C Cursiefen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1040-50. 2004
  2. ncbi Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin
    Claus Cursiefen
    Department of Ophthalmology and Nikolaus Fiebiger Zentrum for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 43:2127-35. 2002
  3. ncbi Spontaneous corneal hem- and lymphangiogenesis in mice with destrin-mutation depend on VEGFR3 signaling
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Am J Pathol 166:1367-77. 2005
  4. ncbi Acute bilateral blindness caused by accidental methanol intoxication during fire "eating"
    C Cursiefen
    Department of Ophthalmology, , Germany
    Br J Ophthalmol 86:1064-5. 2002
  5. ncbi Corneal neovascularization after nonmechanical versus mechanical corneal trephination for non-high-risk keratoplasty
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Cornea 21:648-52. 2002
  6. ncbi Pericyte recruitment in human corneal angiogenesis: an ultrastructural study with clinicopathological correlation
    C Cursiefen
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Br J Ophthalmol 87:101-6. 2003
  7. ncbi Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cornea 22:273-81. 2003
  8. ncbi Impact of short-term versus long-term topical steroids on corneal neovascularization after non-high-risk keratoplasty
    C Cursiefen
    Department of Ophthalmology, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Graefes Arch Clin Exp Ophthalmol 239:514-21. 2001
  9. ncbi Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis
    D Hos
    Department of Ophthalmology, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, Erlangen, Germany
    Exp Eye Res 87:427-32. 2008
  10. ncbi [Antiangiogenic therapy at the ocular surface: when, what and why?]
    F Bock
    Augenklinik mit Poliklinik, Labor für Okuläre Angiogenese, Lymphangiogenese und Transplantatimmunologie, Universitat Erlangen Nurnberg, Universitäts Augenklinik Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland
    Ophthalmologe 108:230-6. 2011

Collaborators

Detail Information

Publications81

  1. ncbi VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1040-50. 2004
    ..We conclude that VEGF-A recruitment of monocytes/macrophages plays a crucial role in inducing inflammatory neovascularization by supplying/amplifying signals essential for pathological hemangiogenesis and lymphangiogenesis...
  2. ncbi Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin
    Claus Cursiefen
    Department of Ophthalmology and Nikolaus Fiebiger Zentrum for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 43:2127-35. 2002
    ..To determine whether lymphatic vessels exist in vascularized human corneas, by using immunohistochemistry with novel markers for lymphatic endothelium...
  3. ncbi Spontaneous corneal hem- and lymphangiogenesis in mice with destrin-mutation depend on VEGFR3 signaling
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Am J Pathol 166:1367-77. 2005
    ....
  4. ncbi Acute bilateral blindness caused by accidental methanol intoxication during fire "eating"
    C Cursiefen
    Department of Ophthalmology, , Germany
    Br J Ophthalmol 86:1064-5. 2002
  5. ncbi Corneal neovascularization after nonmechanical versus mechanical corneal trephination for non-high-risk keratoplasty
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Cornea 21:648-52. 2002
    ..To analyze the influence of mechanical versus nonmechanical trephination of donor and host corneas on superficial, peripheral corneal neovascularization occurring after non-high-risk keratoplasty...
  6. ncbi Pericyte recruitment in human corneal angiogenesis: an ultrastructural study with clinicopathological correlation
    C Cursiefen
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Br J Ophthalmol 87:101-6. 2003
    ..This study analyses whether, and if so when, pathological vessels in human corneal neovascularisation (CN) acquire pericyte coverage. This can be of importance for future angioregressive therapeutic strategies...
  7. ncbi Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology
    Claus Cursiefen
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cornea 22:273-81. 2003
    ..This has changed with the recent discovery of the lymphatic endothelial markers vascular endothelial growth factor receptor 3, LYVE-1 (a lymphatic endothelium-specific hyaluronan receptor), Prox 1, and Podoplanin...
