patients suffering from severe environmental hypothermia...
  40. ncbi request reprint Identification and resuscitation of the trauma patient in shock
    Michael N Cocchi
    Department of Emergency Medicine, Harvard Affiliated Emergency Medicine Residency, Beth Israel Deaconess Medical Center, One Deaconess Road, West Campus Clinical Center, 2nd Floor, Boston, MA 02215, USA
    Emerg Med Clin North Am 25:623-42, vii. 2007
    ..Resuscitation strategies (delayed resuscitation, damage control resuscitation), end points of resuscitation, and the role of blood products and pro-coagulants for resuscitation are discussed...
  41. doi request reprint Pulmonary embolism presenting as flank pain: a case series
    Michael Amesquita
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Emerg Med 42:e97-100. 2012
    ..The current case series reveals the unexpected and initially unrecognized CT finding of a pulmonary infarct in two patients presenting with flank pain; a third patient presented with flank pain and was also found to have a PE...
  42. ncbi request reprint Sepsis: the changing times
    Nathan I Shapiro
    Crit Care Med 33:2700-1. 2005
  43. ncbi request reprint Central venous-arterial carbon dioxide difference as an indicator of cardiac index
    Joseph Cuschieri
    Department of Surgery, Henry Ford Health Systems, Detroit, MI, USA
    Intensive Care Med 31:818-22. 2005
    ..A central venous pCO(2), which is easier to obtain, may provide similar information. The purpose of this study was to examine the correlation between the central venous-arterial pCO(2) difference and CI...
  44. ncbi request reprint A central venous pressure goal of 8-12 mm Hg for all patients in septic shock
    Michael W Donnino
    Crit Care Med 35:1441. 2007