Johannes F de Boer

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Review of polarization sensitive optical coherence tomography and Stokes vector determination
    Johannes F de Boer
    Harvard Medical School, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biomed Opt 7:359-71. 2002
  2. ncbi request reprint Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
    Johannes F de Boer
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 28:2067-9. 2003
  3. ncbi request reprint Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination
    Mircea Mujat
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, BAR 704, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:041205. 2007
  4. ncbi request reprint Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging
    Teresa C Chen
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 123:1715-20. 2005
  5. pmc Diagnostic capability of spectral-domain optical coherence tomography for glaucoma
    Huijuan Wu
    Glaucoma Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Am J Ophthalmol 153:815-826.e2. 2012
  6. ncbi request reprint Comment on "Optical-fiber-based Mueller optical coherence tomography"
    B Hyle Park
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 7, Boston, Massachusetts 02114, USA
    Opt Lett 29:2873-4; discussion 2875-7. 2004
  7. doi request reprint Three-dimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imaging
    Yueli Chen
    Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, Massachusetts 02114, USA
    J Biomed Opt 14:024016. 2009
  8. ncbi request reprint Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography
    Ki Hean Kim
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114 USA
    Opt Express 15:18130-40. 2007
  9. ncbi request reprint Optic axis determination accuracy for fiber-based polarization-sensitive optical coherence tomography
    B Hyle Park
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, BAR 7, Boston, Massachusetts 02114, USA
    Opt Lett 30:2587-9. 2005
  10. ncbi request reprint Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography
    Barry Cense
    Harvard Medical School and Wellman Center of Photomedicine, Massachusetts General Hospital, Boston, 02114, USA
    Invest Ophthalmol Vis Sci 45:2606-12. 2004

