Research Topics
Genomes and Genes
| Philip L De JagerSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
A genome-wide scan for common variants affecting the rate of age-related cognitive declinePhilip L De Jager
Institute for the Neurosciences, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Neurobiol Aging 33:1017.e1-15. 2012....- Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cellsPhilip L De Jager
Harvard Medical School Partners Center for Genomics and Genetics, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, NRB 168C, Boston, MA 02115, USA
Brain 131:1701-11. 2008.... - Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility lociPhilip L De Jager
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Nat Genet 41:776-82. 2009.... - Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk scorePhilip L De Jager
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Lancet Neurol 8:1111-9. 2009..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS... - Identifying patient subtypes in multiple sclerosis and tailoring immunotherapy: challenges for the futurePhilip L De Jager
PhD Brigham and Women s Hospital Neurology, Boston, MA, USA
Ther Adv Neurol Disord 2:8-19. 2009..The tools and methods to gain insight into the heterogeneity of MS patients are available today; we must now realize their potential in enhancing the care of MS patients... 
New therapeutic approaches for multiple sclerosisPhilip L De Jager
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Annu Rev Med 58:417-32. 2007....- Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosusPhilip L De Jager
Department of Neurology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
Arthritis Rheum 54:1279-82. 2006..This variability in activation threshold may, in turn, affect an individual's susceptibility to SLE. This study assessed the role of genetic variation within the TLR-9 gene in susceptibility to SLE... - Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosisPhilip L De Jager
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Eur J Hum Genet 14:317-21. 2006.... - The role of the CD58 locus in multiple sclerosisPhilip L De Jager
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:5264-9. 2009.... - Risk alleles for multiple sclerosis identified by a genomewide studyDavid A Hafler
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
N Engl J Med 357:851-62. 2007..Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis... - A coding variant in CR1 interacts with APOE-ε4 to influence cognitive declineBrendan T Keenan
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Mol Genet 21:2377-88. 2012..We thus implicate C1q and MBL, which bind to LHR-D, as likely targets of the variant's effect and suggest that CR1 may be an important intermediate in the clearance of Aβ42 particles by C1q... - CR1 is associated with amyloid plaque burden and age-related cognitive declineLori B Chibnik
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
Ann Neurol 69:560-9. 2011..We leveraged available neuropsychological and autopsy data from 2 cohort studies to investigate whether these loci are associated with cognitive decline and AD neuropathology... - Functional screening of Alzheimer pathology genome-wide association signals in DrosophilaJoshua M Shulman
Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Hum Genet 88:232-8. 2011..Our strategy of coupling genome-wide association in humans with functional screening in a model organism is likely to be a powerful approach for gene discovery in AD and other complex genetic disorders... - Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility lociNikolaos A Patsopoulos
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Ann Neurol 70:897-912. 2011..To perform a 1-stage meta-analysis of genome-wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional consequences of new susceptibility loci... 
Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLABruce A C Cree
Department of Neurology, University of California San Francisco, USA
Arch Neurol 66:226-33. 2009....- Alzheimer disease susceptibility loci: evidence for a protein network under natural selectionTowfique Raj
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences Department of Neurology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Am J Hum Genet 90:720-6. 2012..The context for selection is probably unrelated to AD itself; it is likely that these genes interact in another context, such as in immune cells, where we observe cis-regulatory effects at several of the selected AD loci... - The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferationDavid M Kofler
Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA
J Immunol 187:3286-91. 2011..These findings indicate that the MS risk allele in the CD6 locus is associated with altered proliferation of CD4(+) T cells and demonstrate the influence of a disease-related allelic variant on important immunological characteristics... - IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor productionLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 5:e1000322. 2009..We demonstrate that multiple variants independently correlate with sIL-2RA levels... - Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levelsDavid Reich
Department of Genetics, Harvard Medical School, New Research Building, Boston, MA 02115, USA
Am J Hum Genet 80:716-26. 2007..0x10-12 for IL-6 SR, and P<2.0x10-9 for IL-6. These results also serve as an important proof of principle, showing that admixture mapping can not only coarsely localize but can also fine map a phenotypically important variant... - A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosisZongqi Xia
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 5:e14169. 2010..We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset Alzheimer's Disease (AD) influence brain volume and cognition in MS patients... - Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responsesLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 182:1541-7. 2009..In summary, we propose that before disease onset, strong genetic factors associated with disease risk dictate sIL-2RA levels that may be further modulated with onset of chronic systemic inflammation associated with MS... - Intermediate phenotypes identify divergent pathways to Alzheimer's diseaseJoshua M Shulman
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, USA
