Research Topics
| Johannes F de BoerSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomographyJohannes F de Boer
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
Opt Lett 28:2067-9. 2003..A significant SNR gain of several hundredfold is found for acquisition in the spectral domain. The SNR benefit is demonstrated experimentally in a hybrid time-domain-spectral-domain OCT system...- Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determinationMircea Mujat
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, BAR 704, Boston, Massachusetts 02114, USA
J Biomed Opt 12:041205. 2007..25 deg/100 microm. We also demonstrate, for the first time, a quantitative birefringence map of an in vivo human retinal nerve fiber layer... - Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imagingTeresa C Chen
Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
Arch Ophthalmol 123:1715-20. 2005..To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution... 
Diagnostic capability of spectral-domain optical coherence tomography for glaucomaHuijuan Wu
Glaucoma Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
Am J Ophthalmol 153:815-826.e2. 2012..To determine the diagnostic capability of spectral-domain optical coherence tomography in glaucoma patients with visual field defects...
Three-dimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imagingYueli Chen
Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, Massachusetts 02114, USA
J Biomed Opt 14:024016. 2009....- Comment on "Optical-fiber-based Mueller optical coherence tomography"B Hyle Park
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 7, Boston, Massachusetts 02114, USA
Opt Lett 29:2873-4; discussion 2875-7. 2004..Opt. Lett. 25, 1355 (2000)]... - Imaging of optic nerve head drusen: improvements with spectral domain optical coherence tomographyKayoung Yi
Harvard Medical School, Department of Ophthalmology, Glaucoma Service, Massachusetts General Hospital, Boston, MA, USA
J Glaucoma 18:373-8. 2009..To demonstrate a new algorithm that can determine the shape, location, and volume of optic nerve head drusen (ONHD), which were imaged with spectral domain optical coherence tomography (SDOCT)... - Imaging the human vocal folds in vivo with optical coherence tomography: a preliminary experienceAdam M Klein
Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
Ann Otol Rhinol Laryngol 115:277-84. 2006..To our knowledge, this study is the first application of PS-OCT for in vivo imaging of the human vocal folds... - Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomographyKi Hean Kim
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114 USA
Opt Express 15:18130-40. 2007..Both intensity and polarization-sensitive images could be acquired simultaneously at 18.5K axial scans/s. In vivo 3D images of human fingertips and oral cavity tissue are presented as a demonstration... - Optic axis determination accuracy for fiber-based polarization-sensitive optical coherence tomographyB Hyle Park
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, BAR 7, Boston, Massachusetts 02114, USA
Opt Lett 30:2587-9. 2005..We discuss the accuracy of optic axis determination due to a fundamental limit on the accuracy with which a polarization state can be determined as a function of signal-to-noise ratio... - Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomographyBarry Cense
Harvard Medical School and Wellman Center of Photomedicine, Massachusetts General Hospital, Boston, 02114, USA
Invest Ophthalmol Vis Sci 45:2606-12. 2004..The data do not invalidate the clinical value of a phase-retardation measurement, but affect the conversion of phase retardation to RNFL thickness... - Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomographySeemantini K Nadkarni
Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
J Am Coll Cardiol 49:1474-81. 2007..The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT)... - In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomographyNader Nassif
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
Opt Lett 29:480-2. 2004..In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW... - Polarization-sensitive optical coherence tomography of invasive basal cell carcinomaJohn Strasswimmer
Wellman Center of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
J Biomed Opt 9:292-8. 2004..These results indicate that PS-OCT can identify features that distinguish normal skin from tumor and may have the potential to guide surgeons in the treatment of aggressive skin cancer... - Diffusive and directional intracellular dynamics measured by field-based dynamic light scatteringChulmin Joo
Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Opt Express 18:2858-71. 2010..01 sec. In addition, we observed disrupted directional processes on the timescale of 1 approximately 5 sec by the application of a microtubule polymerization inhibitor, Colchicine, and ATP depletion... - Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic componentsB Hyle Park
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Opt Lett 29:2512-4. 2004..The relative importance of diattenuation versus birefringence to angular displacement of Stokes vectors on a Poincaré sphere was quantified... - Reproducibility of retinal nerve fiber layer thickness measurements using spectral domain optical coherence tomographyHuijuan Wu
Glaucoma Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
J Glaucoma 20:470-6. 2011.... - Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomographyMark C Pierce
Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Burns 30:511-7. 2004..In conclusion, PS-OCT is capable of imaging and quantifying collagen denaturation in burned human skin, providing a new parameter against which post-injury outcome may be compared... - Advances in optical coherence tomography imaging for dermatologyMark C Pierce
Wellman Center for Photomedicine Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
J Invest Dermatol 123:458-63. 2004..In particular, combining the previously described structural and Doppler imaging functions with polarization-sensitive imaging increases the utility of the technique for rapid, non-invasive investigations in the skin... - Spectral domain optical coherence tomography and glaucomaTeresa C Chen
Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Int Ophthalmol Clin 48:29-45. 2008 - Histologic correlation of in vivo optical coherence tomography images of the human retinaTeresa C Chen
Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA
Am J Ophthalmol 141:1165-8. 2006..To correlate in vivo human retina optical coherence tomography (OCT)3 images with histology... - In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imagingConor L Evans
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom St, Boston, MA 02114, USA
Opt Express 17:8892-906. 2009..The development of a time-lapse OCT system, capable of automated, multidimensional acquisition, further provided insights into the growth and chemotherapeutic response of ovarian cancer... - Comprehensive volumetric optical microscopy in vivoSeok H Yun
Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
Nat Med 12:1429-33. 2006..Our pilot study results suggest that this technology may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects... - Birefringence measurements in human skin using polarization-sensitive optical coherence tomographyMark C Pierce
Harvard Medical School, Massachusetts General Hospital, Wellman Center for Photomedicine, 50 Blossom Street Boston, Massachusetts 02114, USA
J Biomed Opt 9:287-91. 2004..Examples of PS-OCT images from skin sites following wound healing and repair are also presented and discussed... - In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomographyBarry Cense
Wellman Laboratories of Photomedicine, Harvard Medical School and Massachusetts General Hospital, 50 Blossom Street BAR 714, Boston, MA 02114, USA
J Biomed Opt 9:121-5. 2004..A trend in the preliminary measurements shows that the nerve fiber layer located inferior and superior to the optic nerve head is more birefringent than the thinner layer of nerve fiber tissue in the temporal and nasal regions... - In vivo three-dimensional imaging of neovascular age-related macular degeneration using optical frequency domain imaging at 1050 nmDaniel M de Bruin
Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Invest Ophthalmol Vis Sci 49:4545-52. 2008..Three patients presenting with blurred vision and exudative AMD were imaged before and after anti-VEGF treatment with ranibizumab... - Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomographyKi Hean Kim
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
J Vis 8:17.1-11. 2008..In summary, we show that SD-OCT can monitor the progression of retinal degeneration in transgenic mice... - Depth-resolved measurement of transient structural changes during action potential propagationTaner Akkin
Harvard Medical School and Wellman Center for Photomedicine at Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biophys J 93:1347-53. 2007..Noncontact optical measurements demonstrate nanometer-scale transient movement on a 1-ms timescale associated with action potential propagation in crayfish and lobster nerves... - Imaging the mucosa of the human vocal fold with optical coherence tomographyJames A Burns
Department of Surgery, Harvard Medical School, Boston, MA 02114, USA
Ann Otol Rhinol Laryngol 114:671-6. 2005..We believe that these imaging techniques will have applications in the exploration of solutions to vocal fold scarring and in imaging vocal fold disorders in the clinic and operating room... - Review of polarization sensitive optical coherence tomography and Stokes vector determinationJohannes F de Boer
Harvard Medical School, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biomed Opt 7:359-71. 2002..Effect of multiple scattering and speckle on the accuracy and noise of the computed Stokes parameters is discussed. Future directions for development of PS-OCT instrumentation for biological and medical applications is given... - Spectral-domain optical coherence phase and multiphoton microscopyChulmin Joo
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
Opt Lett 32:623-5. 2007..We also demonstrate the visualization of actin filaments in a fixed cell specimen, which is confirmed by simultaneous multiphoton fluorescence imaging... - Determination of burn depth by polarization-sensitive optical coherence tomographyShyam M Srinivas
Beckman Laser Institute, Department of Biomedical Engineering and Surgery, University of California-Irvine, Irvine, CA 92612, USA
J Biomed Opt 9:207-12. 2004..PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients... - Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imagingChulmin Joo
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Opt Lett 30:2131-3. 2005..We demonstrate subnanometer level path-length sensitivity and present images obtained on reflection from a known phase object and human epithelial cheek cells... - Imaging the internal structure of the rat cochlea using optical coherence tomography at 0.827 microm and 1.3 micromBrian J F Wong
Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
Otolaryngol Head Neck Surg 130:334-8. 2004..The purpose of this study was to use high-speed optical coherence tomography (OCT) to obtain cross-sectional images of the rat cochlea... - Spectral-domain optical coherence reflectometric sensor for highly sensitive molecular detectionChulmin Joo
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Opt Lett 32:2426-8. 2007..We present subfemtomole detection sensitivity for etching of SiO(2) molecules and demonstrate its application as a biosensor by measuring biotin-streptavidin binding in a microfluidic device... - Measurement of morphologic changes induced by trauma with the use of coherence tomography in porcine vocal cordsNader A Nassif
Department of Physics and Astronomy, University of California, Irvine, Orange, CA 92868-3201, USA
Otolaryngol Head Neck Surg 133:845-50. 2005..The OCT image corresponded closely with histology. CONCLUSION: OCT is a powerful imaging tool with the potential for use in real time and has potential for multiple clinical applications in the larynx...
Research Grants
- Video Rate OCT for Evaluating GlaucomaBORIS PARK; Fiscal Year: 2007..e. GDx, HRT, OCT3, Humphrey visual field, etc) detection of glaucoma and vision loss. ..