Research Grants

  1. Video Rate OCT for Evaluating Glaucoma
    BORIS PARK; Fiscal Year: 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Review of polarization sensitive optical coherence tomography and Stokes vector determination
    Johannes F de Boer
    Harvard Medical School, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biomed Opt 7:359-71. 2002
    ..Effect of multiple scattering and speckle on the accuracy and noise of the computed Stokes parameters is discussed. Future directions for development of PS-OCT instrumentation for biological and medical applications is given...
  2. ncbi request reprint Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
    Johannes F de Boer
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 28:2067-9. 2003
    ..A significant SNR gain of several hundredfold is found for acquisition in the spectral domain. The SNR benefit is demonstrated experimentally in a hybrid time-domain-spectral-domain OCT system...
  3. ncbi request reprint Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination
    Mircea Mujat
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, BAR 704, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:041205. 2007
    ..25 deg/100 microm. We also demonstrate, for the first time, a quantitative birefringence map of an in vivo human retinal nerve fiber layer...
  4. ncbi request reprint Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging
    Teresa C Chen
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 123:1715-20. 2005
    ..To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution...
  5. pmc Diagnostic capability of spectral-domain optical coherence tomography for glaucoma
    Huijuan Wu
    Glaucoma Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Am J Ophthalmol 153:815-826.e2. 2012
    ..To determine the diagnostic capability of spectral-domain optical coherence tomography in glaucoma patients with visual field defects...
  6. ncbi request reprint Comment on "Optical-fiber-based Mueller optical coherence tomography"
    B Hyle Park
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 7, Boston, Massachusetts 02114, USA
    Opt Lett 29:2873-4; discussion 2875-7. 2004
    ..Opt. Lett. 25, 1355 (2000)]...
  7. doi request reprint Three-dimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imaging
    Yueli Chen
    Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, Massachusetts 02114, USA
    J Biomed Opt 14:024016. 2009
    ....
  8. ncbi request reprint Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography
    Ki Hean Kim
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114 USA
    Opt Express 15:18130-40. 2007
    ..Both intensity and polarization-sensitive images could be acquired simultaneously at 18.5K axial scans/s. In vivo 3D images of human fingertips and oral cavity tissue are presented as a demonstration...
  9. ncbi request reprint Optic axis determination accuracy for fiber-based polarization-sensitive optical coherence tomography
    B Hyle Park
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, BAR 7, Boston, Massachusetts 02114, USA
    Opt Lett 30:2587-9. 2005
    ..We discuss the accuracy of optic axis determination due to a fundamental limit on the accuracy with which a polarization state can be determined as a function of signal-to-noise ratio...
  10. ncbi request reprint Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography
    Barry Cense
    Harvard Medical School and Wellman Center of Photomedicine, Massachusetts General Hospital, Boston, 02114, USA
    Invest Ophthalmol Vis Sci 45:2606-12. 2004
    ..Early detection of RNFL changes may enable treatment to prevent permanent loss of vision. Polarization-sensitive optical coherence tomography (PS-OCT) can provide objective information on RNFL thickness and birefringence...
  11. pmc Imaging of optic nerve head drusen: improvements with spectral domain optical coherence tomography
    Kayoung Yi
    Harvard Medical School, Department of Ophthalmology, Glaucoma Service, Massachusetts General Hospital, Boston, MA, USA
    J Glaucoma 18:373-8. 2009
    ..To demonstrate a new algorithm that can determine the shape, location, and volume of optic nerve head drusen (ONHD), which were imaged with spectral domain optical coherence tomography (SDOCT)...
  12. ncbi request reprint Imaging the human vocal folds in vivo with optical coherence tomography: a preliminary experience
    Adam M Klein
    Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    Ann Otol Rhinol Laryngol 115:277-84. 2006
    ....
  13. pmc Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components
    B Hyle Park
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Opt Lett 29:2512-4. 2004
    ..The relative importance of diattenuation versus birefringence to angular displacement of Stokes vectors on a Poincaré sphere was quantified...
  14. pmc Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography
    Seemantini K Nadkarni
    Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 49:1474-81. 2007
    ..The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT)...
  15. ncbi request reprint Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma
    John Strasswimmer
    Wellman Center of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Biomed Opt 9:292-8. 2004
    ..These results indicate that PS-OCT can identify features that distinguish normal skin from tumor and may have the potential to guide surgeons in the treatment of aggressive skin cancer...
  16. pmc Diffusive and directional intracellular dynamics measured by field-based dynamic light scattering
    Chulmin Joo
    Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Opt Express 18:2858-71. 2010
    ..01 sec. In addition, we observed disrupted directional processes on the timescale of 1 approximately 5 sec by the application of a microtubule polymerization inhibitor, Colchicine, and ATP depletion...
  17. ncbi request reprint In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography
    Nader Nassif
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 29:480-2. 2004
    ..In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW...
  18. pmc Reproducibility of retinal nerve fiber layer thickness measurements using spectral domain optical coherence tomography
    Huijuan Wu
    Glaucoma Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Glaucoma 20:470-6. 2011
    ....
  19. ncbi request reprint Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography
    Mark C Pierce
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Burns 30:511-7. 2004
    ..In conclusion, PS-OCT is capable of imaging and quantifying collagen denaturation in burned human skin, providing a new parameter against which post-injury outcome may be compared...
  20. ncbi request reprint Advances in optical coherence tomography imaging for dermatology
    Mark C Pierce
    Wellman Center for Photomedicine Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
    J Invest Dermatol 123:458-63. 2004
