Darlene Dartt

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells
    Victoria E McGilligan
    Schepens Eye Research Institute Massachusetts Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America Centre for Molecular Biosciences, University of Ulster, Coleraine, N Ireland
    PLoS ONE 8:e74010. 2013
  2. pmc Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation
    Darlene A Dartt
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:4455-66. 2011
  3. ncbi request reprint Tear lipocalin: structure and function
    Darlene A Dartt
    Schepens Eye Research Institute and Harvard Medical School, Boston, MA 02114, USA
    Ocul Surf 9:126-38. 2011
  4. pmc Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion
    Darlene A Dartt
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:5720-9. 2011
  5. pmc Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland
    Darlene A Dartt
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:3381-90. 2011
  6. pmc Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases
    Darlene A Dartt
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Prog Retin Eye Res 28:155-77. 2009
  7. ncbi request reprint Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland
    Chika Funaki
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 293:C1551-60. 2007
  8. ncbi request reprint Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland
    Vanja Tepavcevic
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:1075-81. 2003
  9. pmc ERK/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture
    Marie A Shatos
    Department of Ophthalmology, Shepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 49:3351-9. 2008
  10. pmc Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation
    Marie A Shatos
    Schepens Eye Research Institute, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 50:1619-25. 2009

Research Grants

  1. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2007
  2. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene A Dartt; Fiscal Year: 2010
  3. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2005
  4. CONTROL OF CONJUNCTIVAL GOBLET CELL MUCIN PRODUCTION
    Darlene Dartt; Fiscal Year: 2002
  5. Planning Grant:Research on Blinding Eye Diseases (RMI)
    Darlene Dartt; Fiscal Year: 2006
  6. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
  7. Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution
    Darlene A Dartt; Fiscal Year: 2010
  8. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2009
  9. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2000
  10. CONTROL OF CONJUNCTIVAL GOBLET CELL MUCOUS PRODUCTION
    Darlene Dartt; Fiscal Year: 1993

