Philip L De Jager
Affiliation: Harvard University
Bove R, Healy B, Secor E, Vaughan T, Katic B, Chitnis T, et al
. Patients report worse MS symptoms after menopause: findings from an online cohort. Mult Scler Relat Disord. 2015;4:18-24 pubmed publisher
..Further, this study highlights a utility for online research platforms, which allow for rapid generation of hypotheses that then require validation in clinical settings. ..
Bihlmeyer N, Brody J, Smith A, Lunetta K, Nalls M, Smith J, et al
. Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014;15:159 pubmed publisher
..57%. This effect was consistent between European and African ancestry cohorts, men and women, and major causes of death (cancer and cardiovascular disease), demonstrating the broad positive impact of genomic diversity on human survival. ..
Bove R, Vaughan T, Chitnis T, Wicks P, De Jager P. Women's experiences of menopause in an online MS cohort: A case series. Mult Scler Relat Disord. 2016;9:56-9 pubmed publisher
..Qualitative responses in this study illustrated several specific themes that require quantitative testing in clinic-based cohorts. ..
De Jager P, Chibnik L, Cui J, Reischl J, Lehr S, Simon K, et al
. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol. 2009;8:1111-9 pubmed publisher
..Future iterations of the wGRS might therefore make a contribution to algorithms that can predict a diagnosis of MS in a clinical or research setting. ..
De Jager P, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, et al
. Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. Eur J Hum Genet. 2006;14:317-21 pubmed
De Jager P, Baecher Allan C, Maier L, Arthur A, Ottoboni L, Barcellos L, et al
. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009;106:5264-9 pubmed publisher
De Jager P, Jia X, Wang J, de Bakker P, Ottoboni L, Aggarwal N, et al
. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009;41:776-82 pubmed publisher
De Jager P, Shulman J, Chibnik L, Keenan B, Raj T, Wilson R, et al
. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiol Aging. 2012;33:1017.e1-15 pubmed publisher
De Jager P, Bennett D. An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome. JAMA Neurol. 2013;70:719-26 pubmed publisher