ALAN D D'ANDREA

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Targeting DNA repair pathways in AML
    ALAN D D'ANDREA
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Best Pract Res Clin Haematol 23:469-73. 2010
  2. pmc Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin
    Céline Jacquemont
    Howard Hughes Medical Institute, Chevy Chase, MD, USA
    Mol Cancer 11:26. 2012
  3. pmc BRCA1: a missing link in the Fanconi anemia/BRCA pathway
    ALAN D D'ANDREA
    Departments of Radiation Oncology and Pediatrics, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Discov 3:376-8. 2013
  4. pmc CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors
    Clark C Chen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cancer 8:24. 2009
  5. ncbi request reprint The Fanconi Anemia/BRCA signaling pathway: disruption in cisplatin-sensitive ovarian cancers
    ALAN D D'ANDREA
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell Cycle 2:290-2. 2003
  6. ncbi request reprint The Fanconi anaemia/BRCA pathway
    ALAN D D'ANDREA
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Rev Cancer 3:23-34. 2003
  7. pmc Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance
    Gary P H Ho
    Dana Farber Cancer Institute, Department of Radiation Oncology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 26:7005-15. 2006
  8. ncbi request reprint Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin
    Rocio Montes De Oca
    Dana Farber Cancer Institute, Department of Radiation Oncology, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    Blood 105:1003-9. 2005
  9. ncbi request reprint Regulation of monoubiquitinated PCNA by DUB autocleavage
    Tony T Huang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 8:339-47. 2006
  10. ncbi request reprint The interplay of Fanconi anemia proteins in the DNA damage response
    XiaoZhe Wang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    DNA Repair (Amst) 3:1063-9. 2004

Research Grants

  1. Hematopoiesis by Ubiquitination and Deubiquitination
    ALAN D ANDREA; Fiscal Year: 2005
  2. Abnormalities/Signal Transduction/Hematopoietic Disease
    ALAN D ANDREA; Fiscal Year: 2006
  3. MOLECULAR PATHOGENESIS OF FANCONI ANEMIA
    ALAN D ANDREA; Fiscal Year: 2003
  4. Core--Pilot grant program
    ALAN D ANDREA; Fiscal Year: 2005
  5. Regulation of the Fanconi Anemia Pathway by Ubiquitination
    ALAN D ANDREA; Fiscal Year: 2007
  6. MOLECULAR PATHOGENESIS OF FANCONI ANEMIA
    ALAN D ANDREA; Fiscal Year: 2007
  7. STRUCTURE AND FUNCTION OF THE ERYTHROPOIETIN RECEPTOR
    ALAN D ANDREA; Fiscal Year: 1993
  8. HEMATOPOIETIC CELL GROWTH AND DEUBIQUITINATING ENZYMES
    ALAN D ANDREA; Fiscal Year: 2000
  9. Regulation of the Fanconi Anemia Pathway by Ubiquitination
    ALAN DAVID D apos ANDREA; Fiscal Year: 2010

Collaborators

Detail Information

Publications69

  1. doi request reprint Targeting DNA repair pathways in AML
    ALAN D D'ANDREA
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Best Pract Res Clin Haematol 23:469-73. 2010
    ..Biomarkers in the Fanconi anemia repair pathway may provide a predictor to identify this subset of patients who are sensitive to this new class of drugs...
  2. pmc Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin
    Céline Jacquemont
    Howard Hughes Medical Institute, Chevy Chase, MD, USA
    Mol Cancer 11:26. 2012
    ....
  3. pmc BRCA1: a missing link in the Fanconi anemia/BRCA pathway
    ALAN D D'ANDREA
    Departments of Radiation Oncology and Pediatrics, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Discov 3:376-8. 2013
    ..Interestingly, the woman had validated germline mutations in both BRCA1 alleles. These findings further implicate BRCA1 in the Fanconi anemia/BRCA pathway and have important implications for BRCA1 genetic testing...
