Charles A Czeisler

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Modafinil for excessive sleepiness associated with shift-work sleep disorder
    Charles A Czeisler
    Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 353:476-86. 2005
  2. pmc Deterioration of neurobehavioral performance in resident physicians during repeated exposure to extended duration work shifts
    Clare Anderson
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Sleep 35:1137-46. 2012
  3. pmc Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study
    Charles A Czeisler
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mayo Clin Proc 84:958-72. 2009
  4. ncbi request reprint Effects of health care provider work hours and sleep deprivation on safety and performance
    Steven W Lockley
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Jt Comm J Qual Patient Saf 33:7-18. 2007
  5. pmc Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans
    Derk Jan Dijk
    Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e30037. 2012
  6. pmc Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment
    Scott Grady
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychopharmacology 35:1910-20. 2010
  7. ncbi request reprint Effect of reducing interns' work hours on serious medical errors in intensive care units
    Christopher P Landrigan
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1838-48. 2004
  8. pmc Uncovering residual effects of chronic sleep loss on human performance
    Daniel A Cohen
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sci Transl Med 2:14ra3. 2010
  9. ncbi request reprint Effective implementation of work-hour limits and systemic improvements
    Christopher P Landrigan
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Jt Comm J Qual Patient Saf 33:19-29. 2007
  10. pmc Improved neurobehavioral performance during the wake maintenance zone
    Julia A Shekleton
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Sleep Med 9:353-62. 2013

Detail Information

Publications76

  1. ncbi request reprint Modafinil for excessive sleepiness associated with shift-work sleep disorder
    Charles A Czeisler
    Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 353:476-86. 2005
    ..Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder...
  2. pmc Deterioration of neurobehavioral performance in resident physicians during repeated exposure to extended duration work shifts
    Clare Anderson
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Sleep 35:1137-46. 2012
    ..In this study, the authors quantify the time course of neurobehavioral deterioration due to repeated exposure to EDWS during a 3-week residency rotation...
  3. pmc Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study
    Charles A Czeisler
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mayo Clin Proc 84:958-72. 2009
    ....
  4. ncbi request reprint Effects of health care provider work hours and sleep deprivation on safety and performance
    Steven W Lockley
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Jt Comm J Qual Patient Saf 33:7-18. 2007
    ..They also report making 300% more fatigue-related medical errors that lead to a patient's death...
  5. pmc Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans
    Derk Jan Dijk
    Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e30037. 2012
    ..The extent to which the phase and amplitude of multiple rhythms are similarly affected during altered timing of light exposure and the sleep-wake cycle has not been fully characterized...
  6. pmc Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment
    Scott Grady
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychopharmacology 35:1910-20. 2010
    ..These features suggest that modafinil might be a particularly relevant countermeasure against the deleterious effects of prolonged work hours, shift work, and transmeridian travel...
  7. ncbi request reprint Effect of reducing interns' work hours on serious medical errors in intensive care units
    Christopher P Landrigan
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1838-48. 2004
    ..Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors...
  8. pmc Uncovering residual effects of chronic sleep loss on human performance
    Daniel A Cohen
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sci Transl Med 2:14ra3. 2010
    ..Thus, extended wake during the circadian night reveals the cumulative detrimental effects of chronic sleep loss on performance, with potential adverse health and safety consequences...
  9. ncbi request reprint Effective implementation of work-hour limits and systemic improvements
    Christopher P Landrigan
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Jt Comm J Qual Patient Saf 33:19-29. 2007
    ..Sleep deprivation, ubiquitous among nurses and physicians, recently has been shown to greatly increase rates of serious medical errors and occupational injuries among health care workers in the United States...
  10. pmc Improved neurobehavioral performance during the wake maintenance zone
    Julia A Shekleton
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Sleep Med 9:353-62. 2013
    ..The study examined the influence of the WMZ on neurobehavioral performance under normal conditions and following sleep deprivation...
  11. pmc Impact of extended-duration shifts on medical errors, adverse events, and attentional failures
    Laura K Barger
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Med 3:e487. 2006
    ..Our current study assessed whether extended-duration shifts worked by interns are associated with significant medical errors, adverse events, and attentional failures in a diverse population of interns across the United States...
  12. ncbi request reprint Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness
    James K Wyatt
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Sleep 27:374-81. 2004
    ....
