Genomes and Genes
Affiliation: Harvard University
- Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in DrosophilaFabio Demontis
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Development 136:983-93. 2009..Thus, maximal dMyc transcriptional activity depends on InR to control muscle mass, which in turn induces a systemic behavioral response to allocate body size and proportions...
- FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during agingFabio Demontis
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Cell 143:813-25. 2010..These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging...