Sven Diederichs

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression
    Sven Diederichs
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Cell 131:1097-108. 2007
  2. pmc Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites
    Sven Diederichs
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129 2020, USA
    Proc Natl Acad Sci U S A 105:9284-9. 2008
  3. pmc Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
    Ira Surolia
    Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 466:243-7. 2010
  4. ncbi Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing
    Sven Diederichs
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 66:6097-104. 2006
  5. pmc A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors
    Gromoslaw A Smolen
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 21:2131-6. 2007
  6. pmc Detection of mutations in EGFR in circulating lung-cancer cells
    Shyamala Maheswaran
    Massachusetts General Hospital Cancer Center, Boston 02129, USA
    N Engl J Med 359:366-77. 2008

Collaborators

  • Daphne W Bell
  • Jan Freudenberg
  • Lecia V Sequist
  • Daniel Irimia
  • Philip L De Jager
  • Thomas J Lynch
  • Rodney A Stewart
  • Ira Surolia
  • Shyamala Maheswaran
  • Daniel A Haber
  • Gromoslaw A Smolen
  • Stephan P Pirnie
  • David Hafler
  • Vasant Chellappa
  • Yves Chretien
  • Deborah Collier
  • Joshua Korzenik
  • Khaleda Haider
  • John H Stone
  • Sheila Le
  • Timothy W Behrens
  • Tammy Gillis
  • Daniel K Podolsky
  • Mandakolathur Murali
  • Ethan Dow
  • Annette Lee
  • Ajit Varki
  • BRUCE SANDS
  • David R Driscoll
  • Peter K Gregersen
  • Donald Bloch
  • Haoyuan Liu
  • Kendra N Taylor
  • Annaiah Cariappa
  • Shiv Pillai
  • Ilka Netravali
  • Jesse Moya
  • Marcy E MacDonald
  • Roberto Elia
  • Sunitha Nagrath
  • Lindsey Ulkus
  • Brian Brannigan
  • Jeffrey Settleman
  • Subba Digumarthy
  • Ronald G Tompkins
  • Alona Muzikansky
  • A John Iafrate
  • Chey V Collura
  • Elizabeth Inserra
  • Mehmet Toner
  • Dennis C Sgroi
  • A Thomas Look
  • Randall T Peterson
  • Heather L Provencher
  • Benjamin J Schott
  • Beth Muir

Detail Information

Publications6

  1. ncbi Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression
    Sven Diederichs
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Cell 131:1097-108. 2007
    ..The multiple roles of Argonautes in the RNAi effector phase and miRNA biogenesis and maturation suggest coordinate regulation of microRNA expression and function...
  2. pmc Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites
    Sven Diederichs
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129 2020, USA
    Proc Natl Acad Sci U S A 105:9284-9. 2008
    ..Codelivery of Ago2 with shRNA constructs or siRNA duplexes thus provides a strategy to enhance the efficacy and the specificity of RNAi in experimental and potentially therapeutic settings...
  3. pmc Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
    Ira Surolia
    Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 466:243-7. 2010
    ..9 in subjects with type I diabetes. Functionally defective SIAE rare and polymorphic variants represent a strong genetic link to susceptibility in relatively common human autoimmune disorders...
  4. ncbi Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing
    Sven Diederichs
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 66:6097-104. 2006
    ..Thus, genetic variants in miRNA precursors are common in cancer cells but are unlikely to have physiologic significance...
  5. pmc A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors
    Gromoslaw A Smolen
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 21:2131-6. 2007
    ..We specifically show that these defects are primarily due to the diminished migratory capacity of NC cells. The identification of RADIL as a regulator of NC migration defines a role for the Rap pathway in this process...
  6. pmc Detection of mutations in EGFR in circulating lung-cancer cells
    Shyamala Maheswaran
    Massachusetts General Hospital Cancer Center, Boston 02129, USA
    N Engl J Med 359:366-77. 2008
    ..Molecular characterization of circulating tumor cells may provide a strategy for noninvasive serial monitoring of tumor genotypes during treatment...