  13. pmc Sex difference in the near-24-hour intrinsic period of the human circadian timing system
    Jeanne F Duffy
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:15602-8. 2011
    ..0 h (35% vs. 14%; P < 0.01). The shorter average intrinsic circadian period observed in women may have implications for understanding sex differences in habitual sleep duration and insomnia prevalence...
  14. pmc Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history
    Anne Marie Chang
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sleep 36:1239-46. 2013
    ..Here, we compared the effects of illuminance history on the alerting response to a subsequent light stimulus...
  15. ncbi request reprint Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent
    James K Wyatt
    Division of Sleep Medicine, Department of Medicine, Brigham and Women a Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Sleep 29:609-18. 2006
    ..To investigate the effects of a physiologic and a pharmacologic dose of exogenous melatonin on sleep latency and sleep efficiency in sleep episodes initiated across a full range of circadian phases...
  16. pmc Plasticity of the intrinsic period of the human circadian timing system
    Frank A J L Scheer
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e721. 2007
    ..Both findings have important implications for the treatment of circadian rhythm sleep disorders and human space exploration...
  17. ncbi request reprint The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care
    Jeffrey M Rothschild
    Divisions of General Internal Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 33:1694-700. 2005
    ..We sought to study the incidence and nature of adverse events and serious errors in the critical care setting...
  18. ncbi request reprint Scheduling of sleep/darkness affects the circadian phase of night shift workers
    Nayantara Santhi
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, BL 438M, Boston, MA 02115, USA
    Neurosci Lett 384:316-20. 2005
    ..These results have applications to night shift workers, particularly in occupations in which alterations in the timing of light exposure cannot be achieved during working hours...
  19. pmc Sex differences in phase angle of entrainment and melatonin amplitude in humans
    Sean W Cain
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115 5817, USA
    J Biol Rhythms 25:288-96. 2010
    ....
  20. ncbi request reprint Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans
    Steven W Lockley
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sleep 29:161-8. 2006
    ..To assess the wavelength-dependent sensitivity of the acute effects of ocular light exposure on alertness, performance, waking electroencephalogram (EEG), and cortisol...
  21. pmc Human responses to bright light of different durations
    Anne Marie Chang
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 221 Longwood Avenue, Suite 438, Boston, MA 02115, USA
    J Physiol 590:3103-12. 2012
    ..These results provide strong evidence for a non-linear resetting response of the human circadian pacemaker to light duration...
  22. pmc Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 34:309-18. 2013
    ..Interventions to improve age-related sleep complaints should thus target this change in awakenings...
  23. pmc Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans
    Joshua J Gooley
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 96:E463-72. 2011
    ..Millions of individuals habitually expose themselves to room light in the hours before bedtime, yet the effects of this behavior on melatonin signaling are not well recognized...
  24. ncbi request reprint Extended work duration and the risk of self-reported percutaneous injuries in interns
    Najib T Ayas
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:1055-62. 2006
    ..Extended-duration work shifts are associated with increased risks of automobile crash, particularly during a commute from work. Interns may be at risk for other occupation-related injuries...
  25. ncbi request reprint Sleep and wakefulness out of phase with internal biological time impairs learning in humans
    Kenneth P Wright
    Harvard Medical School, USA
    J Cogn Neurosci 18:508-21. 2006
    ..In addition, our results demonstrate that exposure to dim light (approximately 25 lx) is sufficient to expand the range of entrainment in humans...
  26. pmc The impact of sleep timing and bright light exposure on attentional impairment during night work
    Nayantara Santhi
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Biol Rhythms 23:341-52. 2008
    ..These results have important implications for managing patients with shift work disorder...
  27. ncbi request reprint Extended work shifts and the risk of motor vehicle crashes among interns
    Laura K Barger
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 352:125-34. 2005
    ..Long work hours and work shifts of an extended duration (> or =24 hours) remain a hallmark of medical education in the United States. Yet their effect on health and safety has not been evaluated with the use of validated measures...
  28. pmc Human phase response curve to a single 6.5 h pulse of short-wavelength light
    Melanie Rüger
    Circadian Physiology Program, Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Physiol 591:353-63. 2013
    ..The 480 nm PRC induced ∼75% of the response of the 10,000 lux white light PRC. These results may contribute to a re-evaluation of dosing guidelines for clinical light therapy and the use of light as a fatigue countermeasure...