Collaborators

Detail Information

Publications44

  1. pmc Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells
    Victoria E McGilligan
    Schepens Eye Research Institute Massachusetts Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America Centre for Molecular Biosciences, University of Ulster, Coleraine, N Ireland
    PLoS ONE 8:e74010. 2013
    ..aureus via the caspase 1 pathway to secrete mature IL1-β. Thus goblet cells contribute to the innate immune response in the conjunctiva by activation of the NLRP3 inflammasome. ..
  2. pmc Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation
    Darlene A Dartt
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:4455-66. 2011
    ..Stimulated secretion is terminated by preventing the increase in [Ca(2+)](i) and activation of ERK1/2 by RvD1 and RvE1...
  3. ncbi request reprint Tear lipocalin: structure and function
    Darlene A Dartt
    Schepens Eye Research Institute and Harvard Medical School, Boston, MA 02114, USA
    Ocul Surf 9:126-38. 2011
    ..Additional research is warranted to determine the actual functions of TLC in tears and the presence of its receptor on the ocular surface...
  4. pmc Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion
    Darlene A Dartt
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:5720-9. 2011
    ..To determine whether α(1D)-adrenergic receptors (α(1D)-AR) and P2X(7) receptors interact by determining their effect on ATP release, intracellular [Ca(2+)] ([Ca(2+)](i)), and protein secretion in rat lacrimal gland acini...
  5. pmc Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland
    Darlene A Dartt
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:3381-90. 2011
    ..To determine the interaction of M3 muscarinic receptors (M3AChR) and P2X(7) receptors to increase intracellular [Ca2+] ([Ca2+]i) and stimulate protein secretion in rat lacrimal gland cells...
  6. pmc Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases
    Darlene A Dartt
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Prog Retin Eye Res 28:155-77. 2009
    ..This review focuses on the neural regulation of lacrimal gland secretion under normal and dry eye conditions...
  7. ncbi request reprint Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland
    Chika Funaki
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 293:C1551-60. 2007
    ..We conclude that increasing cellular cAMP levels inhibits p44/p42 MAPK activity and that this could account for potentiation of secretion obtained when cAMP was elevated and Ca(2+) and PKC were increased by agonists...
  8. ncbi request reprint Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland
    Vanja Tepavcevic
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:1075-81. 2003
    ..To determine the effects of epidermal growth factor (EGF) on lacrimal gland secretion of proteins and characterize its signal-transducing components...
  9. pmc ERK/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture
    Marie A Shatos
    Department of Ophthalmology, Shepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 49:3351-9. 2008
    ..To determine whether activation of the ERK pathway by EGF leads to rat and human goblet cell proliferation...
  10. pmc Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation
    Marie A Shatos
    Schepens Eye Research Institute, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 50:1619-25. 2009
    ..To determine whether a constitutively active protein kinase C (PKC)-alpha stimulates rat and human conjunctival goblet cell proliferation through activation of ERK 1/2...
  11. doi request reprint Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells
    J David Rios
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 86:629-36. 2008
    ..OPC-12759 increased the phosphorylation of the EGFR and MAPK in a time-dependent manner. We concluded that OPC-12759 stimulates secretion from cultured conjunctival goblet cells by activating the EGFR, which then induces MAPK activity...
  12. pmc Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland
    Robin R Hodges
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:2781-9. 2005
    ..To determine whether alpha(1)-adrenergic receptors use the nitric oxide (NO)/cGMP pathway to stimulate protein secretion by rat lacrimal gland...
  13. pmc Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation
    Jian Gu
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Exp Eye Res 86:322-34. 2008
    ..EGF, TGF-alpha and HB-EGF all stimulated the activation of signaling intermediates and caused goblet cell proliferation...
  14. ncbi request reprint Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells
    Yoshitaka Horikawa
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:2535-44. 2003
    ..To compare activation of the p42/p44 mitogen-activated protein kinase (MAPK) by cholinergic agonists and epidermal growth factor (EGF) in cultured human and rat goblet cells...
  15. ncbi request reprint Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland
    Isao Ota
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Am J Physiol Cell Physiol 284:C168-78. 2003
    ..We conclude that, in the lacrimal gland, activation of MAPK plays an inhibitory role in alpha(1)-adrenergically and cholinergically stimulated protein secretion and that these agonists use different signaling mechanisms to activate MAPK...
  16. ncbi request reprint Role of Ca2+ and protein kinase C in cholinergic, and alpha1-adrenergic agonists and EGF stimulated mitogen-activated protein kinase activity in lacrimal gland
    Jose D Rios
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Adv Exp Med Biol 506:185-90. 2002
  17. pmc Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells
    Lili Chen
    Schepens Eye Research Institute, Department of Ophthalmology, Boston, MA 02114, USA
    Am J Physiol Cell Physiol 291:C946-56. 2006
    ....
  18. pmc Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation
    Marie A Shatos
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 50:614-20. 2009
    ..The authors determined the role of the protein kinase C (PKC) isoforms cPKCalpha and nPKCepsilon in EGF-stimulated proliferation of cultured rat and human conjunctival goblet cells...
  19. ncbi request reprint Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion
    Robin R Hodges
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Adv Exp Med Biol 506:237-41. 2002
  20. ncbi request reprint Isolation and characterization of human goblet cells in vitro: regulation of proliferation and activation of mitogen-activated protein kinase by EGF and carbachol
    Marie A Shatos
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Adv Exp Med Biol 506:301-5. 2002
  21. ncbi request reprint Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion
    Harumi Kanno
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 284:C988-98. 2003
    ..We conclude that carbachol transactivates the EGFR to activate MAPK, leading to conjunctival goblet cell secretion. In addition, carbachol also activates Pyk2 and p60Src that could play a role in the transactivation of the EGFR...
  22. ncbi request reprint Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome
    Yolanda Diebold
