Immaculata DeVivo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Genome-wide association study of relative telomere length
    Jennifer Prescott
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19635. 2011
  2. pmc Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II
    Karestan C Koenen
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Psychiatry 9:29. 2009
  3. pmc Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers
    I De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Med Genet 37:336-41. 2000
  4. pmc A prospective study of relative telomere length and postmenopausal breast cancer risk
    Immaculata De Vivo
    Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1152-6. 2009
  5. ncbi request reprint A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer risk
    Immaculata De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 63:5236-8. 2003
  6. pmc A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk
    Immaculata De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:12263-8. 2002
  7. ncbi request reprint Association of CYP1B1 polymorphisms and breast cancer risk
    Immaculata De Vivo
    Department of Epidemiology, Harvard Center for Cancer Prevention, Harvard School of Public Health, and the Channing Laboratory, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:489-92. 2002
  8. pmc Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 20:335-44. 2009
  9. pmc Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2436-44. 2008
  10. pmc Novel breast cancer risk alleles and endometrial cancer risk
    Monica McGrath
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, MA 02115, USA
    Int J Cancer 123:2961-4. 2008

Research Grants

  1. Whole genome amplification and DNA pooling strategies
    Immaculata DeVivo; Fiscal Year: 2004

Detail Information

Publications77

  1. pmc Genome-wide association study of relative telomere length
    Jennifer Prescott
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19635. 2011
    ..10, such as those for variants at the TERC locus. In general, common genetic variants associated with telomere length homeostasis have been difficult to detect. Potential biological and technical issues are discussed...
  2. pmc Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II
    Karestan C Koenen
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Psychiatry 9:29. 2009
    ..Although twin studies suggest genetic influences account for substantial variance in PTSD risk, little progress has been made in identifying variants in specific genes that influence liability to this common, debilitating disorder...
  3. pmc Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers
    I De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Med Genet 37:336-41. 2000
    ..These data provide evidence that germline mutations in PTEN may be a more frequent predisposing factor for cancers in women than previously suggested...
  4. pmc A prospective study of relative telomere length and postmenopausal breast cancer risk
    Immaculata De Vivo
    Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1152-6. 2009
    ..07). Our results provide little support for an important role of telomere length, as measured in peripheral blood leukocytes, as a biomarker of breast cancer risk...
  5. ncbi request reprint A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer risk
    Immaculata De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 63:5236-8. 2003
    ..Our findings suggest that the increased production of hPR-B by the +331 G/A polymorphism may predispose women to breast cancer development through increased hPR-B-dependent stimulation of mammary cell growth...
  6. pmc A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk
    Immaculata De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:12263-8. 2002
    ..After including a second population of controls, these associations remained intact. Our findings suggest that the +331G/A hPR gene polymorphism may contribute to endometrial cancer risk by increasing expression of the hPR-B isoform...
  7. ncbi request reprint Association of CYP1B1 polymorphisms and breast cancer risk
    Immaculata De Vivo
    Department of Epidemiology, Harvard Center for Cancer Prevention, Harvard School of Public Health, and the Channing Laboratory, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:489-92. 2002
    ..Carriers of the m1 leu and m2 ser alleles had modestly higher estradiol levels but similar estrone and estrone sulfate levels. The results presented do not support a strong association between m1 and m2 and the risk of breast cancer...
  8. pmc Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 20:335-44. 2009
    ..Furthermore, we did not observe any clear gene-environment interactions between caffeine metabolizing genes and ovarian cancer. Future studies evaluating mechanisms by which coffee mediates this relationship are warranted...
  9. pmc Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2436-44. 2008
    ..These results suggest that women with certain genetic variants may have a higher risk of ovarian cancer associated with genital talc use. Additional research is needed on these interactions and the underlying biological mechanisms...
  10. pmc Novel breast cancer risk alleles and endometrial cancer risk
    Monica McGrath
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, MA 02115, USA
    Int J Cancer 123:2961-4. 2008
    ..The molecular mechanisms underlying these differences remain to be defined...
  11. ncbi request reprint No evidence of a role for PPARgamma Pro12Ala polymorphism in endometrial cancer susceptibility
    Randi A Paynter
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Pharmacogenetics 14:851-6. 2004
    ..Consistent with previous findings for breast cancer, these results suggest that the PPARgamma ProAla polymorphism does not play a major role in mediating circulating oestrogen levels or endometrial cancer susceptibility...