    ..In particular, combining the previously described structural and Doppler imaging functions with polarization-sensitive imaging increases the utility of the technique for rapid, non-invasive investigations in the skin...
  21. pmc Spectral domain optical coherence tomography and glaucoma
    Teresa C Chen
    Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Int Ophthalmol Clin 48:29-45. 2008
  22. ncbi request reprint Histologic correlation of in vivo optical coherence tomography images of the human retina
    Teresa C Chen
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA
    Am J Ophthalmol 141:1165-8. 2006
    ..To correlate in vivo human retina optical coherence tomography (OCT)3 images with histology...
  23. doi request reprint Analysis of normal retinal nerve fiber layer thickness by age, sex, and race using spectral domain optical coherence tomography
    Tarek Alasil
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital and the Harvard Catalyst Program, Boston, MA, USA
    J Glaucoma 22:532-41. 2013
    ..To determine the effects of age, sex, and race on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by the spectral domain optical coherence tomography (SD-OCT) Spectralis machine (Heidelberg Engineering)...
  24. ncbi request reprint In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography
    Barry Cense
    Wellman Laboratories of Photomedicine, Harvard Medical School and Massachusetts General Hospital, 50 Blossom Street BAR 714, Boston, MA 02114, USA
    J Biomed Opt 9:121-5. 2004
    ..A trend in the preliminary measurements shows that the nerve fiber layer located inferior and superior to the optic nerve head is more birefringent than the thinner layer of nerve fiber tissue in the temporal and nasal regions...
  25. doi request reprint In vivo three-dimensional imaging of neovascular age-related macular degeneration using optical frequency domain imaging at 1050 nm
    Daniel M de Bruin
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 49:4545-52. 2008
    ..Three patients presenting with blurred vision and exudative AMD were imaged before and after anti-VEGF treatment with ranibizumab...
  26. ncbi request reprint Birefringence measurements in human skin using polarization-sensitive optical coherence tomography
    Mark C Pierce
    Harvard Medical School, Massachusetts General Hospital, Wellman Center for Photomedicine, 50 Blossom Street Boston, Massachusetts 02114, USA
    J Biomed Opt 9:287-91. 2004
    ..Examples of PS-OCT images from skin sites following wound healing and repair are also presented and discussed...
  27. pmc In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging
    Conor L Evans
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom St, Boston, MA 02114, USA
    Opt Express 17:8892-906. 2009
    ..The development of a time-lapse OCT system, capable of automated, multidimensional acquisition, further provided insights into the growth and chemotherapeutic response of ovarian cancer...
  28. pmc Comprehensive volumetric optical microscopy in vivo
    Seok H Yun
    Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 12:1429-33. 2006
    ..Our pilot study results suggest that this technology may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects...
  29. ncbi request reprint Imaging the mucosa of the human vocal fold with optical coherence tomography
    James A Burns
    Department of Surgery, Harvard Medical School, Boston, MA 02114, USA
    Ann Otol Rhinol Laryngol 114:671-6. 2005
    ..Optical coherence tomography (OCT), a noncontact, noninvasive technology that provides cross-sectional images by means of backscattered light, offers the potential for delineating these layers in vivo...
  30. pmc Depth-resolved measurement of transient structural changes during action potential propagation
    Taner Akkin
    Harvard Medical School and Wellman Center for Photomedicine at Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biophys J 93:1347-53. 2007
    ..Noncontact optical measurements demonstrate nanometer-scale transient movement on a 1-ms timescale associated with action potential propagation in crayfish and lobster nerves...
  31. doi request reprint Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography
    Ki Hean Kim
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
    J Vis 8:17.1-11. 2008
    ..In summary, we show that SD-OCT can monitor the progression of retinal degeneration in transgenic mice...
  32. ncbi request reprint Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging
    Chulmin Joo
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 30:2131-3. 2005
    ..We demonstrate subnanometer level path-length sensitivity and present images obtained on reflection from a known phase object and human epithelial cheek cells...
  33. ncbi request reprint Determination of burn depth by polarization-sensitive optical coherence tomography
    Shyam M Srinivas
    Beckman Laser Institute, Department of Biomedical Engineering and Surgery, University of California Irvine, Irvine, CA 92612, USA
    J Biomed Opt 9:207-12. 2004
    ..PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients...
  34. ncbi request reprint Spectral-domain optical coherence phase and multiphoton microscopy
    Chulmin Joo
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Opt Lett 32:623-5. 2007
    ..We also demonstrate the visualization of actin filaments in a fixed cell specimen, which is confirmed by simultaneous multiphoton fluorescence imaging...
  35. ncbi request reprint Measurement of morphologic changes induced by trauma with the use of coherence tomography in porcine vocal cords
    Nader A Nassif
    Department of Physics and Astronomy, University of California, Irvine, Orange, CA 92868 3201, USA
    Otolaryngol Head Neck Surg 133:845-50. 2005
    ..To evaluate the ability of optical coherence tomography (OCT) (a noncontact, high-resolution imaging technique that generates detailed cross-sectional images of tissue structure) to image and document acute response to trauma in the larynx...
  36. ncbi request reprint Imaging the internal structure of the rat cochlea using optical coherence tomography at 0.827 microm and 1.3 microm
    Brian J F Wong
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
    Otolaryngol Head Neck Surg 130:334-8. 2004
    ..The purpose of this study was to use high-speed optical coherence tomography (OCT) to obtain cross-sectional images of the rat cochlea...
  37. ncbi request reprint Spectral-domain optical coherence reflectometric sensor for highly sensitive molecular detection
    Chulmin Joo
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Lett 32:2426-8. 2007
    ..We present subfemtomole detection sensitivity for etching of SiO(2) molecules and demonstrate its application as a biosensor by measuring biotin-streptavidin binding in a microfluidic device...

Research Grants1

  1. Video Rate OCT for Evaluating Glaucoma
    BORIS PARK; Fiscal Year: 2007
    ..e. GDx, HRT, OCT3, Humphrey visual field, etc) detection of glaucoma and vision loss. ..