Richard D Cummings
Affiliation: Harvard University
Mickum M, Prasanphanich N, Song X, Dorabawila N, Mandalasi M, Lasanajak Y, et al
. Identification of Antigenic Glycans from Schistosoma mansoni by Using a Shotgun Egg Glycan Microarray. Infect Immun. 2016;84:1371-1386 pubmed publisher
Kudelka M, Hinrichs B, Darby T, Moreno C, Nishio H, Cutler C, et al
. Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk. Proc Natl Acad Sci U S A. 2016;113:14787-14792 pubmed publisher
..These studies functionally validate Cosmc as an IBD risk factor and implicate it in regulating the spatial pattern of dysbiosis and sex bias in IBD. ..
Gao C, Hanes M, Byrd Leotis L, Wei M, Jia N, Kardish R, et al
. Unique Binding Specificities of Proteins toward Isomeric Asparagine-Linked Glycans. Cell Chem Biol. 2019;26:535-547.e4 pubmed publisher
Sun X, Ju T, Cummings R. Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers. BMC Cancer. 2018;18:827 pubmed publisher
..Our results demonstrate multiple mechanisms for Tn expression in CRCs. ..
Noll A, Yu Y, Lasanajak Y, Duska McEwen G, Buck R, Smith D, et al
. Human DC-SIGN binds specific human milk glycans. Biochem J. 2016;473:1343-53 pubmed publisher
..These results demonstrate that DC-SIGN among the many hGBP expressed by DCs binds to Î±-fucosylated HMGs, and suggest that such interactions may be important in influencing immune responses in the developing infant. ..
Cummings R. The Haystack Is Full of Needles: Technology Rescues Sugars!. Mol Cell. 2017;68:827-829 pubmed publisher
..2017) provides a novel algorithm for glycoproteomics in which complex glycopeptides can be identified in complex mixtures to aid in characterizing both the site of glycosylation and the glycan structure...
Mickum M, Rojsajjakul T, Yu Y, Cummings R. Schistosoma mansoni Î±1,3-fucosyltransferase-F generates the Lewis X antigen. Glycobiology. 2016;26:270-85 pubmed publisher
Noll A, Gourdine J, Yu Y, Lasanajak Y, Smith D, Cummings R. Galectins are human milk glycan receptors. Glycobiology. 2016;26:655-69 pubmed publisher
..These results demonstrate that galectins selectively bind to HMGs and suggest the possibility that galectin-HMG interactions may play a role in infant immunity. ..
Byrd Leotis L, Cummings R, Steinhauer D. The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase. Int J Mol Sci. 2017;18: pubmed publisher
..As more is understood about both HA and NA, the relevance for functional balance between HA and NA continues to expand, with potential implications for interspecies transmission, host adaptation, and pathogenicity. ..