Nika Danial

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Bad-deficient mice develop diffuse large B cell lymphoma
    Ann M Ranger
    Howard Hughes Medical Institute and Department of Pathology, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:9324-9. 2003
  2. ncbi Homeostatic functions of BCL-2 proteins beyond apoptosis
    Nika N Danial
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Adv Exp Med Biol 687:1-32. 2010
  3. ncbi BAD: undertaker by night, candyman by day
    N N Danial
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 27:S53-70. 2008
  4. ncbi Dual role of proapoptotic BAD in insulin secretion and beta cell survival
    Nika N Danial
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Med 14:144-53. 2008
  5. ncbi BCL-2 family proteins: critical checkpoints of apoptotic cell death
    Nika N Danial
    Department of Pathology, Harvard Medical School and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 13:7254-63. 2007
  6. ncbi Targeting the cell death-survival equation
    Edward J Benz
    Dana-Farber Cancer Institute, Harvard University, Boston, MA 02115, USA
    Clin Cancer Res 13:7250-3. 2007
  7. ncbi Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
    Anna C Schinzel
    Howard Hughes Medical Institute and Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:12005-10. 2005
  8. ncbi BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
    Nika N Danial
    Howard Hughes Medical Institute, Dana Faber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:952-6. 2003
  9. ncbi beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
    Jakob D Wikstrom
    Tufts University, Department of Pharmacology and Experimental Therapeutics, 136 Harrison Ave, Boston, MA 02111, USA
    Diabetes 56:2569-78. 2007
  10. ncbi Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration
    Maria Simarro
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
    Biochem Biophys Res Commun 401:440-6. 2010

Research Grants

  1. The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival
    Nika N Danial; Fiscal Year: 2010
  2. Dissecting the Death Pathway in the Islet beta-cell
    Nika Danial; Fiscal Year: 2005
  3. BAD Intergrates Glycolysis and Apoptosis
    Nika Danial; Fiscal Year: 2007
  4. The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival
    Nika Danial; Fiscal Year: 2009

Collaborators

Detail Information

Publications15

  1. ncbi Bad-deficient mice develop diffuse large B cell lymphoma
    Ann M Ranger
    Howard Hughes Medical Institute and Department of Pathology, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:9324-9. 2003
    ..Exposure of Bad-null mice to sublethal gamma-irradiation resulted in an increased incidence of pre-T cell and pro-/pre-B cell lymphoblastic leukemia/lymphoma. Thus, proapoptotic BAD suppresses tumorigenesis in the lymphocyte lineage...
  2. ncbi Homeostatic functions of BCL-2 proteins beyond apoptosis
    Nika N Danial
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Adv Exp Med Biol 687:1-32. 2010
    ....
  3. ncbi BAD: undertaker by night, candyman by day
    N N Danial
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 27:S53-70. 2008
    ..By executing its 'day' and 'night' jobs in metabolism and apoptosis, respectively, BAD helps coordinate mitochondrial fuel metabolism and the apoptotic machinery...
  4. ncbi Dual role of proapoptotic BAD in insulin secretion and beta cell survival
    Nika N Danial
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Med 14:144-53. 2008
    ..Furthermore, we show that BAD regulates the physiologic adaptation of beta cell mass during high-fat feeding. Our findings provide genetic proof of the bifunctional activities of BAD in both beta cell survival and insulin secretion...
  5. ncbi BCL-2 family proteins: critical checkpoints of apoptotic cell death
    Nika N Danial
    Department of Pathology, Harvard Medical School and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 13:7254-63. 2007
    ....
  6. ncbi Targeting the cell death-survival equation
    Edward J Benz
    Dana-Farber Cancer Institute, Harvard University, Boston, MA 02115, USA
    Clin Cancer Res 13:7250-3. 2007
  7. ncbi Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
    Anna C Schinzel
    Howard Hughes Medical Institute and Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:12005-10. 2005
    ....
  8. ncbi BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
    Nika N Danial
    Howard Hughes Medical Institute, Dana Faber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:952-6. 2003
    ..This combination of proteomics, genetics and physiology indicates an unanticipated role for BAD in integrating pathways of glucose metabolism and apoptosis...
  9. ncbi beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
    Jakob D Wikstrom
    Tufts University, Department of Pharmacology and Experimental Therapeutics, 136 Harrison Ave, Boston, MA 02111, USA
    Diabetes 56:2569-78. 2007
    ..This study offers insight into the different metabolic states of beta-cell mitochondria...
  10. ncbi Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration
    Maria Simarro
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
    Biochem Biophys Res Commun 401:440-6. 2010
    ..Our results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration...
  11. ncbi Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death
    Soumya Sinha Roy
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 33:377-88. 2009
    ..Thus, phospho-regulatory mechanisms converge on Bad to switch between the survival and apoptotic functions of mitochondrial calcium signaling by activating a mechanism whereby a BH3-only protein bypasses Bax/Bak and engages the PTP...
  12. ncbi Cell death: critical control points
    Nika N Danial
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 116:205-19. 2004
    ..The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics...
  13. ncbi Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death
    Joslyn K Brunelle
    Department of Medicine, Northwestern University Medical School, 240 East Huron Avenue, Chicago, IL 60611, USA
    Mol Cell Biol 27:1222-35. 2007
    ..Collectively, these results demonstrate that anoxia-induced cell death requires the loss of Mcl-1 protein and inhibition of the electron transport chain to negate Bcl-X(L)/Bcl-2 proteins...
  14. ncbi OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
    Christian Frezza
    Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy
    Cell 126:177-89. 2006
    ..The proapoptotic BCL-2 family member BID, which widens cristae junctions, also disrupts OPA1 oligomers. Thus, OPA1 has genetically and molecularly distinct functions in mitochondrial fusion and in cristae remodeling during apoptosis...
  15. ncbi Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas
    Kalindi D Hettiarachchi
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Exp Toxicol Pathol 60:295-306. 2008
    ....

Research Grants7

  1. The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival
    Nika N Danial; Fiscal Year: 2010
    ..The studies described in this proposal may lead to identification of a new therapeutic target in diabetes. ..
  2. Dissecting the Death Pathway in the Islet beta-cell
    Nika Danial; Fiscal Year: 2005
    ..abstract_text> ..
  3. BAD Intergrates Glycolysis and Apoptosis
    Nika Danial; Fiscal Year: 2007
    ..Danial's development as an independent investigator. Dr. Korsmeyer, a world leader in the fields of oncogenesis and apoptosis, has an excellent record of training and fostering independent investigators. ..
  4. The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival
    Nika Danial; Fiscal Year: 2009
    ..The studies described in this proposal may lead to identification of a new therapeutic target in diabetes. ..