William Francis Crowley

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Drug development and clinical research in the UK
    William Francis Crowley
    Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 369:174-5. 2007
  2. ncbi request reprint Clinical research in the United States at a crossroads: proposal for a novel public-private partnership to establish a national clinical research enterprise
    William F Crowley
    Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    JAMA 291:1120-6. 2004
  3. pmc Oligogenic basis of isolated gonadotropin-releasing hormone deficiency
    Gerasimos P Sykiotis
    Harvard Reproductive Endocrine Sciences Center and the Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:15140-4. 2010
  4. ncbi request reprint Reversal of idiopathic hypogonadotropic hypogonadism
    Taneli Raivio
    Harvard Center for Reproductive Endocrine Sciences and the Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    N Engl J Med 357:863-73. 2007
  5. pmc Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons
    Ravikumar Balasubramanian
    Harvard Reproductive Endocrine Sciences Center of Excellence, Reproductive Endocrine Unit of the Department of Medicine of the Massachusetts General Hospital and Endocrine Division of the Brigham and Women s Hospital, Boston, MA 02114, USA
    Neuroendocrinology 92:81-99. 2010
  6. ncbi request reprint The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit, Department of Medicine, National Center for Infertility Research, Pediatric Surgical Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:152-60. 2002
  7. pmc The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism
    Andrew A Dwyer
    Harvard Reproductive Endocrine Sciences Center and Reproductive Endocrine Unit of Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:4235-43. 2010
  8. doi request reprint Deciphering genetic disease in the genomic era: the model of GnRH deficiency
    Gerasimos P Sykiotis
    Harvard Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 2:32rv2. 2010
  9. pmc Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation
    Nelly Pitteloud
    Harvard Reproductive Endocrine Sciences Center and Reproductive Endocrine Unit of the Department of Medicine, Boston, MA 02114, USA
    Neuroendocrinology 90:260-8. 2009
  10. ncbi request reprint Mass spectrometric and physiological validation of a sensitive, automated, direct immunoassay for serum estradiol using the Architect
    Patrick M Sluss
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Chim Acta 388:99-105. 2008

