A Desai

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles
    A Desai
    Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    J Cell Biol 141:703-13. 1998
  2. ncbi Tubulin and FtsZ structures: functional and therapeutic implications
    A Desai
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Bioessays 20:523-7. 1998
  3. pmc Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles
    T J Mitchison
    Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Mol Biol Cell 16:3064-76. 2005
  4. ncbi The spindle: a dynamic assembly of microtubules and motors
    T Wittmann
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 3:E28-34. 2001
  5. pmc Bipolarization and poleward flux correlate during Xenopus extract spindle assembly
    T J Mitchison
    Cell Division Group, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Mol Biol Cell 15:5603-15. 2004
  6. ncbi XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly
    C E Walczak
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Cell 84:37-47. 1996
  7. pmc Functional analysis of kinetochore assembly in Caenorhabditis elegans
    K Oegema
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    J Cell Biol 153:1209-26. 2001
  8. pmc Implication of a novel multiprotein Dam1p complex in outer kinetochore function
    I M Cheeseman
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Cell Biol 155:1137-45. 2001
  9. ncbi Cytoplasmic forms of fission yeast casein kinase-1 associate primarily with the particulate fraction of the cell
    P C Wang
    Cold Spring Harbor Laboratory, New York 11724 2220
    J Biol Chem 269:12014-23. 1994
  10. ncbi Purification and assay of a septin complex from Drosophila embryos
    K Oegema
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Methods Enzymol 298:279-95. 1998

Collaborators

Detail Information

Publications11

  1. pmc Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles
    A Desai
    Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    J Cell Biol 141:703-13. 1998
    ..We discuss the possible biological implications of the existence of two distinct anaphase A mechanisms and their differential contributions to poleward chromosome movement in different cell types...
  2. ncbi Tubulin and FtsZ structures: functional and therapeutic implications
    A Desai
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Bioessays 20:523-7. 1998
    ..This structural inferiority complex has finally been lifted by two recent papers describing the structures of the alpha beta tubulin dimer and FtsZ, a protein similar to tubulin that is essential for cell division in prokaryotes...
  3. pmc Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles
    T J Mitchison
    Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Mol Biol Cell 16:3064-76. 2005
    ..The response to microtubule destabilization suggests that an unidentified tensile element acts in parallel with these conventional factors, generating spindle shortening force...
  4. ncbi The spindle: a dynamic assembly of microtubules and motors
    T Wittmann
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 3:E28-34. 2001
    ..Here we describe the structural and dynamic properties of the spindle, and introduce the current concepts regarding how a bipolar spindle is assembled and how it functions to segregate chromosomes...
  5. pmc Bipolarization and poleward flux correlate during Xenopus extract spindle assembly
    T J Mitchison
    Cell Division Group, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Mol Biol Cell 15:5603-15. 2004
    ..Our results highlight the importance of two processes, chromatin-initiated microtubule nucleation, and sliding forces generated between antiparallel microtubules, in self-organization of spindle bipolarity and poleward flux...
  6. ncbi XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly
    C E Walczak
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Cell 84:37-47. 1996
    ..XKCM1 thus exhibits a novel activity for a kinesin-related protein by promoting microtubule depolymerization during mitotic spindle assembly...
  7. pmc Functional analysis of kinetochore assembly in Caenorhabditis elegans
    K Oegema
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    J Cell Biol 153:1209-26. 2001
    ..Furthermore, kinetochore assembly and the recruitment of CeINCENP to chromosomes are independent. These results suggest distinct roles for the kinetochore and the chromosomal passengers in mitotic chromosome segregation...
  8. pmc Implication of a novel multiprotein Dam1p complex in outer kinetochore function
    I M Cheeseman
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Cell Biol 155:1137-45. 2001
    ..These and other analyses implicate the four newly identified subunits and the Dam1p complex as a whole in outer kinetochore function where they are well positioned to facilitate the association of chromosomes with spindle microtubules...
  9. ncbi Cytoplasmic forms of fission yeast casein kinase-1 associate primarily with the particulate fraction of the cell
    P C Wang
    Cold Spring Harbor Laboratory, New York 11724 2220
    J Biol Chem 269:12014-23. 1994
    ..These results suggest that of the four members of the casein kinase-1 family recognized in fission yeast, one member, Cki2, may contribute to the regulation of cell morphology...
  10. ncbi Purification and assay of a septin complex from Drosophila embryos
    K Oegema
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Methods Enzymol 298:279-95. 1998
  11. ncbi Lysozyme refolding with cyclodextrins: structure-activity relationship
    A Desai
    Department of Chemistry, Central Michigan University, Dow 346, Mt Pleasant, MI 48859, USA
    Biochimie 88:1435-45. 2006
    ..CDs may show properties similar to chaotropic agents, which may help explain their anti-aggregation and protein refolding ability. Besides alpha-CD, a number of other neutral CDs were found to be effective protein folding aids...