Bruce J Dezube

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Primary Kaposi sarcoma of the subcutaneous tissue
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA
    World J Surg Oncol 6:94. 2008
  2. pmc Pathology of rituximab-induced Kaposi sarcoma flare
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA
    BMC Clin Pathol 8:7. 2008
  3. pmc Kaposi sarcoma in unusual locations
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA
    BMC Cancer 8:190. 2008
  4. ncbi request reprint Emerging targets and novel strategies in the treatment of AIDS-related Kaposi's sarcoma: bidirectional translational science
    Bruce J Dezube
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Cell Physiol 209:659-62. 2006
  5. ncbi request reprint Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study
    Bruce J Dezube
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Clin Oncol 24:1389-94. 2006
  6. ncbi request reprint Imatinib-induced regression of AIDS-related Kaposi's sarcoma
    Henry B Koon
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, CC 913, Boston, MA 02215, USA
    J Clin Oncol 23:982-9. 2005
  7. ncbi request reprint HIV-associated anal squamous cell cancer: an otherwise preventable disease
    Panagiotis A Konstantinopoulos
    Division of Hematology Oncology, and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 24:4516-7. 2006
  8. pmc Targeted therapy for Kaposi sarcoma
    Ryan J Sullivan
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    BioDrugs 23:69-75. 2009
  9. ncbi request reprint Management of AIDS-related Kaposi sarcoma: advances in target discovery and treatment
    Bruce J Dezube
    AIDS Malignancy Research and Treatment Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS Read 14:236-8, 243-4, 251-3. 2004
  10. doi request reprint Human immunodeficiency virus-associated primary lung cancer in the era of highly active antiretroviral therapy: a multi-institutional collaboration
    Gabriela A D'Jaen
    Division of Hematology Oncology, Virginia Mason Medical Center, Seattle, WA, USA
    Clin Lung Cancer 11:396-404. 2010

Detail Information

Publications85

  1. pmc Primary Kaposi sarcoma of the subcutaneous tissue
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA
    World J Surg Oncol 6:94. 2008
    ..Primary KS of the subcutaneous tissue is an exceptional manifestation of this low-grade vascular neoplasm...
  2. pmc Pathology of rituximab-induced Kaposi sarcoma flare
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA
    BMC Clin Pathol 8:7. 2008
    ..CONCLUSION: Rituximab-induced KS flare appears to be related to HHV8 activation. Effective management of iatrogenic KS flare therefore depends upon the control of HHV8 viremia in conjunction with specific chemotherapy for KS...
  3. pmc Kaposi sarcoma in unusual locations
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA
    BMC Cancer 8:190. 2008
    ..KS in these atypical sites may prove difficult to diagnose, resulting in patient mismanagement. Theories to explain the rarity and development of KS in these unusual sites are discussed...
  4. ncbi request reprint Emerging targets and novel strategies in the treatment of AIDS-related Kaposi's sarcoma: bidirectional translational science
    Bruce J Dezube
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Cell Physiol 209:659-62. 2006
    ..Recent and future clinical trials of molecularly targeted therapy for the treatment of KS are a prelude to a shift in the paradigm of how KS is managed...
  5. ncbi request reprint Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study
    Bruce J Dezube
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Clin Oncol 24:1389-94. 2006
    ..The aim of this trial was to extend these initial observations...
  6. ncbi request reprint Imatinib-induced regression of AIDS-related Kaposi's sarcoma
    Henry B Koon
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, CC 913, Boston, MA 02215, USA
    J Clin Oncol 23:982-9. 2005
    ..We investigated the response of KS to the PDGF receptor (PDGFR)/c-kit inhibitor, imatinib mesylate, and investigated the effect of this therapy on critical signal transduction intermediates...
  7. ncbi request reprint HIV-associated anal squamous cell cancer: an otherwise preventable disease
    Panagiotis A Konstantinopoulos
    Division of Hematology Oncology, and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 24:4516-7. 2006
  8. pmc Targeted therapy for Kaposi sarcoma
    Ryan J Sullivan
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    BioDrugs 23:69-75. 2009
    ..This review focuses on these emerging targets in the treatment of patients with KS and also highlights important clinicopathologic characteristics...
