Research Topics
| Michael W DonninoSummaryAffiliation: Harvard University Country: USA Publications
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Publications
APACHE II scoring to predict outcome in post-cardiac arrestMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States Department of Medicine, Division of Pulmonary Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States Electronic address
Resuscitation 84:651-6. 2013..The goal of the current investigation was to assess the Acute Physiology and Chronic Health Evaluation II score in post-cardiac arrest...
Performance of SAPS II and SAPS III scores in post-cardiac arrestJ D Salciccioli
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Minerva Anestesiol 78:1341-7. 2012..Our objective was to determine if SAPS II and SAPS III scores predict outcomes in post-cardiac arrest patients...
A pilot study examining the severity and outcome of the post-cardiac arrest syndrome: a comparative analysis of two geographically distinct hospitalsMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Circulation 126:1478-83. 2012..We tested whether hospital-independent factors would account for the difference in outcome between 2 geographically distinct hospitals...- Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjectsHoward A Smithline
Department of Emergency Medicine, Tufts University School of Medicine and Baystate Medical Center, Springfield, MA, USA
BMC Clin Pharmacol 12:4. 2012..The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects... - Statin therapy is associated with decreased mortality in patients with infectionMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Acad Emerg Med 16:230-4. 2009..The objective was to investigate the association between statin therapy and mortality in emergency department (ED) patients with suspected infection... - Coronary artery bypass graft surgery depletes plasma thiamine levelsMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Nutrition 26:133-6. 2010..The stress of surgery and critical disease depletes electrolytes, minerals, and essential biochemical substrates. We hypothesized that critical illness (represented by major surgery) would result in decreased thiamine levels over time... - Thiamine deficiency in critically ill patients with sepsisMichael W Donnino
Department of Emergency Medicine and Internal Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Crit Care 25:576-81. 2010..The objective of the study was to determine the prevalence of absolute thiamine deficiency (TD) in critically ill patients with sepsis and to examine the association between thiamine levels and lactic acidosis... - The development and implementation of cardiac arrest centersMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, WCC2, Boston, MA 02215, United States
Resuscitation 82:974-8. 2011..This paper may assist other potential clinical sites that are considering or actively developing cardiac arrest centers of their own... - Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shockMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, One Deaconess Road, West Clinical Center 2, Boston, MA 02215, USA
Crit Care 15:R189. 2011..Moreover, statin therapy may decrease CoQ10 levels, but whether this occurs acutely remains unknown. We measured CoQ10 levels in septic shock patients enrolled in a randomized trial of simvastatin versus placebo... - Inadequate blood volume collected for culture: a survey of health care professionalsMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Hospital, One Deaconess Road, Boston, MA 02215, USA
Mayo Clin Proc 82:1069-72. 2007..Because volume remains the most important determinant for the optimal yield of organisms, these findings raise an important quality assurance issue... - Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should knowMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Ann Emerg Med 50:715-21. 2007..Further, physician knowledge of this disease is vital because the failure to diagnose results in severe neurologic morbidity and possible mortality, but the treatment is safe and effective... - Effective lactate clearance is associated with improved outcome in post-cardiac arrest patientsMichael W Donnino
Beth Israel Deaconess Medical Center, Department of Emergency Medicine, One Deaconess Road, CC2 Boston, MA, United States
Resuscitation 75:229-34. 2007..We investigated whether early, high lactate clearance was associated with reduced mortality in post-cardiac arrest patients... - Distinctive acid-base pattern in Wernicke's encephalopathyMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Ann Emerg Med 50:722-5. 2007..Observation of this acid-base disturbance should prompt clinicians to consider thiamine deficiency disorders as a possible cause... - Determining disease severity in severe sepsis and septic shockMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Road, West CC2, Boston, MA 02215, USA
Intern Emerg Med 1:219-20. 2006 - Performance of severity of illness scoring systems in emergency department patients with infectionMichael D Howell
Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Acad Emerg Med 14:709-14. 2007.... - The rapid shallow breathing index as a predictor of failure of noninvasive ventilation for patients with acute respiratory failureKatherine M Berg
Department of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215 USA
Respir Care 57:1548-54. 2012..The rapid shallow breathing index (RSBI) is a validated tool for predicting readiness for extubation. We evaluated the ability of the RSBI to predict failure of NIV and mortality in ARF... - Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patientsDavid W Callaway
Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Trauma 66:1040-4. 2009..No study has defined the role of these markers in the triage and management of the normotensive injured elderly patient... - Prevalence and characteristics of nonlactate and lactate expressors in septic shockAndrea Freyer Dugas
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Crit Care 27:344-50. 2012..The study's objective was to determine the proportion and patient characteristics of patients in vasopressor-dependent septic shock who presented without lactatemia... - Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infectionTodd A Seigel
