Utkan Demirci

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Single cell epitaxy by acoustic picolitre droplets
    Utkan Demirci
    Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lab Chip 7:1139-45. 2007
  2. pmc Statistical modeling of single target cell encapsulation
    Sangjun Moon
    Demirci Bio Acoustic MEMS in Medicine Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21580. 2011
  3. pmc Living bacterial sacrificial porogens to engineer decellularized porous scaffolds
    Feng Xu
    Demirci Bio Acoustic MEMS in Medicine Laboratory, Department of Medicine, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19344. 2011
  4. pmc Drop-on-demand single cell isolation and total RNA analysis
    Sangjun Moon
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17455. 2011
  5. pmc Blood banking in living droplets
    Josh Samot
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17530. 2011
  6. pmc Enumeration of CD4+ T-cells using a portable microchip count platform in Tanzanian HIV-infected patients
    Sangjun Moon
    Demirci Bio Acoustic MEMS Laboratory, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21409. 2011
  7. pmc Portable microfluidic chip for detection of Escherichia coli in produce and blood
    Shuqi Wang
    Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Int J Nanomedicine 7:2591-600. 2012
  8. pmc Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing
    Umut Atakan Gurkan
    Demirci Bio Acoustic MEMS in Medicine BAMM Labs at the HST BWH Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biotechnol J 6:138-49. 2011
  9. ncbi request reprint Cell encapsulating droplet vitrification
    Utkan Demirci
    Harvard Massachusetts Institute of Technology Health Sciences and Technology, Cambridge, MA, USA
    Lab Chip 7:1428-33. 2007
  10. pmc Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
    Savas Tasoglu
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Small 9:3374-84. 2013

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Single cell epitaxy by acoustic picolitre droplets
    Utkan Demirci
    Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lab Chip 7:1139-45. 2007
    ..Overall, the techniques described have the potential for widespread impact on many high-throughput testing applications in the biological and health sciences...
  2. pmc Statistical modeling of single target cell encapsulation
    Sangjun Moon
    Demirci Bio Acoustic MEMS in Medicine Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21580. 2011
    ..Here, we explain theoretically and validate experimentally a model to isolate and pattern single target cells from heterogeneous mixtures without using complex peripheral systems...
  3. pmc Living bacterial sacrificial porogens to engineer decellularized porous scaffolds
    Feng Xu
    Demirci Bio Acoustic MEMS in Medicine Laboratory, Department of Medicine, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19344. 2011
    ..This 3D porous network method combined with bioprinting has the potential to be broadly applicable and compatible with tissue specific applications allowing seeding of stem cells and other cell types...
  4. pmc Drop-on-demand single cell isolation and total RNA analysis
    Sangjun Moon
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17455. 2011
    ..This automated platform enabling high-throughput cell manipulation for subsequent genomic analysis employs fewer handling steps compared to existing methods...
  5. pmc Blood banking in living droplets
    Josh Samot
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17530. 2011
    ..This approach enables the vitrification of large volumes of blood in a short amount of time, and makes it a viable and scalable biotechnology tool for blood cryopreservation...
  6. pmc Enumeration of CD4+ T-cells using a portable microchip count platform in Tanzanian HIV-infected patients
    Sangjun Moon
    Demirci Bio Acoustic MEMS Laboratory, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21409. 2011
    ..The World Health Organization (WHO) has pointed out or recommended that a handheld, point-of-care, reliable, and affordable CD4 count platform is urgently needed in resource-scarce settings...
  7. pmc Portable microfluidic chip for detection of Escherichia coli in produce and blood
    Shuqi Wang
    Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Int J Nanomedicine 7:2591-600. 2012
    ..The presented technology can be broadly applied to other pathogens at the POC, enabling various applications including surveillance of food supply and monitoring of bacteriology in patients with burn wounds...
  8. pmc Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing
    Umut Atakan Gurkan
    Demirci Bio Acoustic MEMS in Medicine BAMM Labs at the HST BWH Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biotechnol J 6:138-49. 2011
    ..The emerging technologies are reviewed from a POC perspective considering cost effectiveness, portability, sensitivity, throughput and ease of use for resource-limited settings...
  9. ncbi request reprint Cell encapsulating droplet vitrification
    Utkan Demirci
    Harvard Massachusetts Institute of Technology Health Sciences and Technology, Cambridge, MA, USA
    Lab Chip 7:1428-33. 2007
    ..The method was successfully applied to five different mammalian cell types: AML-12 hepatocytes, NIH-3T3 fibroblasts, HL-1 cardiomyocytes, mouse embryonic stem cells, and RAJI cells...
  10. pmc Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
    Savas Tasoglu
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Small 9:3374-84. 2013
    ..Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm. ..