  9. ncbi request reprint Management of AIDS-related Kaposi sarcoma: advances in target discovery and treatment
    Bruce J Dezube
    AIDS Malignancy Research and Treatment Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS Read 14:236-8, 243-4, 251-3. 2004
    ....
  10. doi request reprint Human immunodeficiency virus-associated primary lung cancer in the era of highly active antiretroviral therapy: a multi-institutional collaboration
    Gabriela A D'Jaen
    Division of Hematology Oncology, Virginia Mason Medical Center, Seattle, WA, USA
    Clin Lung Cancer 11:396-404. 2010
    ..We also sought to compare behavioral characteristics and immunologic features of HIV-LC patients with HIV-positive patients without LC...
  11. doi request reprint HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases
    Jorge Castillo
    Division of Hematology Oncology, The Miriam Hospital, Brown University Warren Alpert Medical School, Providence, Rhode Island 02906, USA
    Am J Hematol 83:804-9. 2008
    ..PBL is an aggressive B-cell lymphoma that presents in both oral and extra-oral sites of chronically HIV-infected immunosuppressed young men...
  12. ncbi request reprint Images in HIV/AIDS. HIV-associated squamous cell carcinoma of the anus
    Panagiotis A Konstantinopoulos
    Division of Hematology Oncology, Beth Israel Deconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    AIDS Read 16:301-2. 2006
  13. ncbi request reprint Multicentric Castleman's disease masquerading as HIV-related lymphoma
    Farshid Dayyani
    Department of Medicine, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Am J Med Sci 334:317-9. 2007
    ..His back pain subsided, lymphadenopathy regressed, and he became KSHV/HHV8 negative. Albeit a rare condition, Castleman's disease should always be considered in immunocompromised patients suspected of having lymphoma...
  14. ncbi request reprint HIV and the breast
    Benjamin E Gewurz
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    AIDS Read 15:392-6, 399-402. 2005
    ..In the era of HAART, HIV-infected patients with malignancy--particularly those who have robust CD4+ T-cell counts and well-controlled HIV viral loads--should be treated similarly to their HIV-negative counterparts...
  15. ncbi request reprint C-Kit (CD117) expression in AIDS-related, classic, and African endemic Kaposi sarcoma
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Appl Immunohistochem Mol Morphol 13:162-6. 2005
    ..Furthermore, the expression of c-kit does not correspond with the presence of HHV8 (LNA-1) immunoreactivity in KS lesions...
  16. pmc HIV-associated bladder cancer: a case series evaluating difficulties in diagnosis and management
    Elizabeth M Gaughan
    Department of Medicine Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    BMC Urol 9:10. 2009
    ..To date, only a limited number of cases of bladder cancer have been linked with HIV infection. We sought to describe the clinical characteristics of HIV-associated bladder cancer...
  17. pmc HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease
    Ryan J Sullivan
    Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Infect Dis 47:1209-15. 2008
    ..The scope of this review is to present contemporary knowledge about the epidemiology, virology, and immunology of Kaposi sarcoma-associated herpesvirus and to highlight several key oncogene products that may be targets for chemotherapy...
  18. ncbi request reprint Histological characterization of regression in acquired immunodeficiency syndrome-related Kaposi's sarcoma
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, and Department of Pathology, 330 Brookline Avenue, Boston, MA 02215, USA
    J Cutan Pathol 31:26-34. 2004
    ..KS regression has not been well characterized histologically. Therefore, this study was undertaken to characterize the histopathology of pharmacologically induced regressed cutaneous KS...
  19. pmc The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter
    Hong Li
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 76:11880-8. 2002
    ..This work demonstrates that the K12 transcript contains variable, complex repeat elements, is spliced and is expressed from a novel KSHV promoter...