  8. ncbi Impact of short-term versus long-term topical steroids on corneal neovascularization after non-high-risk keratoplasty
    C Cursiefen
    Department of Ophthalmology, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Graefes Arch Clin Exp Ophthalmol 239:514-21. 2001
    ....
  9. ncbi Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis
    D Hos
    Department of Ophthalmology, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, Erlangen, Germany
    Exp Eye Res 87:427-32. 2008
    ..The lower lymphangiogenic potency of older mice may explain the better outcome of corneal transplantations in old recipients, supporting the concept that lymphangiogenesis is an important risk-factor for corneal transplant rejection...
  10. ncbi [Antiangiogenic therapy at the ocular surface: when, what and why?]
    F Bock
    Augenklinik mit Poliklinik, Labor für Okuläre Angiogenese, Lymphangiogenese und Transplantatimmunologie, Universitat Erlangen Nurnberg, Universitäts Augenklinik Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland
    Ophthalmologe 108:230-6. 2011
    ..A literature review in PubMed and own clinical and experimental data form the basis for a discussion of the indications, current therapeutic options and potential side-effects of local antiangiogenic therapy at the ocular surface...
  11. ncbi [Standardized semiquantitative analysis of corneal neovascularization using projected corneal photographs--pilot study after perforating corneal keratoplasty before immune reaction]
    C Cursiefen
    Augenklinik mit Poliklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen
    Klin Monbl Augenheilkd 218:484-91. 2001
    ....
  12. ncbi Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation
    B O Bachmann
    Department of Anatomy II, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Br J Ophthalmol 93:1075-80. 2009
    ..We analysed whether the inhibition of post-keratoplasty revascularisation in mice with partly regressed corneal vessels ("intermediate-risk") improves graft survival...
  13. ncbi Adenoma of the nonpigmented ciliary epithelium mimicking a malignant melanoma of the iris
    C Cursiefen
    Department of Ophthalmology, University Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Germany
    Arch Ophthalmol 117:113-6. 1999
    ..Postoperative visual acuity was 20/40 OD after 6 weeks. An adenoma of the nonpigmented ciliary epithelium may mimic an amelanotic malignant melanoma of the iris and should be considered in its differential diagnosis...
  14. ncbi Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor alpha, and transforming growth factor beta1 in human corneas with neovascularization
    C Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Cornea 19:526-33. 2000
    ..To analyze presence and distribution of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)alpha, and TGFbeta1 in human corneas with neovascularization due to different corneal diseases...
  15. ncbi Blood-aqueous barrier breakdown after penetrating keratoplasty with simultaneous extracapsular cataract extraction and posterior chamber lens implantation
    N X Nguyen
    Department of Ophthalmology and University Eye Hospital, Schwabachanlage 6, University Erlangen Nurnberg, 91054 Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 239:114-7. 2001
    ....
  16. ncbi Tumour-associated lymphangiogenesis in conjunctival malignant melanoma
    P Zimmermann
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Br J Ophthalmol 93:1529-34. 2009
    ..To evaluate whether tumour-associated lymphangiogenesis, that is the formation of new lymphatic vessels (LVs) induced by a tumour, occurs in and around conjunctival malignant melanoma (MM)...
  17. ncbi [Visual rehabilitation and intraocular pressure elevation due to immunological graft rejection following penetrating keratoplasty]
    N X Nguyen
    Augenklinik mit Poliklinik der Universität Erlangen Nürnberg, Schwabachanlage 6, 91054 Erlangen
    Klin Monbl Augenheilkd 218:492-7. 2001
    ..Aim of this study was to evaluate the visual rehabilitation and the development of intraocular pressure during and after graft rejection...
  18. ncbi Orbital lymphangioma with positive immunohistochemistry of lymphatic endothelial markers (vascular endothelial growth factor receptor 3 and podoplanin)
    C Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 239:628-32. 2001
    ..Existence of true orbital lymphangiomas has been questioned in recent years. Therefore an orbital lymphangioma was analyzed with two new specific markers of lymphatic endothelium...
