JAMES DECAPRIO

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor
    Debrah A Fine
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    PLoS Pathog 8:e1002949. 2012
  2. doi A cornucopia of human polyomaviruses
    James A DeCaprio
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Nat Rev Microbiol 11:264-76. 2013
  3. doi How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40
    James A DeCaprio
    Department of Medical Oncology, Dana Farber Cancer Institute, USA
    Virology 384:274-84. 2009
  4. pmc Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation
    Syed Hamid Ali
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 78:2749-57. 2004
  5. ncbi The carboxyl-terminal domain of large T antigen rescues SV40 host range activity in trans independent of acetylation
    Danielle L Poulin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Virology 349:212-21. 2006
  6. pmc Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens
    Jingwei Cheng
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Semin Cancer Biol 19:218-28. 2009
  7. ncbi Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
    Larisa Litovchick
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 26:539-51. 2007
  8. pmc Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53
    Darrell R Borger
    Dana Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Mayer Building 457, 44 Binney Street, Boston, Massachusetts 02115, USA
    J Virol 80:4292-303. 2006
  9. ncbi SV40 large T antigen promotes dephosphorylation of p130
    Jennifer Y Lin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 278:46482-7. 2003
  10. ncbi Telomerase maintains telomere structure in normal human cells
    Kenkichi Masutomi
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 114:241-53. 2003

Research Grants

  1. Interaction Between SV40 Large T and p185 Cullin
    JAMES DECAPRIO; Fiscal Year: 2006
  2. RB-Related Proteins in SV40 T Transformation
    JAMES DECAPRIO; Fiscal Year: 2007
  3. RB-Related Proteins in SV40T Transformation
    James A DeCaprio; Fiscal Year: 2010
  4. RB-RELATED PROTEINS AND SV40 T TRANSFORMATION
    JAMES DECAPRIO; Fiscal Year: 2002
  5. Interaction Between SV40 Large T and p185 Cullin
    James A DeCaprio; Fiscal Year: 2010

Collaborators

  • Syed H Ali
  • William Hahn
  • Jingwei Cheng
  • Larisa Litovchick
  • Debrah A Fine
  • Michael P Washburn
  • Laurence Florens
  • Darrell R Borger
  • Danielle L Poulin
  • Kenkichi Masutomi
  • Jennifer Y Lin
  • Guillaume Adelmant
  • Marc Vidal
  • Luxuan Guo
  • Megha Padi
  • Soundarapandian Velmurgan
  • Michael A Calderwood
  • David E Hill
  • Ying Zhang
  • Anna Korkhin
  • Christian Berrios
  • Michael E Cusick
  • Jarrod A Marto
  • Orit Rozenblatt-Rosen
  • Robert L James
  • Rosa Yoon
  • Brian S Schaffhausen
  • Michele M Fluck
  • X Shirley Liu
  • Selene K Swanson
  • Xiaopeng Zhu
  • Soundarapandian Velmurugan
  • Subhashini Sadasivam
  • Runsheng Chen
  • Shuichi Kaneko
  • Seishi Murakami
  • Mary W Brooks
  • Evan Y Yu
  • Jennifer L Currier
  • Geoffrey B Metz
  • Ittai Ben-Porath
  • Shilagardy Khurts
  • Robert A Weinberg
  • Sheila A Stewart

Detail Information

Publications10

  1. pmc Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor
    Debrah A Fine
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    PLoS Pathog 8:e1002949. 2012
    ..FAM111A functions as a host range restriction factor that is specifically targeted by SV40 LT...
  2. doi A cornucopia of human polyomaviruses
    James A DeCaprio
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Nat Rev Microbiol 11:264-76. 2013
    ..This Review describes the similarities and differences among the new human polyomaviruses and discusses how these viruses might interact with their human host...
  3. doi How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40
    James A DeCaprio
    Department of Medical Oncology, Dana Farber Cancer Institute, USA
    Virology 384:274-84. 2009
    ..More recent studies have revealed how E1A and LT combine the activity of Rb and the other cellular associated proteins to perturb expression of many genes during viral infection and tumor formation...
  4. pmc Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation
    Syed Hamid Ali
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 78:2749-57. 2004
    ..Considering the significance of other TAg-interacting proteins in regulation of the cell cycle, p185/Cul7 may also regulate an important growth control pathway...
  5. ncbi The carboxyl-terminal domain of large T antigen rescues SV40 host range activity in trans independent of acetylation
    Danielle L Poulin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Virology 349:212-21. 2006
    ..The carboxyl-terminal region of T Ag contains a biological function essential for the SV40 viral life cycle...
  6. pmc Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens
    Jingwei Cheng
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Semin Cancer Biol 19:218-28. 2009
    ..The unique contributions of SV40 LT and ST and PY MT to cellular transformation have provided significant insights into our understanding of tumor suppressors, oncogenes and the process of oncogenesis...
  7. ncbi Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
    Larisa Litovchick
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 26:539-51. 2007
    ..This work reveals an evolutionarily conserved multisubunit protein complex that contains p130 and E2F4, but not pRB, and mediates the repression of cell cycle-dependent genes in quiescence...
  8. pmc Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53
    Darrell R Borger
    Dana Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Mayer Building 457, 44 Binney Street, Boston, Massachusetts 02115, USA
    J Virol 80:4292-303. 2006
    ..Therefore, the binding of p53 serves to modify SV40 LT by targeting CBP and p300 binding to direct the acetylation of SV40 LT...
  9. ncbi SV40 large T antigen promotes dephosphorylation of p130
    Jennifer Y Lin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 278:46482-7. 2003
    ..These results suggest that T Ag recruits a phosphatase activity in a DNA J domain-dependent manner to reduce the phosphorylation of p130...
  10. ncbi Telomerase maintains telomere structure in normal human cells
    Kenkichi Masutomi
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 114:241-53. 2003
    ..Together, these observations support the view that telomerase and telomere structure are dynamically regulated in normal human cells and that telomere length alone is unlikely to trigger entry into replicative senescence...

Research Grants27

  1. Interaction Between SV40 Large T and p185 Cullin
    JAMES DECAPRIO; Fiscal Year: 2006
    ..In addition, this proposal seeks to identify additional binding proteins of p185, to characterize the p185 ubiquitinating activity, and to determine if p185 serves as a tumor suppressor in a knockout mouse model. ..
  2. RB-Related Proteins in SV40 T Transformation
    JAMES DECAPRIO; Fiscal Year: 2007
    ..Using a variety of genetic, biochemical, and molecular approaches, we will focus on determining the specific contribution of p300 and CBP to T Ag transformation. ..
  3. RB-Related Proteins in SV40T Transformation
    James A DeCaprio; Fiscal Year: 2010
    ..We will test if two protein complexes termed DREAM and NuRD that bind to p130 and p107 are also inactivated by T Ag and determine if DREAM and NuRD also serve as tumor suppressors. ..
  4. RB-RELATED PROTEINS AND SV40 T TRANSFORMATION
    JAMES DECAPRIO; Fiscal Year: 2002
    ..In the course of the work, they will attempt to better understand the normal transformation suppression functions of the pRB-related proteins, p130 and p107. ..
  5. Interaction Between SV40 Large T and p185 Cullin
    James A DeCaprio; Fiscal Year: 2010
    ..This proposal seeks to determine if CUL7 and FBXW8 are tumor suppressor genes that are important for normal growth and SV40 induced cellular oncogenesis. ..