Research Grants

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Drug development and clinical research in the UK
    William Francis Crowley
    Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 369:174-5. 2007
  2. ncbi request reprint Clinical research in the United States at a crossroads: proposal for a novel public-private partnership to establish a national clinical research enterprise
    William F Crowley
    Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    JAMA 291:1120-6. 2004
    ..All participants in the US health care delivery system must come together to focus on system-wide improvements that will benefit the public...
  3. pmc Oligogenic basis of isolated gonadotropin-releasing hormone deficiency
    Gerasimos P Sykiotis
    Harvard Reproductive Endocrine Sciences Center and the Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:15140-4. 2010
    ....
  4. ncbi request reprint Reversal of idiopathic hypogonadotropic hypogonadism
    Taneli Raivio
    Harvard Center for Reproductive Endocrine Sciences and the Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    N Engl J Med 357:863-73. 2007
    ..Idiopathic hypogonadotropic hypogonadism was previously thought to require lifelong therapy. We describe 15 men in whom reversal of idiopathic hypogonadotropic hypogonadism was sustained after discontinuation of hormonal therapy...
  5. pmc Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons
    Ravikumar Balasubramanian
    Harvard Reproductive Endocrine Sciences Center of Excellence, Reproductive Endocrine Unit of the Department of Medicine of the Massachusetts General Hospital and Endocrine Division of the Brigham and Women s Hospital, Boston, MA 02114, USA
    Neuroendocrinology 92:81-99. 2010
    ..These insights now provide practicing clinicians with targeted genetic diagnostic strategies and also impact on clinical management...
  6. ncbi request reprint The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit, Department of Medicine, National Center for Infertility Research, Pediatric Surgical Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:152-60. 2002
    ..Viewing IHH in the full context of its developmental, genetic, and biochemical complexity permits greatest insight into its phenotypic variability...
  7. pmc The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism
    Andrew A Dwyer
    Harvard Reproductive Endocrine Sciences Center and Reproductive Endocrine Unit of Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:4235-43. 2010
    ..This study aims to examine the etiology and long-term natural history of this disorder...
  8. doi request reprint Deciphering genetic disease in the genomic era: the model of GnRH deficiency
    Gerasimos P Sykiotis
    Harvard Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 2:32rv2. 2010
    ....
  9. pmc Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation
    Nelly Pitteloud
    Harvard Reproductive Endocrine Sciences Center and Reproductive Endocrine Unit of the Department of Medicine, Boston, MA 02114, USA
    Neuroendocrinology 90:260-8. 2009
    ..This study aimed to elucidate this phenomenon using a human disease model of GnRH deficiency (idiopathic hypogonadotropic hypogonadism, IHH) in which GnRH input can be experimentally controlled...
  10. ncbi request reprint Mass spectrometric and physiological validation of a sensitive, automated, direct immunoassay for serum estradiol using the Architect
    Patrick M Sluss
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Chim Acta 388:99-105. 2008
    ..The challenge for all currently available direct methods for measuring E(2) is to provide accuracy and precision across a wide dynamic range...
  11. ncbi request reprint Hypogonadotropic hypogonadism and cerebellar ataxia: detailed phenotypic characterization of a large, extended kindred
    Stephanie B Seminara
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:1607-12. 2002
    ..This unique family suggests that a common genetic mechanism is responsible for the syndrome of progressive hypogonadotropism and cerebellar ataxia...
  12. ncbi request reprint Genetic approaches to unraveling reproductive disorders: examples of bedside to bench research in the genomic era
    Stephanie B Seminara
    Reproductive Endocrine Unit and Harvard Wide Reproductive Endocrine Sciences Center and National Center for Infertility Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocr Rev 23:382-92. 2002
    ..The themes of rare and novel phenotypes, genetically homogenous populations, and genotype/phenotype correlations are emphasized...
  13. ncbi request reprint Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54
    J Carl Pallais
    Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, United States
    Mol Cell Endocrinol 254:70-7. 2006
    ..Taken together, these observations help to tease apart the neuroendocrine and gonadal phenotypes of patients bearing mutations in GPR54...
  14. pmc Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine and Harvard Reproductive Endocrine Science Centers, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:6281-6. 2006
    ..These mutations also account for some of the mixed pedigrees, thus challenging the current idea that KS and nIHH are distinct entities...
  15. ncbi request reprint The GPR54 gene as a regulator of puberty
    Stephanie B Seminara
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 349:1614-27. 2003
    ..We conducted studies in humans and mice to identify the genetic factors that determine the onset of puberty...
  16. ncbi request reprint Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome
    Judith M Adams
    Reproductive Endocrine Unit, BHX 5, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:4343-50. 2004
    ....
  17. ncbi request reprint GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone
    Astrid U Meysing
    Reproductive Endocrine Unit, Bartlett Hall Extension 5, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3189-98. 2004
    ....
  18. pmc The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men
    Nelly Pitteloud
    Reproductive Endocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 93:2686-92. 2008
    ..Our objective was to determine the importance of testosterone (T), estradiol (E(2)), and GnRH pulse frequency to FSH regulation in men...
  19. pmc Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men
    Nelly Pitteloud
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:784-91. 2008
    ..Studies on the regulation of LH secretion by sex steroids in men are conflicting...
  20. pmc Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes
    Gerasimos P Sykiotis
    Harvard Reproductive Endocrine Sciences Center and the Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:3019-27. 2010
    ..Interestingly, several IHH-associated genes are expressed in multiple compartments of the hypothalamic-pituitary-gonadal axis...
  21. pmc Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Department of Medicine and Harvard Reproductive Endocrine Science Centers, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:17447-52. 2007
    ..Homozygous loss-of-function PROK2 mutations cause both KS and nIHH...
  22. ncbi request reprint Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes
    Nelly Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine and National Center for Infertility Research, Bartlett Hall Extension 5, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, United States
    Mol Cell Endocrinol 254:60-9. 2006
    ....
  23. ncbi request reprint A locus for autosomal recessive idiopathic hypogonadotropic hypogonadism on chromosome 19p13.3
    James S Acierno
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:2947-50. 2003
    ..3 was established with a maximal two point LOD score of 5.17. Because numerous genes and hypothetical proteins are mapped to this region, further studies will be necessary to determine the precise genetic defect in this family...
  24. pmc Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum
    Lindsay W Cole
    Reproductive Endocrine Unit of the Department of Medicine, Harvard Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3551-9. 2008
    ..Mice deficient in prokineticin 2(PROK2) and prokineticin receptor2 (PROKR2) exhibit variable olfactory bulb dysgenesis and GnRH neuronal migration defects reminiscent of human GnRH deficiency...
  25. ncbi request reprint Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine, National Center for Infertility Research, General Clinical Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:4128-36. 2002
    ....
  26. ncbi request reprint Interplay between dose and frequency of GnRH administration in determining pituitary gonadotropin responsiveness
    Virginia A Hughes
    Harvard Reproductive Endocrine Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Mass 02114 USA
    Neuroendocrinology 87:142-50. 2008
    ..The dynamic interaction between these variables during physiological and pathophysiological states has yet to be examined...
  27. pmc Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function
    Paul A Boepple
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 93:1809-14. 2008
    ..Our aim was to explore the relative roles of gonadal sex steroids and inhibin B in the regulation of FSH across a spectrum of seminiferous epithelium function...
  28. ncbi request reprint Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene
    Nelly Pitteloud
    Reproductive Endocrine Unit and National Center for Infertility Research, Bartlett Hall Extension 5, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:1317-22. 2005
    ....
  29. ncbi request reprint Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta)
    Suresh Ramaswamy
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, and Harvard Reproductive Endocrine Sciences Center, Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    Endocrinology 148:3364-70. 2007
    ..These findings support the notion that GPR54 is desensitized by continuous exposure to ligand, and they raise the possibility of an intratesticular role of GPR54...
  30. ncbi request reprint An instrument for determining the amount of NIH support for clinical investigations at one academic health center
    Ann E Taylor
    Harvard Medical School, Clinical Research Support Office, Clinical Research Program, Massachusetts General Hospital, MA 02114, USA
    Acad Med 77:824-30. 2002
    ..The authors report on an instrument to quantify the National Institutes of Health (NIH)-funded component of clinical research at one institution...
  31. ncbi request reprint Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications
    Stephanie B Seminara
    Reproductive Endocrinology Unit, Massachusetts General Hospital, Boston, 02114, USA
    Endocrinology 147:2122-6. 2006
    ..e. precocious puberty, endometriosis, uterine fibroids, and prostate cancer)...
  32. pmc TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood
    Elena Gianetti
    Harvard Center for Reproductive Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:2857-67. 2010
    ....
  33. ncbi request reprint Acute stress masking the biochemical phenotype of partial androgen insensitivity syndrome in a patient with a novel mutation in the androgen receptor
    Nelly Pitteloud
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:1053-8. 2004
    ..This case highlights the necessity for caution when interpreting gonadotropin levels during acute stress...
  34. pmc New genes controlling human reproduction and how you find them
    William F Crowley
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Trans Am Clin Climatol Assoc 119:29-37; discussion 37-8. 2008
    ..This paper discusses several of the more important discoveries in this rapidly evolving field and puts them into a developmental and physiologic context...
  35. pmc GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:11703-8. 2009
    ..Our results establish mutations in GNRH1 as a genetic cause of nIHH...
  36. doi request reprint Changing models of biomedical research
    William F Crowley
    Harvard Reproductive Endocrine Sciences Center, Department of Medicine, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Sci Transl Med 1:1cm1. 2009
    ....