  19. ncbi Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts
    F Bock
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Exp Eye Res 87:462-70. 2008
    ..Therefore the semiautomatic method can be used to detect even small effects on hem and lymphangiogenesis in murine corneal flatmounts with greater precision...
  20. ncbi Ocular findings in ichthyosis follicularis, atrichia, and photophobia syndrome
    C Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Arch Ophthalmol 117:681-4. 1999
    ..A defective tear film, recurrent atopic keratoconjunctival inflammations, or a primary anomaly of corneal epithelial adhesion are potential causes for the corneal defects. Photophobia is most likely due to corneal abnormalities...
  21. ncbi Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:2666-73. 2004
    ....
  22. ncbi Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
    Kazuichi Maruyama
    Ocular Immunology Group, The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2363-72. 2005
    ..The novel finding that CD11b+ macrophages are critical for the development of inflammation-dependent lymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis...
  23. ncbi Changes in donor corneal lenticule thickness after Descemet's stripping automated endothelial keratoplasty (DSAEK) with organ-cultured corneas
    P Pogorelov
    Department of Opthalmology, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Br J Ophthalmol 93:825-9. 2009
    ....
  24. ncbi Persisting retinal ganglion cell axons in blind atrophic human eyes
    C Cursiefen
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 239:158-64. 2001
    ..To evaluate enucleated blind atrophic human eyes for the persistence of retinal ganglion cell axons. This might be of relevance for contact to an electronic prosthesis in the future...
  25. ncbi The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages
    Falk Schroedl
    Department of Anatomy I, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:5222-9. 2008
    ..To date, there is no report on its expression in the posterior human uvea. The purpose of this study was to investigate the expression of LYVE-1 in normal human choroids...
  26. ncbi Corneal (lymph)angiogenesis--from bedside to bench and back: a tribute to Judah Folkman
    Birgit Regenfuss
    Department of Ophthalmology and Interdisciplinary Center for Clinical Research IZKF, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Lymphat Res Biol 6:191-201. 2008
    ....
  27. ncbi Bilateral zonular cataract associated with the mitochondrial cytopathy of Pearson syndrome
    C Cursiefen
    Department of Ophthalmology, University Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Germany
    Am J Ophthalmol 125:260-1. 1998
    ..To report a child with the mitochondrial cytopathy of Pearson syndrome and zonular cataract...
  28. ncbi Migraine and tension headache in high-pressure and normal-pressure glaucoma
    C Cursiefen
    Department of Ophthalmology and the Institute of Medical Informatics, Biometry and Epidemiology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Ophthalmol 129:102-4. 2000
    ..To analyze the association of normal-pressure glaucoma and migraine...
  29. ncbi Oculocerebral non-Hodgkin's lymphoma with uveal involvement: development of an epibulbar tumor after vitrectomy
    C Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Arch Ophthalmol 118:1437-40. 2000
    ..We conclude that, following vitrectomy, a primary ocular lymphoma may extend through the sclerotomy lesion and present as an epibulbar tumor. Uveal involvement may occur in oculocerebral non-Hodgkin's lymphoma...
  30. ncbi Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 25:443-7. 2006
    ..To study the time course of angiogenesis and lymphangiogenesis in the cornea after a short inflammatory insult. This might be helpful for the timing of corneal transplantation in high-risk eyes...
  31. ncbi Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation
    Bjoern O Bachmann
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Arch Ophthalmol 126:71-7. 2008
    ....
  32. ncbi Silicone oil-associated optic nerve degeneration
    M Budde
    Department of Ophthalmology and Eye Hospital, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Am J Ophthalmol 131:392-4. 2001
    ..To report the frequency and extent of silicone oil migration into the optic nerve during silicone oil endotamponade...
