Fabio Demontis

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila
    Fabio Demontis
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 136:983-93. 2009
  2. pmc FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:813-25. 2010
  3. pmc The influence of skeletal muscle on systemic aging and lifespan
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA Division of Developmental Biology, Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN, 38105, USA
    Aging Cell 12:943-9. 2013
  4. pmc Mechanisms of muscle growth and atrophy in mammals and Drosophila
    Rosanna Piccirillo
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts Department of Oncology, IRCCS, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Dev Dyn 243:201-15. 2014
  5. pmc Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dis Model Mech 6:1339-52. 2013
  6. ncbi request reprint Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Division of Developmental Biology, Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA Electronic address
    Cell Rep 7:1481-94. 2014

Collaborators

Detail Information

Publications6

  1. pmc Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila
    Fabio Demontis
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 136:983-93. 2009
    ..Thus, maximal dMyc transcriptional activity depends on InR to control muscle mass, which in turn induces a systemic behavioral response to allocate body size and proportions...
  2. pmc FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:813-25. 2010
    ..These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging...
  3. pmc The influence of skeletal muscle on systemic aging and lifespan
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA Division of Developmental Biology, Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN, 38105, USA
    Aging Cell 12:943-9. 2013
    ..Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging. ..
  4. pmc Mechanisms of muscle growth and atrophy in mammals and Drosophila
    Rosanna Piccirillo
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts Department of Oncology, IRCCS, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Dev Dyn 243:201-15. 2014
    ..Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy...
  5. pmc Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dis Model Mech 6:1339-52. 2013
    ....
  6. ncbi request reprint Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Division of Developmental Biology, Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA Electronic address
    Cell Rep 7:1481-94. 2014
    ..Altogether, these findings highlight a key role for myokine signaling in the integration of signaling events in muscle and distant tissues during aging. ..