  12. ncbi request reprint Association between self-reported environmental tobacco smoke exposure and lung cancer: modification by GSTP1 polymorphism
    David P Miller
    Department of Environmental Heath, Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 104:758-63. 2003
    ..Furthermore, the presence of the GSTP1 GG genotype appears to enhance the magnitude of the association between ETS exposure and lung cancer. Larger studies will be needed to confirm these preliminary findings...
  13. pmc Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 124:729-33. 2009
    ..16-1.18 per allele at the alpha=0.05 level in the pooled analysis. Our results do not provide strong support for an association between these breast cancer susceptibility alleles and epithelial ovarian cancer risk...
  14. pmc Lycopene and other carotenoid intake in relation to risk of uterine leiomyomata
    Kathryn L Terry
    Channing Laboratory, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 198:37.e1-8. 2008
    ..Carotenoids have antioxidant properties and have been associated with reduced risks of some cancers. We hypothesized that carotenoid intake may reduce the risk of diagnosed uterine leiomyoma (UL)...
  15. ncbi request reprint HSD17B1 gene polymorphisms and risk of endometrial and breast cancer
    Veronica Wendy Setiawan
    Department of Epidemiology, Harvard School of Public Health and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:213-9. 2004
    ..05) was suggested. These findings suggest that the HSD17B1 may be associated with circulating estradiol levels and interact with body mass index in postmenopausal breast cancer...
  16. ncbi request reprint Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard Center for Cancer Prevention, Harvard School of Public Health, Room 105, Building II, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:520-4. 2004
    ....
  17. ncbi request reprint CYP19 (aromatase) haplotypes and endometrial cancer risk
    Randi A Paynter
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 116:267-74. 2005
    ..Our data suggest that there is a high-frequency CYP19 haplotype related to higher estrogen to androgen ratios and increased risk of endometrial cancer and that this association may primarily pertain to postmenopausal women...
  18. ncbi request reprint Combinations of the variant genotypes of GSTP1, GSTM1, and p53 are associated with an increased lung cancer risk
    David P Miller
    Department of Environmental Heath, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Res 62:2819-23. 2002
    ..03 (95% CI, 1.47-11.1); for the P1-p53 DV the AOR was 5.10 (95% CI, 1.42-18.30). Specific DVs of GSTM1, GSTP1, and p53 codon 72 are associated with a higher lung cancer risk. This susceptibility is highest among younger individuals...
  19. pmc Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R52. 2008
    ..We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts, adjusting for confounding factors and testing for interactions with smoking...
  20. pmc Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:5974-81. 2005
    ..Our results suggest that possession of two long AR alleles (> or = 22 CAG repeats) may be associated with increased risk of ovarian cancer compared with women with two short AR alleles (<22 CAG repeats)...
  21. pmc Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk
    Kathryn Terry
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States
    Gynecol Oncol 117:255-9. 2010
    ..Given the role of estrogens in endometrial carcinogenesis, we hypothesized that genetic variation in StAR and CYP11A1 genes may influence endometrial cancer risk...
  22. ncbi request reprint Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 28:261-72. 2005
    ..An application to progesterone-receptor haplotypes and endometrial cancer further illustrates that the performance of all these methods depends on how well the observed haplotypes "tag" the unobserved causal variant...
  23. pmc GSTM1 and GSTT1 copy number variation in population-based studies of endometrial cancer risk
    Stalo Karageorgi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:1447-52. 2011
    ..The associations of GSTM1 and GSTT1 polymorphisms with endometrial cancer risk have been inconsistent...
  24. ncbi request reprint Genetic variations in XRCC2 and XRCC3 are not associated with endometrial cancer risk
    Jiali Han
    Department of Nutrition and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:330-1. 2004
  25. ncbi request reprint Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 25:559-65. 2004
    ..Our data suggest, that the CYP1B1 Ser allele may decrease endometrial cancer risk by altering the production of catechol estrogens. However, further studies are warranted to elucidate the role of CYP1B1 in endometrial cancer...
  26. ncbi request reprint Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms
    David P Miller
    Department of Environmental Heath, Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 14:545-51. 2003
    ..We examined the interaction between GSTP1 polymorphisms and cumulative exposure to smoking and their association with lung cancer risk...
  27. ncbi request reprint Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study
    Jiali Han
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 25:189-95. 2004
    ..The gene-environment interaction data suggest that the subtle effects of some of these variants on breast cancer risk may be magnified in the presence of certain exposures...
  28. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
    ....
  29. pmc +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 125:1685-91. 2009
    ..This finding adds to the evidence that the PR has an important etiologic role in breast cancer and should be evaluated in future studies...
