Research Topics
Genomes and Genes
| D L DeMeoSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiencyWoo Jin Kim
Channing Laboratory and the Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Respir Res 13:16. 2012..We investigated whether SNPs in the chromosome 15q region would be modifiers for lung function and COPD in AAT deficiency...- Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgeryCraig P Hersh
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Respir Res 8:59. 2007..In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this variability... - Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility geneDawn L DeMeo
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Hum Genet 85:493-502. 2009..4 x 10(-4). IREB2 protein and mRNA were increased in lung-tissue samples from COPD subjects in comparison to controls. In summary, gene-expression and genetic-association results have implicated IREB2 as a COPD susceptibility gene... - Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiencyDawn L DeMeo
Channing Laboratory, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
Thorax 62:806-13. 2007..A study was undertaken to assess the impact of chronic bronchitis, pneumonia, asthma and sex on the development of COPD in individuals with severe AAT deficiency... - Genetic determinants of emphysema distribution in the national emphysema treatment trialDawn L DeMeo
Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 176:42-8. 2007.... - IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiencyDawn L DeMeo
Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 38:114-20. 2008..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency... - The SERPINE2 gene is associated with chronic obstructive pulmonary diseaseDawn L DeMeo
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Hum Genet 78:253-64. 2006.... 
Heritability of lung function in severe alpha-1 antitrypsin deficiencyD L DeMeo
Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Hum Hered 67:38-45. 2009..Correction for ascertainment and consideration of gene-by-smoking interactions will be crucial for the identification of genes that may modify susceptibility for COPD in families with AAT deficiency...- Polymorphic variation in surfactant protein B is associated with COPD exacerbationsM G Foreman
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Eur Respir J 32:938-44. 2008..In conclusion, genetic variation in surfactant protein B is associated with chronic obstructive pulmonary disease susceptibility and exacerbation frequency... - Attempted replication of reported chronic obstructive pulmonary disease candidate gene associationsCraig P Hersh
Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 33:71-8. 2005..03). Although some evidence for replication was found for SFTPB and HMOX1, none of the previously published COPD genetic associations was convincingly replicated across both study designs... - Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiencyP J Castaldi
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
Am J Epidemiol 170:1005-13. 2009..In the validation sample, the predictive model for FEV(1) explained 50% of the variance in FEV(1), and the model for severe COPD exhibited excellent discrimination (c statistic = 0.88)... - Genetic association analysis of COPD candidate genes with bronchodilator responsivenessWoo Jin Kim
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Respir Med 103:552-7. 2009..SNPs in SFTPB, TGFB1, and GSTP1 genes were not associated with BDR. In conclusion, a polymorphism of EPHX1 was associated with bronchodilator responsiveness phenotypes in subjects with severe COPD... - Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studiesP J Castaldi
Institute for Clinical Researchand Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
Thorax 66:903-9. 2011.... - Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPDI C Sørheim
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
COPD 7:262-8. 2010..In conclusion, polymorphisms in the SOD3 gene were associated with CT emphysema but not COPD susceptibility, highlighting the importance of phenotype definition in COPD genetics studies... - MMP12, lung function, and COPD in high-risk populationsGary M Hunninghake
Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 361:2599-608. 2009..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups... - Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema riskD L DeMeo
Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02446, USA
Thorax 59:259-64. 2004..The role of modifying genetic factors which may interact with environmental factors (such as cigarette smoking) is discussed, and directions for future research are presented... - Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPDD L DeMeo
Channing Laboratory and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Thorax 59:396-400. 2004..We hypothesised that first degree relatives of early onset COPD probands may also have lower values of spirometric parameters such as forced expiratory flow at the mid-portion of forced vital capacity (FEF(25-75)) and FEF(25-75)/FVC... - Variants in FAM13A are associated with chronic obstructive pulmonary diseaseMichael H Cho
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 42:200-2. 2010..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83)... - Microarray data-based prioritization of chronic obstructive pulmonary disease susceptibility genesSoumyaroop Bhattacharya
Pulmonary Medicine, Thorn 8, Brigham and Womens's Hospital, 75 Francis Street, Boston, MA 02115, USA
Proc Am Thorac Soc 3:472. 2006 - Parsing the effects of individual SNPs in candidate genes with family dataThomas J Hoffmann
Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
Hum Hered 69:91-103. 2010..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati... 