  29. ncbi request reprint When policy meets physiology: the challenge of reducing resident work hours
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Orthop Relat Res 449:116-27. 2006
    ..An evidence-based approach is needed to minimize the well-documented risk that current work hour practices confer on resident health and patient safety while optimizing education and continuity of care...
  30. ncbi request reprint Exercise distributed across day and night does not alter circadian period in humans
    Sean W Cain
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 22:534-41. 2007
    ..Exercise distributed across biological day and night does not appear to affect circadian period...
  31. ncbi request reprint Recovery from medical errors: the critical care nursing safety net
    Jeffrey M Rothschild
    Harvard Medical School, Boston, USA
    Jt Comm J Qual Patient Saf 32:63-72. 2006
    ..Patient surveillance and preventing errors from harming patients represent essential nursing responsibilities but have received relatively little study...
  32. pmc Human phase response curve to a 1 h pulse of bright white light
    Melissa A St Hilaire
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Physiol 590:3035-45. 2012
    ..7 h PRC despite representing only 15% of the light exposure duration, consistent with previous studies showing a non-linear duration–response function for the effects of light on circadian resetting...
  33. pmc Does simulator-based clinical performance correlate with actual hospital behavior? The effect of extended work hours on patient care provided by medical interns
    James A Gordon
    Gilbert Program in Medical Simulation, Harvard Medical School, Boston, Massachusetts, USA
    Acad Med 85:1583-8. 2010
    ..This study explored whether the effects of extended work hours on clinical performance, as reported in prior hospital-based studies, could be observed in a simulator-based testing environment...
  34. doi request reprint Sleep disorders, health, and safety in police officers
    Shantha M W Rajaratnam
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    JAMA 306:2567-78. 2011
    ..Sleep disorders often remain undiagnosed. Untreated sleep disorders among police officers may adversely affect their health and safety and pose a risk to the public...
  35. doi request reprint Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light
    Joshua J Gooley
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sci Transl Med 2:31ra33. 2010
    ..These results suggest that light therapy for sleep disorders and other indications might be optimized by stimulating both photoreceptor systems...
  36. pmc Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker
    Melissa A St Hilaire
    Analytic and Modeling Unit, Division of Sleep Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    J Theor Biol 247:583-99. 2007
    ..Further experiments are required to validate fully our model and to understand the exact effect of the sleep-wake cycle as a non-photic stimulus for the human circadian pacemaker...
  37. pmc Medical and genetic differences in the adverse impact of sleep loss on performance: ethical considerations for the medical profession
    Charles A Czeisler
    Division of Sleep Medicine, Department of Medicine, Brigham andWomen s Hospital, Harvard Medical School, 221 Longwood Avenue, Suite 438, Boston, MA 02115, USA
    Trans Am Clin Climatol Assoc 120:249-85. 2009
    ....
  38. ncbi request reprint Interns' compliance with accreditation council for graduate medical education work-hour limits
    Christopher P Landrigan
    Harvard Work Hours, Health and Safety Group, Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    JAMA 296:1063-70. 2006
    ..The Accreditation Council for Graduate Medical Education (ACGME) introduced duty-hour standards in 2003 to reduce work hours...
  39. ncbi request reprint The influence of subjective alertness and motivation on human performance independent of circadian and homeostatic regulation
    Joseph T Hull
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 18:329-38. 2003
    ..Such studies also may aid in the development of countermeasures to improve human performance...
  40. ncbi request reprint Temporal dynamics of late-night photic stimulation of the human circadian timing system
    Jamie M Zeitzer
    Div of Sleep Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Ste 438, Boston, MA 02115, USA
    Am J Physiol Regul Integr Comp Physiol 289:R839-44. 2005
    ....
  41. ncbi request reprint Risks of complications by attending physicians after performing nighttime procedures
    Jeffrey M Rothschild
    Division of General Medicine and Primary Care, Brigham and Women s Hospital, 1620 Tremont St, Boston, MA 02120 1613, USA
    JAMA 302:1565-72. 2009
    ..Few data exist on the relationships between experienced physicians' work hours and sleep, and patient safety...
  42. pmc EEG sleep spectra in older adults across all circadian phases during NREM sleep
    Mirjam Munch
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sleep 33:389-401. 2010
    ..We aimed to examine the electroencephalographic (EEG) sleep spectra during non-rapid eye movement (NREM) sleep when sleep was scheduled at all times of day...