  20. pmc The rising challenge of non-AIDS-defining cancers in HIV-infected patients
    John F Deeken
    Division of Hematology Oncology, Georgetown University Medical Center, 3800 Reservoir Rd NW, Washington, DC 20007, USA
    Clin Infect Dis 55:1228-35. 2012
    ..This review presents data on the epidemiology and etiology of NADCs, as well as ongoing research into this evolving aspect of the HIV epidemic...
  21. ncbi request reprint Signal transduction targets in Kaposi's sarcoma
    Ryan Sullivan
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Oncol 18:456-62. 2006
    ....
  22. doi request reprint Gastroenteropancreatic neuroendocrine tumors in patients with HIV infection: a trans-Atlantic series
    Piro Lito
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Med Sci 337:1-4. 2009
    ..Non-AIDS-defining cancers are an important problem in HIV-infected patients. The occurrence of neuroendocrine (NE) tumors in sites other than the lung and skin has not been well characterized in the setting of concurrent HIV infection...
  23. ncbi request reprint Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors
    Anna Berkenblit
    Beth Israel Deaconess Medical Center, and Harvard Cancer Center, Boston, MA, USA
    Clin Cancer Res 13:584-90. 2007
    ..A phase I clinical trial was undertaken to determine the maximum tolerated dose, toxicity profile, and pharmacokinetics of STA-4783 in combination with paclitaxel...
  24. ncbi request reprint HIV-associated intramammary lymphadenopathy
    Panagiotis A Konstantinopoulos
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Breast J 13:192-5. 2007
    ....
  25. doi request reprint Human immunodeficiency virus--associated renal cell carcinoma: a transatlantic case series
    Elizabeth M Gaughan
    Department of Medicine Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Genitourin Cancer 6:86-90. 2008
    ..Our aim was to describe the risk factors, clinical findings, pathology, and response to therapy of RCC in patients infected with HIV...
  26. ncbi request reprint Capravirine, a nonnucleoside reverse-transcriptase inhibitor in patients infected with HIV-1: a phase 1 study
    Benjamin E Gewurz
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Infect Dis 190:1957-61. 2004
    ..The day 15 median (mean) HIV-1 load decreased by 1.34 (1.45) log(10) copies/mL in the patients receiving 25 mg/kg/day. Capravirine demonstrated potent antiviral activity, even in antiretroviral-experienced patients...
  27. pmc Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    N Engl J Med 363:1693-703. 2010
    ..We explored the therapeutic efficacy of inhibiting ALK in such tumors in an early-phase clinical trial of crizotinib (PF-02341066), an orally available small-molecule inhibitor of the ALK tyrosine kinase...
  28. doi request reprint Antimicrobial and non-antimicrobial tetracyclines in human cancer trials
    Christopher Richards
    Department of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
    Pharmacol Res 63:151-6. 2011
    ....
  29. ncbi request reprint Human immunodeficiency virus-associated hemophagocytosis with iron-deficiency anemia and massive splenomegaly
    Lisa O Sproat
    Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Infect Dis 37:e170-3. 2003
    ..Clinical resolution occurred only after a splenectomy was performed...
  30. ncbi request reprint Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study
    Mary Cianfrocca
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Clin Oncol 20:153-9. 2002
    ..Secondary aims were to evaluate tumor response, pharmacokinetics, and changes in blood levels of MMP-2, MMP-9, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF)...
  31. ncbi request reprint HIV-related gynecomastia
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Breast J 9:131-2. 2003
  32. ncbi request reprint Kaposi's sarcoma
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, USA
    Ear Nose Throat J 83:157. 2004
  33. ncbi request reprint Images in HIV/AIDS. Sweet syndrome and syphilis in an HIV-infected person
    Laura E Johnson
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    AIDS Read 18:134-5. 2008
  34. pmc Detection of JC virus DNA and proteins in the bone marrow of HIV-positive and HIV-negative patients: implications for viral latency and neurotropic transformation
    Chen S Tan
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 199:881-8. 2009
    ....
