Research Topics
| Ronald DesrosiersSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Vaccine protection against simian immunodeficiency virus in monkeys using recombinant gamma-2 herpesvirusJohn P Bilello
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
J Virol 85:12708-20. 2011....- Evidence against extracellular exposure of a highly immunogenic region in the C-terminal domain of the simian immunodeficiency virus gp41 transmembrane proteinThomas S Postler
New England Primate Research Center, Department of Microbiology and Immunobiology, Harvard Medical School, Southborough, Massachusetts, USA
J Virol 86:1145-57. 2012..Together, these data support the conventional model of SIV envelope as a type Ia transmembrane protein with a single membrane-spanning domain and without any extracellular loops... 
Prospects for an AIDS vaccineRonald C Desrosiers
New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA
Nat Med 10:221-3. 2004- Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virusTomek Swigut
New England Primate Research Center, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
J Virol 78:13335-44. 2004..These results indicate that nef does serve to limit the virus-specific CD8 cellular response of the host and that the ability to downregulate MHC class I contributes importantly to the totality of nef function... - Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infectionA Kaur
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Eur J Immunol 31:3207-17. 2001..These results document the occurrence of CTL escape in a host that does not develop AIDS, and adds to the growing body of evidence that CTL exert significant selective pressure in SIV infection... - Identification of highly attenuated mutants of simian immunodeficiency virusR C Desrosiers
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
J Virol 72:1431-7. 1998.... - Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virusR P Johnson
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 71:7711-8. 1997.... - Protective immunity induced by live attenuated simian immunodeficiency virusR P Johnson
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Curr Opin Immunol 10:436-43. 1998.... - Glycosylation of gp41 of simian immunodeficiency virus shields epitopes that can be targets for neutralizing antibodiesEloisa Yuste
Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
J Virol 82:12472-86. 2008.... - Construction and in vitro properties of SIVmac mutants with deletions in "nonessential" genesJ S Gibbs
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102
AIDS Res Hum Retroviruses 10:607-16. 1994.... - Effects of reverse-transcriptase mutations M184V and E89G on simian immunodeficiency virus in Rhesus monkeysM C Newstein
Department of Microbiology and Molecular Genetics, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA
J Infect Dis 184:1262-7. 2001..These results demonstrate that the E89G mutation has a significant negative impact on SIVmac fitness, whereas SIVmac bearing M184V achieved high, sustained virus loads, perhaps with a compensatory effect of the P272S mutation... - Construction and in vitro properties of SIVmac mutants with deletions in "nonessential" genesJ S Gibbs
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102
AIDS Res Hum Retroviruses 10:333-42. 1994.... - Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4R E Means
Department of Microbiology and Molecular Genetics, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA
J Virol 75:3903-15. 2001..In addition, these studies suggest a correlation between decreased dependence on CD4 and increased sensitivity to antibody-mediated neutralization... - Efficient transcription and replication of simian immunodeficiency virus in the absence of NF-kappaB and Sp1 binding elementsP O Ilyinskii
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
J Virol 70:3118-26. 1996..Therefore, the surprisingly high replicative capacity of NF-kappaB and Sp1 binding site mutants of SIVmac is due to unique features or the enhancer/promoter region... - Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genesJ S Gibbs
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102
AIDS Res Hum Retroviruses 10:343-50. 1994..This collection of HIV-1 deletion mutants will be useful for elucidating the functions of these genes and for investigating antiviral immunity in animal models... - Immune evasion strategies of the primate lentivirusesD T Evans
Division of Microbiology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772-9102, USA
Immunol Rev 183:141-58. 2001..Here we review these mechanisms of immune evasion considering contributions from both human and non-human primate systems... - Comparison of simian immunodeficiency virus isolatesH W Kestler
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772
Nature 331:619-22. 1988..4). These results and other observations provide strong evidence that isolates previously referred to as STLV-IIIAGM and HTLV-IV by others are not authentic, but were derived from cell cultures infected with SIVMAC-251... - Rhesus monkey rhadinovirus ORF57 induces gH and gL glycoprotein expression through posttranscriptional accumulation of target mRNAsYoung C Shin
New England Primate Research Center, 1 Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
J Virol 85:7810-7. 2011.... - Simian immunodeficiency virus from the sooty mangabey and rhesus macaque is modified with O-linked carbohydrateElizabeth Stansell
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
J Virol 85:582-95. 2011..These data demonstrate the presence of non- and monosialylated core 1 O-linked carbohydrate on the gp120s of SIVmac and SIVsm and the lack of these modifications on HIV-1 and SIVcpz gp120s... - Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformationS C Murthy
