Bradford C Dickerson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Medial temporal lobe function and structure in mild cognitive impairment
    Bradford C Dickerson
    Department of Neurology, Gerontology Research Unit, Massachusetts General Hospital, MGH East 149 2691, 149 13th Street, Charlestown, MA 02129, USA
    Ann Neurol 56:27-35. 2004
  2. pmc Advances in quantitative magnetic resonance imaging-based biomarkers for Alzheimer disease
    Bradford C Dickerson
    Frontotemporal Dementia Unit, Departments of Neurology and Psychiatry, Massachusetts Alzheimer s Disease Research Center, Athinoula A, Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Alzheimers Res Ther 2:21. 2010
  3. pmc Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 30:432-40. 2009
  4. pmc Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths
    B C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 39:10-8. 2008
  5. pmc Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Gen Psychiatry 64:1443-50. 2007
  6. pmc Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics
    Bradford C Dickerson
    MGH Frontotemporal Dementia Unit, Boston, Massachusetts, USA
    J Neurol Neurosurg Psychiatry 82:45-51. 2011
  7. pmc Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuropsychologia 46:1624-35. 2008
  8. pmc The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 19:497-510. 2009
  9. pmc Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging
    Bradford C Dickerson
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Behav Neurol 21:63-75. 2009
  10. pmc Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study
    B C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Hippocampus 17:1060-70. 2007

Detail Information

Publications54

  1. ncbi request reprint Medial temporal lobe function and structure in mild cognitive impairment
    Bradford C Dickerson
    Department of Neurology, Gerontology Research Unit, Massachusetts General Hospital, MGH East 149 2691, 149 13th Street, Charlestown, MA 02129, USA
    Ann Neurol 56:27-35. 2004
    ..We hypothesize that increased activation in MTL regions reflects a compensatory response to accumulating AD pathology and may serve as a marker for impending clinical decline...
  2. pmc Advances in quantitative magnetic resonance imaging-based biomarkers for Alzheimer disease
    Bradford C Dickerson
    Frontotemporal Dementia Unit, Departments of Neurology and Psychiatry, Massachusetts Alzheimer s Disease Research Center, Athinoula A, Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Alzheimers Res Ther 2:21. 2010
    ..This commentary provides a perspective on a recently published paper and how it illustrates progress and challenges in the field...
  3. pmc Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 30:432-40. 2009
    ..These differential morphometric effects of aging and AD may reflect distinct biologic processes and ultimately may provide insights into the anatomic substrates of change in memory-related functions of MTL cortex...
  4. pmc Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths
    B C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 39:10-8. 2008
    ....
  5. pmc Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Gen Psychiatry 64:1443-50. 2007
    ....
  6. pmc Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics
    Bradford C Dickerson
    MGH Frontotemporal Dementia Unit, Boston, Massachusetts, USA
    J Neurol Neurosurg Psychiatry 82:45-51. 2011
    ....
  7. pmc Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuropsychologia 46:1624-35. 2008
    ..We hope these insights will translate into the incorporation of measures of task-related brain function into diagnostic assessment or therapeutic monitoring, such as for use in clinical trials...
  8. pmc The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 19:497-510. 2009
    ....
  9. pmc Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging
    Bradford C Dickerson
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Behav Neurol 21:63-75. 2009
    ....
  10. pmc Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study
    B C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Hippocampus 17:1060-70. 2007
    ..These fronto-temporal brain regions act together as a large-scale memory-related network, the components of which make distinct yet interacting contributions during encoding that predict subsequent successful free recall performance...
  11. ncbi request reprint Advances in functional magnetic resonance imaging: technology and clinical applications
    Bradford C Dickerson
    Gerontology Research Unit, Alzheimer s Disease Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Neurotherapeutics 4:360-70. 2007
    ....
  12. pmc Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease
    Bradford C Dickerson
    Department of Neurology and the Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    NeuroRx 2:348-60. 2005
    ....
  13. pmc The episodic memory system: neurocircuitry and disorders
    Bradford C Dickerson
    Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuropsychopharmacology 35:86-104. 2010
    ..A growing body of evidence is converging on a functional organization of the cortical, subcortical, and MTL structures that support the fundamental features of episodic memory in humans and animals...
  14. ncbi request reprint Functional magnetic resonance imaging of cholinergic modulation in mild cognitive impairment
    Bradford C Dickerson
    Gerontology Research Unit, Department of Neurology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Curr Opin Psychiatry 19:299-306. 2006
    ..This review will focus on functional magnetic resonance imaging and its use in measuring the effects of cholinergic modulation in mild cognitive impairment...
  15. pmc Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults
    B C Dickerson
    Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, MA, USA
    Neurology 76:1395-402. 2011
    ....
