Affiliation: Harvard University
- Middle cerebral artery occlusion in Macaca fascicularis: acute and chronic stroke evolutionHELEN E D'ARCEUIL
Neuroradiology Section, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
J Med Primatol 35:78-86. 2006..This paper describes the care of animals undergoing this stroke procedure, the range of outcomes we experienced and the cause of mortality in this model...
- Three-dimensional high-resolution diffusion tensor imaging and tractography of the developing rabbit brainHelen D'Arceuil
Neuroradiology Section, Massachusetts General Hospital, Boston, Mass, USA
Dev Neurosci 30:262-75. 2008..Therefore, ex vivo DTI tractography is a potentially powerful tool for neuroscience investigations and may also reveal effects (such as fiber tract pruning during development) which may be important targets for in vivo human studies...
- A comparison of CH3-DTPA-GD (NMS60) and GD-DTPA for evaluation of acute myocardial ischemiaH E D'Arceuil
Lucas MRS I Center, Department of Radiology, Stanford University, CA, USA
Int J Cardiovasc Imaging 21:539-47. 2005....
- Near-infrared frequency-domain optical spectroscopy and magnetic resonance imaging: a combined approach to studying cerebral maturation in neonatal rabbitsH E D'Arceuil
Neuroradiology Section, Martinos Center for Biomedical Imaging, Room 2301, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
J Biomed Opt 10:11011. 2005..HbT, which reflects blood volume, peaked at postnatal day P17, as expected since the capillary density increases up to P17 when the microvasculature matures...
- An MRA study of vascular stenosis in a pig model using CH3-DTPA-Gd (NMS60) and Gd-DTPAHELEN E D'ARCEUIL
Lucas MRS I Center, Department of Radiology, Stanford University, Stanford, CA 94305 5105, USA
Magn Reson Imaging 22:1243-8. 2004....
- The effects of brain tissue decomposition on diffusion tensor imaging and tractographyHelen D'Arceuil
Athinoula Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MGH NMR Center, Rm 2301, Bldg 149, 13th St, Charlestown, MA 02129, USA
Neuroimage 36:64-8. 2007..Elapsed time between death and tissue fixation has a major effect upon the brain's diffusion properties and should be born in mind when interpreting fixed brain DTI...
- A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDSRobert A Fuller
Massachusetts General Hospital NMR Center and Neuroradiology Division, Harvard Medical School, Charlestown, MA, USA
BMC Neurosci 5:10. 2004..Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo 1H MRS study of the SIV/macaque model of neuroAIDS...
- In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDSJane B Greco
Massachusetts General Hospital NMR Center and Neuroradiology Division, Charlestown, Massachusetts, USA
Magn Reson Med 51:1108-14. 2004..Similar events are likely to occur in acutely HIV-infected people, and may explain the neurobehavioral symptoms associated with acute HIV infection...
- Comparisons of brain metabolites observed by HRMAS 1H NMR of intact tissue and solution 1H NMR of tissue extracts in SIV-infected macaquesEva M Ratai
Massachusetts General Hospital NMR Center and Neuroradiology Division, 149 13th St, Charlestown, MA 02129, USA
NMR Biomed 18:242-51. 2005..This is most prominent in the cases of NAA/Cr and Cho/Cr. We conclude that both methods provide substantially the same information for most major brain metabolites, with the exception of the Cho resonance...
- Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brainMargaret R Lentz
NMR Center and Neuroradiology Division, Massachusetts General Hospital, 55 Fruit St, GRB 285, Boston, MA 02114-2696, USA
Radiology 235:461-8. 2005..CONCLUSION: NAA/Cr is a sensitive marker of neuronal injury, not necessarily neuronal loss, and best correlates with synaptophysin, a marker of synaptodendritic dysfunction...
- New insights into the neuroimmunity of SIV infection by magnetic resonance spectroscopyR Gilberto Gonzalez
Harvard Medical School, Boston, MA 02115, USA
J Neuroimmune Pharmacol 1:152-9. 2006..These observations explain the clinical success of antiretroviral therapy in reducing the incidence of HIV-associated dementia and minor cognitive/motor disorder and suggest novel targets for drug development...
- In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brainEva Maria Ratai
Neuroradiology Division, Department of Radiology and A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
BMC Neurosci 10:63. 2009..Metabolic changes in the frontal cortex, basal ganglia and white matter in 18 SIV-infected macaques were investigated using MRS during the first month of infection...
- Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDSEva Maria Ratai
AA Martinos Center for Biomedical Imaging and Neuroradiology Division, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
PLoS ONE 5:e10523. 2010....
- Serial diffusion tensor MRI after transient and permanent cerebral ischemia in nonhuman primatesYutong Liu
Martinos Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129 2060, USA
Stroke 38:138-45. 2007....
- 3D micro-CT imaging of the postmortem brainAlex de Crespigny
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Neurosci Methods 171:207-13. 2008..For simple measurements, such as tumor volume and non-destructive postmortem brain screening, microCT may prove to be a valuable alternative to standard histopathology or microMRI...
- Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillationsGeorge Themelis
Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
J Biomed Opt 12:014033. 2007..Preliminary results show the potential of this NIRS method to measure pCBF and pCBV relative changes in neonatal pigs...
- A nonlinear mesh-warping technique for correcting brain deformation after strokeYutong Liu
Department of Radiology, A.A. Martinos Center, Charlestown, MA 02129-2060, USA
Magn Reson Imaging 24:1069-75. 2006..This technique was able to deliver satisfactory warping results. It is simple and robust and can be utilized in many applications for comparison of multimodality medical images and histological sections...
- Dynamic susceptibility contrast perfusion imaging of cerebral ischemia in nonhuman primates: comparison of Gd-DTPA and NMS60Yutong Liu
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Magn Reson Imaging 22:461-6. 2005..Along with its previously demonstrated advantage for T1-enhanced imaging, the current results show that NMS60 is a viable contrast agent for use in stroke patients...
- CT and conventional and diffusion-weighted MR imaging in acute stroke: study in 691 patients at presentation to the emergency departmentMark E Mullins
Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, GRB285, Boston, MA 02114, USA
Radiology 224:353-60. 2002..After 12 hours, accuracy was equivalent. CONCLUSION: In the diagnosis of stroke in the early period (<12 hours after presentation), DW MR imaging is superior to conventional MR imaging and CT...