  35. ncbi request reprint Investigational agents for treatment of AIDS-related Kaposi's sarcoma
    Panagiotis A Konstantinopoulos
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Expert Opin Investig Drugs 16:495-504. 2007
    ....
  36. doi request reprint Human immunodeficiency virus-associated lung carcinoma presenting as cutaneous metastases
    Ayad Hamdan
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Lung Cancer 10:441-4. 2009
    ..With the growing problem of non-AIDS-defining cancers in the current era of HAART, clinicians should be aware that skin lesions in the HIV-infected individual might represent metastatic disease...
  37. ncbi request reprint Images in HIV/AIDS. Pericardial primary effusion lymphoma
    Julia M Braza
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    AIDS Read 17:250-2. 2007
  38. ncbi request reprint Unusual Sites of Malignancies: CASE 3. AIDS-related Kaposi's sarcoma of the gastrointestinal tract
    Weei Yuarn Huang
    Departments of Pathology and Medicine Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 23:2098-9. 2005
  39. ncbi request reprint A passive immunotherapy, (PE)HRG214, in patients infected with human immunodeficiency virus: a phase I study
    Bruce J Dezube
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 187:500-3. 2003
    ..24 log(10) and 0.58 log(10), respectively, and, at day 29, were 0.24 log(10 ) and 2.2 log(10), respectively. HRG, administered as a single dose, is reasonably well tolerated and achieves adequate plasma concentrations...
  40. ncbi request reprint A phase I study of ultra low dose interleukin-2 and stem cell factor in patients with HIV infection or HIV and cancer
    Manisha H Shah
    Division of Hematology Oncology, Department of Internal Medicine, Ohio State University, Columbus, USA
    Clin Cancer Res 12:3993-6. 2006
    ..To determine the safety, toxicity, and immune modulation of this combination of cytokines in vivo, we conducted a first-in-man phase I study...
  41. ncbi request reprint Breast enlargement in 13 men who were seropositive for human immunodeficiency virus
    Devon L Evans
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Infect Dis 35:1113-9. 2002
    ..Although most causes of breast enlargement in HIV-infected men are likely to be benign, malignancies other than carcinoma are of concern...
  42. ncbi request reprint Protein electrophoresis and immunoglobulin analysis in HIV-infected patients
    Panagiotis A Konstantinopoulos
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Pathol 128:596-603. 2007
    ..One manifestation of this B-cell response is low-concentration monoclonal banding in 4.4% of the patients studied...
  43. ncbi request reprint Management of AIDS-related Kaposi's sarcoma: advances in target discovery and treatment
    Bruce J Dezube
    Beth Isreal Deaconess Medical Center, Harvard Medical School, USA
    Expert Rev Anticancer Ther 2:193-200. 2002
    ..The next 5 years may also bring a better understanding of the pharmacokinetic interactions among the many agents in the Kaposi's sarcoma and AIDS armamentariums...
  44. ncbi request reprint Monoclonal antibody hNM01 in HIV-infected patients: a phase I study
    Bruce J Dezube
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Clin Virol 31:S45-7. 2004
    ..hNM01 is a humanized monoclonal antibody that binds to the V(3) region of the HIV-1 envelope protein gp120. This binding leads to the activation of complement and the disruption of the viral envelope...
  45. doi request reprint Human Immunodeficiency Virus-associated anaplastic large cell lymphoma
    Kimberly Perez
    Division of Hematology Oncology, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI 02906, USA
    Leuk Lymphoma 51:430-8. 2010
    ..The administration of chemotherapy and early stages at presentation were identified as good prognostic factors, while the use of HAART showed a statistical trend toward improved survival in HIV-associated ALCL...
  46. ncbi request reprint Advances in the pathobiology and treatment of Kaposi sarcoma
    Liron Pantanowitz
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Oncol 16:443-9. 2004
    ..This article reviews the new and important information regarding the epidemiology, biology, and management of Kaposi sarcoma that was published in the last year...