  16. ncbi request reprint Functional MRI in the early detection of dementias
    B C Dickerson
    Gerontology Research Unit, Alzheimer s Disease Research Center, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, and Department of Neurology, Harvard Medical School, Boston, MA, USA
    Rev Neurol (Paris) 162:941-4. 2006
    ..Finally, the use of fMRI as a biomarker in clinical trials of putative neurotherapeutics for dementias will be discussed...
  17. pmc Quantitating severity and progression in primary progressive aphasia
    Bradford C Dickerson
    Frontotemporal Dementia Unit, Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Mol Neurosci 45:618-28. 2011
    ....
  18. pmc Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals
    Liang Wang
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 51:910-7. 2010
    ..Research is ongoing to determine if impaired connectivity between these regions may serve as a predictor of memory decline related to early Alzheimer's disease...
  19. pmc The cortical signature of prodromal AD: regional thinning predicts mild AD dementia
    Akram Bakkour
    Department of Psychiatry, Massachusetts Alzheimer s Disease Research Center and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neurology 72:1048-55. 2009
    ..Here we investigated whether the cortical signature of AD-related thinning is present in individuals with questionable AD dementia (QAD) and whether a greater degree of regional cortical thinning predicts mild AD dementia...
  20. ncbi request reprint An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
    Rahul S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
    Neuroimage 31:968-80. 2006
    ....
  21. pmc Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease
    Maija Pihlajamaki
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Alzheimer Dis Assoc Disord 24:28-36. 2010
    ..Altered fMRI activity of the posteromedial areas of the brain default network may be an early indicator of risk for AD...
  22. doi request reprint Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the Social Impairment Rating Scale
    Kevin C Bickart
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Neurol Neurosurg Psychiatry 85:438-48. 2014
    ..Ultimately, we hope it will be useful as a longitudinal outcome measure in natural history studies and in clinical trials of putative interventions to improve social functioning...
  23. pmc Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers
    Yakeel T Quiroz
    Psychology Department, Center for Memory and Brain, Boston University, Boston, Massachusetts, USA
    J Neurol Neurosurg Psychiatry 84:556-61. 2013
    ..Sporadic late-onset Alzheimer's disease (AD) dementia has been associated with a 'signature' of cortical atrophy in paralimbic and heteromodal association regions measured with MRI...
  24. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  25. pmc Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability
    Liang Wang
    Frontotemporal Dementia Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Hippocampus 20:345-51. 2010
    ....
  26. pmc Functional alterations in memory networks in early Alzheimer's disease
    Reisa A Sperling
    Department of Neurology, Center for Alzheimer s Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuromolecular Med 12:27-43. 2010
    ..Research is ongoing to determine if these early network alterations will serve as sensitive predictors of clinical decline, and eventually, as markers of pharmacological response to potential disease-modifying treatments for AD...
  27. pmc Model-based segmentation of hippocampal subfields in ultra-high resolution in vivo MRI
    Koen Van Leemput
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, USA
    Med Image Comput Comput Assist Interv 11:235-43. 2008
    ..We validate the proposed technique by comparing our segmentation results with corresponding manual delineations in ultra-high resolution MRI scans of five individuals...
  28. ncbi request reprint A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild Alzheimer's disease
    Christopher I Wright
    Laboratory of Aging and Emotion of the Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:1388-95. 2007
    ..The current study investigates functional alterations in the amygdala in aging and mild AD, and their relationships with neuropsychiatric symptoms...
  29. doi request reprint Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    Eric E Smith
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arch Neurol 65:94-100. 2008
    ..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...
  30. ncbi request reprint The effects of aging and Alzheimer's disease on cerebral cortical anatomy: specificity and differential relationships with cognition
    Akram Bakkour
    Frontotemporal Dementia Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 76:332-44. 2013
    ....
  31. pmc Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD
    David A Wolk
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychologia 51:1094-102. 2013
    ....
  32. pmc MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults
    Bradford C Dickerson
    Frontotemporal Dementia Unit, Department of Neurology, Massachusetts Alzheimer s Disease Research Center, and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston
    Neurology 78:84-90. 2012
    ..We implemented these criteria using an MRI biomarker previously associated with AD dementia, testing the hypothesis that individuals at high risk for preclinical AD would be at elevated risk for cognitive decline...
  33. pmc Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity
    St├ęphane P Poulin
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 194:7-13. 2011
    ..There also appear to be specific relationships between the level of amygdala atrophy and neuropsychiatric symptoms that deserve further investigation...
  34. pmc Differential hemodynamic response in affective circuitry with aging: an FMRI study of novelty, valence, and arousal
    Yoshiya Moriguchi
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Cogn Neurosci 23:1027-41. 2011
    ..These findings have relevance for understanding age-related differences in memory and affect regulation...