  33. ncbi Surgery of the cornea: corneal, limbal stem cell and amniotic membrane transplantation
    F E Kruse
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Dev Ophthalmol 41:159-70. 2008
    ..To demonstrate surgical treatment options for complications of severe forms of dry eye at the cornea, limbus and conjunctiva...
  34. ncbi Immunohistochemical classification of primary and recurrent macular corneal dystrophy in Germany: subclassification of immunophenotype I A using a novel keratan sulfate antibody
    C Cursiefen
    Department of Ophthalmology and University Eye Hospital, University of Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 73:593-600. 2001
    ..The mAb 3D12/H7 allows a further subclassification of immunophenotype I A into type I A1 and 2. This points to a broader spectrum of MCD immunophenotypes and indirectly to a broader corneal proteoglycan pathology in MCD...
  35. ncbi Ocular findings in Fryns syndrome
    C Cursiefen
    Department of Ophthalmology, University Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Germany
    Acta Ophthalmol Scand 78:710-3. 2000
    ..The prevalence is about 0.7 per 10,000 births. Reported ocular features include microphthalmus, "cloudy cornea", irregularities of Bowman's layer, thickened posterior lens capsule and retinal dysplasia...
  36. ncbi Blockade of VEGFR3-signalling specifically inhibits lymphangiogenesis in inflammatory corneal neovascularisation
    Felix Bock
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 246:115-9. 2008
    ....
  37. ncbi Absence of blood and lymphatic vessels in the developing human cornea
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 25:722-6. 2006
    ..The normal human cornea is devoid of both blood and lymphatic vessels and actively maintains this avascularity (corneal angiogenic privilege). Whether and when corneal angiogenic privilege is achieved during development is unknown...
  38. ncbi Short- and long-term safety profile and efficacy of topical bevacizumab (Avastin) eye drops against corneal neovascularization
    Yanyan Koenig
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1375-82. 2009
    ..To evaluate the short- and long-term in vivo safety and efficacy of topical bevacizumab (Avastin) application for treatment of corneal neovascularization secondary to a variety of corneal diseases...
  39. ncbi Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation
    Deniz Hos
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 6, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:1836-42. 2008
    ....
  40. ncbi Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
    Lu Chen
    Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
    Nat Med 10:813-5. 2004
    ..Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery...
  41. ncbi Pseudoexfoliation syndrome in eyes with ischemic central retinal vein occlusion. A histopathologic and electron microscopic study
    C Cursiefen
    Department of Ophthalmology, University Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Acta Ophthalmol Scand 79:476-8. 2001
    ..These deposits could explain an association of CRVO and PEX...
  42. ncbi [Topical application of EGF for the therapy of persisting corneal erosion under cetuximab treatment]
    C G Förster
    Augenklinik, Universitatsklinikum Erlangen, Schwabachanlage 6, 91054 Erlangen, Deutschland
    Ophthalmologe 105:269-73. 2008
    ..Inhibition of EGFR also influences corneal wound healing as EGF stimulates the proliferation of epithelial cells...
  43. ncbi [Transitory intrathoracic and -abdominal pressure elevation in the history of 64 patients with normal pressure glaucoma]
    D Krist
    Augenklinik mit Poliklinik der Universität Erlangen Nürnberg, Schwabachanlage 6, 91054 Erlangen
    Klin Monbl Augenheilkd 218:209-13. 2001
    ..Aim of this study was to evaluate patients with normal-tension glaucoma for the exposure to potential, clinically undetected transient elevations of intraocular tension due to increased intrathoracic and -abdominal pressure...
  44. ncbi Intraocular lymphatics in ciliary body melanomas with extraocular extension: functional for lymphatic spread?
    Ludwig M Heindl
    Department of Ophthalmology and Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Germany
    Arch Ophthalmol 128:1001-8. 2010
    ..To assess the functional significance of intraocular tumor-associated lymphatic vessels in ciliary body melanomas with extraocular extension...
