Affiliation: Harvard University
Demay M. Mechanism of vitamin D receptor action. Ann N Y Acad Sci. 2006;1068:204-13 pubmed
..In contrast, the cutaneous phenotype of VDR ablation is a direct consequence of absence of ligand-independent VDR actions in epidermal keratinocytes. ..
Liu E, Martins J, Zhang W, Demay M. Molecular analysis of enthesopathy in a mouse model of hypophosphatemic rickets. Development. 2018;145: pubmed publisher
..These results support a role for enhanced BMP and IHH signaling in the development of enthesopathy in XLH. ..
Demay M, Sabbagh Y, Carpenter T. Calcium and vitamin D: what is known about the effects on growing bone. Pediatrics. 2007;119 Suppl 2:S141-4 pubmed
..The major receptor-dependent actions of 1,25-dihydroxyvitamin D on skeletal development are indirect and are a reflection of the role of this hormone on intestinal calcium absorption. ..
Liu E, Raimann A, Chae B, Martins J, Baccarini M, Demay M. c-Raf promotes angiogenesis during normal growth plate maturation. Development. 2016;143:348-55 pubmed publisher
..Thus, c-Raf plays an important role in growth plate maturation by regulating vascular invasion, which is crucial for replacement of terminally differentiated hypertrophic chondrocytes by bone. ..
Saini V, Zhao H, Petit E, Gori F, Demay M. Absence of vitamin D receptor (VDR)-mediated PPARÎ³ suppression causes alopecia in VDR-null mice. FASEB J. 2017;31:1059-1066 pubmed publisher
..Saini, V., Zhao, H., Petit, E. T., Gori, F., Demay, M. B. Absence of vitamin D receptor (VDR)-mediated PPARÎ³ suppression causes alopecia in VDR-null mice. ..
Papaioannou G, Petit E, Liu E, Baccarini M, Pritchard C, Demay M. Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem. 2017;292:3164-3171 pubmed publisher
..These data further demonstrated that Raf kinases are required for phosphate-induced ERK1/2 phosphorylation in cultured hypertrophic chondrocytes and perform essential, but partially redundant roles in growth plate maturation. ..