  4. pmc CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors
    Clark C Chen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cancer 8:24. 2009
    ..These observations suggest that DNA repair deficient tumors should exhibit increased sensitivity to CHK1 inhibition. Here we offer experimental evidence in support of this hypothesis...
  5. ncbi request reprint The Fanconi Anemia/BRCA signaling pathway: disruption in cisplatin-sensitive ovarian cancers
    ALAN D D'ANDREA
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell Cycle 2:290-2. 2003
    ..The serial inactivation and reactivation of the FA/BRCA pathway has important implications for the diagnosis and treatment of ovarian cancers and related cancers...
  6. ncbi request reprint The Fanconi anaemia/BRCA pathway
    ALAN D D'ANDREA
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Rev Cancer 3:23-34. 2003
    ..Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability--a common feature of many human cancers...
  7. pmc Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance
    Gary P H Ho
    Dana Farber Cancer Institute, Department of Radiation Oncology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 26:7005-15. 2006
    ..These findings further support the functional connection of ATM/ATR kinases and FANCD2 in the DNA damage response and support a role for the FA pathway in the coordination of the S phase of the cell cycle...
  8. ncbi request reprint Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin
    Rocio Montes De Oca
    Dana Farber Cancer Institute, Department of Radiation Oncology, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    Blood 105:1003-9. 2005
    ..We hypothesize that the carboxy terminus of FANCD2-44 plays a critical role in sensing or repairing DNA damage...
  9. ncbi request reprint Regulation of monoubiquitinated PCNA by DUB autocleavage
    Tony T Huang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 8:339-47. 2006
    ..Our results define a regulatory mechanism for protein ubiquitination that involves the signal-induced degradation of an inhibitory DUB...
  10. ncbi request reprint The interplay of Fanconi anemia proteins in the DNA damage response
    XiaoZhe Wang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    DNA Repair (Amst) 3:1063-9. 2004
    ..e., ATM, ATR, and NBS1). Also, somatic (acquired) disruption of the FA pathway in human tumors appears to account for their chromosome instability and crosslinker hypersensitivity...
  11. pmc UAF1 is a subunit of multiple deubiquitinating enzyme complexes
    Martin A Cohn
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:5343-51. 2009
    ..We postulate that additional WD40-containing proteins may also form complexes with other human deubiquitinating enzymes and thereby regulate their activity and substrate specificity...
  12. pmc WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex
    Younghoon Kee
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 285:11252-7. 2010
    ..We provide a model in which WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP complexes...
  13. pmc Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24
    Jung Min Kim
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 111:5215-22. 2008
    ..Dysregulated loading of the FA core complex accounts, at least in part, for the characteristic cellular and developmental abnormalities in FA...
  14. pmc DNA polymerase POLN participates in cross-link repair and homologous recombination
    George Lucian Moldovan
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02215, USA
    Mol Cell Biol 30:1088-96. 2010
    ..Our data indicate that this novel polymerase-helicase complex participates in homologous recombination repair and is essential for cellular protection against DNA cross-links...
  15. pmc Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated
    Richard D Kennedy
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Clin Invest 117:1440-9. 2007
    ..Pharmaceutical inhibition of ATM may have a role in the treatment of FA pathway-deficient human cancers...
  16. ncbi request reprint Interaction of FANCD2 and NBS1 in the DNA damage response
    Koji Nakanishi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Nat Cell Biol 4:913-20. 2002
    ..NBS1 and FANCD2 therefore cooperate in two distinct cellular functions, one involved in the DNA crosslink response and one involved in the S-phase checkpoint response...
  17. pmc Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype
    Jung Min Kim
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 16:314-20. 2009
    ..Our results indicate that mouse Usp1 functions downstream in the FA pathway. Deubiquitination is a critical event required for Fancd2 nuclear foci assembly, release from chromatin, and function in DNA repair...
