David G Cox

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study
    David G Cox
    Program in Genetic and Molecular Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R3. 2007
  2. pmc Breast cancer susceptibility loci and mammographic density
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Breast Cancer Res 10:R66. 2008
  3. pmc T.I.M.S: TaqMan Information Management System, tools to organize data flow in a genotyping laboratory
    Stephanie Monnier
    International Agency for Research on Cancer, F 69372, Lyon, France
    BMC Bioinformatics 6:246. 2005
  4. pmc TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, USA
    BMC Cancer 7:175. 2007
  5. ncbi The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 18:621-5. 2007
  6. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
  7. pmc Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    BMC Cancer 6:217. 2006
  8. ncbi Quantification of the power of Hardy-Weinberg equilibrium testing to detect genotyping error
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Hered 61:10-4. 2006
  9. ncbi Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States)
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 17:81-3. 2006
  10. ncbi The erbB2/HER2/neu receptor polymorphism Ile655Val and breast cancer risk
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Pharmacogenet Genomics 15:447-50. 2005

Detail Information

Publications41

  1. pmc A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study
    David G Cox
    Program in Genetic and Molecular Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R3. 2007
    ..Polymorphisms in the PTGS2 gene have been associated with various diseases, including inflammatory bowel disease and cancer of the lung, colorectum, and breast...
  2. pmc Breast cancer susceptibility loci and mammographic density
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Breast Cancer Res 10:R66. 2008
    ....
  3. pmc T.I.M.S: TaqMan Information Management System, tools to organize data flow in a genotyping laboratory
    Stephanie Monnier
    International Agency for Research on Cancer, F 69372, Lyon, France
    BMC Bioinformatics 6:246. 2005
    ..It produces large amounts of data that are difficult to process by hand. Laboratories not equipped with a Laboratory Information Management System (LIMS) need tools to organize the data flow...
  4. pmc TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, USA
    BMC Cancer 7:175. 2007
    ..Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results...
  5. ncbi The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 18:621-5. 2007
    ..Neither SNP is independently associated with overall breast cancer risk. Some indication of gene-by-gene interaction was observed; however, no consistent direction of interaction was apparent...
  6. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
    ..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...
  7. pmc Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    BMC Cancer 6:217. 2006
    ..We investigated whether variants at both polymorphisms, while not independently associated with breast cancer risk, could influence breast cancer risk when considered together...
  8. ncbi Quantification of the power of Hardy-Weinberg equilibrium testing to detect genotyping error
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Hered 61:10-4. 2006
    ..While these methods are fairly reliable, they are also costly and time consuming...
  9. ncbi Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States)
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 17:81-3. 2006
    ..29, 95% CI 1.08-1.53, p-heterogeneity = 0.29). These results confirm prior findings that AURKA represents a low penetrance breast cancer susceptibility gene...
  10. ncbi The erbB2/HER2/neu receptor polymorphism Ile655Val and breast cancer risk
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Pharmacogenet Genomics 15:447-50. 2005
    ..68, 95% confidence interval 0.47-0.98). We conclude that this polymorphism is not associated with an increase in breast cancer risk, and may in fact be associated with a modest decrease in risk...
  11. ncbi Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:178-9. 2006
  12. ncbi No association between BRCA2 N372H and breast cancer risk
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:1353-4. 2005
  13. pmc AACR Special Conference: SNPs, haplotypes, and cancer - applications in molecular epidemiology, Key Biscayne, Florida, USA, 13-17 September 2003
    David G Cox
    Department of Epidemiology and Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Breast Cancer Res 6:E9. 2004
    ..Questions were also posed as to determining the functional relevance of single nucleotide polymorphisms in molecular epidemiology. Finally, future directions, using specific examples, were addressed...
  14. ncbi No association between GPX1 Pro198Leu and breast cancer risk
    David G Cox
    Epidemiology Department, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1821-2. 2004
  15. pmc Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Breast Cancer Res 7:R171-5. 2005
    ..Truncation mutations in the BRCA1 gene cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population and account for little of the overall incidence of sporadic breast cancer...
  16. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  17. pmc Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Breast Cancer Res Treat 115:613-22. 2009
    ..We comprehensively evaluated genetic variants in DNA repair genes with premenopausal breast cancer risk...
  18. pmc Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma
    Danielle M Backes
    Department of Epidemiology, Brown Public Health, Brown University, Providence, RI 02912, USA
    J Neurooncol 113:229-38. 2013
    ..However, our analyses were not corrected for multiple comparisons and need to be interpreted with caution. Our findings with FCER1A SNPs provide further support for the link between allergies and risk of glioma...