  11. pmc Lensless imaging for point-of-care testing
    Sangjun Moon
    Bio Acoustic MEMS in Medicine Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6376-9. 2009
    ..5 +/- 2.4% overall platform performance (n = 9 devices). This integrated platform has potential for point-of-care testing (POCT) to rapidly capture, image and count specific cell types from unprocessed whole blood...
  12. pmc Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets
    Sangjun Moon
    Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA, USA
    Tissue Eng Part C Methods 16:157-66. 2010
    ..This platform to print 3D tissue constructs may be beneficial for regenerative medicine applications by enabling the fabrication of printed replacement tissues...
  13. ncbi request reprint A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings
    Xuanhong Cheng
    Surgical Services and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 45:257-61. 2007
    ..86, 0.90, and 0.97, respectively. Specificity is 0.94 or higher at all thresholds. This device can serve as a functional cartridge for fast, accurate, affordable, and simple CD4 cell counting in resource-limited settings...
  14. pmc Efficient on-chip isolation of HIV subtypes
    Shuqi Wang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Harvard MIT Health Sciences and Technology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne St, 267, Cambridge, MA 02139, USA
    Lab Chip 12:1508-15. 2012
    ..The presented immuno-sensing device enables the development of POC on-chip technologies to monitor viral load and guide antiretroviral treatment (ART) in resource-constrained settings...
  15. pmc Smart interface materials integrated with microfluidics for on-demand local capture and release of cells
    Umut Atakan Gurkan
    Postdoctoral Research Fellow in Medicine, Harvard Medical School, Brigham and Women s Hospital, Harvard MIT Health Sciences and Technology, 65 Landsdowne St PRB 252, Cambridge, MA 02139, USA
    Adv Healthc Mater 1:661-8. 2012
    ..Local capture and on-demand local release of cells are demonstrated with spatial and temporal control in a microfluidic system...
  16. pmc Nanoplasmonic quantitative detection of intact viruses from unprocessed whole blood
    Fatih Inci
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    ACS Nano 7:4733-45. 2013
    ..Thus, this broadly applicable detection platform holds great promise to be implemented at POC settings, hospitals, and primary care settings. ..
  17. pmc Nanoliter droplet vitrification for oocyte cryopreservation
    Xiaohui Zhang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nanomedicine (Lond) 7:553-64. 2012
    ..Oocyte cryopreservation remains largely experimental, with live birth rates of only 2-4% per thawed oocyte. In this study, we present a nanoliter droplet technology for oocyte vitrification...
  18. ncbi request reprint Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices
    Xuanhong Cheng
    BioMEMS Resource Center and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Lab Chip 7:746-55. 2007
    ....
  19. pmc Release of magnetic nanoparticles from cell-encapsulating biodegradable nanobiomaterials
    Feng Xu
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    ACS Nano 6:6640-9. 2012
    ....
  20. pmc Emerging technologies for assembly of microscale hydrogels
    Umut Atakan Gurkan
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Adv Healthc Mater 1:149-58. 2012
    ..In this review, we survey emerging microscale hydrogel assembly methods offering rapid, scalable microgel assembly in 3D, and provide future perspectives and discuss potential applications...
  21. doi request reprint Engineered 3D tissue models for cell-laden microfluidic channels
    Young S Song
    Bio Acoustic MEMS in Medicine Lab, HST Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne Street 252, Cambridge, MA 02139, USA
    Anal Bioanal Chem 395:185-93. 2009
    ..This is important since our results reveal that there is a close correlation between nutrient profiles and cell viability across the hydrogel...
  22. pmc Integrating microfluidics and lensless imaging for point-of-care testing
    Sangjun Moon
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biosens Bioelectron 24:3208-14. 2009
    ..The integrated platform points a promising direction for point-of-care testing (POCT) to rapidly capture, image and count subpopulations of cells from blood samples in an automated matter...
  23. pmc Microporous cell-laden hydrogels for engineered tissue constructs
    Jae Hong Park
    Department of Medicine, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne Street, Rm 265, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 106:138-48. 2010
    ..Based on their enhanced diffusive properties, microporous cell-laden hydrogels containing a microengineered fluidic channel can be a useful tool for generating tissue structures for regenerative medicine and drug discovery applications...
  24. pmc Nano/Microfluidics for diagnosis of infectious diseases in developing countries
    Won Gu Lee
    Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    Adv Drug Deliv Rev 62:449-57. 2010
    ..In this paper, we review recent advances in nano/microfluidic technologies for clinical point-of-care applications at resource-limited settings in developing countries...
  25. pmc Microfluidics for cryopreservation
    Young S Song
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lab Chip 9:1874-81. 2009
    ..This method introduces microfluidic technologies to the field of biopreservation, opening the door to future advancements at the interface of these fields...
