D L DeMeo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency
    Woo Jin Kim
    Channing Laboratory and the Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Respir Res 13:16. 2012
  2. pmc Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 8:59. 2007
  3. pmc Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene
    Dawn L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:493-502. 2009
  4. pmc Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency
    Dawn L DeMeo
    Channing Laboratory, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    Thorax 62:806-13. 2007
  5. pmc Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
  6. pmc IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency
    Dawn L DeMeo
    Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 38:114-20. 2008
  7. pmc The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 78:253-64. 2006
  8. doi request reprint Heritability of lung function in severe alpha-1 antitrypsin deficiency
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Hum Hered 67:38-45. 2009
  9. pmc Polymorphic variation in surfactant protein B is associated with COPD exacerbations
    M G Foreman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J 32:938-44. 2008
  10. pmc Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
    Craig P Hersh
    Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:71-8. 2005

Research Grants

Detail Information

Publications41

  1. pmc Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency
    Woo Jin Kim
    Channing Laboratory and the Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Respir Res 13:16. 2012
    ..We investigated whether SNPs in the chromosome 15q region would be modifiers for lung function and COPD in AAT deficiency...
  2. pmc Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 8:59. 2007
    ..In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this variability...
  3. pmc Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene
    Dawn L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:493-502. 2009
    ..4 x 10(-4). IREB2 protein and mRNA were increased in lung-tissue samples from COPD subjects in comparison to controls. In summary, gene-expression and genetic-association results have implicated IREB2 as a COPD susceptibility gene...
  4. pmc Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency
    Dawn L DeMeo
    Channing Laboratory, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    Thorax 62:806-13. 2007
    ..A study was undertaken to assess the impact of chronic bronchitis, pneumonia, asthma and sex on the development of COPD in individuals with severe AAT deficiency...
  5. pmc Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
    ....
  6. pmc IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency
    Dawn L DeMeo
    Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 38:114-20. 2008
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency...
  7. pmc The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 78:253-64. 2006
    ....
  8. doi request reprint Heritability of lung function in severe alpha-1 antitrypsin deficiency
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Hum Hered 67:38-45. 2009
    ..Correction for ascertainment and consideration of gene-by-smoking interactions will be crucial for the identification of genes that may modify susceptibility for COPD in families with AAT deficiency...
  9. pmc Polymorphic variation in surfactant protein B is associated with COPD exacerbations
    M G Foreman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J 32:938-44. 2008
    ..In conclusion, genetic variation in surfactant protein B is associated with chronic obstructive pulmonary disease susceptibility and exacerbation frequency...
  10. pmc Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
    Craig P Hersh
    Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:71-8. 2005
    ..03). Although some evidence for replication was found for SFTPB and HMOX1, none of the previously published COPD genetic associations was convincingly replicated across both study designs...
  11. pmc Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency
    P J Castaldi
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Am J Epidemiol 170:1005-13. 2009
    ..In the validation sample, the predictive model for FEV(1) explained 50% of the variance in FEV(1), and the model for severe COPD exhibited excellent discrimination (c statistic = 0.88)...
  12. pmc Genetic association analysis of COPD candidate genes with bronchodilator responsiveness
    Woo Jin Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Med 103:552-7. 2009
    ..SNPs in SFTPB, TGFB1, and GSTP1 genes were not associated with BDR. In conclusion, a polymorphism of EPHX1 was associated with bronchodilator responsiveness phenotypes in subjects with severe COPD...
  13. pmc Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies
    P J Castaldi
    Institute for Clinical Researchand Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Thorax 66:903-9. 2011
    ....
  14. pmc Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD
    I C Sørheim
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    COPD 7:262-8. 2010
    ..In conclusion, polymorphisms in the SOD3 gene were associated with CT emphysema but not COPD susceptibility, highlighting the importance of phenotype definition in COPD genetics studies...
  15. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  16. pmc Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02446, USA
    Thorax 59:259-64. 2004
    ..The role of modifying genetic factors which may interact with environmental factors (such as cigarette smoking) is discussed, and directions for future research are presented...
  17. pmc Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD
    D L DeMeo
    Channing Laboratory and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thorax 59:396-400. 2004
    ..We hypothesised that first degree relatives of early onset COPD probands may also have lower values of spirometric parameters such as forced expiratory flow at the mid-portion of forced vital capacity (FEF(25-75)) and FEF(25-75)/FVC...