  19. ncbi A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  20. ncbi Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 28:261-72. 2005
    ..An application to progesterone-receptor haplotypes and endometrial cancer further illustrates that the performance of all these methods depends on how well the observed haplotypes "tag" the unobserved causal variant...
  21. pmc Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium
    Mia M Gaudet
    Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Epidemiol Biomarkers Prev 18:1610-6. 2009
    ....
  22. doi Large-scale evaluation of genetic variants in candidate genes for colorectal cancer risk in the Nurses' Health Study and the Health Professionals' Follow-up Study
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:311-9. 2008
    ..00003). The SNP500Cancer database and the Illumina GoldenGate Assay allowed us to test a larger number of SNPs than previously possible. We identified several SNPs worthy of investigation in larger studies...
  23. pmc Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R18. 2007
    ....
  24. ncbi The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US Caucasian women
    Jiali Han
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Carcinog 45:694-700. 2006
    ..This study suggests that the Arg72Pro polymorphism may play a role in skin carcinogenesis...
  25. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci...
  26. pmc The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk
    Annamaria Pezzotti
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5356. 2009
    ....
  27. pmc Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women
    Jennifer Prescott
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e37815. 2012
    ..Our results suggest that the small magnitude of difference in hormone levels associated with common genetic variants is likely insufficient to detectably contribute to breast cancer risk...
  28. ncbi Renin-angiotensin system polymorphisms and risk of hypertension: influence of environmental factors
    John P Forman
    Renal Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Clin Hypertens (Greenwich) 10:459-66. 2008
    ..These data suggest that demographic and dietary factors may influence the associations between RAS polymorphisms and hypertension and could explain heterogeneity in prior studies...
  29. doi Study designs for genome-wide association studies
    Peter Kraft
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Adv Genet 60:465-504. 2008
    ..We close with a discussion of the limitations of multistage designs...
  30. pmc Mannose-binding lectin 2 gene and risk of adult glioma
    Dominique S Michaud
    Department of Epidemiology, Brown Public Health, Brown University, Providence, Rhode Island, USA
    PLoS ONE 8:e61117. 2013
    ..The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated with risk of several cancers...
  31. pmc Polymorphisms in xenobiotic metabolizing genes, intakes of heterocyclic amines and red meat, and postmenopausal breast cancer
    Hae Jeung Lee
    a Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nutr Cancer 65:1122-31. 2013
    ..These results do not support the hypothesis that genetic polymorphisms of xenobiotic enzymes involved in the metabolism of HCAs may modify the associations between intakes of red meat or meat-related mutagens and breast cancer risk. ..
  32. pmc A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation
    Andrea D Coviello
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002805. 2012
    ..The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance...
  33. ncbi The XRCC1 -77T->C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage
    Reto Brem
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Carcinogenesis 27:2469-74. 2006
    ..These results suggest that the -77T-->C genotype or another variant in linkage disequilibrium influences the cellular response to DNA damage, although the underlying molecular mechanisms remain to be established...
  34. ncbi Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    ..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer...
  35. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  36. ncbi ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity
    Sandra Angèle
    DNA Repair Group, International Agency for Research on Cancer, Lyon Cedex, France
    Cancer Res 63:8717-25. 2003
    ..75; 95% CI, 1.09-2.81) and that ATM variants may impact on radiation sensitivity...
  37. ncbi Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy
    Norman Moullan
    DNA Repair Group, International Agency for Research on Cancer IARC, Lyon, Cedex, France
    Cancer Epidemiol Biomarkers Prev 12:1168-74. 2003
    ..33; 95% CI, 1.24-15.12). Distinct combinations of XRCC1 polymorphisms appear to be associated with either an increased BC risk or the possibility of developing an adverse radiotherapy response seen in some BC patients...
  38. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  39. ncbi Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies
    Heather Spencer Feigelson
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, Georgia 30329, USA
    Cancer Res 66:2468-75. 2006
    ..Although the probability that these ER-negative findings are false-positive results is high, these findings were consistent across each cohort examined and warrant further study...
  40. ncbi CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Veronica Wendy Setiawan
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007
    ..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility...
  41. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...

Research Grants3

  1. Genome Wide Association Study: Variants Influencing Steroid Hormone Levels
    David Cox; Fiscal Year: 2007
    ....
  2. Mitochondrial Haplogroups and Breast Cancer Risk
    David Cox; Fiscal Year: 2007
    ..Further understanding of the importance of inherited mitochondrial variation on breast cancer risk will aid future research in screening and treatment to lower the burden of breast cancer, making it very relevant to public health. ..