Research Topics
| Utkan DemirciSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Single cell epitaxy by acoustic picolitre dropletsUtkan Demirci
Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lab Chip 7:1139-45. 2007..Overall, the techniques described have the potential for widespread impact on many high-throughput testing applications in the biological and health sciences...- Cell encapsulating droplet vitrificationUtkan Demirci
Harvard Massachusetts Institute of Technology Health Sciences and Technology, Cambridge, MA, USA
Lab Chip 7:1428-33. 2007..The method was successfully applied to five different mammalian cell types: AML-12 hepatocytes, NIH-3T3 fibroblasts, HL-1 cardiomyocytes, mouse embryonic stem cells, and RAJI cells... 
Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testingUmut Atakan Gurkan
Demirci Bio Acoustic MEMS in Medicine BAMM Labs at the HST BWH Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Biotechnol J 6:138-49. 2011..The emerging technologies are reviewed from a POC perspective considering cost effectiveness, portability, sensitivity, throughput and ease of use for resource-limited settings...
Lensless imaging for point-of-care testingSangjun Moon
Bio Acoustic MEMS in Medicine Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Conf Proc IEEE Eng Med Biol Soc 2009:6376-9. 2009..5 +/- 2.4% overall platform performance (n = 9 devices). This integrated platform has potential for point-of-care testing (POCT) to rapidly capture, image and count specific cell types from unprocessed whole blood...- Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel dropletsSangjun Moon
Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA, USA
Tissue Eng Part C Methods 16:157-66. 2010..This platform to print 3D tissue constructs may be beneficial for regenerative medicine applications by enabling the fabrication of printed replacement tissues... - Nanoliter droplet vitrification for oocyte cryopreservationXiaohui Zhang
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Nanomedicine (Lond) 7:553-64. 2012..Oocyte cryopreservation remains largely experimental, with live birth rates of only 2-4% per thawed oocyte. In this study, we present a nanoliter droplet technology for oocyte vitrification... - Smart interface materials integrated with microfluidics for on-demand local capture and release of cellsUmut Atakan Gurkan
Postdoctoral Research Fellow in Medicine, Harvard Medical School, Brigham and Women s Hospital, Harvard MIT Health Sciences and Technology, 65 Landsdowne St PRB 252, Cambridge, MA 02139, USA
Adv Healthc Mater 1:661-8. 2012..Local capture and on-demand local release of cells are demonstrated with spatial and temporal control in a microfluidic system... - Release of magnetic nanoparticles from cell-encapsulating biodegradable nanobiomaterialsFeng Xu
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
ACS Nano 6:6640-9. 2012.... - Emerging technologies for assembly of microscale hydrogelsUmut Atakan Gurkan
Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Adv Healthc Mater 1:149-58. 2012..In this review, we survey emerging microscale hydrogel assembly methods offering rapid, scalable microgel assembly in 3D, and provide future perspectives and discuss potential applications... - Efficient on-chip isolation of HIV subtypesShuqi Wang
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Harvard MIT Health Sciences and Technology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne St, 267, Cambridge, MA 02139, USA
Lab Chip 12:1508-15. 2012..The presented immuno-sensing device enables the development of POC on-chip technologies to monitor viral load and guide antiretroviral treatment (ART) in resource-constrained settings... - Portable microfluidic chip for detection of Escherichia coli in produce and bloodShuqi Wang
Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
Int J Nanomedicine 7:2591-600. 2012..The presented technology can be broadly applied to other pathogens at the POC, enabling various applications including surveillance of food supply and monitoring of bacteriology in patients with burn wounds... - Blood banking in living dropletsJosh Samot
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e17530. 2011..This approach enables the vitrification of large volumes of blood in a short amount of time, and makes it a viable and scalable biotechnology tool for blood cryopreservation... - Microporous cell-laden hydrogels for engineered tissue constructsJae Hong Park
Department of Medicine, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne Street, Rm 265, Cambridge, Massachusetts 02139, USA
Biotechnol Bioeng 106:138-48. 2010..Based on their enhanced diffusive properties, microporous cell-laden hydrogels containing a microengineered fluidic channel can be a useful tool for generating tissue structures for regenerative medicine and drug discovery applications... - Microengineering methods for cell-based microarrays and high-throughput drug-screening applicationsFeng Xu
Department of Medicine, Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Biofabrication 3:034101. 2011..We conclude that among the emerging microengineering approaches, bioprinting holds great potential to provide repeatable 3D cell-based constructs with high temporal, spatial control and versatility... - Nano/Microfluidics for diagnosis of infectious diseases in developing countriesWon Gu Lee
Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Adv Drug Deliv Rev 62:449-57. 2010..In this paper, we review recent advances in nano/microfluidic technologies for clinical point-of-care applications at resource-limited settings in developing countries... - Rapid automated cell quantification on HIV microfluidic devicesMohamad A Alyassin
Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Lab Chip 9:3364-9. 2009..e. CD4 counts... - Engineered 3D tissue models for cell-laden microfluidic channelsYoung S Song
Bio Acoustic MEMS in Medicine Lab, HST Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne Street 252, Cambridge, MA 02139, USA
Anal Bioanal Chem 395:185-93. 2009..This is important since our results reveal that there is a close correlation between nutrient profiles and cell viability across the hydrogel... - Simple filter microchip for rapid separation of plasma and viruses from whole bloodShuqi Wang
Bio Acoustic MEMS in Medicine Laboratory, Department of Medicine, Division of Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Int J Nanomedicine 7:5019-28. 2012..1% ± 8.3% to 82.5% ± 4.1%. These results are first steps towards developing disposable point-of-care diagnostics and monitoring devices for resource-constrained settings, as well as hospital and primary care settings... - Living bacterial sacrificial porogens to engineer decellularized porous scaffoldsFeng Xu
Demirci Bio Acoustic MEMS in Medicine Laboratory, Department of Medicine, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e19344. 2011..This 3D porous network method combined with bioprinting has the potential to be broadly applicable and compatible with tissue specific applications allowing seeding of stem cells and other cell types... - Enumeration of CD4+ T-cells using a portable microchip count platform in Tanzanian HIV-infected patientsSangjun Moon
Demirci Bio Acoustic MEMS Laboratory, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e21409. 2011..The World Health Organization (WHO) has pointed out or recommended that a handheld, point-of-care, reliable, and affordable CD4 count platform is urgently needed in resource-scarce settings... - Microcirculation within grooved substrates regulates cell positioning and cell docking inside microfluidic channelsAmir Manbachi
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA
Lab Chip 8:747-54. 2008..Therefore, our studies suggest that microscale shear stresses greatly influence cellular docking, immobilization, and retention in fluidic systems and should be considered for the design of cell-based microdevices... - Microfluidics for cryopreservationYoung S Song
Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lab Chip 9:1874-81. 2009..This method introduces microfluidic technologies to the field of biopreservation, opening the door to future advancements at the interface of these fields... - Engineering hydrogels as extracellular matrix mimicsHikmet Geckil
Health Sciences and Technology, Harvard MIT Health Sciences and Technology, Bio Acoustic MEMS in Medicine BAMM Laboratory, 65 Landsdowne St, 267, 02139 Cambridge, MA, USA
Nanomedicine (Lond) 5:469-84. 2010..In this article, we detail the progress of the current state-of-the-art engineering methods to create cell-encapsulating hydrogel tissue constructs as well as their applications in in vitro models in biomedicine... - Lensless imaging for simultaneous microfluidic sperm monitoring and sortingXiaohui Zhang
Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lab Chip 11:2535-40. 2011.... - Integrating microfluidics and lensless imaging for point-of-care testingSangjun Moon
Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Biosens Bioelectron 24:3208-14. 2009..The integrated platform points a promising direction for point-of-care testing (POCT) to rapidly capture, image and count subpopulations of cells from blood samples in an automated matter... - Emerging technologies in medical applications of minimum volume vitrificationXiaohui Zhang
Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Nanomedicine (Lond) 6:1115-29. 2011..Therefore, the synergistic integration of nanoscale technologies with cryogenics has the potential to improve biopreservation methods... - Statistical modeling of single target cell encapsulationSangjun Moon
Demirci Bio Acoustic MEMS in Medicine Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e21580. 2011..Here, we explain theoretically and validate experimentally a model to isolate and pattern single target cells from heterogeneous mixtures without using complex peripheral systems... - Multi-scale heat and mass transfer modelling of cell and tissue cryopreservationFeng Xu
Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Philos Trans A Math Phys Eng Sci 368:561-83. 2010..These multi-scale approaches allow us to study cell and tissue cryopreservation... - Vitrification and levitation of a liquid droplet on liquid nitrogenYoung S Song
Bio Acoustic Microelectromechanical Systems in Medicine Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Center for Bioengineering, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:4596-600. 2010..e., Stefan, Biot, and Fourier numbers). We explain theoretically and observe experimentally a threshold droplet radius during the vitrification of a cryoprotectant droplet in the presence of the Leidenfrost effect... - Automated and adaptable quantification of cellular alignment from microscopic images for tissue engineering applicationsFeng Xu
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Department of Medicine, Center for Biomedical Engineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
Tissue Eng Part C Methods 17:641-9. 2011..92). Therefore, the BEAS method introduced in this study could enable accurate, convenient, and adaptable evaluation of engineered tissue constructs and biomaterials in terms of cellular alignment and organization... - Drop-on-demand single cell isolation and total RNA analysisSangjun Moon