  43. pmc Acute sleep deprivation and circadian misalignment associated with transition onto the first night of work impairs visual selective attention
    Nayantara Santhi
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e1233. 2007
    ....
  44. pmc Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans
    Kenneth P Wright
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Biol Rhythms 20:168-77. 2005
    ..This finding has important implications for understanding physiological organization by the brain's master circadian clock and may have implications for understanding mechanisms underlying circadian sleep disorders...
  45. pmc Assessment of drowsiness based on ocular parameters detected by infrared reflectance oculography
    Clare Anderson
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Sleep Med 9:907-20, 920A-920B. 2013
    ..Here, we examine how these parameters reflect changes in drowsiness, and how they relate to objective and subjective indices of the drowsy state in a controlled laboratory setting...
  46. ncbi request reprint Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light
    Laura K Barger
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Regul Integr Comp Physiol 286:R1077-84. 2004
    ..73, P < 0.05) such that the closer to the DLMO(25%), the greater the phase shift. These data suggest that exercise may help to facilitate circadian adaptation to schedules requiring a delay in the sleep-wake cycle...
  47. pmc The human circadian system adapts to prior photic history
    Anne Marie Chang
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 221 Longwood Avenue, Suite 438, Boston, MA 02115, USA
    J Physiol 589:1095-102. 2011
    ..This plasticity has important implications for the optimization of light therapy for the treatment of circadian rhythm sleep disorders...
  48. pmc Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology
    Andrew J K Phillips
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 26:441-53. 2011
    ..Our findings suggest that feedback from behavioral choices to physiology could play an important role in spontaneous internal desynchrony...
  49. ncbi request reprint Effect of reducing interns' weekly work hours on sleep and attentional failures
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 351:1829-37. 2004
    ....
  50. pmc Entrainment of the human circadian pacemaker to longer-than-24-h days
    Claude Gronfier
    Division of Sleep Medicine, Department of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:9081-6. 2007
    ..The implications of these findings are important because they could be used to treat circadian misalignment associated with space flight and circadian rhythm sleep disorders such as shift-work disorder...
  51. pmc Evaluation of a single-channel nasal pressure device to assess obstructive sleep apnea risk in laboratory and home environments
    Kate E Crowley
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Sleep Med 9:109-16. 2013
    ....
  52. ncbi request reprint Relationship between alertness, performance, and body temperature in humans
    Kenneth P Wright
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1370-7. 2002
    ..These results support the hypothesis that body temperature modulates neurobehavioral function in humans...
  53. pmc Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects
    Jeanne F Duffy
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 28:799-807. 2007
    ..These findings suggest an age-related reduction in the phase-delaying response to moderate light levels. However, our findings alone do not explain the altered phase relationship between sleep and circadian rhythms associated with aging...
  54. pmc Diurnal spectral sensitivity of the acute alerting effects of light
    Shadab A Rahman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA
    Sleep 37:271-81. 2014
    ..Previous studies have demonstrated short-wavelength sensitivity for the acute alerting response to nocturnal light exposure. We assessed daytime spectral sensitivity in alertness, performance, and waking electroencephalogram (EEG)...
  55. pmc Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption
    Orfeu M Buxton
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sci Transl Med 4:129ra43. 2012
    ..Thus, in humans, prolonged sleep restriction with concurrent circadian disruption alters metabolism and could increase the risk of obesity and diabetes...
  56. ncbi request reprint Adaptation of human pineal melatonin suppression by recent photic history
    Kurt A Smith
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Suite 438, Boston, MA 02115, USA
    J Clin Endocrinol Metab 89:3610-4. 2004
    ..Further elucidation of these properties could prove useful in potentiating light therapies for circadian and affective disorders...
  57. pmc A phase response curve to single bright light pulses in human subjects
    Sat Bir S Khalsa
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 549:945-52. 2003
    ..Phase shifts derived using the melatonin onsets showed larger magnitudes than those derived from the melatonin offsets. These data provide a comprehensive characterization of the human PRC under highly controlled laboratory conditions...
  58. ncbi request reprint Searching night and day: a dissociation of effects of circadian phase and time awake on visual selective attention and vigilance
    Todd S Horowitz
    Division of Sleep Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Psychol Sci 14:549-57. 2003
    ..The locus of sleepiness effects on search is probably downstream from the bottleneck of attentional selection. Observers did trade accuracy for speed when sleepy. This implicates decision-stage impairments...