    Schepens Eye Research Institute Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 84:500-12. 2007
    ..We conclude that the conjunctiva is a target tissue in Sjögren's syndrome-related inflammation in this murine model...
  23. ncbi request reprint OPC-12759 increases proliferation of cultured rat conjunctival goblet cells
    Jose D Rios
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114 2500, USA
    Cornea 25:573-81. 2006
    ..To determine if the gastroprotective drug OPC-12759 increased proliferation of rat conjunctival goblet cells in culture...
  24. ncbi request reprint Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland
    Emiliano Ghinelli
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts USA
    Invest Ophthalmol Vis Sci 44:3352-7. 2003
    ....
  25. ncbi request reprint Isolation and characterization of cultured human conjunctival goblet cells
    Marie A Shatos
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:2477-86. 2003
    ..To isolate and characterize goblet cells from normal human conjunctival tissue to determine whether epidermal growth factor (EGF) receptors are present and whether EGF can influence goblet cell proliferation...
  26. ncbi request reprint Role of mitogen-activated protein kinase in cholinergic stimulation of conjunctival goblet cell secretion
    Darlene A Dartt
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Adv Exp Med Biol 506:297-300. 2002
  27. pmc Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response
    Jose David Rios
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford St, 02114 Boston, MA, USA
    Exp Eye Res 80:477-91. 2005
    ....
  28. pmc Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells
    Robin R Hodges
    Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 85:836-44. 2007
    ..We conclude that PKC and intracellular Ca(2+) activate Pyk2 and Src and phosphorylate the EGF receptor leading to stimulation of MAPK in conjunctival goblet cells...
  29. ncbi request reprint Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion
    Robin R Hodges
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 45:3974-81. 2004
    ..This study was undertaken to determine whether activation of PKCalpha alone would induce lacrimal gland protein secretion by examining the effects of overexpression of constitutively active PKCalpha...
  30. ncbi request reprint Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation
    J David Rios
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 48:1543-51. 2007
    ....
  31. ncbi request reprint Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK
    Robin R Hodges
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:3352-9. 2006
    ....
  32. ncbi request reprint Regulatory pathways in lacrimal gland epithelium
    Robin R Hodges
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int Rev Cytol 231:129-96. 2003
    ..In this review, we summarize the latest information regarding the regulatory pathways, which control secretion from the lacrimal gland, and their roles in the pathogenesis of dry eye syndromes...
  33. ncbi request reprint Control of mucin production by ocular surface epithelial cells
    Darlene A Dartt
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 78:173-85. 2004
    ..By understanding these mechanisms under normal conditions, treatments can be designed for diseases of the mucous production of the ocular surface...
  34. ncbi request reprint Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion
    Darlene A Dartt
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 78:337-45. 2004
    ..This review will focus on the effects of the EGF family of growth factors on the lacrimal gland and their interactions with the pathways stimulated by the neurotransmitters released from nerves...
  35. ncbi request reprint Regulation of mucin and fluid secretion by conjunctival epithelial cells
    Darlene A Dartt
    The Department of Ophthalmology, The Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Prog Retin Eye Res 21:555-76. 2002
    ..Growth factors regulate goblet cell secretion, but their effects on stratified squamous cell secretion are unknown...
  36. pmc Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland
    Robin R Hodges
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 50:5681-9. 2009
    ..To characterize the effects of P2X(7) purinergic receptors on lacrimal gland function...
  37. ncbi request reprint VEGF-dependent conjunctivalization of the corneal surface
    Antonia M Joussen
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Invest Ophthalmol Vis Sci 44:117-23. 2003
    ..To investigate the mechanisms governing corneal neovascularization and the appearance of goblet cells in a murine model of limbal insufficiency...
  38. doi request reprint Preoperative characteristics and a potential mechanism of chronic dry eye after LASIK
    Keiko Konomi
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 49:168-74. 2008
    ..To determine whether measurable preoperative characteristics predispose patients to chronic dry eye after laser in situ keratomileusis (LASIK)...
  39. pmc Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice
    Bruce Turpie
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Am J Pathol 175:1136-47. 2009
    ..Together, these results indicate that TSP-1 deficiency results in a spontaneous form of chronic dry eye and aberrant histopathology associated with Sjögren's syndrome...
  40. ncbi request reprint Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes
    Whaseon Lee-Kwon
    Johns Hopkins Univ School of Medicine, 925 Ross Research Bldg, 720 Rutland Ave, Baltimore, MD 21205 2195, USA
    Am J Physiol Cell Physiol 285:C1527-36. 2003
    ..These results suggest that PKCalpha is not necessary for the Ca2+-dependent formation of the NHE3 plasma membrane complex, although it is necessary for decreasing the membrane amounts of NHE3, probably by stimulating NHE3 endocytosis...
  41. ncbi request reprint EGF-induced ERK phosphorylation independent of PKC isozymes in human corneal epithelial cells
    Ke Ping Xu
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912, USA
    Invest Ophthalmol Vis Sci 43:3673-9. 2002
    ..To investigate the role of protein kinase C (PKC) isozymes in epithelial growth factor (EGF)-induced activation of extracellular signal-regulated kinase (ERK) and cell proliferation in cultured human corneal epithelial cells...
  42. pmc Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini
    Galina V Jerdeva
    Department of Pharmaceutical Sciences, University of Southern California School of Pharmacy, 1985 Zonal Ave, Los Angeles, California 90033, USA
    Am J Physiol Cell Physiol 289:C1052-68. 2005
    ..We propose that DN-PKC-epsilon alters lacrimal acinar apical actin remodeling, leading to inhibition of stimulated exocytosis and transcytosis...
  43. ncbi request reprint Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes
    Joanna E Graham
    Centre for Molecular Biosciences, University of Ulster, Coleraine, Northern Ireland
    Invest Ophthalmol Vis Sci 48:5616-23. 2007
    ..To compare the bacterial population of the ocular surface of normal and dry eye subjects using conventional culture and 16S rDNA PCR...