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772
J Virol 63:3307-14. 1989..5 kilobases). Although some analogies can be drawn between STP and LMP (lymphocyte membrane protein) of Epstein-Barr virus, STP is not related in sequence to LMP... - Simian homologues of human herpesvirus 8B Damania
New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772-9102, USA
Philos Trans R Soc Lond B Biol Sci 356:535-43. 2001..Rhadinoviruses that infect hominoids and Old World monkeys include Kaposi's sarcoma-associated herpesvirus, also known as HHV-8, and rhesus monkey rhadinovirus... - A genetic system for rhesus monkey rhadinovirus: use of recombinant virus to quantitate antibody-mediated neutralizationJohn P Bilello
New England Primate Research Center/Harvard Medical School, One Pine Hill Drive, P.O. Box 9102, Southborough, MA 01772-9102, USA
J Virol 80:1549-62. 2006..This cosmid-based genetic system and the reporter virus neutralization assay will facilitate study of the contribution of individual RRV glycoproteins to entry into different cell types, particularly fibroblasts and B cells... - HIV vaccine design: insights from live attenuated SIV vaccinesWayne C Koff
International AIDS Vaccine Initiative, New York, New York 10038, USA
Nat Immunol 7:19-23. 2006..Here, the strategies defining key components of the protective immune response elicited by these vaccines are discussed... - p6gag of human and simian immunodeficiency viruses is tolerant to small in-frame deletions downstream of the late domainCheryl A Pikora
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
Virology 346:479-89. 2006..These results demonstrate an overall high tolerance of SIV and HIV to two amino acid deletions within p6gag downstream of the late domain... - Identification of two N-linked glycosylation sites within the core of the simian immunodeficiency virus glycoprotein whose removal enhances sensitivity to soluble CD4Cheryl Pikora
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01722, USA
J Virol 79:12575-83. 2005..Thus, glycans at positions 3 and 11 of SIV239 gp120 may be particularly important for shielding the CD4-binding site from antibody recognition... - Virion envelope content, infectivity, and neutralization sensitivity of simian immunodeficiency virusEloisa Yuste
New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772 9102, USA
J Virol 79:12455-63. 2005..The striking increase in infectivity that results from truncation in the context of SIV316 appears to be due principally to an increase in inherent infectivity per spike... - Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaquesJörn E Schmitz
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 113, 330 Brookline Ave, Boston, Massacusetts 02215, USA
J Virol 79:8131-41. 2005.... - Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasmaEloisa Yuste
New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical Scool, One Pine Hill Drive, Box 9102, Southborough, Massachusetts 01772-9102, USA
J Virol 80:3030-41. 2006..We further conclude that the structures of gp41 from SIVmac239 and HIV-1 are sufficiently similar such that epitopes engrafted into SIVmac239 can be readily recognized by the cognate anti-HIV-1 monoclonal antibodies... - Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virusAmitinder Kaur
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
Virology 357:199-214. 2007..05) and peak neutralizing antibody titers pre-challenge (P value 0.06). These findings support continued study of recombinant herpesviruses as a vaccine approach for AIDS... - Induction of a virus-specific effector-memory CD4+ T cell response by attenuated SIV infectionMarie Claire Gauduin
Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, and Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital, Boston 02115, USA
J Exp Med 203:2661-72. 2006..The ability of SIVDeltanef to induce a high frequency virus-specific CD4+ T cell response with direct effector function may play a key role in protective immunity produced by vaccination with attenuated SIV strains... - A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120Simon Beddows
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Room W 805, New York, NY 10021, USA
Virology 360:329-40. 2007..When antibodies able to neutralize HIV-1(JR-FL) were detected, antigen depletion studies showed they were not directed at the V3 region but were targeted at other, undefined gp120 and also non-gp120 epitopes... - Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectinAndrea Marzi
Institute for Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany
Virology 368:322-30. 2007..Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12... - Infectivity and neutralization of simian immunodeficiency virus with FLAG epitope insertion in gp120 variable loopsMelissa E Laird
New England Primate Research Center, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
J Virol 81:10838-48. 2007.... - Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the peripheryKeith Mansfield
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
J Virol 82:4135-48. 2008.... - Potent antibody-mediated neutralization and evolution of antigenic escape variants of simian immunodeficiency virus strain SIVmac239 in vivoShuji Sato
New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772, USA
J Virol 82:9739-52. 2008.... - Importance of the V1/V2 loop region of simian-human immunodeficiency virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibody responseMelissa E Laird
New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
J Virol 82:11054-65. 2008..These data demonstrate that the V1/V2 region of HIV-1 gp120 is principally responsible for the strain specificity of the neutralizing antibody response in monkeys infected with these prototypic SHIVs... - Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239David T Evans
