Deborah J Culley

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The memory effects of general anesthesia persist for weeks in young and aged rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 96:1004-9, table of contents. 2003
  2. ncbi request reprint Altered hippocampal gene expression 2 days after general anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, 02115, USA
    Eur J Pharmacol 549:71-8. 2006
  3. pmc Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, Oxford, United Kingdom
    Hippocampus 18:245-50. 2008
  4. doi request reprint Spatial memory is intact in aged rats after propofol anesthesia
    In Ho Lee
    Department of Anesthesiology, Korea University Guro Hospital, Seoul, Republic of Korea
    Anesth Analg 107:1211-5. 2008
  5. pmc Isoflurane affects the cytoskeleton but not survival, proliferation, or synaptogenic properties of rat astrocytes in vitro
    D J Culley
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Br J Anaesth 110:i19-28. 2013
  6. doi request reprint Perceived value of Board certification and the Maintenance of Certification in Anesthesiology Program (MOCA®)
    Deborah J Culley
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Anesth 25:12-9. 2013
  7. pmc Isoflurane decreases self-renewal capacity of rat cultured neural stem cells
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 115:754-63. 2011
  8. pmc The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels
    Yuanlin Dong
    Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arch Neurol 66:620-31. 2009
  9. ncbi request reprint Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats
    Deborah J Culley
    Department of Anesthesiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 99:1393-7; table of contents. 2004
  10. pmc The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β
    Xu Wu
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 33:1364-78. 2012