  35. pmc Mental state attribution and the temporoparietal junction: an fMRI study comparing belief, emotion, and perception
    Deborah Zaitchik
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuropsychologia 48:2528-36. 2010
    ..An explanation is offered that focuses on the differences between verbal stimuli and visual stimuli, and between a process of sentence comprehension and a process of visual detection...
  36. pmc Antisaccade task reflects cortical involvement in mild cognitive impairment
    Hilary W Heuer
    From the Memory and Aging Center H W H, J B M, E L K, B L M, J H K, A L B, Department of Neurology, University of California, San Francisco and Frontotemporal Disorders Unit B C D, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston
    Neurology 81:1235-43. 2013
    ....
  37. pmc Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation
    Saul L Miller
    Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:2181-6. 2008
    ....
  38. pmc Naming impairment in Alzheimer's disease is associated with left anterior temporal lobe atrophy
    Kimiko Domoto-Reilly
    Frontotemporal Dementia Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuroimage 63:348-55. 2012
    ..These findings lend further support to theories that include a prominent role for the anterior temporal lobe in tasks that rely on semantic memory...
  39. pmc Intrinsic amygdala-cortical functional connectivity predicts social network size in humans
    Kevin C Bickart
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 32:14729-41. 2012
    ..e., the mentalizing and mirror networks), and were behaviorally specific in that amygdala connectivity did not correlate with other self-report measures of sociality...
  40. pmc Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI
    Koen Van Leemput
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hippocampus 19:549-57. 2009
    ..Unlike manual segmentations, our automated technique is fully reproducible, and fast enough to enable routine analysis of the hippocampal subfields in large imaging studies...
  41. ncbi request reprint Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis
    Kim A Celone
    Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:10222-31. 2006
    ..These data may also provide functional evidence of the interaction between neocortical and medial temporal lobe pathology in early AD...
  42. pmc A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hippocampus 21:461-6. 2011
    ..These results are consistent with a division of labor in the MTL and the dual process model...
  43. pmc An MRI-based method for measuring volume, thickness and surface area of entorhinal, perirhinal, and posterior parahippocampal cortex
    Eric Feczko
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 30:420-31. 2009
    ..This novel protocol enables the reliable measurement of both the thickness and surface area of ERC, PRC, and PPHC...
  44. pmc Hemispheric differences in amygdala contributions to response monitoring
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neuroreport 20:398-402. 2009
    ....
  45. pmc Fractionating verbal episodic memory in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage 54:1530-9. 2011
    ....
  46. pmc You don't say: dynamic aphasia, another variant of primary progressive aphasia?
    David L Perez
    Department of Neurology, Center for Brain Mind Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Alzheimers Dis 34:139-44. 2013
    ..This case of isolated progressive dynamic aphasia extends the current boundaries of PPA diagnostic variants...
  47. pmc Age-related changes in the thickness of cortical zones in humans
    Scott M McGinnis
    Frontotemporal Dementia Unit, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Brain Topogr 24:279-91. 2011
    ..This model offers explicitly testable hypotheses and suggests the possibility that normal aging may potentially allow for multiple opportunities for intervention to promote the structural integrity of the cerebral cortex...
  48. pmc Amygdala volume and social network size in humans
    Kevin C Bickart
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA
    Nat Neurosci 14:163-4. 2011
    ..These findings indicate that the amygdala is important in social behavior...
  49. pmc Dissociable large-scale networks anchored in the right anterior insula subserve affective experience and attention
    Alexandra Touroutoglou
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02115, USA
    Neuroimage 60:1947-58. 2012
    ....
  50. ncbi request reprint Neuroanatomical correlates of extraversion and neuroticism
    Christopher I Wright
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 16:1809-19. 2006
    ..In contrast, no such correlations were observed for the volume of the amygdala. The results suggest that specific aspects of regional prefrontal anatomy are associated with specific personality traits...
  51. ncbi request reprint Prevalence and effects of lobar microhemorrhages in early-stage dementia
    Alireza Atri
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 2:305-12. 2005
    ..The prevalence and effects of LMH detectable by gradient echo MRI (GE-MRI) in early-stage dementia are unknown...
  52. doi request reprint Atrophy accelerates with conversion from mild cognitive impairment to Alzheimer disease
    Susanne G Mueller
    Neurology 70:1728-9. 2008
  53. ncbi request reprint The entorhinal cortex: an anatomical mediator of genetic vulnerability to Alzheimer's disease?
    Bradford C Dickerson
    Lancet Neurol 6:471-3. 2007

Research Grants6