  30. ncbi request reprint The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 18:621-5. 2007
    ..Neither SNP is independently associated with overall breast cancer risk. Some indication of gene-by-gene interaction was observed; however, no consistent direction of interaction was apparent...
  31. pmc The progesterone receptor Val660-->Leu polymorphism and breast cancer risk
    Immaculata De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Breast Cancer Res 6:R636-9. 2004
    ..It has been reported that the PROGINS allele, which is in complete linkage disequilibrium with a missense substitution in exon 4 (G/T, valine-->leucine, at codon 660), is associated with a decreased risk for breast cancer...
  32. pmc MDM2 SNP309 is associated with endometrial cancer risk
    Kathryn Terry
    Department of Epidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:983-6. 2008
    ..87; 95% confidence interval, 1.29-2.73) for endometrial cancer. We observed no association between age at diagnosis and genotype. Women carrying two copies of the MDM2 SNP309 variant may be at greater risk of endometrial cancer...
  33. pmc Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pharmacogenet Genomics 19:239-43. 2009
    ..Our data suggest that these UGT polymorphisms do not contribute significantly to endometrial cancer risk...
  34. ncbi request reprint A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 63:8536-41. 2003
    ....
  35. ncbi request reprint No association between MTHFR 677 C->T or 1298 A->C polymorphisms and endometrial cancer risk
    Randi A Paynter
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1088-9. 2004
  36. ncbi request reprint Association between catechol-O-methyltransferase and phobic anxiety
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Psychiatry 161:1703-5. 2004
    ..The authors assessed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and scores on the phobic anxiety scale of the Crown-Crisp Experimental Index...
  37. ncbi request reprint Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
    ..However, our findings of differences in associations for UGT1A1 and AIB1 genotypes with breast density by menopausal status needs additional corroboration...
  38. pmc Genetic variation in the progesterone receptor gene and ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 161:442-51. 2005
    ..76, 95% confidence interval: 0.62, 0.92). Associations were similar after stratifying by ovarian cancer histologies and risk factors...
  39. ncbi request reprint Androgen receptor polymorphisms and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, 181 Longwood Avenue, Boston, MA 02115, USA
    Int J Cancer 118:1261-8. 2006
    ..supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html)...
  40. pmc A prospective study of telomere length and the risk of skin cancer
    Jiali Han
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Invest Dermatol 129:415-21. 2009
    ..85 (95% CI, 0.94-3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations...
  41. ncbi request reprint Estrogen receptor beta (ESR2 ) polymorphisms and endometrial cancer (United States)
    Veronica Wendy Setiawan
    Channing Laboratory, Department of Epidemiology, Harvard School of Public Health 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 15:627-33. 2004
    ..We validated and screened for variants in the ESR2 gene and examined whether they are associated with endometrial cancer risk...
  42. ncbi request reprint Polymorphisms in O6-methylguanine DNA methyltransferase and endometrial cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School 181 Longwood Avenue, Boston, MA 02115, USA
    Carcinogenesis 27:2281-5. 2006
    ..41; 95%CI, 0.19-0.86). These data suggest that these two polymorphisms may influence endometrial cancer risk...
  43. pmc Reproductive factors and postmenopausal hormone use in relation to endometrial cancer risk in the Nurses' Health Study cohort 1976-2004
    Stalo Karageorgi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 126:208-16. 2010
    ..0008, P-interaction-E+P = 0.02). The findings from this study underscore the importance of hormonal mechanisms in endometrial carcinogenesis...
  44. ncbi request reprint Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States)
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 18:1123-30. 2007
    ..These data suggest that these three polymorphisms are not important in determining genetic susceptibility to endometrial cancer, although larger sample sizes are needed to confirm these findings...
  45. pmc No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer
    Geyu Liang
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:1043-5. 2011
    ..Recent reports have shown that telomere length was associated with the risk of various cancers, but the results have been inconsistent...
  46. ncbi request reprint Hormonal and reproductive factors and the risk of bladder cancer in women
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 163:236-44. 2006
    ..Findings suggest that menopausal status and age at menopause may play a role in modifying bladder cancer risk among women...
  47. pmc Genetic variants in telomere-maintaining genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 129:247-53. 2011
    ..05). We did not observe significant associations for SCC or BCC risk. Our study provides evidence for the contribution of genetic variants in the telomere-maintaining genes to melanoma susceptibility...