COPD: problems in diagnosis and measurementS T Weiss
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Eur Respir J Suppl 41:4s-12s. 2003....- Clinical determinants of exacerbations in severe, early-onset COPDM G Foreman
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Eur Respir J 30:1124-30. 2007..The familial aggregation of exacerbations suggests a genetic basis for susceptibility to chronic obstructive pulmonary disease exacerbations... - Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility geneCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 182:605-13. 2010..Several family-based studies have identified genetic linkage for lung function and airflow obstruction to chromosome 2q... - National Emphysema Treatment Trial state of the art: genetics of emphysemaCraig P Hersh
Channing Laboratory, Center for Genomic Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Am Thorac Soc 5:486-93. 2008.... - Genetic association analysis of functional impairment in chronic obstructive pulmonary diseaseCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 173:977-84. 2006..This variation may reflect different COPD subtypes, which may have different genetic predispositions... - Power and design considerations for a general class of family-based association tests: quantitative traitsChristoph Lange
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Am J Hum Genet 71:1330-41. 2002..We also compare the general FBAT approach with PDT and QTDT. The practical relevance of our theoretical considerations is illustrated by their application to an asthma study... - Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary diseaseDawn L DeMeo
Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 170:1294-301. 2004..LOD scores of greater than two were also observed for chromosomes 16, 20, and 22 with the smokers-only analysis, which may suggest gene-by-smoking interactions in these regions... - Genomic screening and replication using the same data set in family-based association testingKristel Van Steen
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Nat Genet 37:683-91. 2005..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do... - Concordance of genotypes in pre- and post-lung transplantation DNA samplesDawn L DeMeo
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 33:402-5. 2005.... - Ambient air pollution and oxygen saturationDawn L DeMeo
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 170:383-7. 2004..Further investigation may contribute to our understanding of the mechanisms through which particulates may increase respiratory and cardiac morbidity among vulnerable populations... - Genetic determinants of functional impairment in chronic obstructive pulmonary diseaseCraig P Hersh
Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Proc Am Thorac Soc 3:476. 2006 - The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)Juan C Celedon
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Hum Mol Genet 13:1649-56. 2004..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers... - Genetic linkage and association analysis of COPD-related traits on chromosome 8pCraig P Hersh
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
COPD 3:189-94. 2006..07). Despite the reduced support for linkage upon further analysis, it remains possible that chromosome 8p contains a gene that influences COPD susceptibility. There is marginal, though not convincing, evidence for association with MSR1... - Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management ProgramD L DeMeo
Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Genet Epidemiol 23:335-48. 2002..No evidence for association was found between Arg130Gln and airway responsiveness, asthma diagnosis, or asthma severity... - Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhoodGary M Hunninghake
Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 120:84-90. 2007..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity... - Predictors of survival in severe, early onset COPDCraig P Hersh
Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Ave, Boston, MA 02115, USA
Chest 126:1443-51. 2004..CONCLUSION: In this cohort, recent smoking status predicted increased mortality independent of the effects of lifetime smoking intensity. Smoking cessation may confer a survival benefit even among patients with very severe COPD... - Lung transplantation at the turn of the centuryD L DeMeo
Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
Annu Rev Med 52:185-201. 2001..However, ongoing advances in immune tolerance and standardized training of physicians in the care of transplant patients should carry lung transplant forward in the twenty-first century... - The Yin and Yang of COPD: sex/gender differences in the National Emphysema Treatment TrialDawn L DeMeo
Am J Respir Crit Care Med 176:222-3. 2007 - Transmission of lymphocytic choriomeningitis virus by organ transplantationStaci A Fischer
Rhode Island Hospital and Brown Medical School, Providence, USA
N Engl J Med 354:2235-49. 2006..One recipient, who received ribavirin and reduced levels of immunosuppressive therapy, survived. CONCLUSIONS: We document two clusters of LCMV infection transmitted through organ transplantation... - Smoke and mirrors: Mouse models as a reflection of human chronic obstructive pulmonary diseaseSteven D Shapiro
Am J Respir Crit Care Med 170:929-31. 2004 - Testing and estimating gene-environment interactions in family-based association studiesStijn Vansteelandt
Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, S9, B 9000 Gent, Belgium
Biometrics 64:458-67. 2008..Simulation studies show that the proposed methodology is sufficiently powered for realistic sample sizes and that it provides valid tests and effect size estimators in the presence of admixture and stratification...
Research Grants
- Asthma Candidate Genes in Alpha 1-Antitrypsin DeficiencyDawn DeMeo; Fiscal Year: 2007..The identification of modifying factors of COPD in AAT deficiency may have significant public health relevance to COPD patients without AAT deficiency. ..