  26. pmc Multi-scale heat and mass transfer modelling of cell and tissue cryopreservation
    Feng Xu
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Philos Trans A Math Phys Eng Sci 368:561-83. 2010
    ..These multi-scale approaches allow us to study cell and tissue cryopreservation...
  27. pmc Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules
    Imran Rizvi
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 110:E1974-83. 2013
    ..The microfluidic platform developed here potentially provides a flow-informed framework complementary to conventional mechanism-based therapeutic strategies, with broad applicability to other lethal malignancies...
  28. pmc Microengineering methods for cell-based microarrays and high-throughput drug-screening applications
    Feng Xu
    Department of Medicine, Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biofabrication 3:034101. 2011
    ..We conclude that among the emerging microengineering approaches, bioprinting holds great potential to provide repeatable 3D cell-based constructs with high temporal, spatial control and versatility...
  29. pmc Rapid automated cell quantification on HIV microfluidic devices
    Mohamad A Alyassin
    Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    Lab Chip 9:3364-9. 2009
    ..e. CD4 counts...
  30. pmc Simple filter microchip for rapid separation of plasma and viruses from whole blood
    Shuqi Wang
    Bio Acoustic MEMS in Medicine Laboratory, Department of Medicine, Division of Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int J Nanomedicine 7:5019-28. 2012
    ..1% ± 8.3% to 82.5% ± 4.1%. These results are first steps towards developing disposable point-of-care diagnostics and monitoring devices for resource-constrained settings, as well as hospital and primary care settings...
  31. pmc Acute on-chip HIV detection through label-free electrical sensing of viral nano-lysate
    Hadi Shafiee
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Small 9:2553-63, 2478. 2013
    ..The presented method offers a rapid and portable tool that can be used as a detection technology at the POC in resource-constrained settings, as well as hospital and primary care settings. ..
  32. pmc Microcirculation within grooved substrates regulates cell positioning and cell docking inside microfluidic channels
    Amir Manbachi
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA
    Lab Chip 8:747-54. 2008
    ..Therefore, our studies suggest that microscale shear stresses greatly influence cellular docking, immobilization, and retention in fluidic systems and should be considered for the design of cell-based microdevices...
  33. pmc Lensless imaging for simultaneous microfluidic sperm monitoring and sorting
    Xiaohui Zhang
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lab Chip 11:2535-40. 2011
    ....
  34. pmc Engineering hydrogels as extracellular matrix mimics
    Hikmet Geckil
    Health Sciences and Technology, Harvard MIT Health Sciences and Technology, Bio Acoustic MEMS in Medicine BAMM Laboratory, 65 Landsdowne St, 267, 02139 Cambridge, MA, USA
    Nanomedicine (Lond) 5:469-84. 2010
    ..In this article, we detail the progress of the current state-of-the-art engineering methods to create cell-encapsulating hydrogel tissue constructs as well as their applications in in vitro models in biomedicine...
  35. pmc Micro-a-fluidics ELISA for rapid CD4 cell count at the point-of-care
    Shuqi Wang
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Sci Rep 4:3796. 2014
    ..The developed system can be extended to multiple areas for ELISA-related assays. ..
  36. pmc Quantum dot-based HIV capture and imaging in a microfluidic channel
    Yun Gon Kim
    Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, United States
    Biosens Bioelectron 25:253-8. 2009
    ..This on-chip HIV capture and imaging platform creates new avenues for point-of-care diagnostics and monitoring applications of infectious diseases...
  37. pmc Point-of-care assays for tuberculosis: role of nanotechnology/microfluidics
    Shuqi Wang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biotechnol Adv 31:438-49. 2013
    ..Here, we review the current assays used for TB diagnosis, and highlight the recent advances in nanotechnology and microfluidics that potentially enable new approaches for TB diagnosis in resource-constrained settings...
  38. pmc Emerging technologies in medical applications of minimum volume vitrification
    Xiaohui Zhang
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nanomedicine (Lond) 6:1115-29. 2011
    ..Therefore, the synergistic integration of nanoscale technologies with cryogenics has the potential to improve biopreservation methods...
  39. pmc Automated and adaptable quantification of cellular alignment from microscopic images for tissue engineering applications
    Feng Xu
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Department of Medicine, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    Tissue Eng Part C Methods 17:641-9. 2011
    ..92). Therefore, the BEAS method introduced in this study could enable accurate, convenient, and adaptable evaluation of engineered tissue constructs and biomaterials in terms of cellular alignment and organization...
  40. pmc Vitrification and levitation of a liquid droplet on liquid nitrogen
    Young S Song
    Bio Acoustic Microelectromechanical Systems in Medicine Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Center for Bioengineering, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:4596-600. 2010
    ..e., Stefan, Biot, and Fourier numbers). We explain theoretically and observe experimentally a threshold droplet radius during the vitrification of a cryoprotectant droplet in the presence of the Leidenfrost effect...