  47. ncbi request reprint Spectrum of human papillomavirus-related dysplasia and carcinoma of the anus in HIV-infected patients
    Lori A Panther
    Department of Internal Medicine, Division of Infectious Diseases, Harvard Medical School, Boston, Massachusetts, USA
    AIDS Read 15:79-82, 85-6, 88, 91. 2005
    ..All HIV-positive patients with invasive cancer of the anal canal, particularly those with CD4+ cell counts greater than 200/microL and those receiving HAART, should be managed in the same manner as their HIV-negative counterparts...
  48. ncbi request reprint Plasma cell disorders in HIV-infected patients: from benign gammopathy to multiple myeloma
    Bruce J Dezube
    AIDS Malignancy Research and Treatment Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    AIDS Read 14:372-4, 377-9. 2004
    ..In the next few years, it is anticipated that these approaches will be applied more frequently to HIV-infected persons with myeloma...
  49. ncbi request reprint Characterization of Kaposi sarcoma-associated herpesvirus/human herpesvirus-8 infection of human vascular endothelial cells: early events
    Bruce J Dezube
    Division of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 100:888-96. 2002
    ..Although most lytic transcripts accrued until passage, open-reading frame-74 RNAs fluctuated with a fixed periodicity, suggesting that early replication after infection of MVDECs was synchronous...
  50. ncbi request reprint Alpha-chemokine-mediated signal transduction in human Kaposi's sarcoma spindle cells
    Jian Feng Wang
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Biochim Biophys Acta 1691:129-39. 2004
    ..IL-8 also enhanced the chemotaxis of KS cells. These results reveal that chemokine-induced signaling pathways may mediate cell growth, transcriptional activation and cell migration in KS...
  51. ncbi request reprint A6, a urokinase plasminogen activator (uPA)-derived peptide in patients with advanced gynecologic cancer: a phase I trial
    Anna Berkenblit
    Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Kirstein 106A, 330 Brookline Avenue, Boston, MA 02215, USA
    Gynecol Oncol 99:50-7. 2005
    ....
  52. pmc Case of fatal sickle cell intrahepatic cholestasis despite use of exchange transfusion in an African-American patient
    Daniel B Costa
    Department of Medicine, Division of Hemotology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Natl Med Assoc 98:1183-7. 2006
    ..Our case suggests that poor prognostic factors for adult SCIC patients treated with exchange transfusion may include older age and underlying hepatic disease...
  53. ncbi request reprint Growth hormone receptor (GH)-expressing carcinoid tumors after recombinant human GH therapy for human immunodeficiency virus-related lipodystrophy
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Infect Dis 36:370-2. 2003
    ..This case report serves as a cautionary note regarding the use of potentially oncogenic recombinant human growth hormone therapy to treat human immunodeficiency virus-positive persons...
  54. doi request reprint Pitfalls of diagnosis based on abnormal flow cytometry and [(18)F]fluorodeoxyglucose positron emission tomography
    Parul Bhargava
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Clin Lymphoma Myeloma 8:117-20. 2008
    ..It further underscores the importance of adequate clinical correlation and a low threshold for performing open biopsies in such patients...
  55. ncbi request reprint November 2002: a 72-year-old woman with a pineal gland mass
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA
    Brain Pathol 13:235-6, 239. 2003
    ..The behavior of this circumventricular organ lymphoma was comparable to both peripheral and primary central nervous system lymphomas...
  56. pmc Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium
    Yehoshua Maor
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Genes Cancer 3:512-20. 2012
    ..This suggests a potential mechanism by which CBD exerts its effects on KSHV-infected endothelium and supports the further examination of CBD as a novel targeted agent for the treatment of Kaposi sarcoma...
  57. ncbi request reprint Ovarian carcinoma with thyroid metastases causing clinical hypothyroidism: a case report
    Lara M Skarf
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, CC 913, Boston, MA 02215, USA
    Gynecol Oncol 102:394-6. 2006
    ..We present a case of metastatic ovarian cancer to the thyroid resulting in clinical hypothyroidism...