Department of Emergency Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Emerg Med 42:254-9. 2012..The presence of systemic inflammatory response criteria aids in recognition of infection, although the reliability of these markers is variable... - International validation of the out-of-hospital cardiac arrest score in the United StatesSabina Hunziker
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Crit Care Med 39:1670-4. 2011..The aim of this study is to externally validate this score in an independent patient population in the United States... - Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patientsMichael N Cocchi
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States
Resuscitation 83:991-5. 2012..Therapeutic options are limited. Previous data suggest a benefit of coenzyme Q(10) (CoQ(10)) in post-arrest patients. We hypothesized that plasma CoQ(10) levels would be low after CA and associated with poorer outcomes... - Prevalence and significance of lactic acidosis in diabetic ketoacidosisKristin Cox
Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA 02215, USA
J Crit Care 27:132-7. 2012..The objective of this study was to determine the prevalence of lactic acidosis in DKA and its association with intensive care unit (ICU) length of stay (LOS) and mortality... - Predictors of bacteremia in emergency department patients with suspected infectionMaureen Chase
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Emerg Med 30:1691-7. 2012..The goal of this study is to identify clinical variables associated with bacteremia. Such data could provide a rational basis for blood culture testing in emergency department (ED) patients with suspected infection... - Neurologic recovery after therapeutic hypothermia in patients with post-cardiac arrest myoclonusJason M Lucas
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States
Resuscitation 83:265-9. 2012..The concept that early myoclonus heralds a uniformly poor prognosis may need to be reconsidered in the era of post-cardiac arrest mild therapeutic hypothermia... - Relative adrenal insufficiency in post-cardiac arrest shock is under-recognizedJoseph B Miller
Henry Ford Hospital, Department of Emergency Medicine, 2799 West Grand Boulevard, Detroit, MI 48202, United States
Resuscitation 76:221-5. 2008..We sought to investigate current clinical practice pertaining to the evaluation for relative adrenal insufficiency in post-cardiac arrest shock... - The utility of head computed tomography in the emergency department evaluation of syncopeNikhil Goyal
Department of Emergency Medicine, Henry Ford Hospital, 2799 W Grand Blvd, CFP 2, Detroit, MI 48226, USA
Intern Emerg Med 1:148-50. 2006..We undertook the following investigation to determine whether HCT aids in the diagnostic investigation of syncope... - ED patients with vertigo: can we identify clinical factors associated with acute stroke?Maureen Chase
Beth Israel Deaconess Medical Center, Department of Emergency Medicine, One Deaconess Road, West, Clinical Center 2, Boston, MA 02215, USA
Am J Emerg Med 30:587-91. 2012..Misdiagnosis of acute stroke may result in significant morbidity and mortality. Magnetic resonance imaging (MRI) is superior to computer tomography (CT) for diagnosis of acute stroke but is costly with limited availability... - Prevalence of elevated troponin I in end-stage renal disease patients receiving hemodialysisMichael W Donnino
Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA
Acad Emerg Med 11:979-81. 2004..The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis... - Cannabinoid hyperemesis: a case seriesMichael W Donnino
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Emerg Med 40:e63-6. 2011..Traditionally, cannabinoids have been used recreationally or as antiemetics; however, recent reports suggest that chronic abuse can result in the paradoxical effect of a cyclic vomiting syndrome, termed cannabinoid hyperemesis... - The role of cranial computed tomography in the immediate post-cardiac arrest periodMichael N Cocchi
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Intern Emerg Med 5:533-8. 2010..8% of patients had clinically significant abnormalities identified. The exact role of neuroimaging in this population is still in evolution, and further prospective evaluation is warranted... - Critical care and emergency medicineEmanuel P Rivers
Department of Emergency Medicine, Henry Ford Hospital, Case Western Reserve University, Detroit, Michigan, USA
Curr Opin Crit Care 8:600-6. 2002.... - Rapid rewarming of hypothermic patient using arctic sun deviceMichael N Cocchi
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
J Intensive Care Med 27:128-30. 2012..Clinicians may wish to consider the use of these devices when attempting to warm patients suffering from severe environmental hypothermia... - Identification and resuscitation of the trauma patient in shockMichael N Cocchi
Department of Emergency Medicine, Harvard Affiliated Emergency Medicine Residency, Beth Israel Deaconess Medical Center, One Deaconess Road, West Campus Clinical Center, 2nd Floor, Boston, MA 02215, USA
Emerg Med Clin North Am 25:623-42, vii. 2007..Resuscitation strategies (delayed resuscitation, damage control resuscitation), end points of resuscitation, and the role of blood products and pro-coagulants for resuscitation are discussed... - Pulmonary embolism presenting as flank pain: a case seriesMichael Amesquita
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Emerg Med 42:e97-100. 2012..The current case series reveals the unexpected and initially unrecognized CT finding of a pulmonary infarct in two patients presenting with flank pain; a third patient presented with flank pain and was also found to have a PE... - Sepsis: the changing timesNathan I Shapiro
Crit Care Med 33:2700-1. 2005 - A central venous pressure goal of 8-12 mm Hg for all patients in septic shockMichael W Donnino
Crit Care Med 35:1441. 2007 - Central venous-arterial carbon dioxide difference as an indicator of cardiac indexJoseph Cuschieri
Department of Surgery, Henry Ford Health Systems, Detroit, MI, USA
Intensive Care Med 31:818-22. 2005..Substitution of a central for a mixed venous-arterial pCO(2) difference provides an accurate alternative method for calculation of cardiac output...