CHARLES DIMITROFF

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking
    Steven R Barthel
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:19491-6. 2009
  2. pmc Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation
    Steven R Barthel
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 286:21717-31. 2011
  3. pmc Leveraging fluorinated glucosamine action to boost antitumor immunity
    Charles J Dimitroff
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, United States
    Curr Opin Immunol 25:206-13. 2013
  4. pmc Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen
    Charles J Dimitroff
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 112:1008-18. 2003
  5. pmc Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells
    Charles J Dimitroff
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer Res 65:5750-60. 2005
  6. ncbi request reprint Ameliorating skin-homing receptors on malignant T cells with a fluorosugar analog of N-acetylglucosamine: P-selectin ligand is a more sensitive target than E-selectin ligand
    Leyla Descheny
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 126:2065-73. 2006
  7. pmc Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:148-157.e3. 2008
  8. pmc Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis
    Madeliene E Gainers
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:8509-18. 2007
  9. ncbi request reprint Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin
    Charles J Dimitroff
    Harvard Skin Disease Research Center, Department of Dermatology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cancer Res 64:5261-9. 2004
  10. pmc Analysis of glycosyltransferase expression in metastatic prostate cancer cells capable of rolling activity on microvascular endothelial (E)-selectin
    Steven R Barthel
    Department of Dermatology, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Boston, MA 02115, USA
    Glycobiology 18:806-17. 2008

Research Grants

  1. Mechanistic Analysis of Anti-inflammatory Activity by Fluorosugars
    Charles J Dimitroff; Fiscal Year: 2010
  2. Bone-Homing Molecules on Human Prostate Tumor Cells
    CHARLES DIMITROFF; Fiscal Year: 2004
  3. CLA as a Mediator of Human Prostate Tumor Metastasis
    CHARLES DIMITROFF; Fiscal Year: 2005
  4. Analysis of Homing Receptors in Prostate Cancer
    CHARLES DIMITROFF; Fiscal Year: 2007
  5. Analysis of Homing Receptors in Prostate Cancer
    CHARLES DIMITROFF; Fiscal Year: 2009
  6. Mechanistic Analysis of Anti-inflammatory Activity by Fluorosugars
    CHARLES DIMITROFF; Fiscal Year: 2009
  7. Analysis of Homing Receptors in Prostate Cancer
    Charles J Dimitroff; Fiscal Year: 2010