  58. ncbi request reprint High resolution anoscopy findings for men who have sex with men: inaccuracy of anal cytology as a predictor of histologic high-grade anal intraepithelial neoplasia and the impact of HIV serostatus
    Lori A Panther
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Infect Dis 38:1490-2. 2004
    ..The presence of any abnormal anal cytological finding indicates a potential for high-grade dysplasia on histological examination of MSM...
  59. ncbi request reprint Unusual sites of Hodgkin's lymphoma: CASE 1. HIV-associated Hodgkin's lymphoma of the stomach
    John Doweiko
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 22:4227-8. 2004
  60. ncbi request reprint Management of AIDS-related Kaposi's sarcoma
    Giuseppe Di Lorenzo
    Department of Molecular and Clinical Endocrinology and Oncology, University of Federico II, Naples, Italy
    Lancet Oncol 8:167-76. 2007
    ....
  61. ncbi request reprint Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus
    Camilo Raggo
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
    Cancer Res 65:5084-95. 2005
    ..Neither gene has been previously implicated in tumorigenesis. Our data suggest that KSHV-mediated transformation involves exploitation of the hitherto unrealized oncogenic properties of RDC1 and Neuritin...
  62. ncbi request reprint Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team
    Ariela Noy
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Oncol 23:990-8. 2005
    ..We report a 24-week, randomized, double-blinded, placebo-controlled phase III trial with the phase II dose, 5 mg intranasally every other day...
  63. ncbi request reprint Matrix metalloproteinases in the progression and regression of Kaposi's sarcoma
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA
    J Cutan Pathol 33:793-8. 2006
    ..Their role in KS regression has not been investigated. The aim of this study was to evaluate the expression of multiple MMPs in developing and pharmacologically regressed KS lesions...
  64. ncbi request reprint Thrombotic complications in patients infected with HIV in the era of highly active antiretroviral therapy: a case series
    Michael C Jacobson
    University of Washington School of Medicine, Seattle, Washington, USA
    Clin Infect Dis 39:1214-22. 2004
    ....
  65. ncbi request reprint Reasons for a deficit of breast cancer among HIV-infected patients
    Liron Pantanowitz
    J Clin Oncol 22:1347-8; author reply 1349-50. 2004
  66. ncbi request reprint Editorial comment: multiple myeloma and HIV infection--causal or casual coincidence?
    Liron Pantanowitz
    AIDS Read 13:386-7. 2003
  67. ncbi request reprint HIV infection masquerading as monoclonal gammopathy of undetermined significance
    Chuanyi M Lu
    N Engl J Med 349:1192-3. 2003
  68. ncbi request reprint Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma
    Steven A Miles
    AIDS Malignancy Consortium Operations Center, University of Alabama at Birmingham, 2001 Third Avenue South, Room 1078, Birmingham, AL 35223, USA
    AIDS 16:421-9. 2002
    ..To assess the efficacy, safety and tolerance of oral 9-cis-retinoic acid in HIV-infected patients with Kaposi's sarcoma...
  69. ncbi request reprint AIDS-related malignancies: emerging challenges in the era of highly active antiretroviral therapy
    Matthew C Cheung
    Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Oncologist 10:412-26. 2005
    ..This article provides an up-to-date review of the epidemiology, pathogenesis, clinical features, and treatment of various AIDS-related malignancies that are likely to be encountered by an oncologist practicing in the current HAART era...
  70. ncbi request reprint HHV8 is not limited to Kaposi's sarcoma
    Liron Pantanowitz
    Mod Pathol 18:1148; author reply 1149-50. 2005
  71. ncbi request reprint Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
    Gerd Fatkenheuer
    Department of Internal Medicine, Division of Infectious Diseases, Haus 11, University of Cologne, Joseph Stelzmann Strasse 9, D 50924 Cologne, Germany
    Nat Med 11:1170-2. 2005
    ..6 log(10) copies/ml at all twice daily doses >or=100 mg. These results provide proof of concept that CCR5 antagonism is a viable antiretroviral therapeutic approach...