  18. doi request reprint FANCD2 activates transcription of TAp63 and suppresses tumorigenesis
    Eunmi Park
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell 50:908-18. 2013
    ..Taken together, Usp1 inhibition may be a useful strategy for upregulating TAp63 and preventing or treating squamous cell cancers in the general non-FA population. ..
  19. ncbi request reprint Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex
    Przemyslaw Kowal
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:2047-55. 2007
    ..FANCF mutants bearing amino acid substitutions in this C-terminal surface fail to interact with other components of the FA complex, indicating that this surface is critical for the proper assembly of the FA core complex...
  20. pmc Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway
    XiaoZhe Wang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 27:3098-108. 2007
    ..Chk1-mediated phosphorylation of FANCE is required for a function independent of FANCD2 monoubiquitination...
  21. ncbi request reprint S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51
    Toshiyasu Taniguchi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 100:2414-20. 2002
    ....
  22. pmc RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger
    Kailin Yang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:19085-91. 2010
    ..Taken together, our results identify a novel RAD18-PCNA(Ub)-SNM1A pathway required for nuclear focus formation and ICL resistance...
  23. doi request reprint Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway
    Min Huang
    Department of Radiation Oncology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, United States
    DNA Repair (Amst) 10:1203-12. 2011
    ..Further, MSH2 was co-purified and co-immunoprecipitated with FA core complex components. Taken together, our results suggest that human MutS homologs and FANCM complexes function as redundant DNA damage sensors of the FA pathway...
  24. ncbi request reprint Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors
    Toshiyasu Taniguchi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Guy s King s and St Thomas School of Medicine, London, UK
    Nat Med 9:568-74. 2003
    ..We propose a model for ovarian tumor progression in which the initial methylation of FANCF is followed by FANCF demethylation and ultimately results in cisplatin resistance...
  25. ncbi request reprint The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly
    Allan M Gurtan
    Biological and Biomedical Sciences Program, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:10896-905. 2006
    ..We propose a model in which FANCL, via its WD40 region, binds the FA complex and, via its PHD, recruits an as-yet-unidentified E2 for mono-ubiquitination of FANCD2...
  26. pmc Regulation of the Fanconi anemia pathway by a SUMO-like delivery network
    Kailin Yang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 25:1847-58. 2011
    ..We propose that the regulated targeting of USP1/UAF1 to its DNA repair substrates, FANCD2-Ub and PCNA-Ub, by SLD-SIM interactions coordinates homologous recombination and translesion DNA synthesis...
  27. pmc Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage
    Neil Johnson
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 35:327-39. 2009
    ..Cdk1 inhibition may therefore selectively sensitize BRCA1-proficient cancer cells to DNA-damaging treatments by disrupting BRCA1 function...
  28. pmc Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin
    XiaoZhe Wang
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 24:5850-62. 2004
    ..These complexes appear to be required for normal homology-directed DNA repair...
  29. ncbi request reprint The Fanconi Anemia/BRCA pathway: new faces in the crowd
    Richard D Kennedy
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2925-40. 2005
    ....
  30. pmc Inhibition of homologous recombination by the PCNA-interacting protein PARI
    George Lucian Moldovan
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell 45:75-86. 2012
    ..Thus, we propose that PARI is a long sought-after factor that suppresses inappropriate recombination events at mammalian replication forks...
  31. pmc ATR couples FANCD2 monoubiquitination to the DNA-damage response
    Paul R Andreassen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:1958-63. 2004
    ....
  32. pmc Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
    Neil Johnson
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:875-82. 2011
    ..Because reduced Cdk1 activity impaired BRCA1 function and consequently, repair by homologous recombination, inhibition of Cdk1 represents a plausible strategy for expanding the utility of PARP inhibitors to BRCA-proficient cancers...
  33. pmc Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis
    Younghoon Kee
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 23:555-60. 2009
    ..Nondegradable mutant forms of FANCM retain the FA core complex in the chromatin and disrupt the FA pathway. Our data provide a novel mechanism for the cell cycle-dependent regulation of the FA pathway...