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint The memory effects of general anesthesia persist for weeks in young and aged rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 96:1004-9, table of contents. 2003
    ..Therefore, isoflurane and nitrous oxide anesthesia produces a sustained learning impairment in aged rats...
  2. ncbi request reprint Altered hippocampal gene expression 2 days after general anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, 02115, USA
    Eur J Pharmacol 549:71-8. 2006
    ..These results demonstrate that in rats general anesthesia is associated with persistent changes in hippocampal gene expression, suggesting that recovery of the brain from anesthesia is considerably slower than generally recognized...
  3. pmc Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, Oxford, United Kingdom
    Hippocampus 18:245-50. 2008
    ..This factor should be considered carefully in experimental design and in cross-study comparisons of lesion effects on behavior...
  4. doi request reprint Spatial memory is intact in aged rats after propofol anesthesia
    In Ho Lee
    Department of Anesthesiology, Korea University Guro Hospital, Seoul, Republic of Korea
    Anesth Analg 107:1211-5. 2008
    ..No studies have investigated this question in aged subjects, however, so we designed an experiment to examine the long-term effects of propofol anesthesia on spatial working memory...
  5. pmc Isoflurane affects the cytoskeleton but not survival, proliferation, or synaptogenic properties of rat astrocytes in vitro
    D J Culley
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Br J Anaesth 110:i19-28. 2013
    ..We hypothesized that astroglia, which are strongly implicated in neuronal well-being and synapse formation and function, are vulnerable to adverse effects of isoflurane...
  6. doi request reprint Perceived value of Board certification and the Maintenance of Certification in Anesthesiology Program (MOCA®)
    Deborah J Culley
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Anesth 25:12-9. 2013
    ..To determine the attitudes and perceptions of diplomates of the American Board of Anesthesiology (ABA) regarding the value of Board certification, Maintenance of Certification (MOC),and the specific components...
  7. pmc Isoflurane decreases self-renewal capacity of rat cultured neural stem cells
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 115:754-63. 2011
    ..In models, isoflurane produces neural and behavioral deficits in vitro and in vivo. This study tested the hypothesis that neural stem cells are adversely affected by isoflurane such that it inhibits proliferation and kills these cells...
  8. pmc The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels
    Yuanlin Dong
    Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arch Neurol 66:620-31. 2009
    ..Subjects Naive mice, H4 human neuroglioma cells, and H4 human neuroglioma cells stably transfected to express full-length amyloid precursor protein...
  9. ncbi request reprint Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats
    Deborah J Culley
    Department of Anesthesiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 99:1393-7; table of contents. 2004
    ..05). There were no differences in total number of errors (P < or = 0.06). Thus, spatial memory is impaired for 2 wk after general anesthesia in aged rats independent of whether nitrous oxide is used...
  10. pmc The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β
    Xu Wu
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 33:1364-78. 2012
    ..These results suggest that isoflurane may increase the levels of proinflammatory cytokines, which may cause neuroinflammation, leading to promotion of AD neuropathogenesis...
  11. pmc Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice
    Hui Zheng
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Anesthesiology 118:516-26. 2013
    ..The authors set out to assess the effects of the anesthetic sevoflurane on neurotoxicity in pregnant mice and on learning and memory in fetal and offspring mice...
  12. doi request reprint Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory
    Yiying Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA
    Ann Neurol 71:687-98. 2012
    ..However, the in vivo relevance, underlying mechanisms, and functional consequences of these findings remain largely to be determined...
  13. pmc The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions
    Bin Zhang
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Biol Chem 283:11866-75. 2008
    ..Pending in vivo confirmation, these data may have profound implications for anesthesia care in elderly patients, and especially those with AD...
  14. ncbi request reprint The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
    Anesthesiology 104:988-94. 2006
    ....
  15. ncbi request reprint General anesthesia does not reduce life expectancy in aged rats
    Deborah J Culley
    Department of Anesthesia, Division on Aging, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesth Analg 102:956-9. 2006
    ..There was no difference in long-term survival between the control and anesthesia groups. Hence, general anesthesia with 1.2% isoflurane-70% nitrous oxide-30% oxygen does not reduce life expectancy in aged Fischer 344 rats...
  16. ncbi request reprint Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats
    Deborah J Culley
    Department of Anesthesiology Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesth Analg 105:83-8. 2007
    ....
  17. pmc Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults
    Arvind Palanisamy
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 114:521-8. 2011
    ..This study tested the hypothesis that fetal rats exposed to isoflurane during maternal anesthesia on gestational day 14, which corresponds to the second trimester in humans, would be behaviorally abnormal as adults...
  18. ncbi request reprint Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery
    Deborah J Culley
    Harvard Medical School, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesthesiology 106:836-42. 2007
  19. ncbi request reprint Spatial memory performance 2 weeks after general anesthesia in adult rats
    Catherine Crosby
    Department of Physiology, Harvard University, Cambridge, MA, USA
    Anesth Analg 101:1389-92. 2005
    ..005). Hence, in adult rats, previous general anesthesia is not associated with impaired learning 2 wk later. In fact, previous 1.2% isoflurane-70% nitrous oxide improves maze performance 2 wk later...
  20. doi request reprint Academic productivity of directors of ACGME-accredited residency programs in surgery and anesthesiology
    Deborah J Culley
    From the Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California and Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts
    Anesth Analg 118:200-5. 2014
    ....
  21. ncbi request reprint General anesthetic-induced neurotoxicity: an emerging problem for the young and old?
    Deborah J Culley
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Curr Opin Anaesthesiol 20:408-13. 2007
    ..We review this evidence and put the studies into perspective for the practicing clinician...
  22. ncbi request reprint Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesthesiology 100:309-14. 2004
    ..This experiment was designed to test the hypothesis that learning of new information is particularly susceptible to prolonged disruption after general anesthesia...
  23. ncbi request reprint Hemorrhagic stroke after spinal anesthesia and minor surgery
    Thuc Tran
    Department of Anaesthesia, Harvard Medical School, Boston, MA, USA
    J Clin Anesth 16:293-5. 2004
    ..Possible roles of preexisting migrainous headaches and perioperative ephedrine are discussed, but, as in most cases of perioperative stroke, the possibilities are numerous and the cause of the stroke difficult to determine...
  24. ncbi request reprint The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, Massachusetts 02129 2060, USA
    J Neurosci 27:1247-54. 2007
    ..Accumulation of aggregated Abeta in the media can then promote apoptosis. The result is a vicious cycle of isoflurane-induced apoptosis, Abeta generation and aggregation, and additional rounds of apoptosis, leading to cell death...
  25. ncbi request reprint Nitrous oxide in neuroanesthesia: tried and true or toxin?
    Deborah J Culley
    Anesthesiology 108:553-4. 2008
  26. pmc Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine
    Guohua Zhang
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Neurosci 28:4551-60. 2008
    ....
  27. ncbi request reprint Mechanisms of postoperative neurobehavioral deficits and stroke may differ
    Deborah J Culley
    Anesth Analg 97:601; author reply 601. 2003
  28. ncbi request reprint Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 4404, USA
    J Gerontol A Biol Sci Med Sci 61:1300-6. 2006
    ....

Research Grants2

  1. Cellular Mechanisms of General Anesthetic Mediated Neurotoxicity
    Deborah Culley; Fiscal Year: 2007
    ..Accordingly, this research has implications for understanding anesthetic-related neurotoxicity and behavioral impairments in the young as well as the old. ..