  48. pmc Telomere length and genetic analyses in population-based studies of endometrial cancer risk
    Jennifer Prescott
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 116:4275-82. 2010
    ..When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic...
  49. pmc Genetic associations with sporadic neuroendocrine tumor risk
    Monica Ter-Minassian
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 32:1216-22. 2011
    ..Our findings support further investigation of the potential role of IL12A and DAD1 in the etiology of NET...
  50. pmc Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk
    Stalo Karageorgi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 121:54-8. 2011
    ..Endometrial adenocarcinoma is linked to excessive exposure to estrogens. We hypothesized that single nucleotide polymorphisms (SNPs) in genes HSD17b2 and HSD17b4 may alter the enzyme activity, estradiol levels and risk of disease...
  51. pmc Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer
    Monica Ter-Minassian
    Department of Environmental Health, Harvard School of Public Health, Boston 02115, MA, USA
    Carcinogenesis 29:2147-52. 2008
    ..17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC...
  52. ncbi request reprint Intake of fruits and vegetables, carotenoids, folate, and vitamins A, C, E and risk of bladder cancer among women (United States)
    Crystal N Holick
    Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 16:1135-45. 2005
    ..To examine the relation between fruits and vegetables, carotenoids, folate, and vitamins A, C, E and the risk of bladder cancer in a prospective study of women...
  53. ncbi request reprint GATA5 activation of the progesterone receptor gene promoter in breast cancer cells is influenced by the +331G/A polymorphism
    Gordon S Huggins
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA, USA
    Cancer Res 66:1384-90. 2006
    ..Our findings suggest that GATA5 interacts with the +331G/A polymorphism to stimulate hPR-B expression in mammary cells, which may contribute to breast cancer susceptibility...
  54. ncbi request reprint Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass
    Asli Memisoglu
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Bldg II Rm 105, Boston, MA 02115, USA
    Hum Mol Genet 12:2923-9. 2003
    ..These data suggest that PPAR gamma genotype is an important factor in physiological responses to dietary fat in humans...
  55. pmc Reproductive characteristics and risk of uterine leiomyomata
    Kathryn L Terry
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Fertil Steril 94:2703-7. 2010
    ..To evaluate whether menstrual and reproductive characteristics may influence development of uterine leiomyomata since sex steroid hormones have been hypothesized to play a role in their development...
  56. pmc Perineal use of talcum powder and endometrial cancer risk
    Stalo Karageorgi
    Department of Environmental Health, Harvard School of Public Health, and Department of Medicine, Brigham and Women s Hospital, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:1269-75. 2010
    ..However, the relationship between talcum powder use and other gynecologic malignancies such as endometrial cancer has not been examined, and little information is available on nonhormonal risk factors for endometrial cancer...
  57. pmc Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    BMC Cancer 6:239. 2006
    ..Glutathione S-transferases (GSTs) also detoxify tobacco smoke constituents, and polymorphisms within the GSTM1 and GSTT1 genes can result in a complete lack of enzyme activity...
  58. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
    ..Our hypothesis is that variant alleles in key genes involved in the IGF pathway will influence the development of endometrial cancer...
  59. ncbi request reprint Telomere length, cigarette smoking, and bladder cancer risk in men and women
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:815-9. 2007
    ..We also observed a significant difference in telomere length across categories of pack-years of smoking (P = 0.01). These findings suggest that truncated telomeres are associated with an increased risk of bladder cancer...
  60. ncbi request reprint Smoking and the risk of endometrial cancer: results from the Nurses' Health Study
    Akila N Viswanathan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 114:996-1001. 2005
    ..The findings provide insight into disease etiology and suggest that the influence of smoking on endometrial cancer risk occurs even in early adulthood, is long-lasting, and may not be attributed solely to short-term hormonal modulation...
  61. pmc Relative telomere length and cognitive decline in the Nurses' Health Study
    ELIZABETH E DEVORE
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Neurosci Lett 492:15-8. 2011
    ..g. the differences that we observe between women who are 73 versus 74 years of age); thus, our results suggest that telomere length is not a particularly powerful marker of impending cognitive decline...
  62. ncbi request reprint Multiple displacement amplification prior to single nucleotide polymorphism genotyping in epidemiologic studies
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Biotechnol Lett 25:1031-6. 2003
    ..These results suggest that MDA will provide a sufficiently robust amplification of limiting samples of genomic DNA that can be used for SNP genotyping in large case-control studies of complex diseases...