Research Grants33

  1. LHRH PHYSIOLOGY IN MAN: IN VIVO AND IN VITRO APPROACHES
    William Crowley; Fiscal Year: 2000
    ....
  2. NATIONAL CENTER FOR INFERTILITY RESEARCH AT MGH
    William Crowley; Fiscal Year: 2006
    ....
  3. THE NEUROENDOCRINE CONTROL OF REPRODUCTION IN THE HUMAN
    William Crowley; Fiscal Year: 2006
    ..They also lay the groundwork that provides a context for the exploration of new tools to gain further insights into the complexities of reproductive dysfunction in the male. ..
  4. TRAINING PROGRAM IN REPRODUCTIVE & DEVELOPMENTAL BIOLOGY
    William Crowley; Fiscal Year: 2007
    ..This institutional training grant represents a critical stabilizing element in these programs and is a critical link that enables talented trainees to achieve subsequent independent careers in Reproduction and Developmental Biology. ..
  5. LHRH PHYSIOLOGY IN MAN: IN VIVO AND IN VITRO APPROACHES
    William Crowley; Fiscal Year: 1991
    ..Such information is a critical step for the understanding and definition of abnormalities of the male reproductive system...
  6. LHRH PHYSIOLOGY IN MAN: IN VIVO AND IN VITRO APPROACHES
    William Crowley; Fiscal Year: 1993
    ....
  7. THE NEUROENDOCRINE CONTROL OF REPRODUCTION IN THE HUMAN
    William Francis Crowley; Fiscal Year: 2010
    ..We will use the complementary tools of clinical research in humans, targeted gene deletions in mice, biochemistry, and molecular biology to fully elucidate the biology of this system in the human. ..