  45. ncbi Tumor-associated lymphangiogenesis in the development of conjunctival squamous cell carcinoma
    Ludwig M Heindl
    Department of Ophthalmology and Eye Hospital, Ophthalmic Pathology Laboratory, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 117:649-58. 2010
    ....
  46. ncbi Intraocular tumor-associated lymphangiogenesis a novel prognostic factor for ciliary body melanomas with extraocular extension?
    Ludwig M Heindl
    Department of Ophthalmology and Eye Hospital, Ophthalmic Pathology Laboratory, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 117:334-42. 2010
    ..To evaluate whether intraocular tumor-associated lymphangiogenesis contributes to prognosis of ciliary body melanomas with extraocular extension and to study its association with other tumor characteristics...
  47. ncbi Intraocular lymphangiogenesis in malignant melanomas of the ciliary body with extraocular extension
    Ludwig M Heindl
    Department of Ophthalmology and Eye Hospital, Ophthalmic Pathology Laboratory, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:1988-95. 2009
    ....
  48. ncbi Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis
    Felix Bock
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 48:2545-52. 2007
    ..Bevacizumab (Avastin; Roche, Welwyn Garden City, UK) is a recombinant, humanized, monoclonal antibody against VEGF-A that has been approved by the U.S. Food and Drug Administration for the treatment of colon carcinomas...
  49. ncbi Safety profile of topical VEGF neutralization at the cornea
    Felix Bock
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:2095-102. 2009
    ..Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface...
  50. ncbi Immune privilege and angiogenic privilege of the cornea
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Chem Immunol Allergy 92:50-7. 2007
    ..Recent evidence indicates that there is considerable overlap in the molecular mechanisms maintaining corneal 'angiogenic' and 'immune privilege'...
  51. ncbi Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
    Claus Cursiefen
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:11405-10. 2006
    ..VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible for suppressing inflammatory corneal angiogenesis...
  52. ncbi [DMEK: Descemet membrane endothelial keratoplasty]
    C Cursiefen
    Augenklinik mit Poliklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen
    Ophthalmologe 107:370-6. 2010
    ....
  53. ncbi Breast carcinoma metastatic to the eyelid presenting as the first sign of insufficient chemotherapy
    F Colombo
    Department of Ophthalmology and Eye Hospital, , Erlangen, Germany
    Ophthalmologica 215:136-7. 2001
    ..Breast carcinoma metastatic to the eyelid represented in this patient the only sign of insufficient chemotherapy...
  54. ncbi [Retained Descemet's membrane after penetrating keratoplasty for macular corneal dystrophy]
    L M Heindl
    Augenklinik mit Poliklinik der Universität Erlangen Nürnberg, Schwabachanlage 6, 91054 Erlangen, Deutschland
    Ophthalmologe 107:55-9. 2010
    ..Trypan-blue-assisted descemetorhexis was performed, and histopathology confirmed the diagnosis of retained Descemet's membrane. Four months later, the graft was clear with good visual acuity and no sign of retrocorneal membrane...
  55. ncbi [Manufacture of autologous serum eye drops for out-patient therapy : cooperation between ophthalmic clinic and transfusion medicine department]
    T Dietrich
    Augenklinik mit Poliklinik, Universitatsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland
    Ophthalmologe 105:1036-8, 1040-2. 2008
    ....
  56. ncbi [Topical inhibition of angiogenesis at the cornea. Safety and efficacy]
    B Regenfuss
    Augenklinik mit Poliklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054, Erlangen
    Ophthalmologe 106:399-406. 2009
    ..The efficacy and safety of novel topical inhibitors of corneal neovascularisation will be discussed...
  57. ncbi Recurrent optic nerve head infarctions associated with combined factor V Leiden- and factor II:G20210A-mutation
    C Cursiefen
    Department of Ophthalmology, University Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Acta Ophthalmol Scand 77:625-7. 1999
    ..To demonstrate the association of bilateral recurrent optic nerve head infarctions with thrombophilia due to combined factor V:R506Q- and factor II:G20210A-mutation...