  18. pmc Variants in FAM13A are associated with chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:200-2. 2010
    ..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83)...
  19. pmc Microarray data-based prioritization of chronic obstructive pulmonary disease susceptibility genes
    Soumyaroop Bhattacharya
    Pulmonary Medicine, Thorn 8, Brigham and Womens s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:472. 2006
  20. pmc Parsing the effects of individual SNPs in candidate genes with family data
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 69:91-103. 2010
    ..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati...
  21. ncbi request reprint COPD: problems in diagnosis and measurement
    S T Weiss
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J Suppl 41:4s-12s. 2003
    ....
  22. ncbi request reprint Clinical determinants of exacerbations in severe, early-onset COPD
    M G Foreman
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Eur Respir J 30:1124-30. 2007
    ..The familial aggregation of exacerbations suggests a genetic basis for susceptibility to chronic obstructive pulmonary disease exacerbations...
  23. pmc Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 182:605-13. 2010
    ..Several family-based studies have identified genetic linkage for lung function and airflow obstruction to chromosome 2q...
  24. pmc National Emphysema Treatment Trial state of the art: genetics of emphysema
    Craig P Hersh
    Channing Laboratory, Center for Genomic Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Am Thorac Soc 5:486-93. 2008
    ....
  25. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  26. pmc Power and design considerations for a general class of family-based association tests: quantitative traits
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 71:1330-41. 2002
    ..We also compare the general FBAT approach with PDT and QTDT. The practical relevance of our theoretical considerations is illustrated by their application to an asthma study...
  27. ncbi request reprint Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1294-301. 2004
    ..LOD scores of greater than two were also observed for chromosomes 16, 20, and 22 with the smokers-only analysis, which may suggest gene-by-smoking interactions in these regions...
  28. ncbi request reprint Genomic screening and replication using the same data set in family-based association testing
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 37:683-91. 2005
    ..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do...
  29. pmc Concordance of genotypes in pre- and post-lung transplantation DNA samples
    Dawn L DeMeo
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:402-5. 2005
    ....
  30. ncbi request reprint Ambient air pollution and oxygen saturation
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:383-7. 2004
    ..Further investigation may contribute to our understanding of the mechanisms through which particulates may increase respiratory and cardiac morbidity among vulnerable populations...
  31. pmc Genetic determinants of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:476. 2006
  32. ncbi request reprint The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  33. ncbi request reprint Genetic linkage and association analysis of COPD-related traits on chromosome 8p
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    COPD 3:189-94. 2006
    ..07). Despite the reduced support for linkage upon further analysis, it remains possible that chromosome 8p contains a gene that influences COPD susceptibility. There is marginal, though not convincing, evidence for association with MSR1...
  34. ncbi request reprint Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program
    D L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genet Epidemiol 23:335-48. 2002
    ..No evidence for association was found between Arg130Gln and airway responsiveness, asthma diagnosis, or asthma severity...
  35. ncbi request reprint Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
    Gary M Hunninghake
    Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:84-90. 2007
    ..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity...
  36. ncbi request reprint Predictors of survival in severe, early onset COPD
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 126:1443-51. 2004
    ..The purpose of this study was to determine the mortality rate and predictors of survival in subjects with severe, early onset COPD...
  37. ncbi request reprint Lung transplantation at the turn of the century
    D L DeMeo
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Annu Rev Med 52:185-201. 2001
    ..However, ongoing advances in immune tolerance and standardized training of physicians in the care of transplant patients should carry lung transplant forward in the twenty-first century...
  38. ncbi request reprint The Yin and Yang of COPD: sex/gender differences in the National Emphysema Treatment Trial
    Dawn L DeMeo
    Am J Respir Crit Care Med 176:222-3. 2007
  39. ncbi request reprint Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  40. ncbi request reprint Smoke and mirrors: Mouse models as a reflection of human chronic obstructive pulmonary disease
    Steven D Shapiro
    Am J Respir Crit Care Med 170:929-31. 2004
  41. ncbi request reprint Testing and estimating gene-environment interactions in family-based association studies
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, S9, B 9000 Gent, Belgium
    Biometrics 64:458-67. 2008
    ..Simulation studies show that the proposed methodology is sufficiently powered for realistic sample sizes and that it provides valid tests and effect size estimators in the presence of admixture and stratification...

Research Grants2

  1. Asthma Candidate Genes in Alpha 1-Antitrypsin Deficiency
    Dawn DeMeo; Fiscal Year: 2007
    ..The identification of modifying factors of COPD in AAT deficiency may have significant public health relevance to COPD patients without AAT deficiency. ..