  34. pmc The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response
    Min Huang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 39:259-68. 2010
    ..Therefore, we propose that FANCM/FAAP24 plays a role in ICL-induced checkpoint activation through regulating RPA recruiment at ICL-stalled replication forks...
  35. ncbi request reprint DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes
    Richard D Kennedy
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 24:3799-808. 2006
    ....
  36. ncbi request reprint Dedicated to the core: understanding the Fanconi anemia complex
    Allan M Gurtan
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    DNA Repair (Amst) 5:1119-25. 2006
    ..A general model has emerged for the FA pathway as an arm of the DNA-damage response following ICLs. This review will summarize the current understanding of the FA core complex and propose a model for its activity...
  37. pmc PARI overexpression promotes genomic instability and pancreatic tumorigenesis
    Kevin W O'Connor
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Cancer Res 73:2529-39. 2013
    ..Taken together, our findings offered a preclinical proof-of-concept for PARI as candidate therapeutic target to treat PDAC...
  38. pmc Regulation of Rev1 by the Fanconi anemia core complex
    Hyungjin Kim
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Struct Mol Biol 19:164-70. 2012
    ..We propose that the Fanconi anemia core complex regulates cross-link repair by channeling lesions to damage bypass pathways and preventing large DNA insertions and deletions...
  39. ncbi request reprint A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway
    Martin A Cohn
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 28:786-97. 2007
    ..Taken together, our results describe a mechanism of regulation of the deubiquitinating enzyme, USP1, and of DNA repair...
  40. ncbi request reprint Regulation of the Fanconi anemia pathway by monoubiquitination
    Richard C Gregory
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Mayer 640, 44 Binney Street, Boston, MA 02115, USA
    Semin Cancer Biol 13:77-82. 2003
    ..Here, we review the recent studies describing the regulated monoubiquitination of the FANCD2 protein and discuss the interaction of the FA pathway with other DNA damage response pathways...
  41. ncbi request reprint The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC
    Toshiyasu Taniguchi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, and the Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 100:2457-62. 2002
    ..Our data indicate that FANCE is a component of the nuclear FA complex in vivo and is required for the monoubiquitination of FANCD2 and the downstream events in the FA pathway...
  42. ncbi request reprint A novel diagnostic screen for defects in the Fanconi anemia pathway
    Akiko Shimamura
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 100:4649-54. 2002
    ..A combination of retroviral gene transfer and FANCD2 immunoblotting provides a rapid subtyping assay for patients newly diagnosed with FA. These new FA screening assays would allow efficient testing of broad populations at risk...
  43. ncbi request reprint The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair
    Kanchan D Mirchandani
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Exp Cell Res 312:2647-53. 2006
    ..This article will review evidence implicating FA proteins in multiple aspects of DNA cross-link repair and propose a model to explain the selectivity of the FA pathway toward DNA cross-linking agents...
  44. ncbi request reprint Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway
    Deborah Chirnomas
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cancer Ther 5:952-61. 2006
    ..We believe that this study shows an efficient, high-throughput method for identifying new compounds that may sensitize cancer cells to DNA-damaging chemotherapy...
  45. pmc Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells
    Patrizia Vinciguerra
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3834-42. 2010
    ..Based on these observations, we suggest that cytokinesis failure followed by apoptosis may contribute to bone marrow failure in patients with FA...
  46. pmc Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007
    ..Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I...
  47. pmc The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly
    Kanchan D Mirchandani
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    DNA Repair (Amst) 7:902-11. 2008
    ..Our results suggest a role for the FA core complex in regulating Rev1-dependent DNA damage tolerance independently of FANCD2, FANCI, and PCNA monoubiquitination...
  48. ncbi request reprint Regulation of DNA repair by ubiquitylation
    Tony T Huang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 7:323-34. 2006
    ..These pathways involve the monoubiquitylation of key DNA-repair proteins that have regulatory functions in homologous recombination and translesion DNA synthesis, and involve the polyubiquitylation of nucleotide-excision-repair proteins...