New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102
J Virol 79:7707-20. 2005..Given the extraordinary difficulty in protecting against SIV(mac)239, these results are encouraging and support further evaluation of lentiviruses that are limited to a single cycle of infection as a preclinical AIDS vaccine approach... - Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac23Eun-Young Kim
Division of Infectious Diseases, The Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
J Virol 79:4886-95. 2005..These findings show that recombination can occur readily in vivo after mucosal SIV exposure and thus contributes to the generation of viral genetic diversity and enhancement of viral fitness... - Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDSAmitinder Kaur
Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 77:5749-58. 2003..The underlying mechanism may be a dysfunction of memory B and CD8(+) T lymphocytes associated with SIV-induced impairment of CMV-specific CD4(+) T-cell help... - Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infectionTodd M Allen
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
J Virol 76:10507-11. 2002..By themselves, these strong CTL responses failed to control SIVmac239 replication... - Importance of B-cell responses for immunological control of variant strains of simian immunodeficiency virusWelkin E Johnson
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA
J Virol 77:375-81. 2003.... - Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery systemDavid T Evans
New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772-9102, USA
J Virol 77:2400-9. 2003..Nevertheless, this study demonstrates the potential of mucosal priming by the Salmonella type III secretion system to direct SIV-specific cellular immune responses to the gastrointestinal mucosa in a primate model... - A nucleotide substitution in the tRNA(Lys) primer binding site dramatically increases replication of recombinant simian immunodeficiency virus containing a human immunodeficiency virus type 1 reverse transcriptaseKelly Soderberg
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Virol 76:5803-6. 2002..RT/SHIV/TC provides an improved system for study of the impact of drug resistance mutations in HIV-1 RT in a relevant animal model... - Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replicationTodd M Allen
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
J Virol 76:4108-12. 2002..Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls... - Determinants of increased replicative capacity of serially passaged simian immunodeficiency virus with nef deleted in rhesus monkeysLouis Alexander
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
J Virol 77:6823-35. 2003..These results delineate sequence changes in SIV that can compensate for the loss of the nef gene to partially restore replicative and pathogenic potential in rhesus monkeys... - Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificitiesWelkin E Johnson
New England Regional Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772-9102, USA
J Virol 77:9993-10003. 2003..This reagent set and information should now be useful for defining the physical, structural, thermodynamic, and kinetic factors that influence relative sensitivity to antibody-mediated neutralization... - CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicityBridget A Puffer
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Virol 76:2595-605. 2002..Finally, genetic modification of viral Envs to enhance CD4 independence may also result in improved humoral immune responses... - Removal of N-linked glycosylation sites in the V1 region of simian immunodeficiency virus gp120 results in redirection of B-cell responses to V3Kelly Stefano Cole
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Virol 78:1525-39. 2004..In addition, our results demonstrate that the absence of N-linked carbohydrates at specific sites can influence the exposure of epitopes quite distant in the linear sequence... - Public health. A sound rationale needed for phase III HIV-1 vaccine trialsDennis R Burton
Scripps Research Institute, La Jolla, California, USA
Science 303:316. 2004 - Cell tropism of simian immunodeficiency virus in culture is not predictive of in vivo tropism or pathogenesisJuan T Borda
Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
Am J Pathol 165:2111-22. 2004..These data combined with the absence of macrophage-associated lesions in SIVmac239/316-infected animals indicate that in vitro cell tropism is not predictive of in vivo tropism or disease pathogenesis... - Viral persistance: HIV's strategies of immune system evasionWelkin E Johnson
New England Regional Primate Research Center, One Pine Hill Drive, Southborough, Massachusetts 01772-9102, USA
Annu Rev Med 53:499-518. 2002..The future success of antiviral therapies and vaccination strategies may depend largely on understanding how and to what degree each of these factors (and presumably others) contributes to immune evasion... - A novel approach for producing lentiviruses that are limited to a single cycle of infectionDavid T Evans
New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA
J Virol 78:11715-25. 2004..Single-cycle SIV produced by this approach will be useful for addressing questions relating to viral dynamics and viral pathogenesis and for evaluation as an experimental AIDS vaccine in rhesus macaques... - A replication-competent, neutralization-sensitive variant of simian immunodeficiency virus lacking 100 amino acids of envelopeWelkin E Johnson
Department of Microbiology and Molecular Genetics, New England Regional Primate Research Center, One Pine Hill Drive, Box 9102, Southborough, MA 01772-9102, USA
