Research Topics
| J P CulverSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activationGary Strangman
Harvard U, Cambridge
Neuroimage 17:719-31. 2002..This may reflect, at least in part, the superior contrast-to-noise ratio for oxyhemoglobin relative to deoxyhemoglobin (from optical measurements), rather than physiology related to BOLD signal interpretation...- Quantitative small animal fluorescence tomography using an ultrafast gated image intensifierSachin V Patwardhan
Dept of Radiol, Washington Univ Sch of Med, St Louis, MO 63110, USA
Conf Proc IEEE Eng Med Biol Soc 1:2675-8. 2006..Here we present a time-resolved, charged coupled device (CCD) based system for quantitative small animal fluorescence tomography... - Volumetric diffuse optical tomography of brain activityJoseph P Culver
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 28:2061-3. 2003..A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance... - Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemiaJoseph P Culver
Department of Physics and Astronomy, Cerebrovascular Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, U S A
J Cereb Blood Flow Metab 23:911-24. 2003.... - Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imagingJ P Culver
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
Med Phys 30:235-47. 2003..In addition, we find that point spread function measurements provide a useful and comprehensive representation of system performance... - Bulk optical properties of healthy female breast tissueT Durduran
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
Phys Med Biol 47:2847-61. 2002..The new information on healthy breast tissue provides insight about the potential contrasts available for diffuse optical tomography of breast tumours... - Near-field diffraction tomography with diffuse photon density wavesX Li
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 61:4295-309. 2000..g., the slab medium). Limitations and potential improvements of the near-field diffraction tomography are also discussed... - Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy?D A Boas
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Phys Med Biol 48:2405-18. 2003..A more precise estimate of the flow-consumption ratio will require better estimates of the model parameters or flow information, as can be provided by combining NIRS with fMRI... - In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopiesC Cheung
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
Phys Med Biol 46:2053-65. 2001.... 
Quantitative diffuse optical tomography for small animals using an ultrafast gated image intensifierSachin V Patwardhan
Washington University School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
J Biomed Opt 13:011009. 2008..Experiments with tissue simulating phantoms demonstrate the feasibility of reconstructing the absorption and scattering optical properties in a small animal imaging system...- Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomographyEdward E Graves
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 5404, Charlestown, Massachusetts 02129, USA
J Opt Soc Am A Opt Image Sci Vis 21:231-41. 2004.... - Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomographyAng Li
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 29:256-8. 2004..We demonstrate this improvement with simulations and a dynamic blood phantom experiment... - Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imagingMaria Angela Franceschini
NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Psychophysiology 40:548-60. 2003..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging... - Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulationAndrew M Siegel
Tufts University Bioengineering Center, Medford, MA 02155, USA
Phys Med Biol 48:1391-403. 2003.... - Optode positional calibration in diffuse optical tomographyJonathan J Stott
Harvard Medical School Massachusetts Institute of Technology Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Massachusetts 02129, USA
Appl Opt 42:3154-62. 2003..We present a technique for simultaneously calibrating optode positions and reconstructing images that significantly improves image quality, as we demonstrate with simulations and phantom experiments... - Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobinJoseph P Culver
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Neuroimage 27:947-59. 2005..These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms... 
Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomographyBenjamin W Zeff
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:12169-74. 2007..These results demonstrate that high-density DOT is a practical and powerful tool for mapping function in the human cortex...- A novel technique for light delivery through branched or bent anatomic structuresJoseph S Friedberg
Thomas Jefferson University Hospital, Philadelphia, PA, USA
J Thorac Cardiovasc Surg 126:1963-7. 2003..Such a technique could potentially expand the role of photodynamic therapy to treat tumors currently viewed as inaccessible to visible light... - Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrestJoseph P Culver
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
Adv Exp Med Biol 510:293-7. 2003..The new instrument and concept may also be applicable to human studies especially in infants and neonates permitting noninvasive monitoring of cerebral hemodynamics and oxygen (see [4] and [2] for examples of NIR spectroscopy)... - Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imagingAlex H Bamett
Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Appl Opt 42:3095-108. 2003..We sample from the exact posterior and show robustness to numerical model error. This opens up the possibility of simultaneous DOT and MR for quantitative cortically constrained functional neuroimaging...