L Demetrius

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Thermodynamics and kinetics of protein folding: an evolutionary perspective
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA
    J Theor Biol 217:397-411. 2002
  2. ncbi request reprint Alzheimer's as a metabolic disease
    Lloyd A Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02135, USA
    Biogerontology 14:641-9. 2013
  3. pmc The inverse association of cancer and Alzheimer's: a bioenergetic mechanism
    Lloyd A Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J R Soc Interface 10:20130006. 2013
  4. doi request reprint Evolutionary entropy predicts the outcome of selection: Competition for resources that vary in abundance and diversity
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Theor Popul Biol 83:39-54. 2013
  5. doi request reprint An inverse-Warburg effect and the origin of Alzheimer's disease
    Lloyd A Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Biogerontology 13:583-94. 2012
  6. pmc Cancer as a dynamical phase transition
    Paul Cw Davies
    BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, AZ 85287 1504, USA
    Theor Biol Med Model 8:30. 2011
  7. ncbi request reprint The origin of allometric scaling laws in biology
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 243:455-67. 2006
  8. pmc Evolutionary entropy: a predictor of body size, metabolic rate and maximal life span
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Bull Math Biol 71:800-18. 2009
  9. pmc Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans
    Lloyd Demetrius
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    EMBO Rep 6:S39-44. 2005
  10. ncbi request reprint Caloric restriction, metabolic rate, and entropy
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Gerontol A Biol Sci Med Sci 59:B902-15. 2004

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Thermodynamics and kinetics of protein folding: an evolutionary perspective
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA
    J Theor Biol 217:397-411. 2002
    ..Folding rate of this class of proteins is positively correlated with the thermodynamic stability of the folded state...
  2. ncbi request reprint Alzheimer's as a metabolic disease
    Lloyd A Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02135, USA
    Biogerontology 14:641-9. 2013
    ..A view of Alzheimer's as a metabolic disease-a condition consistent with mitochondrial dysregulation and the Inverse Warburg effect, will entail a radically new approach to diagnostic and therapeutic strategies. ..
  3. pmc The inverse association of cancer and Alzheimer's: a bioenergetic mechanism
    Lloyd A Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J R Soc Interface 10:20130006. 2013
    ..We furthermore exploit the molecular mechanisms underlying the diseases to propose common therapeutic strategies for cancer and AD based on metabolic intervention...
  4. doi request reprint Evolutionary entropy predicts the outcome of selection: Competition for resources that vary in abundance and diversity
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Theor Popul Biol 83:39-54. 2013
    ..Accordingly, the entropic selection principle represents a general rule for explaining the processes of adaptation and evolution at each of these levels...
  5. doi request reprint An inverse-Warburg effect and the origin of Alzheimer's disease
    Lloyd A Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Biogerontology 13:583-94. 2012
    ....
  6. pmc Cancer as a dynamical phase transition
    Paul Cw Davies
    BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, AZ 85287 1504, USA
    Theor Biol Med Model 8:30. 2011
    ..A number of implications for preventative and therapeutic strategies are outlined...
  7. ncbi request reprint The origin of allometric scaling laws in biology
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 243:455-67. 2006
    ..The new model is universal in the sense that it applies to unicellular organisms, plants and animals...
  8. pmc Evolutionary entropy: a predictor of body size, metabolic rate and maximal life span
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Bull Math Biol 71:800-18. 2009
    ..This predictive property, when integrated with the macroscopic representation of entropy, is the basis for enormous differences in morphometric and life-history parameters across species...
  9. pmc Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans
    Lloyd Demetrius
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    EMBO Rep 6:S39-44. 2005
  10. ncbi request reprint Caloric restriction, metabolic rate, and entropy
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Gerontol A Biol Sci Med Sci 59:B902-15. 2004
    ..We affirm that in the case of humans, a species with late sexual maturity, broad reproductive span and small litter size, and hence high entropy, the response of life span to caloric restriction will be negligible...
  11. ncbi request reprint Thermodynamics and evolution
    L Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 206:1-16. 2000
    ....
  12. ncbi request reprint Darwinian fitness
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Theor Popul Biol 72:323-45. 2007
    ..These studies thus provide support for the general claim that entropy is the appropriate measure of Darwinian fitness and constitutes an evolutionary parameter with broad predictive and explanatory powers...