  72. ncbi request reprint HIV-associated monoclonal gammopathy: a retrospective analysis of 25 patients
    Sashi Amara
    Virginia Mason Medical Center, Seattle, WA 98111, USA
    Clin Infect Dis 43:1198-205. 2006
    ..We sought to describe the laboratory findings and clinical course of MGUS, including association with plasma cell disorders, other malignancies, and infections, in 25 HIV-infected patients with a detectable serum monoclonal protein...
  73. doi request reprint HIV-associated multicentric Castleman's disease
    Justin Stebbing
    Department of Medical Oncology, Imperial College School of Science, Technology and Medicine, The Hammersmith Hospitals NHS Trust, London, United Kingdom
    Am J Hematol 83:498-503. 2008
    ..MCD represents a model of disease at the interplay between tumor biology, infection, and immunology...
  74. doi request reprint Human immunodeficiency virus-associated prostate cancer: clinicopathological findings and outcome in a multi-institutional study
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA
    BJU Int 101:1519-23. 2008
    ....
  75. ncbi request reprint AIDS-related non-Hodgkin lymphoma: still a problem in the era of HAART
    David M Aboulafia
    Division of Hematology, University of Washington, Seattle, USA
    AIDS Read 14:605-17. 2004
    ..Here we review the epidemiologic and pathobiologic features of AIDS-related lymphoma along with clinical evaluation and treatment options in patients with this disease...
  76. ncbi request reprint Kaposi sarcoma of the larynx
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA
    AIDS Read 16:194-5. 2006
  77. ncbi request reprint Acute myeloid leukemia in patients infected with HIV-1
    David M Aboulafia
    Division of Hematology Oncology, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    AIDS 16:865-76. 2002
    ..Myelodysplasia is a frequent consequence of HIV infection, but acute myeloid leukemia (AML) is rare. Clinical presentations and outcomes of patients with HIV and subsequent AML are reviewed...
  78. ncbi request reprint Editorial comment: bone lesions in Kaposi sarcoma
    Liron Pantanowitz
    AIDS Read 17:204. 2007
  79. pmc Higher prevalence of monoclonal gammopathy of undetermined significance in African Americans than whites--the unknown role of underlying HIV infection
    Panagiotis A Konstantinopoulos
    J Natl Med Assoc 98:1860-1. 2006
    ..Future epidemiologic studies dealing with plasma cell disorders should carefully examine the relationship between race, HIV infection status, prevalence of MGUS and its ultimate progression to MM...
  80. ncbi request reprint Extracavitary primary effusion lymphoma of the anorectum
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Springfield, MA, USA
    Clin Lymphoma Myeloma 6:149-52. 2005
    ..5 years. The purpose of this report is to add another case to the emerging literature regarding the heterogeneous category of extraserous human herpesvirus-8-associated lymphomas...
  81. ncbi request reprint Editorial comment: plasmablastic lymphoma--a diagnostic and therapeutic puzzle
    Liron Pantanowitz
    AIDS Read 17:448-9. 2007
  82. ncbi request reprint The growing problem of non-AIDS-defining malignancies in HIV
    Liron Pantanowitz
    Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts, USA
    Curr Opin Oncol 18:469-78. 2006
    ..As HIV-infected individuals live longer due to highly active antiretroviral therapy, their risk of dying from one of these cancers is increased. The recent literature pertaining to non-AIDS-defining cancers is reviewed...
  83. ncbi request reprint Pegylated liposomal doxorubicin as second-line therapy in the treatment of patients with advanced classic Kaposi sarcoma: a retrospective study
    Giuseppe Di Lorenzo
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Cancer 112:1147-52. 2008
    ..The current retrospective study investigated the activity and toxicity of PLD in pretreated patients with aggressive, nonvisceral CKS...
  84. doi request reprint Activity and safety of pegylated liposomal doxorubicin as first-line therapy in the treatment of non-visceral classic Kaposi's sarcoma: a multicenter study
    Giuseppe Di Lorenzo
    J Invest Dermatol 128:1578-80. 2008
  85. ncbi request reprint Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
    ....