  49. pmc FANCM: A landing pad for the Fanconi Anemia and Bloom's Syndrome complexes
    Patrizia Vinciguerra
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 36:916-7. 2009
    ....
  50. ncbi request reprint Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis
    Ting Xi Liu
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 5:903-14. 2003
    ....
  51. pmc Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways
    Martin A Cohn
    Department of Radiation Oncology, Division of Genomic Stability and DNA Repair, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 32:306-12. 2008
    ..Interestingly, these two pathways share several features, suggesting a more general mechanism for DNA-repair regulation...
  52. pmc Expanded roles of the Fanconi anemia pathway in preserving genomic stability
    Younghoon Kee
    Department of Radiation Oncology and Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 24:1680-94. 2010
    ..We also focus on the role of the FA pathway as a potential regulator of DNA repair choices in response to double-strand breaks, and its novel functions during the mitotic phase of the cell cycle...
  53. ncbi request reprint Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways
    Toshiyasu Taniguchi
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 109:459-72. 2002
    ..Biallelic disruption of FANCD2 results in both MMC and IR hypersensitivity...
  54. ncbi request reprint Direct DNA binding activity of the Fanconi anemia D2 protein
    Woo Hyun Park
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:23593-8. 2005
    ..This finding of DNA binding is the first biochemical activity identified for this key protein in the Fanconi anemia pathway...
  55. pmc The USP1/UAF1 complex promotes double-strand break repair through homologous recombination
    Junko Murai
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 31:2462-9. 2011
    ..Disruption of NHEJ in UAF1-deficient cells restored cellular resistance to camptothecin and the PARP inhibitor. Our results indicate that the USP1/UAF1 complex promotes HR, at least in part by suppressing NHEJ...
  56. pmc Chromatin remodeling at DNA double-strand breaks
    Brendan D Price
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cell 152:1344-54. 2013
    ....
  57. pmc Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
    Hyungjin Kim
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genes Dev 26:1393-408. 2012
    ..Here, we review recent advances in our understanding of the downstream ICL repair steps initiated by ubiquitin-mediated FA pathway activation...
  58. doi request reprint Transcriptional Repressor ZBTB1 Promotes Chromatin Remodeling and Translesion DNA Synthesis
    Hyungjin Kim
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Mol Cell 54:107-18. 2014
    ..We propose that ZBTB1 is required for localizing phospho-KAP-1 to chromatin and enhancing RAD18 accessibility. Collectively, our study implicates a ubiquitin-binding protein in orchestrating chromatin remodeling during DNA repair. ..
  59. doi request reprint Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells
    Helena Mistry
    Corresponding Authors Kalindi Parmar, Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215
    Mol Cancer Ther 12:2651-62. 2013
    ..The identification of USP1 inhibitors therefore opens up a new approach for leukemia therapy...
  60. pmc Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer
    Kyle R Cron
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 8:e73710. 2013
    ..Proteasome inhibition is a promising strategy for NSCLC radiosensitization via inhibition of NF-κB-mediated expression of Fanconi Anemia/HR DNA repair genes. ..
  61. pmc A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy
    Josephine Kang
    Harvard Radiation Oncology Program, Boston, MA, USA
    J Natl Cancer Inst 104:670-81. 2012
    ..We hypothesized that a molecular score based on expression of genes that are involved in platinum-induced DNA damage repair could provide such prognostic information...
  62. pmc Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity
    Marina K Ayrapetov
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institutes, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e26064. 2011
    ..Activation of Hif1α through prolylhydroxylase inhibition therefore identifies a new pathway for the development of novel radiation protectors...
  63. doi request reprint DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer
    Brian M Alexander
    Dana Farber Brigham and Women s Cancer Center Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 16:5796-804. 2010
    ....