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Bioengineering, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e17455. 2011..This automated platform enabling high-throughput cell manipulation for subsequent genomic analysis employs fewer handling steps compared to existing methods... - Controlled viable release of selectively captured label-free cells in microchannelsUmut Atakan Gurkan
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lab Chip 11:3979-89. 2011.... - The assembly of cell-encapsulating microscale hydrogels using acoustic wavesFeng Xu
Demirci Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Biomaterials 32:7847-55. 2011..These results indicate that the developed acoustic approach could become an enabling biotechnology tool for tissue engineering, regenerative medicine, pharmacology studies and high throughput screening applications... - Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-careShuqi Wang
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard MIT Health Sciences and Technology, Cambridge, MA 02139, USA
Lab Chip 11:3411-8. 2011.... - A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platformFeng Xu
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Biotechnol J 6:204-12. 2011.... - Paramagnetic levitational assembly of hydrogelsSavas Tasoglu
Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA, Harvard MIT Health Sciences and Technology, Cambridge, MA, 02139, USA
Adv Mater 25:1137-43. 2013..We have performed experimental and theoretical analyses to describe hydrogel motion in a fluidic environment under a magnetic field... - A cell-laden microfluidic hydrogelYibo Ling
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Lab Chip 7:756-62. 2007..Further development of this technique may lead to the generation of biomimetic synthetic vasculature for tissue engineering, diagnostics, and drug screening applications... - Microscale electroporation: challenges and perspectives for clinical applicationsWon Gu Lee
Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Integr Biol (Camb) 1:242-51. 2009.... - Point-of-care assays for tuberculosis: role of nanotechnology/microfluidicsShuqi Wang
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Biotechnol Adv 31:438-49. 2013..Here, we review the current assays used for TB diagnosis, and highlight the recent advances in nanotechnology and microfluidics that potentially enable new approaches for TB diagnosis in resource-constrained settings... - Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architecturesUmut Atakan Gurkan
Harvard Medical School, Division of Biomedical Engineering at Brigham and Women s Hospital, Bio Acoustic MEMS in Medicine BAMM Laboratory, Harvard MIT Health Sciences and Technology, 65 Landsdowne St PRB 252, Cambridge, MA 02139, USA
Adv Mater 25:1192-8. 2013.... - Quantum dot-based HIV capture and imaging in a microfluidic channelYun Gon Kim
Bio Acoustic MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, United States
Biosens Bioelectron 25:253-8. 2009..This on-chip HIV capture and imaging platform creates new avenues for point-of-care diagnostics and monitoring applications of infectious diseases... - Advances in developing HIV-1 viral load assays for resource-limited settingsShuqi Wang
Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Biotechnol Adv 28:770-81. 2010..Emerging approaches based on microfluidics and nanotechnology, which have potential to be integrated into POC HIV-1 viral load assays, are also discussed... - Bioprinting for stem cell researchSavas Tasoglu
Brigham and Women s Hospital, Bio Acoustic MEMS in Medicine Lab, Division of Biomedical Engineering, Department of Medicine, Harvard Medical School, Boston, MA, USA
Trends Biotechnol 31:10-9. 2013..Here, we review recent achievements with bioprinting technologies in stem cell research, and identify future challenges and potential applications including tissue engineering and regenerative medicine, wound healing, and genomics... - Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devicesXuanhong Cheng
BioMEMS Resource Center and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Lab Chip 7:746-55. 2007.... - Coherent array imaging using phased subarrays. Part II: simulations and experimental resultsJeremy A Johnson
Stanford University, Edward L Ginzton Laboratory, Stanford, CA, USA
IEEE Trans Ultrason Ferroelectr Freq Control 52:51-64. 2005..The simulated and experimental test results presented in this paper validate theoretical expectations and illustrate the flexibility of PSA imaging as a way to exchange SNR and frame rate for simplified front-end hardware... - Capacitive micromachined ultrasonic transducers: next-generation arrays for acoustic imaging?Omer Oralkan
Edward L Ginzton Laboratory, and Center for Integrated Systems, Stanford University, Stanford, CA 94305 4070, USA
IEEE Trans Ultrason Ferroelectr Freq Control 49:1596-610. 2002..A tail also was observed in the point spread function (PSF) in the axial direction, indicating the existence of crosstalk. The relative amplitude of this tail with respect to the mainlobe was less than -20 dB... - Forward-viewing CMUT arrays for medical imagingUtkan Demirci
E L Ginzton Laboratory, Stanford University, Stanford, CA 94305 4088, USA
IEEE Trans Ultrason Ferroelectr Freq Control 51:887-95. 2004....
Research Grants
- Point-of-Care Rapid Blood Testing Using Microfluidic DevicesUtkan Demirci; Fiscal Year: 2010....