D L DeMeo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02446, USA
    Thorax 59:259-64. 2004
  2. doi request reprint Heritability of lung function in severe alpha-1 antitrypsin deficiency
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Hum Hered 67:38-45. 2009
  3. pmc Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies
    P J Castaldi
    Institute for Clinical Researchand Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Thorax 66:903-9. 2011
  4. pmc Polymorphic variation in surfactant protein B is associated with COPD exacerbations
    M G Foreman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J 32:938-44. 2008
  5. pmc Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD
    I C Sørheim
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    COPD 7:262-8. 2010
  6. pmc Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency
    P J Castaldi
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Am J Epidemiol 170:1005-13. 2009
  7. pmc Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD
    D L DeMeo
    Channing Laboratory and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thorax 59:396-400. 2004
  8. ncbi request reprint Clinical determinants of exacerbations in severe, early-onset COPD
    M G Foreman
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Eur Respir J 30:1124-30. 2007
  9. ncbi request reprint COPD: problems in diagnosis and measurement
    S T Weiss
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J Suppl 41:4s-12s. 2003
  10. ncbi request reprint Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program
    D L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genet Epidemiol 23:335-48. 2002

Collaborators

Detail Information

Publications11

  1. pmc Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02446, USA
    Thorax 59:259-64. 2004
    ..The role of modifying genetic factors which may interact with environmental factors (such as cigarette smoking) is discussed, and directions for future research are presented...
  2. doi request reprint Heritability of lung function in severe alpha-1 antitrypsin deficiency
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Hum Hered 67:38-45. 2009
    ..Correction for ascertainment and consideration of gene-by-smoking interactions will be crucial for the identification of genes that may modify susceptibility for COPD in families with AAT deficiency...
  3. pmc Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies
    P J Castaldi
    Institute for Clinical Researchand Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Thorax 66:903-9. 2011
    ....
  4. pmc Polymorphic variation in surfactant protein B is associated with COPD exacerbations
    M G Foreman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J 32:938-44. 2008
    ..In conclusion, genetic variation in surfactant protein B is associated with chronic obstructive pulmonary disease susceptibility and exacerbation frequency...
  5. pmc Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD
    I C Sørheim
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    COPD 7:262-8. 2010
    ..In conclusion, polymorphisms in the SOD3 gene were associated with CT emphysema but not COPD susceptibility, highlighting the importance of phenotype definition in COPD genetics studies...
  6. pmc Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency
    P J Castaldi
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Am J Epidemiol 170:1005-13. 2009
    ..In the validation sample, the predictive model for FEV(1) explained 50% of the variance in FEV(1), and the model for severe COPD exhibited excellent discrimination (c statistic = 0.88)...
  7. pmc Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD
    D L DeMeo
    Channing Laboratory and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thorax 59:396-400. 2004
    ..We hypothesised that first degree relatives of early onset COPD probands may also have lower values of spirometric parameters such as forced expiratory flow at the mid-portion of forced vital capacity (FEF(25-75)) and FEF(25-75)/FVC...
  8. ncbi request reprint Clinical determinants of exacerbations in severe, early-onset COPD
    M G Foreman
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Eur Respir J 30:1124-30. 2007
    ..The familial aggregation of exacerbations suggests a genetic basis for susceptibility to chronic obstructive pulmonary disease exacerbations...
  9. ncbi request reprint COPD: problems in diagnosis and measurement
    S T Weiss
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J Suppl 41:4s-12s. 2003
    ....
  10. ncbi request reprint Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program
    D L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genet Epidemiol 23:335-48. 2002
    ..No evidence for association was found between Arg130Gln and airway responsiveness, asthma diagnosis, or asthma severity...
  11. ncbi request reprint Lung transplantation at the turn of the century
    D L DeMeo
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Annu Rev Med 52:185-201. 2001
    ..However, ongoing advances in immune tolerance and standardized training of physicians in the care of transplant patients should carry lung transplant forward in the twenty-first century...