  13. ncbi request reprint Game theory and evolution: finite size and absolute fitness measures
    L Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Math Biosci 168:9-38. 2000
    ..We invoke this formalism to show that ESS are characterized by extremal states of entropy. We illustrate this characterization of ESS by an analysis of the evolution of the sex ratio and the evolution of seed size...
  14. pmc Directionality theory and the evolution of body size
    L Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Biol Sci 267:2385-91. 2000
    ....
  15. ncbi request reprint Complexity and demographic stability in population models
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Theor Popul Biol 65:211-25. 2004
    ..These results thus provide a new conceptual framework for explaining patterns of variation in population numbers observed in natural populations...
  16. ncbi request reprint Darwinian fitness and the intensity of natural selection: studies in sensitivity analysis
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 249:641-53. 2007
    ..Our analysis provides theoretical and empirical support for the ecological and evolutionary significance of sensitivity analysis based on entropy, which is the appropriate measure of Darwinian fitness...
  17. ncbi request reprint Aging in mouse and human systems: a comparative study
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Ann N Y Acad Sci 1067:66-82. 2006
    ..We furthermore contend the view that these limitations can be mitigated by considering the metabolic stability of the two species...
  18. pmc Critique of directionality theory
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Biol Sci 273:1183-6. 2006
  19. pmc Directionality principles in thermodynamics and evolution
    L Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 94:3491-8. 1997
    ....
  20. pmc Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging
    Thore C Brink
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Biogerontology 10:549-64. 2009
    ..This study, in addition, rejects the free radical hypothesis which postulates that the production rate of ROS, and not its stability, determines life span...
  21. pmc Directionality theory: a computational study of an entropic principle in evolutionary processes
    Axel Kowald
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Biol Sci 272:741-9. 2005
    ..Computational analysis, together with complementary empirical studies of evolutionary changes in entropy underscore the universality of the entropic principle as a model of the evolutionary process...
  22. pmc Mortality plateaus and directionality theory
    L Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Biol Sci 268:2029-37. 2001
    ....
  23. pmc Quantum metabolism explains the allometric scaling of metabolic rates
    Lloyd Demetrius
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J R Soc Interface 7:507-14. 2010
    ..The regimes are consistent with a range of behaviours encountered in micelles, plants and animals and provide a conceptual framework for a theory of the metabolic function of living systems...
  24. pmc An entropic characterization of protein interaction networks and cellular robustness
    Thomas Manke
    Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
    J R Soc Interface 3:843-50. 2006
    ..One of its principal achievements is to provide a rationale to study proxies of cellular resilience and rank proteins according to their importance within the global network context...
  25. ncbi request reprint Lethality and entropy of protein interaction networks
    Thomas Manke
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Genome Inform 16:159-63. 2005
    ..It is also applicable to networks in which the processes can be quantified and therefore serves as a link to study questions of structural and dynamical robustness in a unified way...
  26. pmc Directionality theory: an empirical study of an entropic principle in life-history evolution
    Martin Ziehe
    Institut für Forstgenetik und Forstpflanzenzüchtung, Universitat Gottingen, Germany
    Proc Biol Sci 272:1185-94. 2005
    ..This empirical analysis is consistent with directionality theory and provides support for its significance as an explanatory and predictive model of life-history evolution...
  27. ncbi request reprint Stability constraints and protein evolution: the role of chain length, composition and disulfide bonds
    U Bastolla
    Centro de Astrobiología INTA CSIC, 28850 Torrejón de Ardoz and Centro de Biología Molecular Severo Ochoa, Cantoblanco, 28049 Madrid, Spain
    Protein Eng Des Sel 18:405-15. 2005
    ..In particular, disulfide bonds appear to be positively selected in short proteins, whereas they evolve in an effectively neutral way in long proteins...
  28. ncbi request reprint The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human?
    Bart P Braeckman
    Department of Biology, Ghent University, Ledeganckstraat 35, 9000 Ghent, Belgium
    Biogerontology 7:127-33. 2006
    ..Empirical studies using C. elegans (an opportunistic species) and computational studies on human populations (an equilibrium species) are shown to be consistent with these predictions...