  64. ncbi request reprint Biallelic inactivation of BRCA2 in Fanconi anemia
    Niall G Howlett
    Department of Pediatric Oncology, Children s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 297:606-9. 2002
    ..Our results link the six cloned FA genes with BRCA1 and BRCA2 in a common pathway. Germ-line mutation of genes in this pathway may result in cancer risks similar to those observed in families with BRCA1 or BRCA2 mutations...
  65. pmc How the fanconi anemia pathway guards the genome
    George Lucian Moldovan
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Annu Rev Genet 43:223-49. 2009
    ....
  66. doi request reprint Stressed out: endogenous aldehydes damage hematopoietic stem cells
    Kalindi Parmar
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA
    Cell Stem Cell 11:583-4. 2012
    ..Recently in Nature, Garaycoechea et al. (2012), identify aldehyde-mediated genotoxicity of hematopoietic stem cells as a cause for bone marrow failure...
  67. pmc To the rescue: the Fanconi anemia genome stability pathway salvages replication forks
    George Lucian Moldovan
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA
    Cancer Cell 22:5-6. 2012
    ..In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation...
  68. pmc FANCD2 hurdles the DNA interstrand crosslink
    George Lucian Moldovan
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cell 139:1222-4. 2009
    ..In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process...
  69. ncbi request reprint DNA damage discrimination at stalled replication forks by the Rad5 homologs HLTF and SHPRH
    George Lucian Moldovan
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02215, USA
    Mol Cell 42:141-3. 2011
    ..The results have important implications for the suppression of damage-specific mutagenesis and for the maintenance of genomic stability...

Research Grants34

  1. Hematopoiesis by Ubiquitination and Deubiquitination
    ALAN D ANDREA; Fiscal Year: 2005
    ..In the course of these experiments, we hope to determine novel protein regulators of in vivo hematopoietic stem cell growth and differentiation. ..
  2. Abnormalities/Signal Transduction/Hematopoietic Disease
    ALAN D ANDREA; Fiscal Year: 2006
    ..abstract_text> ..
  3. MOLECULAR PATHOGENESIS OF FANCONI ANEMIA
    ALAN D ANDREA; Fiscal Year: 2003
    ..For this specific aim, we will also test the nuclear FA protein complex for direct in vitro DNA binding activity or DNA repair activity, using model DNA templates. ..
  4. Core--Pilot grant program
    ALAN D ANDREA; Fiscal Year: 2005
    ..Resulting in new and immediately applicable medical and therapeutic response to radiation exposure. ..
  5. Regulation of the Fanconi Anemia Pathway by Ubiquitination
    ALAN D ANDREA; Fiscal Year: 2007
    ..Overall, we believe these studies will elucidate the cellular regulatory mechanisms which control the monoubiquitination state of key biological modulators, such as FANCD2. ..
  6. MOLECULAR PATHOGENESIS OF FANCONI ANEMIA
    ALAN D ANDREA; Fiscal Year: 2007
    ....
  7. STRUCTURE AND FUNCTION OF THE ERYTHROPOIETIN RECEPTOR
    ALAN D ANDREA; Fiscal Year: 1993
    ..Other subunits of the EPO-R will be identified by crosslinking and coimmunoprecipitation, and various cloning strategies will be used to isolate the cDNAs encoding these other subunits...
  8. HEMATOPOIETIC CELL GROWTH AND DEUBIQUITINATING ENZYMES
    ALAN D ANDREA; Fiscal Year: 2000
    ..Finally, in Specific Aim #4, we will compare the enhancers of the DUB-I and DUB-2 gene for DNA sequences and binding proteins that determine the basis of cytokine-specific gene induction. ..
  9. Regulation of the Fanconi Anemia Pathway by Ubiquitination
    ALAN DAVID D apos ANDREA; Fiscal Year: 2010
    ..Overall, we believe these studies will elucidate the cellular regulatory mechanisms which control the monoubiquitination state of key biological modulators, such as FANCD2. ..