Aaron M Cypess

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:635-9. 2013
  2. pmc Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 152:3680-9. 2011
  3. pmc Cellular bioenergetics as a target for obesity therapy
    Yu Hua Tseng
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Rev Drug Discov 9:465-82. 2010
  4. pmc Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts
    J Nucl Med 54:1896-901. 2013
  5. pmc Increased FDG uptake in association with reduced extremity fat in HIV patients
    Martin Torriani
    Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Antivir Ther 18:243-8. 2013
  6. pmc Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
    Tim J Schulz
    Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 495:379-83. 2013
  7. ncbi request reprint Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
    Yu Hua Tseng
    Research Division, Joslin Diabetes Center, Children s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Nat Cell Biol 7:601-11. 2005
  8. pmc Deiodinase 2 expression is increased in dorsocervical fat of patients with HIV-associated lipohypertrophy syndrome
    Martin Torriani
    Division of Musculoskeletal Imaging and Intervention and Program in Nutritional Metabolism, Massachusetts General Hospital Longfellow 207, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E602-7. 2012
  9. doi request reprint Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging
    Y Iris Chen
    A Martino s Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Obesity (Silver Spring) 20:1519-26. 2012
  10. doi request reprint Pediatric brown adipose tissue: detection, epidemiology, and differences from adults
    Laura A Drubach
    Department of Radiology, Children s Hospital Boston, Boston, MA 02466, USA
    J Pediatr 159:939-44. 2011

Collaborators

Detail Information

Publications15

  1. pmc Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:635-9. 2013
    ..Although the properties of human neck fat vary substantially between individuals, some human samples share many similarities with classical, also called constitutive, rodent BAT...
  2. pmc Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 152:3680-9. 2011
    ..These two pathways combine to decrease necdin levels and permit the clonal expansion and coordinated gene expression necessary to complete brown adipocyte differentiation...
  3. pmc Cellular bioenergetics as a target for obesity therapy
    Yu Hua Tseng
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Rev Drug Discov 9:465-82. 2010
    ..In this article, we integrate these developments in relation to the classical understandings of cellular bioenergetics to explore the potential for developing novel anti-obesity therapies that target cellular energy expenditure...
  4. pmc Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts
    J Nucl Med 54:1896-901. 2013
    ..Here we used a combination of human and rodent models to assess changes in BAT blood flow and glucose utilization...
  5. pmc Increased FDG uptake in association with reduced extremity fat in HIV patients
    Martin Torriani
    Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Antivir Ther 18:243-8. 2013
    ..This study assesses the relationship between FDG uptake in various fat depots and metabolic/immune parameters among subjects with HIV lipodystrophy...
  6. pmc Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
    Tim J Schulz
    Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 495:379-83. 2013
    ..This sophisticated regulatory mechanism of body temperature may participate in the control of energy balance and metabolic disease...
  7. ncbi request reprint Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
    Yu Hua Tseng
    Research Division, Joslin Diabetes Center, Children s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Nat Cell Biol 7:601-11. 2005
    ..Together these define a key signalling network that is involved in brown preadipocyte determination...
  8. pmc Deiodinase 2 expression is increased in dorsocervical fat of patients with HIV-associated lipohypertrophy syndrome
    Martin Torriani
    Division of Musculoskeletal Imaging and Intervention and Program in Nutritional Metabolism, Massachusetts General Hospital Longfellow 207, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E602-7. 2012
    ....
  9. doi request reprint Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging
    Y Iris Chen
    A Martino s Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Obesity (Silver Spring) 20:1519-26. 2012
    ..In conclusion, we demonstrate the feasibility of measuring BAT volume and function in vivo using routine MRI sequences. The MRI measurement of BAT volume is consistent with quantitative measurement of the tissue ex vivo...
  10. doi request reprint Pediatric brown adipose tissue: detection, epidemiology, and differences from adults
    Laura A Drubach
    Department of Radiology, Children s Hospital Boston, Boston, MA 02466, USA
    J Pediatr 159:939-44. 2011
    ..To evaluate the prevalence and factors affecting the detection of active brown adipose tissue (BAT) in children and adolescents using (18)F-fluorodeoxyglucose positron emission tomography...
  11. pmc The role and importance of brown adipose tissue in energy homeostasis
    Aaron M Cypess
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Curr Opin Pediatr 22:478-84. 2010
    ..This review discusses BAT physiology and evaluates the recent discoveries regarding its development, identification, and function...
  12. pmc Brown fat as a therapy for obesity and diabetes
    Aaron M Cypess
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts, 02215, USA
    Curr Opin Endocrinol Diabetes Obes 17:143-9. 2010
    ..This review evaluates the recent discoveries regarding the identification of functional BAT in adult humans and its potential as a therapy for obesity and diabetes...
  13. pmc Cold but not sympathomimetics activates human brown adipose tissue in vivo
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 109:10001-5. 2012
    ..Agents that mimic cold activation of BAT could provide a promising approach to treating obesity while minimizing systemic effects...
  14. pmc Insulin enhances glucose-stimulated insulin secretion in healthy humans
    Clara Bouche
    Cellular and Molecular Physiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:4770-5. 2010
    ..In addition, hyperinsulinemia increases C-peptide clearance, which may lead to modest underestimation of beta-cell secretory response when using these methods during prolonged dynamic testing...
  15. pmc Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
    ....