Research Grants45

  1. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2007
    ..Knowledge about the molecules inside lacrimal gland cells that cause secretion will be critical to the development of new drugs to produce tear secretion in individuals who have dry eye resulting from aging or Sjogren's syndrome. ..
  2. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene A Dartt; Fiscal Year: 2010
    ....
  3. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2005
    ..lmmunofluorescence microscopy, Western and Northern blot analysis, and RT-PCR will be used to determine how the expression and release of EGF and its family members is regulated. ..
  4. CONTROL OF CONJUNCTIVAL GOBLET CELL MUCIN PRODUCTION
    Darlene Dartt; Fiscal Year: 2002
    ..abstract_text> ..
  5. Planning Grant:Research on Blinding Eye Diseases (RMI)
    Darlene Dartt; Fiscal Year: 2006
    ..Based on these findings, an application for an Interdisciplinary Center for Research on Blinding Eye Diseases will be prepared. ..
  6. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..Study of the signaling pathways that stimulate conjunctival goblet cell proliferation will lead to the development of treatments to replenish the mucin layer in these diseases. ..
  7. Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution
    Darlene A Dartt; Fiscal Year: 2010
    ..This will provide significant insights into developing novel treatments for ocular surface inflammation. ..
  8. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2009
    ..There is no cure for dry eye and as the lacrimal gland is the primary contributor to the aqueous layer of the tear film, replacement of a diseased lacrimal gland using stem cells would improve the health of the ocular surface. ..
  9. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2000
    ....
  10. CONTROL OF CONJUNCTIVAL GOBLET CELL MUCOUS PRODUCTION
    Darlene Dartt; Fiscal Year: 1993
    ....
  11. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 1993
    ....