Guo Min Deng

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Tumor necrosis factor receptor pre-ligand assembly domain is an important therapeutic target in inflammatory arthritis
    Guo Min Deng
    Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA
    BioDrugs 21:23-9. 2007
  2. pmc Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation
    Guo Min Deng
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:4019-26. 2008
  3. ncbi request reprint The role of bacterial DNA in inflammatory and allergic disease
    Guo Min Deng
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA02115, USA
    Recent Pat Inflamm Allergy Drug Discov 2:117-22. 2008
  4. pmc Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice
    Guo Min Deng
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 62:2086-92. 2010
  5. pmc Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway
    Guo Min Deng
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 184:7154-61. 2010
  6. pmc Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice
    Guo Min Deng
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 937, Boston, MA 02115, USA
    Arthritis Rheum 62:2424-31. 2010
  7. ncbi request reprint Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
    Guo Min Deng
    Laboratory of Immunology, Building 10, Room 11N311, 10 Center Drive, MSC 1892, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 11:1066-72. 2005
  8. doi request reprint Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury
    Tong Shi
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 296:G339-47. 2009
  9. ncbi request reprint T Cell CD3ζ Deficiency Enables Multiorgan Tissue Inflammation
    Guo Min Deng
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115
    J Immunol . 2013

Detail Information

Publications9

  1. ncbi request reprint Tumor necrosis factor receptor pre-ligand assembly domain is an important therapeutic target in inflammatory arthritis
    Guo Min Deng
    Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA
    BioDrugs 21:23-9. 2007
    ..The TNFR1 PLAD protein could therefore be useful in treatment of inflammatory arthritis...
  2. pmc Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation
    Guo Min Deng
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:4019-26. 2008
    ..Our results demonstrate that lipid rafts contribute significantly to the pathogenesis of lupus and provide a novel mechanism whereby aggregated lipid rafts represent a potential link between infection and autoimmunity...
  3. ncbi request reprint The role of bacterial DNA in inflammatory and allergic disease
    Guo Min Deng
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA02115, USA
    Recent Pat Inflamm Allergy Drug Discov 2:117-22. 2008
    ..CpG ODN is also found to reverse Th-2 dominant allergic diseases. This review discusses that the role and mechanism of bacterial DNA in inflammatory diseases and allergic disease. In this review patented strategies are also discussed...
  4. pmc Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice
    Guo Min Deng
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 62:2086-92. 2010
    ....
  5. pmc Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway
    Guo Min Deng
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 184:7154-61. 2010
    ..Accordingly, disruption of the TNFR1-mediated signaling pathway and blockade of DC generation may prove to be of therapeutic value in patients with cutaneous lupus erythematosus...
  6. pmc Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice
    Guo Min Deng
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 937, Boston, MA 02115, USA
    Arthritis Rheum 62:2424-31. 2010
    ..This study was undertaken to investigate whether TNFR PLAD limits inflammatory skin injury in a mouse model of SLE...
  7. ncbi request reprint Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
    Guo Min Deng
    Laboratory of Immunology, Building 10, Room 11N311, 10 Center Drive, MSC 1892, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 11:1066-72. 2005
    ..Thus, targeting the PLAD may have clinical value in the treatment of human arthritis and other disorders involving receptors of the TNFR superfamily...
  8. doi request reprint Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury
    Tong Shi
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 296:G339-47. 2009
    ..We conclude that ischemia-mediated aggregation of the actin cytoskeleton leads to the deposition of natural IgM and the activation of complement, as well as tissue injury...
  9. ncbi request reprint T Cell CD3ζ Deficiency Enables Multiorgan Tissue Inflammation
    Guo Min Deng
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115
    J Immunol . 2013
    ..Approaches to restore CD3ζ expression of the surface of T cells should be expected to mitigate tissue inflammation...