  58. ncbi Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 184:535-9. 2010
    ..That may allow for selective, temporary, perioperative antilymphangiogenic treatment to promote graft survival without affecting blood vessels, even after solid organ transplantation...
  59. ncbi Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1117-24. 2004
    ..This study was undertaken to investigate whether deficiencies of these factors altered developmental and inflammation-induced angiogenesis in the cornea and developmental angiogenesis of the iris of mice...
  60. ncbi Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Am J Pathol 171:361-72. 2007
    ..This opens new treatment options for selective inhibition of lymphangiogenesis, eg, in oncology and transplant immunology...
  61. ncbi Genetic heterogeneity of lymphangiogenesis in different mouse strains
    Birgit Regenfuss
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Am J Pathol 177:501-10. 2010
    ..These considerations need to be taken into account when using different mouse strains to study lymphangiogenesis and may also explain different success of antilymphangiogenic treatments in tumor patients...
  62. ncbi Novel expression and characterization of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1) by conjunctival cells
    Lu Chen
    Laboratory of Immunology, Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 46:4536-40. 2005
    ..These cells that normally express LYVE-1 may act as a reservoir for lymphangiogenesis and cell recruitment when the immune system is challenged...
  63. ncbi [Descemet's stripping with automated endothelial keratoplasty (DSAEK)]
    C Cursiefen
    Augenklinik mit Poliklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Ophthalmologe 105:183-90, 192. 2008
    ..Although penetrating keratoplasty remains the gold standard for surgically treating corneal endothelial pathologies, tremendous progress has been made in recent years to improve the technology of (posterior) lamellar keratoplasty...
  64. ncbi Bevacizumab (Avastin) eye drops inhibit corneal neovascularization
    Felix Bock
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 246:281-4. 2008
    ..To analyze the ability of bevacizumab (Avastin) eye drops to inhibit corneal neovascularization. Design: interventional case series involving five patients (age: 42 +/- 14 years)...
  65. ncbi Long-term topical steroid treatment improves graft survival following normal-risk penetrating keratoplasty
    Nhung X Nguyen
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Ophthalmol 144:318-9. 2007
    ..To assess the impact of duration of topical steroid treatment on the incidence of endothelial graft rejection after normal-risk penetrating keratoplasty (PK)...
  66. ncbi Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) on monocytic bone marrow-derived cells in the conjunctiva
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 79:553-61. 2004
    ....
  67. ncbi Risk factors for corneal allograft rejection: intermediate results of a prospective normal-risk keratoplasty study
    Michael Kuchle
    Department of Ophthalmology and University Eye Hospital, University Erlangen Nurnberg, Schwabachanlage 6, Germany
    Graefes Arch Clin Exp Ophthalmol 240:580-4. 2002
    ..To analyze the incidence of and possible risk factors for endothelial corneal allograft rejection in a well-defined population following penetrating normal-risk keratoplasty...
  68. ncbi Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis
    Bjorn Bachmann
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 117:1300-5.e7. 2010
    ..Preoperative corneal neovascularization (CNV) is thought to be associated with an increased rate of corneal graft failure and potentially also graft rejection...
  69. ncbi The Pathogenesis of floppy eyelid syndrome: involvement of matrix metalloproteinases in elastic fiber degradation
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 112:694-704. 2005
    ....
  70. ncbi GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial
    Claus Cursiefen
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Ophthalmology 116:1630-7. 2009
    ..The aim of this study was to test tolerability and efficacy of gene signal (GS)-101 eye drops, an antisense oligonucleotide against insulin receptor substrate-1, versus placebo on inhibition of progressive corneal neovascularization...
