Madalena D Costa

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Multiscale analysis of heart rate dynamics: entropy and time irreversibility measures
    Madalena D Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Avenue, GZ 431, Boston, MA 02215, USA
    Cardiovasc Eng 8:88-93. 2008
  2. pmc Decreased neuroautonomic complexity in men during an acute major depressive episode: analysis of heart rate dynamics
    S J J Leistedt
    Sleep Laboratory, Psychiatric Laboratory Research, Psychiatric Department, Erasme Academic Hospital, Free University of Brussels ULB, Brussels, Belgium
    Transl Psychiatry 1:e27. 2011
  3. pmc Complexity-loss in fetal heart rate dynamics during labor as a potential biomarker of acidemia
    Madalena D Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA Electronic address
    Early Hum Dev 90:67-71. 2014
  4. pmc Complex dynamics of human red blood cell flickering: alterations with in vivo aging
    Madalena Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:020901. 2008
  5. pmc Use of a tracing task to assess visuomotor performance: effects of age, sex, and handedness
    Leia A Stirling
    Wyss Institute for Biologically Inspired Engineering at Harvard University, Center for Life Science, 3 Blackfan Circle, 2nd Floor, Boston, MA 02180, USA
    J Gerontol A Biol Sci Med Sci 68:938-45. 2013
  6. pmc Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals
    Andrew S P Lim
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Sleep 35:633-40B. 2012
  7. pmc Development of a new approach to quantifying stepping stability using ensemble empirical mode decomposition
    Xingran Cui
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Electronic address
    Gait Posture 39:495-500. 2014
  8. pmc Physiological complexity and system adaptability: evidence from postural control dynamics of older adults
    Brad Manor
    Division of Gerontology, Beth Israel Deaconess Medical Center, 110 Francis St Suite 1B, Boston, MA 02215, USA
    J Appl Physiol (1985) 109:1786-91. 2010
  9. pmc Dynamical density delay maps: simple, new method for visualising the behaviour of complex systems
    Anton Burykin
    Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
    BMC Med Inform Decis Mak 14:6. 2014
  10. pmc Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis
    Andrew S P Lim
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 34:1569-81. 2011

Detail Information

Publications13

  1. doi request reprint Multiscale analysis of heart rate dynamics: entropy and time irreversibility measures
    Madalena D Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Avenue, GZ 431, Boston, MA 02215, USA
    Cardiovasc Eng 8:88-93. 2008
    ..These new methods, with careful attention to their limitations, may be useful in diagnostics, risk stratification and detection of toxicity of cardiac drugs...
  2. pmc Decreased neuroautonomic complexity in men during an acute major depressive episode: analysis of heart rate dynamics
    S J J Leistedt
    Sleep Laboratory, Psychiatric Laboratory Research, Psychiatric Department, Erasme Academic Hospital, Free University of Brussels ULB, Brussels, Belgium
    Transl Psychiatry 1:e27. 2011
    ..02) and combined sleep stages 1 and 2 (P<0.02). These findings raise the possibility of using the complexity of physiologic signals as the basis of novel dynamical biomarkers of depression...
  3. pmc Complexity-loss in fetal heart rate dynamics during labor as a potential biomarker of acidemia
    Madalena D Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA Electronic address
    Early Hum Dev 90:67-71. 2014
    ..Continuous fetal heart rate (FHR) monitoring remains central to intrapartum care. However, advances in signal analysis are needed to increase its accuracy in diagnosis of fetal hypoxia...
  4. pmc Complex dynamics of human red blood cell flickering: alterations with in vivo aging
    Madalena Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:020901. 2008
    ..Quantitative assessment of multiscale flickering may provide a way of measuring RBC functionality. Membrane models need to account for the complex properties of these motions and their changes with in vivo senescence...
  5. pmc Use of a tracing task to assess visuomotor performance: effects of age, sex, and handedness
    Leia A Stirling
    Wyss Institute for Biologically Inspired Engineering at Harvard University, Center for Life Science, 3 Blackfan Circle, 2nd Floor, Boston, MA 02180, USA
    J Gerontol A Biol Sci Med Sci 68:938-45. 2013
    ..Participants also performed the Trail Making Test (a measure of executive function)...
  6. pmc Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals
    Andrew S P Lim
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Sleep 35:633-40B. 2012
    ....
  7. pmc Development of a new approach to quantifying stepping stability using ensemble empirical mode decomposition
    Xingran Cui
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Electronic address
    Gait Posture 39:495-500. 2014
    ..27 to 0.73, p<0.05). These initial findings suggest that the SSI, an index based on the ensemble empirical mode decomposition, may be helpful for quantifying gait stability and fall risk during the challenges of everyday walking...
  8. pmc Physiological complexity and system adaptability: evidence from postural control dynamics of older adults
    Brad Manor
    Division of Gerontology, Beth Israel Deaconess Medical Center, 110 Francis St Suite 1B, Boston, MA 02215, USA
    J Appl Physiol (1985) 109:1786-91. 2010
    ..Relatively low baseline complexity may, therefore, indicate control systems that are more vulnerable to cognitive and other stressors...
  9. pmc Dynamical density delay maps: simple, new method for visualising the behaviour of complex systems
    Anton Burykin
    Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
    BMC Med Inform Decis Mak 14:6. 2014
    ..However, capturing important dynamical properties, including nonstationarities may not be feasible from conventional time series graphical representations...
  10. pmc Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis
    Andrew S P Lim
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 34:1569-81. 2011
    ..We then applied this to the study of the temporal dynamics of rest-activity patterns in older individuals...
  11. pmc Frailty and the degradation of complex balance dynamics during a dual-task protocol
    Hyun Gu Kang
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 64:1304-11. 2009
    ....
  12. ncbi request reprint Multiscale entropy analysis of biological signals
    Madalena Costa
    Margret and H A Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 71:021906. 2005
    ....
  13. ncbi request reprint Multiscale entropy analysis of complex physiologic time series
    Madalena Costa
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev Lett 89:068102. 2002
    ..We find that MSE robustly separates healthy and pathologic groups and consistently yields higher values for simulated long-range correlated noise compared to uncorrelated noise...