  63. ncbi request reprint Anthropometric characteristics and risk of uterine leiomyoma
    Kathryn L Terry
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Epidemiology 18:758-63. 2007
    ..Sex steroid hormones and growth factors have been hypothesized to play a role in their development, and anthropometric characteristics may influence uterine leiomyoma risk...
  64. ncbi request reprint No association between a stop codon polymorphism in RAD52 and breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1138-9. 2002
  65. pmc Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e1590. 2008
    ..Since telomeres shorten with age and oxidative stress, both of which are important contributors to the onset of dementia, telomere length might be a valuable biomarker...
  66. pmc A prospective cohort study of coffee consumption and risk of endometrial cancer over a 26-year follow-up
    Youjin Je
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:2487-95. 2011
    ..Coffee has been reported to lower levels of estrogen and insulin, two hormones implicated in endometrial carcinogenesis, but prospective data on the relation between coffee consumption and risk of endometrial cancer are limited...
  67. pmc p21 expression in colon cancer and modifying effects of patient age and body mass index on prognosis
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:2513-21. 2009
    ..Patient BMI also differentially influences prognosis according to p21 CDKN1A status. Our data suggest host-tumor interactions influencing tumor aggressiveness...
  68. pmc Telomere length and risk of Parkinson's disease
    Hao Wang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mov Disord 23:302-5. 2008
    ..the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD...
  69. ncbi request reprint Apolipoprotein E, cardiovascular disease and cognitive function in aging women
    Jae Hee Kang
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Neurobiol Aging 26:475-84. 2005
    ..Thus, APOE genotypes strongly influenced cognitive function and decline; prevention of cardiovascular disease may limit these effects...
  70. ncbi request reprint Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization
    Daniel W Cramer
    Department of Obstetrics, Gynecology and Reproductive Biology, Ob Gyn Epidemiology Center, 221 Longwood Avenue, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 189:1085-92. 2003
    ..Polymorphic variants of the human progesterone receptor gene have been described, but their potential influence on in vitro fertilization outcome have not been studied...
  71. pmc The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
    Yvonne C Lee
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 60:1250-4. 2009
    ..The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility...
  72. ncbi request reprint Nonsteroidal antiinflammatory drug use and risk of bladder cancer in the health professionals follow-up study
    Jeanine M Genkinger
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Int J Cancer 120:2221-5. 2007
    ..We observed no effect-modification by smoking, age or fluid intake. Our results suggest that regular NSAID or acetaminophen use has no substantial impact on bladder cancer risk among men...
  73. doi request reprint CYP1B1 polymorphisms and k-ras mutations in patients with pancreatic ductal adenocarcinoma
    Marta Crous-Bou
    Institut Municipal d Investigacio Medica IMIM, CIBER de Epidemiología y Salud Pública CIBERESP, Barcelona, Spain
    Dig Dis Sci 53:1417-21. 2008
    ..The Val/Val genotype was over five times more frequent in PDA cases with a K-ras mutation than in wild-type cases (OR = 5.25; P = 0.121). In PDA, polymorphisms in CYP1B1 might be related with K-ras activation pathways...
  74. ncbi request reprint The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk
    Yannick Duguay
    Canada Research Chair in Pharmacogenomics, Pharmacogenomics Laboratory, Faculty of Pharmacy, Centre Hospitalier de l Université Laval CHUL Research Center, Hotel Dieu de Quebec, Laval University, Quebec, Canada
    Cancer Res 64:1202-7. 2004
    ..05)]. These observations suggest that lower expression of UGT1A1 decreases the risk of endometrial cancer by reducing the excretion of 2-hydroxyestradiol, the antiproliferative metabolite of E(2), in the endometrium...
  75. ncbi request reprint A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Int J Cancer 121:2225-32. 2007
    ..If confirmed, these results would provide an important target for ovarian cancer prevention...
  76. pmc Dichloroacetate induces apoptosis in endometrial cancer cells
    Jason Y Y Wong
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gynecol Oncol 109:394-402. 2008
    ..5 axis remodeling. The objective of this study was to determine whether DCA induces apoptosis in endometrial cancer cells and to assess apoptotic mechanism...
  77. pmc Telomere maintenance in laser capture microdissection-purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivo
    Masood A Shammas
    Department of Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Clin Cancer Res 14:4971-80. 2008
    ....

Research Grants1

  1. Whole genome amplification and DNA pooling strategies
    Immaculata DeVivo; Fiscal Year: 2004
    ..Results from the pooling experiments will determine whether this method may be sensitive enough for use in nested case-control studies where a small difference in allele frequency is expected. ..