  41. pmc Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-care
    Shuqi Wang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard MIT Health Sciences and Technology, Cambridge, MA 02139, USA
    Lab Chip 11:3411-8. 2011
    ....
  42. pmc A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects
    Xuanhong Cheng
    Surgical Services and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA
    Lab Chip 7:170-8. 2007
    ..93). This CD4 counting microdevice can be used for simple, rapid and affordable CD4 counting in point-of-care and resource-limited settings...
  43. ncbi request reprint A cell-laden microfluidic hydrogel
    Yibo Ling
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 7:756-62. 2007
    ..Further development of this technique may lead to the generation of biomimetic synthetic vasculature for tissue engineering, diagnostics, and drug screening applications...
  44. pmc Nanostructured optical photonic crystal biosensor for HIV viral load measurement
    Hadi Shafiee
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Sci Rep 4:4116. 2014
    ....
  45. pmc Manipulating biological agents and cells in micro-scale volumes for applications in medicine
    Savas Tasoglu
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Chem Soc Rev 42:5788-808. 2013
    ..Then, we illustrate how these mechanisms impact the aforementioned biomedical applications, discuss the associated challenges, and provide perspectives for further development...
  46. pmc Bioprinting for stem cell research
    Savas Tasoglu
    Brigham and Women s Hospital, Bio Acoustic MEMS in Medicine Lab, Division of Biomedical Engineering, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Trends Biotechnol 31:10-9. 2013
    ..Here, we review recent achievements with bioprinting technologies in stem cell research, and identify future challenges and potential applications including tissue engineering and regenerative medicine, wound healing, and genomics...
  47. pmc Controlled viable release of selectively captured label-free cells in microchannels
    Umut Atakan Gurkan
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lab Chip 11:3979-89. 2011
    ....
  48. pmc The assembly of cell-encapsulating microscale hydrogels using acoustic waves
    Feng Xu
    Demirci Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biomaterials 32:7847-55. 2011
    ..These results indicate that the developed acoustic approach could become an enabling biotechnology tool for tissue engineering, regenerative medicine, pharmacology studies and high throughput screening applications...
  49. pmc A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform
    Feng Xu
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Biotechnol J 6:204-12. 2011
    ....
  50. pmc Paramagnetic levitational assembly of hydrogels
    Savas Tasoglu
    Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA, Harvard MIT Health Sciences and Technology, Cambridge, MA, 02139, USA
    Adv Mater 25:1137-43. 2013
    ..We have performed experimental and theoretical analyses to describe hydrogel motion in a fluidic environment under a magnetic field...
  51. pmc Microscale electroporation: challenges and perspectives for clinical applications
    Won Gu Lee
    Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Integr Biol (Camb) 1:242-51. 2009
    ....
  52. pmc Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures
    Umut Atakan Gurkan
    Harvard Medical School, Division of Biomedical Engineering at Brigham and Women s Hospital, Bio Acoustic MEMS in Medicine BAMM Laboratory, Harvard MIT Health Sciences and Technology, 65 Landsdowne St PRB 252, Cambridge, MA 02139, USA
    Adv Mater 25:1192-8. 2013
    ....
  53. pmc Advances in developing HIV-1 viral load assays for resource-limited settings
    Shuqi Wang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biotechnol Adv 28:770-81. 2010
    ..Emerging approaches based on microfluidics and nanotechnology, which have potential to be integrated into POC HIV-1 viral load assays, are also discussed...
  54. ncbi request reprint Capacitive micromachined ultrasonic transducers: next-generation arrays for acoustic imaging?
    Omer Oralkan
    Edward L Ginzton Laboratory, and Center for Integrated Systems, Stanford University, Stanford, CA 94305 4070, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1596-610. 2002
    ..A tail also was observed in the point spread function (PSF) in the axial direction, indicating the existence of crosstalk. The relative amplitude of this tail with respect to the mainlobe was less than -20 dB...
  55. ncbi request reprint Coherent array imaging using phased subarrays. Part II: simulations and experimental results
    Jeremy A Johnson
    Stanford University, Edward L Ginzton Laboratory, Stanford, CA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:51-64. 2005
    ..The simulated and experimental test results presented in this paper validate theoretical expectations and illustrate the flexibility of PSA imaging as a way to exchange SNR and frame rate for simplified front-end hardware...
  56. ncbi request reprint Forward-viewing CMUT arrays for medical imaging
    Utkan Demirci
    E L Ginzton Laboratory, Stanford University, Stanford, CA 94305 4088, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 51:887-95. 2004
    ....

Research Grants3