Vladimir Denic

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Advice to a young scientist (by someone who doesn't know how to give it)
    Vladimir Denic
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mol Biol Cell 26:3681-3. 2015
  2. pmc Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway
    Vladimir Denic
    Department of Molecular and Cellular Biology, Harvard University, Northwest Laboratories, Cambridge, Massachusetts 02138, USA
    Cold Spring Harb Perspect Biol 5:a013334. 2013
  3. pmc No country for old misfolded glycoproteins
    Vladimir Denic
    Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
    Mol Cell 42:715-7. 2011
  4. pmc A portrait of the GET pathway as a surprisingly complicated young man
    Vladimir Denic
    Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
    Trends Biochem Sci 37:411-7. 2012
  5. pmc The mechanism of tail-anchored protein insertion into the ER membrane
    Fei Wang
    Northwest Labs, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Cell 43:738-50. 2011
  6. pmc The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase
    Fei Wang
    Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, Massachusetts 02138, USA
    Nature 512:441-4. 2014
  7. pmc A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum
    Fei Wang
    Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
    Mol Cell 40:159-71. 2010

Collaborators

  • Fei Wang
  • Charlene Chan
  • Nicholas R Weir
  • Andrew Whynot
  • Matthew Tung
  • Emily C Brown
  • Gary Mak
  • Jimmy Zhuang

Detail Information

Publications7

  1. doi request reprint Advice to a young scientist (by someone who doesn't know how to give it)
    Vladimir Denic
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mol Biol Cell 26:3681-3. 2015
    ..So I abandon the conceit of advice and simply give you my story. There are many like it, but this one is mine. Take what you wish from it. ..
  2. pmc Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway
    Vladimir Denic
    Department of Molecular and Cellular Biology, Harvard University, Northwest Laboratories, Cambridge, Massachusetts 02138, USA
    Cold Spring Harb Perspect Biol 5:a013334. 2013
    ..Here we focus on the mechanism of the yeast GET pathway and make a speculative analogy between its membrane insertion step and the ATPase-driven cycle of ABC transporters. ..
  3. pmc No country for old misfolded glycoproteins
    Vladimir Denic
    Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
    Mol Cell 42:715-7. 2011
    ....
  4. pmc A portrait of the GET pathway as a surprisingly complicated young man
    Vladimir Denic
    Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
    Trends Biochem Sci 37:411-7. 2012
    ..The GET pathway is both surprisingly complicated and yet more experimentally tractable than most other membrane insertion mechanisms, and is rapidly revealing new fundamental concepts in membrane protein biogenesis...
  5. pmc The mechanism of tail-anchored protein insertion into the ER membrane
    Fei Wang
    Northwest Labs, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Cell 43:738-50. 2011
    ..Lastly, we show that ATP enhances Get3 dissociation from the membrane, thus freeing Get1-Get2 for new rounds of substrate insertion...
  6. pmc The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase
    Fei Wang
    Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, Massachusetts 02138, USA
    Nature 512:441-4. 2014
    ....
  7. pmc A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum
    Fei Wang
    Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA
    Mol Cell 40:159-71. 2010
    ..Thus, ER-bound TA proteins are sorted at the top of a TMD chaperone cascade that culminates with the formation of Get3-TA protein complexes, which are recruited to the ER membrane for insertion...