  71. ncbi Surgery-related factors influencing corneal neovascularization after low-risk keratoplasty
    Vinh M Lam
    Department of Ophthalmology, , Erlangen, Germany, and Ho Chi Minh Eye Hospital, Ho Chi Minh City, Viet Nam
    Am J Ophthalmol 141:260-266. 2006
    ..The speed of CNV outgrowth was most pronounced in the first weeks after PK making early postoperative controls for CNV growth and initiation of antiangiogenic treatment important...
  72. ncbi Persisting corneal erosion under cetuximab (Erbitux) treatment (epidermal growth factor receptor antibody)
    Claudia G Foerster
    Department of Ophthalmology, University of Erlangen Nuernberg, Erlangen, Germany
    Cornea 27:612-4. 2008
    ..To report persisting corneal erosion and trichomegaly as ocular side effects of cetuximab (Erbitux) treatment, a monoclonal antibody against the epidermal growth factor (EGF) receptor...
  73. ncbi In situ ablation of lens epithelial cells in porcine eyes with the laser photolysis system
    Matthias Pollhammer
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Cataract Refract Surg 33:697-701. 2007
    ..To evaluate the efficacy of the laser photolysis system (LPS) (A.R.C. Laser GmbH) in removing lens epithelial cells (LECs) to prevent posterior capsule opacification (PCO) in an in situ model...
  74. ncbi Impact of short-term versus longterm topical steroid treatment on 'idiopathic' endothelial cell loss after normal-risk penetrating keratoplasty
    Nhung Xuan Nguyen
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen Nurnberg, Germany
    Acta Ophthalmol Scand 85:209-12. 2007
    ..The aim of this study was to investigate whether the prolonged use of a topical steroid after normal-risk PK has a favourable impact on chronic endothelial cell loss...
  75. ncbi Temporal contrast sensitivity using full-field flicker test (Erlangen flicker test) in patients after penetrating keratoplasty
    Nhung X Nguyen
    Department of Ophthalmology and University Eye Hospital, University of Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 240:443-7. 2002
    ....
  76. ncbi Histologic analysis of descemet stripping in posterior lamellar keratoplasty
    Ludwig M Heindl
    Department of Ophthalmology and University Eye Hospital, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Arch Ophthalmol 126:461-4. 2008
    ..To investigate how precise Descemet stripping works in posterior lamellar keratoplasty (Descemet stripping automated endothelial keratoplasty [DSAEK]) for the treatment of corneal endothelial disorders...
  77. ncbi Endothelin-1 and ETA/ETB receptor protein and mRNA: expression in normal and vascularized human corneas
    Alexander Kuhlmann
    Department of Pathology, , Germany
    Cornea 24:837-44. 2005
    ..As potent ETA and ETB receptors are available, the endothelin system may represent an additional target for corneal antiangiogenic therapy...
  78. ncbi Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. 2004
    Lu Chen
    Ocul Immunol Inflamm 15:275-8. 2007
  79. ncbi Influence of photodynamic therapy on expression of vascular endothelial growth factor (VEGF), VEGF receptor 3, and pigment epithelium-derived factor
    Ursula Schmidt-Erfurth
    University Eye Hospital Lübeck, Lubeck, Germany
    Invest Ophthalmol Vis Sci 44:4473-80. 2003
    ..To evaluate the impact of photodynamic therapy (PDT) on expression and distribution of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-3, and pigment epithelium-derived factor (PEDF)...
  80. ncbi Adhesion structures of amniotic membranes integrated into human corneas
    Miklós D Resch
    1st Department of Ophthalmology, Semmelweis University, Budapest, Hungary
    Invest Ophthalmol Vis Sci 47:1853-61. 2006
    ..The aim of this study was to investigate the structural relationship between integrated amniotic membrane (AM) and corneal tissues in various integration patterns, focusing on adhesion structures along the interface...
  81. ncbi HIV and hepatitis B/C infections in patients donating blood for use as autologous serum eye drops
    Volker Weisbach
    , , Krankenhausstrasse 12, D - 91054 Erlangen, Germany
    Br J Ophthalmol 91:1724-5. 2007