Collaborators

Detail Information

Publications16

  1. pmc Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking
    Steven R Barthel
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:19491-6. 2009
    ..These results indicate that alpha1,3 FTs could enhance metastatic efficiency of PCa by triggering an E-selectin-dependent trafficking mechanism...
  2. pmc Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation
    Steven R Barthel
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 286:21717-31. 2011
    ..These data show that Gal-1 and E-selectin ligand reduction by 4-F-GlcNAc is not caused by direct 4-F-GlcNAc glycan incorporation and consequent chain termination but rather by interference with UDP-GlcNAc synthesis...
  3. pmc Leveraging fluorinated glucosamine action to boost antitumor immunity
    Charles J Dimitroff
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, United States
    Curr Opin Immunol 25:206-13. 2013
    ..In this perspective, the prospect of fluorinated glucosamines in eliminating N-acetyllactosamines on antitumor T cells to boost antitumor immunity is presented...
  4. pmc Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen
    Charles J Dimitroff
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 112:1008-18. 2003
    ..These data indicate that 4-F-GlcNAc prevents CHS by inhibiting selectin ligand activity and the capacity of effector T cells to enter antigen-challenged skin without affecting the afferent phase of CHS...
  5. pmc Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells
    Charles J Dimitroff
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer Res 65:5750-60. 2005
    ..These findings implicate a functional role of PSGL-1 in the bone tropism of prostate tumor cells and establish a new perspective into the molecular mechanism of human prostate tumor metastasis...
  6. ncbi request reprint Ameliorating skin-homing receptors on malignant T cells with a fluorosugar analog of N-acetylglucosamine: P-selectin ligand is a more sensitive target than E-selectin ligand
    Leyla Descheny
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 126:2065-73. 2006
    ..These results indicate that 4-F-GlcNAc treatment can selectively downregulate the P-selectin ligand activity and potentially prevent dermal dissemination of cutaneous lymphomas...
  7. pmc Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:148-157.e3. 2008
    ....
  8. pmc Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis
    Madeliene E Gainers
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:8509-18. 2007
    ....
  9. ncbi request reprint Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin
    Charles J Dimitroff
    Harvard Skin Disease Research Center, Department of Dermatology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cancer Res 64:5261-9. 2004
    ..These findings provide novel insight into potential adhesive mechanisms promoting hematogenous dissemination of prostate tumor cells into bone...
  10. pmc Analysis of glycosyltransferase expression in metastatic prostate cancer cells capable of rolling activity on microvascular endothelial (E)-selectin
    Steven R Barthel
    Department of Dermatology, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Boston, MA 02115, USA
    Glycobiology 18:806-17. 2008
    ..These results implicate the importance of alpha1,3 FT3, FT6, and/or FT7 in sLe(X) and ESL synthesis on metastatic PCa cells...
  11. ncbi request reprint Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 168:5645-51. 2002
    ....
  12. ncbi request reprint The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo
    Pilar Alcaide
    Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Invest Dermatol 127:1964-72. 2007
    ..These results demonstrate that both PSGL-1 and CD43 are major E-selectin ligands and are likely to be important during leukocyte recruitment in the development of inflammatory reactions...
  13. pmc Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation
    Filiberto Cedeno-Laurent
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 185:4659-72. 2010
    ..Gal-1hFc will not only be a useful new tool for investigating the role of Gal-1 ligands in leukocyte death and cytokine stimulation, but for studying how Gal-1-Gal-1 ligand binding shapes the intensity of immune responses...
  14. ncbi request reprint Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin
    Charles J Dimitroff
    Department of Dermatology and the Harvard Skin Disease Research Center at Brigham and Women s Hospital, Boston, MA, USA
    Blood 101:602-10. 2003
    ....
  15. pmc Targeting selectins and selectin ligands in inflammation and cancer
    Steven R Barthel
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Harvard Institutes of Medicine, Room 669, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Expert Opin Ther Targets 11:1473-91. 2007
    ....

Research Grants9

  1. Mechanistic Analysis of Anti-inflammatory Activity by Fluorosugars
    Charles J Dimitroff; Fiscal Year: 2010
    ..Our preclinical investigation will demonstrate the utility of fluoro-glucosamines as immunomodulators of cutaneous inflammation and, potentially, help model the effects by complementary and alternative medicines, such as glucosamine. ..
  2. Bone-Homing Molecules on Human Prostate Tumor Cells
    CHARLES DIMITROFF; Fiscal Year: 2004
    ..Molecular analysis of identified E-selectin ligand(s) will provide rationale for the development of anti-metastatic therapeutics against these new targets. ..
  3. CLA as a Mediator of Human Prostate Tumor Metastasis
    CHARLES DIMITROFF; Fiscal Year: 2005
    ..These studies will help reveal the importance of E-selectin ligand(s), namely CLA, in mediating the migration of human prostate tumor cells to bone and stimulate the development of novel anti-metastatic therapeutics, such 4-F-GIcNAc. ..
  4. Analysis of Homing Receptors in Prostate Cancer
    CHARLES DIMITROFF; Fiscal Year: 2007
    ..Results from these analyses will offer new insights into the molecular pathogenesis of prostate tumor metastasis and may provide rationale for development of new therapies targeting homing receptors. ..
  5. Analysis of Homing Receptors in Prostate Cancer
    CHARLES DIMITROFF; Fiscal Year: 2009
    ..Results from these analyses will offer new insights into the molecular pathogenesis of prostate tumor metastasis and may provide rationale for development of new therapies targeting homing receptors. ..
  6. Mechanistic Analysis of Anti-inflammatory Activity by Fluorosugars
    CHARLES DIMITROFF; Fiscal Year: 2009
    ..Our preclinical investigation will demonstrate the utility of fluoro-glucosamines as immunomodulators of cutaneous inflammation and, potentially, help model the effects by complementary and alternative medicines, such as glucosamine. ..
  7. Analysis of Homing Receptors in Prostate Cancer
    Charles J Dimitroff; Fiscal Year: 2010
    ..Results from these analyses will offer new insights into the molecular pathogenesis of prostate tumor metastasis and may provide rationale for development of new therapies targeting homing receptors. ..