C P Crum

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Contemporary theories of cervical carcinogenesis: the virus, the host, and the stem cell
    C P Crum
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mod Pathol 13:243-51. 2000
  2. ncbi request reprint Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63
    G L Mutter
    Division of Women's and Perinatal Pathology, Boston, Massachusetts 02115, USA
    Gynecol Oncol 80:30-6. 2001
  3. pmc Patterns of allelic loss (LOH) in vulvar squamous carcinomas and adjacent noninvasive epithelia
    M C Lin
    Division of Women s and Perinatal Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 152:1313-8. 1998
  4. ncbi request reprint Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis
    J T Keating
    Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Adv Anat Pathol 8:83-92. 2001
  5. ncbi request reprint Expression of the p53 homologue p63 in early cervical neoplasia
    B J Quade
    Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gynecol Oncol 80:24-9. 2001
  6. ncbi request reprint Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2
    D H Castrillon
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 25:1225-30. 2001
  7. ncbi request reprint Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia
    J T Keating
    Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Surg Pathol 25:884-91. 2001
  8. ncbi request reprint Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype
    S Duensing
    Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 61:2356-60. 2001
  9. pmc Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis
    K Levanon
    Department of Medical Oncology, Center of Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Oncogene 29:1103-13. 2010
  10. pmc Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma
    B J Quade
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 154:945-50. 1999

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Contemporary theories of cervical carcinogenesis: the virus, the host, and the stem cell
    C P Crum
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mod Pathol 13:243-51. 2000
    ..New technologies, such as expression arrays, promise to clarify, if not resolve, the complexity of molecular interactions leading to the multiplicity of tumor phenotypes associated with HPV infection of the uterine cervix...
  2. ncbi request reprint Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63
    G L Mutter
    Division of Women's and Perinatal Pathology, Boston, Massachusetts 02115, USA
    Gynecol Oncol 80:30-6. 2001
    ..Whether these cells signify specialized multipotential endometrial cells is not clear, but the similarity of these cells to basal/reserve cells of the cervix and their association with neoplasia merit further study...
  3. pmc Patterns of allelic loss (LOH) in vulvar squamous carcinomas and adjacent noninvasive epithelia
    M C Lin
    Division of Women s and Perinatal Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 152:1313-8. 1998
    ..However, the divergent patterns of LOH observed imply that many genetic alterations in the adjacent vulvar epithelium are not directly related to the invasive carcinoma...
  4. ncbi request reprint Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis
    J T Keating
    Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Adv Anat Pathol 8:83-92. 2001
    ..As new genes are identified and tested, the concept of biomarkers as tools in primary screening and lesion recognition will continue to mature...
  5. ncbi request reprint Expression of the p53 homologue p63 in early cervical neoplasia
    B J Quade
    Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gynecol Oncol 80:24-9. 2001
    ....
  6. ncbi request reprint Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2
    D H Castrillon
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 25:1225-30. 2001
    ..p57KIP2 immunohistochemistry can reliably identify most cases of complete hydatidiform mole irrespective of gestational age and is thus a useful diagnostic adjunct, complementary to ploidy analysis, in the diagnosis of hydatidiform mole...
  7. ncbi request reprint Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia
    J T Keating
    Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Surg Pathol 25:884-91. 2001
    ....
  8. ncbi request reprint Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype
    S Duensing
    Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 61:2356-60. 2001
    ..Our results demonstrate that HPV-16 E7-induced centrosome abnormalities represent an early event during neoplastic progression potentially driving genomic destabilization...
  9. pmc Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis
    K Levanon
    Department of Medical Oncology, Center of Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Oncogene 29:1103-13. 2010
    ..We anticipate that this novel culture system will facilitate the study of SOC pathogenesis, and propose that similar culture systems could be developed for other organ site-specific epithelia...
  10. pmc Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma
    B J Quade
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 154:945-50. 1999
    ..In contrast to other chromosomes studied, LOH on chromosome 10 was frequent in leiomyosarcomas and absent in benign leiomyomas...
  11. doi request reprint Gross abnormalities of the umbilical cord: related placental histology and clinical significance
    P Tantbirojn
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Placenta 30:1083-8. 2009
    ..To evaluate umbilical cord abnormalities predisposing to mechanical cord compression and determine their relationship to adverse clinical outcomes and stasis-associated histologic changes in the placenta...
  12. ncbi request reprint Multimodality therapy in early-stage neuroendocrine carcinoma of the uterine cervix
    D M Boruta
    Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Gynecol Oncol 81:82-7. 2001
    ..01). CONCLUSION: NECC is a highly lethal variant of cervical cancer. The presence of lymph node metastases is the most important prognostic variable. Postoperative VAC or PE appears most likely to improve chances for survival...
  13. ncbi request reprint Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis
    J W Carlson
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Histopathology 51:305-12. 2007
    ..The aims of this study were to (i) determine if a biomarker panel would distinguish small cell carcinomas of the ovary, cervix (SCCCx) and lung (SCCLu) and (ii) potentially determine the histogenesis of SCCOH...