J Virol 76:2075-86. 2002.... - HIV vaccine design and the neutralizing antibody problemDennis R Burton
Departments of Immunology and Molecular Biology, Scripps Research Institute, La Jolla, California, USA
Nat Immunol 5:233-6. 2004 - Reversion of CTL escape-variant immunodeficiency viruses in vivoThomas C Friedrich
Wisconsin National Primate Research Center, Madison, Wisconsin 53715, USA
Nat Med 10:275-81. 2004..In the absence of selective pressure upon transmission to new hosts, these original escape mutations can be lost. This suggests that some HIV CTL epitopes will be maintained in human populations... - Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression followHelen Horton
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
J Virol 76:7187-202. 2002..01). However, despite the induction of virus-specific cellular immune responses and reduced peak viral loads, most animals still suffered from gradual CD4 depletion and progressed to disease... - Extreme dependence of gH and gL expression on ORF57 and association with highly unusual codon usage in rhesus monkey rhadinovirusJohn P Bilello
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
J Virol 82:7231-7. 2008.... - Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptorDavid T Evans
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
J Virol 76:327-37. 2002..Thus, PRA1 associates with envelope glycoproteins from widely divergent lentiviruses... - Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus monkey rhadinovirusAlexandra Schäfer
Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA
Virology 364:21-7. 2007..These data set the stage for the mutational ablation and phenotypic analysis of RRV mutants lacking one or more viral microRNAs... - PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporationPhilippe Blancou
New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
J Gen Virol 86:1785-90. 2005..However, variation in the levels of PRA1 expression did not influence virion production, infectivity or envelope incorporation under the conditions of these assays... - A plea for justice for jailed medical workersSunil K Ahuja
Science 314:924-5. 2006 - Infection and persistence of rhesus monkey rhadinovirus in immortalized B-cell linesJohn P Bilello
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772-9102, USA
J Virol 80:3644-9. 2006..These results establish a naturalistic cell culture system for the study of infection and persistence by RRV in rhesus monkey B cells... - Modulation of Env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivityEloisa Yuste
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
J Virol 78:6775-85. 2004.... - An AIDS vaccine: no time to give upDennis R Burton
Lancet 364:1938. 2004 - Small nuclear RNAs encoded by Herpesvirus saimiri upregulate the expression of genes linked to T cell activation in virally transformed T cellsHeidi L Cook
Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06536, USA
Curr Biol 15:974-9. 2005..These changes indicate an unexpected role for the HSURs in regulating a remarkably defined and physiologically relevant set of host targets involved in the activation of virally transformed T cells during latency... - Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressedXuezhong Cai
Center for Virology, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA
PLoS Pathog 2:e23. 2006..Moreover, the differential regulation of EBV miRNA expression implies distinct roles during infection of different human tissues...
Research Grants
- MOLECULAR BASIS FOR SIV PATHOGENICITYRonald Desrosiers; Fiscal Year: 2007..Finally, a potential role for O-linked carbohydrates in shielding antibody access will be investigated. Results from these studies have the potential to enlighten immunogen design for the elicitation of neutralizing antibodies. ..
- Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and NeutralizationRonald Desrosiers; Fiscal Year: 2009..The experiments will also facilitate use of HHV-8 as a vaccine or gene therapy vector. ..
- MOLECULAR BASIS FOR SIV PATHOGENICITYRonald Desrosiers; Fiscal Year: 2009..Results from these studies have the potential to enlighten immunogen design for the elicitation of neutralizing antibodies. ..
- Gamma-2 Herpesviruses as Vaccine Vectors for AIDSRonald Desrosiers; Fiscal Year: 2009..Thus, it is not unreasonable to envision a recombinant KSHV that is missing several genes and capable of expressing HIV antigens for use as a vaccine in people. ..
- Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and NeutralizationRonald C Desrosiers; Fiscal Year: 2010..The experiments will also facilitate use of HHV-8 as a vaccine or gene therapy vector. ..
- LIVE ATTENUATED MULTIPLY DELETED HIV1 VACCINE FOR AIDSRonald Desrosiers; Fiscal Year: 2004..Through these experiments we will begin the understand the mechanisms of protective immunity and what is needed to induce it. ..
- Contributions of HIV qp41 TM Protein to PathogenesisRonald Desrosiers; Fiscal Year: 2005..Better understanding of these parameters will eventually fuel vaccine and drug development efforts. ..
- MOLECULAR BASIS FOR SIV PATHOGENICITYRonald Desrosiers; Fiscal Year: 1993..If nef is required for the pathogenic potential of the virus, the nef gene product will become an important target for drug development...
- 19th Annual Symposium-Nonhuman Primate Models for AIDSRonald Desrosiers; Fiscal Year: 2001..The conference will also include an opening reception on the day of arrival, an evening poster session with accompanying reception and an evening banquet with a topical speaker. ..
- MOLECULAR BASIS FOR SIV PATHOGENICITYRonald C Desrosiers; Fiscal Year: 2010..Results from these studies have the potential to enlighten immunogen design for the elicitation of neutralizing antibodies. ..