Research Topics
Species | Bradford C DickersonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriersYakeel T Quiroz
Massachusetts General Hospital Frontotemporal Dementia Unit, 149 13th Street, Suite 2691, Charlestown, MA 02129, USA
J Neurol Neurosurg Psychiatry 84:556-61. 2013..Sporadic late-onset Alzheimer's disease (AD) dementia has been associated with a 'signature' of cortical atrophy in paralimbic and heteromodal association regions measured with MRI...
Medial temporal lobe function and structure in mild cognitive impairmentBradford C Dickerson
Department of Neurology, Gerontology Research Unit, Massachusetts General Hospital, MGH East 149 2691, 149 13th Street, Charlestown, MA 02129, USA
Ann Neurol 56:27-35. 2004..We hypothesize that increased activation in MTL regions reflects a compensatory response to accumulating AD pathology and may serve as a marker for impending clinical decline...- Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengthsB C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuroimage 39:10-8. 2008.... - Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairmentBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Arch Gen Psychiatry 64:1443-50. 2007.... - Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studiesBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuropsychologia 46:1624-35. 2008..We hope these insights will translate into the incorporation of measures of task-related brain function into diagnostic assessment or therapeutic monitoring, such as for use in clinical trials... - Quantitating severity and progression in primary progressive aphasiaBradford C Dickerson
Frontotemporal Dementia Unit, Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Mol Neurosci 45:618-28. 2011.... - The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individualsBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Cereb Cortex 19:497-510. 2009.... - Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adultsB C Dickerson
Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, MA, USA
Neurology 76:1395-402. 2011.... - The episodic memory system: neurocircuitry and disordersBradford C Dickerson
Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Neuropsychopharmacology 35:86-104. 2010..A growing body of evidence is converging on a functional organization of the cortical, subcortical, and MTL structures that support the fundamental features of episodic memory in humans and animals... - Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimagingBradford C Dickerson
Department of Neurology, Harvard Medical School, Boston, MA, USA
Behav Neurol 21:63-75. 2009.... - Advances in quantitative magnetic resonance imaging-based biomarkers for Alzheimer diseaseBradford C Dickerson
Frontotemporal Dementia Unit, Departments of Neurology and Psychiatry, Massachusetts Alzheimer s Disease Research Center, Athinoula A, Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Alzheimers Res Ther 2:21. 2010..This commentary provides a perspective on a recently published paper and how it illustrates progress and challenges in the field... - Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface areaBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neurobiol Aging 30:432-40. 2009..These differential morphometric effects of aging and AD may reflect distinct biologic processes and ultimately may provide insights into the anatomic substrates of change in memory-related functions of MTL cortex... - Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristicsBradford C Dickerson
MGH Frontotemporal Dementia Unit, Boston, Massachusetts, USA
J Neurol Neurosurg Psychiatry 82:45-51. 2011.... - Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's diseaseBradford C Dickerson
Department of Neurology and the Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
NeuroRx 2:348-60. 2005.... - Functional MRI in the early detection of dementiasB C Dickerson
Gerontology Research Unit, Alzheimer s Disease Research Center, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, and Department of Neurology, Harvard Medical School, Boston, MA, USA
Rev Neurol (Paris) 162:941-4. 2006..Finally, the use of fMRI as a biomarker in clinical trials of putative neurotherapeutics for dementias will be discussed... - Functional magnetic resonance imaging of cholinergic modulation in mild cognitive impairmentBradford C Dickerson
Gerontology Research Unit, Department of Neurology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Curr Opin Psychiatry 19:299-306. 2006..This review will focus on functional magnetic resonance imaging and its use in measuring the effects of cholinergic modulation in mild cognitive impairment... - Advances in functional magnetic resonance imaging: technology and clinical applicationsBradford C Dickerson
Gerontology Research Unit, Alzheimer s Disease Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Neurotherapeutics 4:360-70. 2007.... - Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI studyB C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Hippocampus 17:1060-70. 2007..These fronto-temporal brain regions act together as a large-scale memory-related network, the components of which make distinct yet interacting contributions during encoding that predict subsequent successful free recall performance... - An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interestRahul S Desikan
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
Neuroimage 31:968-80. 2006.... - Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individualsLiang Wang
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 51:910-7. 2010..Research is ongoing to determine if impaired connectivity between these regions may serve as a predictor of memory decline related to early Alzheimer's disease... - The cortical signature of prodromal AD: regional thinning predicts mild AD dementiaAkram Bakkour
Department of Psychiatry, Massachusetts Alzheimer s Disease Research Center and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Neurology 72:1048-55. 2009..Here we investigated whether the cortical signature of AD-related thinning is present in individuals with questionable AD dementia (QAD) and whether a greater degree of regional cortical thinning predicts mild AD dementia... - Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer diseaseMaija Pihlajamaki
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, MA, USA
Alzheimer Dis Assoc Disord 24:28-36. 2010..Altered fMRI activity of the posteromedial areas of the brain default network may be an early indicator of risk for AD... - Functional alterations in memory networks in early Alzheimer's diseaseReisa A Sperling
Department of Neurology, Center for Alzheimer s Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Neuromolecular Med 12:27-43. 2010..Research is ongoing to determine if these early network alterations will serve as sensitive predictors of clinical decline, and eventually, as markers of pharmacological response to potential disease-modifying treatments for AD... - Model-based segmentation of hippocampal subfields in ultra-high resolution in vivo MRIKoen Van Leemput
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, USA
Med Image Comput Comput Assist Interv 11:235-43. 2008..We validate the proposed technique by comparing our segmentation results with corresponding manual delineations in ultra-high resolution MRI scans of five individuals... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild Alzheimer's diseaseChristopher I Wright
Laboratory of Aging and Emotion of the Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 62:1388-95. 2007..The current study investigates functional alterations in the amygdala in aging and mild AD, and their relationships with neuropsychiatric symptoms... 
Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementiaEric E Smith
Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Arch Neurol 65:94-100. 2008..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...- Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance abilityLiang Wang
Frontotemporal Dementia Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Hippocampus 20:345-51. 2010.... - MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adultsBradford C Dickerson
Frontotemporal Dementia Unit, Department of Neurology, Massachusetts Alzheimer s Disease Research Center, and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston
Neurology 78:84-90. 2012..We implemented these criteria using an MRI biomarker previously associated with AD dementia, testing the hypothesis that individuals at high risk for preclinical AD would be at elevated risk for cognitive decline... - Differential hemodynamic response in affective circuitry with aging: an FMRI study of novelty, valence, and arousalYoshiya Moriguchi
Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Cogn Neurosci 23:1027-41. 2011..These findings have relevance for understanding age-related differences in memory and affect regulation... - Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severityStéphane P Poulin
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Psychiatry Res 194:7-13. 2011..There also appear to be specific relationships between the level of amygdala atrophy and neuropsychiatric symptoms that deserve further investigation... - Mental state attribution and the temporoparietal junction: an fMRI study comparing belief, emotion, and perceptionDeborah Zaitchik
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuropsychologia 48:2528-36. 2010..An explanation is offered that focuses on the differences between verbal stimuli and visual stimuli, and between a process of sentence comprehension and a process of visual detection... - Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysisKim A Celone
Memory Disorders Unit, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 26:10222-31. 2006..These data may also provide functional evidence of the interaction between neocortical and medial temporal lobe pathology in early AD... - Naming impairment in Alzheimer's disease is associated with left anterior temporal lobe atrophyKimiko Domoto-Reilly
Frontotemporal Dementia Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Neuroimage 63:348-55. 2012..These findings lend further support to theories that include a prominent role for the anterior temporal lobe in tasks that rely on semantic memory... - Intrinsic amygdala-cortical functional connectivity predicts social network size in humansKevin C Bickart
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 32:14729-41. 2012..e., the mentalizing and mirror networks), and were behaviorally specific in that amygdala connectivity did not correlate with other self-report measures of sociality... - Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRIKoen Van Leemput
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Hippocampus 19:549-57. 2009..Unlike manual segmentations, our automated technique is fully reproducible, and fast enough to enable routine analysis of the hippocampal subfields in large imaging studies... - A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Hippocampus 21:461-6. 2011..These results are consistent with a division of labor in the MTL and the dual process model... - Hemispheric differences in amygdala contributions to response monitoringFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neuroreport 20:398-402. 2009.... - Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activationSaul L Miller
Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:2181-6. 2008.... - An MRI-based method for measuring volume, thickness and surface area of entorhinal, perirhinal, and posterior parahippocampal cortexEric Feczko
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neurobiol Aging 30:420-31. 2009..This novel protocol enables the reliable measurement of both the thickness and surface area of ERC, PRC, and PPHC... - Age-related changes in the thickness of cortical zones in humansScott M McGinnis
Frontotemporal Dementia Unit, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Brain Topogr 24:279-91. 2011..This model offers explicitly testable hypotheses and suggests the possibility that normal aging may potentially allow for multiple opportunities for intervention to promote the structural integrity of the cerebral cortex... - Fractionating verbal episodic memory in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Neuroimage 54:1530-9. 2011.... - Amygdala volume and social network size in humansKevin C Bickart
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA
Nat Neurosci 14:163-4. 2011..These findings indicate that the amygdala is important in social behavior... - The effects of aging and Alzheimer's disease on cerebral cortical anatomy: Specificity and differential relationships with cognitionAkram Bakkour
Frontotemporal Dementia Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuroimage 76:332-44. 2013.... - Dissociable large-scale networks anchored in the right anterior insula subserve affective experience and attentionAlexandra Touroutoglou
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02115, USA
Neuroimage 60:1947-58. 2012.... - Neuroanatomical correlates of extraversion and neuroticismChristopher I Wright
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Cereb Cortex 16:1809-19. 2006..In contrast, no such correlations were observed for the volume of the amygdala. The results suggest that specific aspects of regional prefrontal anatomy are associated with specific personality traits... - You don't say: dynamic aphasia, another variant of primary progressive aphasia?David L Perez
Department of Neurology, Center for Brain Mind Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Alzheimers Dis 34:139-44. 2013..This case of isolated progressive dynamic aphasia extends the current boundaries of PPA diagnostic variants... - Prevalence and effects of lobar microhemorrhages in early-stage dementiaAlireza Atri
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Neurodegener Dis 2:305-12. 2005..The prevalence and effects of LMH detectable by gradient echo MRI (GE-MRI) in early-stage dementia are unknown... - Atrophy accelerates with conversion from mild cognitive impairment to Alzheimer diseaseSusanne G Mueller
Neurology 70:1728-9. 2008 - The entorhinal cortex: an anatomical mediator of genetic vulnerability to Alzheimer's disease?Bradford C Dickerson
Lancet Neurol 6:471-3. 2007
Research Grants
- Structural-functional MRI Studies of Memory in MCI & ADBradford Dickerson; Fiscal Year: 2007..abstract_text> ..
- Medial temporal lobe subregions in aging, MCI and AD:Structural and functional MBradford Dickerson; Fiscal Year: 2007....
- Medial temporal lobe subregions in aging, MCI and AD:Structural and functional MBradford C Dickerson; Fiscal Year: 2010....