PLoS ONE 5:e11244. 2010..However, little is known of the role of these candidate genes in influencing intermediate phenotypes associated with a diagnosis of AD, including cognitive decline or AD neuropathologic burden... - A 17q12 allele is associated with altered NK cell subsets and functionZongqi Xia
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 188:3315-22. 2012.... - Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgeryAmanda A Fox
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e24593. 2011..We aimed to determine if genetic variants associate with occurrence of in-hospital VnD after CABG surgery... - An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activityLinda Ottoboni
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Sci Transl Med 4:153ra131. 2012..0077). We thus report a transcriptional signature that differentiates subjects with MS into two classes with different levels of disease activity... - Functionally defective germline variants of sialic acid acetylesterase in autoimmunityIra Surolia
Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 466:243-7. 2010..9 in subjects with type I diabetes. Functionally defective SIAE rare and polymorphic variants represent a strong genetic link to susceptibility in relatively common human autoimmune disorders... - Exploring the role of the epigenome in multiple sclerosis: a window onto cell-specific transcriptional potentialAnna Kaliszewska
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, NRB168, and Harvard Medical School, Boston, MA 02115, USA
J Neuroimmunol 248:2-9. 2012.... - Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association dataJoanne H Wang
Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0435, USA
Genome Med 3:3. 2011..Nevertheless, the knowledge of MS genetics remains incomplete, with many risk alleles still to be revealed... - Allelic variant in CTLA4 alters T cell phosphorylation patternsLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:18607-12. 2007..Thus, allelic variation associated with autoimmune disease can alter the signaling threshold of CD4(+) T cells. These experiments provide a rational approach for the dissection of T cell-susceptibility genes in autoimmune diseases... - Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatmentsRobert Gross
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, United States
J Neuroimmunol 233:168-74. 2011..The HLA DRB1 1501 allele explained some of this variation in event-free survival while on GA, and we found suggestive evidence that an IRF8 polymorphism influences event-free survival in IFN β treated subjects... - Applying a new generation of genetic maps to understand human inflammatory diseaseDavid A Hafler
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Rev Immunol 5:83-91. 2005.... - Common risk alleles for inflammatory diseases are targets of recent positive selectionTowfique Raj
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA Harvard Medical School, Boston, MA 02115, USA Program in Medical and Population Genetics, The Broad Institute, Cambridge, MA 02139, USA
Am J Hum Genet 92:517-29. 2013.... - A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibilityDavid Reich
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 37:1113-8. 2005..We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis... - Evaluation of an online platform for multiple sclerosis research: patient description, validation of severity scale, and exploration of BMI effects on disease courseRiley Bove
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Institute for the Neurosciences, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 8:e59707. 2013..com (PLM), for research in multiple sclerosis (MS). An investigation of the role of body mass index (BMI) on MS disease course was conducted to illustrate the utility of the platform... - A common polymorphism near PER1 and the timing of human behavioral rhythmsAndrew S P Lim
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 72:324-34. 2012..However, no common polymorphism has been associated with the timing of directly observed human behavioral rhythms or other physiological markers of circadian timing at the population level... - Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lociEli A Stahl
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 42:508-14. 2010..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles... - Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid ArthritisJing Cui
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 9:e1003394. 2013..These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry... - Gene expression profiling in MS: what is the clinical relevance?Philip L De Jager
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Lancet Neurol 3:269. 2004 - Parkinson's disease: genetics and pathogenesisJoshua M Shulman
Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Annu Rev Pathol 6:193-222. 2011.... - Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitisAshwin N Ananthakrishnan
1 Crohn s and Colitis Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Harvard Medical School, Boston, Massachusetts, USA
Am J Gastroenterol 108:594-601. 2013..The objective of this study is to examine whether there is a difference in the risk of psychiatric comorbidity following surgery in CD and UC... - High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral controlZaza M Ndhlovu
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Blood 121:801-11. 2013..This strategy may have important applications in predictive model development and immune monitoring of HIV-1 vaccine trials... - Multicolored stain-free histopathology with coherent Raman imagingChristian W Freudiger
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA
Lab Invest 92:1492-502. 2012..These stain-free histopathological images show resolutions similar to those obtained by conventional techniques, but do not require tissue fixation, sectioning or staining of the tissue analyzed... - Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured proteinKevin C O'Connor
Center for Neurologic Diseases, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Med 13:211-7. 2007..MOG-specific autoantibodies were identified in a subset of ADEM but only rarely in adult-onset MS cases, indicating that MOG is a more prominent target antigen in ADEM than MS...
Research Grants
- Exploring the consequences of the TNFRSF1A susceptibility allele for MSPhilip L De Jager; Fiscal Year: 2010....