  59. pmc Healthy older adults better tolerate sleep deprivation than young adults
    Jeanne F Duffy
    Brigham and Women s Hospital General Clinical Research Center, Boston, Massachusetts, USA
    J Am Geriatr Soc 57:1245-51. 2009
    ..To determine whether healthy aging is associated with increased sleepiness and whether healthy older adults experience more sleepiness when acutely sleep deprived...
  60. ncbi request reprint Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans
    Jeanne F Duffy
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neurosci Lett 318:117-20. 2002
    ....
  61. ncbi request reprint Sleep- and circadian-dependent modulation of REM density
    Sat Bir S Khalsa
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Sleep Res 11:53-9. 2002
    ....
  62. ncbi request reprint Peak of circadian melatonin rhythm occurs later within the sleep of older subjects
    Jeanne F Duffy
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 282:E297-303. 2002
    ..In healthy older subjects, the relative timing of the melatonin rhythm with respect to sleep may not play a causal role in sleep disruption...
  63. pmc Impact of sleepiness and sleep deficiency on public health--utility of biomarkers
    Charles A Czeisler
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02215, USA
    J Clin Sleep Med 7:S6-8. 2011
    ..It is important to recognize that sleepiness and sleep deficiency are not synonymous...
  64. ncbi request reprint High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 88:4502-5. 2003
    ..Thus photopic lux, the standard unit of illuminance, is inappropriate when quantifying the photic drive required to reset the human circadian pacemaker...
  65. ncbi request reprint Bilateral oculosympathetic paresis associated with loss of nocturnal melatonin secretion in patients with spinal cord injury
    Jamie M Zeitzer
    Division of Sleep Medicine, Harvard Medical School Boston, Massachusetts, USA
    J Spinal Cord Med 28:55-9. 2005
    ..Loss of melatonin production may contribute to the pervasive sleep disruption observed in patients with tetraplegia...
  66. ncbi request reprint Sleep deficit: the performance killer. A conversation with Harvard Medical School Professor Charles A. Czeisler
    Charles A Czeisler
    Harvard Medical School, USA
    Harv Bus Rev 84:53-9, 148. 2006
    ..A sidebar to this article summarizes the latest developments in sleep research...
  67. ncbi request reprint Absence of circadian phase resetting in response to bright light behind the knees
    Kenneth P Wright
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Suite 438, Boston, MA 02115, USA
    Science 297:571. 2002
  68. ncbi request reprint Work hours and sleep in residency training
    Charles A Czeisler
    Sleep 27:371-2. 2004
  69. pmc Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans
    Claude Gronfier
    INSERM U371, 18 Avenue du Doyen Lepine, 69675 Bron Cedex, France
    Am J Physiol Endocrinol Metab 287:E174-81. 2004
    ....
  70. ncbi request reprint Melatonin, sleep, and circadian rhythms
    Frank A J L Scheer
    Sleep Med Rev 9:5-9. 2005
  71. ncbi request reprint Diurnal variation in CSF orexin-A in healthy male subjects
    Scott P Grady
    Portland Diabetes and Endocrinology Center, Portland, OR, USA
    Sleep 29:295-7. 2006
    ..Orexin-A is hypothesized to promote wakefulness, and we examined whether cerebrospinal fluid (CSF) orexin-A levels are higher during the waking period in man...
  72. pmc Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake
    Jamie M Zeitzer
    Department of Psychiatry, Stanford University, Palo Alto, CA 94304, USA
    Sleep 30:1437-43. 2007
    ..To determine the effects of sleep and sleep deprivation on plasma melatonin concentrations in humans and whether these effects are age-dependent...
  73. ncbi request reprint Effects of sleep inertia on cognition
    Adam T Wertz
    JAMA 295:163-4. 2006
  74. pmc Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina
    Farhan H Zaidi
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London W6 8RF, United Kingdom
    Curr Biol 17:2122-8. 2007
    ....
  75. pmc Effect of intern's consecutive work hours on safety, medical education and professionalism
    Christopher P Landrigan
    Crit Care 9:528-30; author reply 528-30. 2005
  76. ncbi request reprint Quantifying consequences of chronic sleep restriction
    Charles A Czeisler
    Harvard Med Sch, Boston, MA
    Sleep 26:247-8; discussion 249. 2003