Marilyn C Cornelis

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
    Genet Epidemiol 34:364-72. 2010
  2. pmc Genome-wide association scan of dental caries in the permanent dentition
    Xiaojing Wang
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA
    BMC Oral Health 12:57. 2012
  3. pmc Gene-environment interactions in genome-wide association studies: a comparative study of tests applied to empirical studies of type 2 diabetes
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 175:191-202. 2012
  4. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
  5. pmc Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 19:1846-55. 2010
  6. pmc Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:327-32. 2010
  7. pmc Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Mol Genet 19:1856-62. 2010
  8. pmc Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 89:1453-8. 2009
  9. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
  10. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011

Detail Information

Publications25

  1. pmc The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
    Genet Epidemiol 34:364-72. 2010
    ..By maximizing knowledge obtained through collaborative GWAS incorporating environmental exposure information, GENEVA aims to enhance our understanding of disease etiology, potentially identifying opportunities for intervention...
  2. pmc Genome-wide association scan of dental caries in the permanent dentition
    Xiaojing Wang
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA
    BMC Oral Health 12:57. 2012
    ..Therefore, we conducted the first genome-wide association study (GWAS) to identify genes affecting susceptibility to caries in adults...
  3. pmc Gene-environment interactions in genome-wide association studies: a comparative study of tests applied to empirical studies of type 2 diabetes
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 175:191-202. 2012
    ..Study findings suggest that methods exploiting G-E independence can be efficient and valid options for investigating G-E interactions in GWAS...
  4. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  5. pmc Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 19:1846-55. 2010
    ..These data provide novel evidence revealing the role of polymorphisms in LEPR in modulating plasma levels of sOB-R and may further our understanding of the complex relationships among leptin, leptin receptor and diabetes-related traits...
  6. pmc Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:327-32. 2010
    ..To investigate the associations between obesity-predisposing genetic variants, cardiovascular biomarkers, and cardiovascular disease (CVD) risk in women with preexisting type 2 diabetes mellitus...
  7. pmc Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Mol Genet 19:1856-62. 2010
    ..Our findings indicate that the genetic variants at ABO locus affect plasma sE-selectin levels and diabetes risk. The genetic associations with diabetes risk were independent of sE-selectin levels...
  8. pmc Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 89:1453-8. 2009
    ..A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D). No study has tested this hypothesis...
  9. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
    ..We sought to identify the common genetic variants associated with IL-18 levels...
  10. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
    ..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2...
  11. pmc Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus
    Danielle M Greenawalt
    Department of Genetics, Merck Research Laboratories, Pasteur, Boston, MA 02115, USA
    Am J Epidemiol 176:423-30. 2012
    ....
  12. pmc Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, and Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 19:2706-15. 2010
    ..05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance...
  13. pmc Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA Channing Division of Network Medicine Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 22:E135-41. 2014
    ..The relationship between a genetic susceptibility to obesity and cognitive restraint, uncontrolled and emotional eating was examined...
  14. doi request reprint Beyond odds ratios--communicating disease risk based on genetic profiles
    Peter Kraft
    Harvard School of Public Health, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Genet 10:264-9. 2009
    ..We argue that other measures--such as sensitivity, specificity, and positive and negative predictive values--are more useful when proposing a genetic profile for risk prediction...
  15. pmc Exploring the genetic architecture of circulating 25-hydroxyvitamin D
    Linda T Hiraki
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Genet Epidemiol 37:92-8. 2013
    ..The absence of a significant polygenic effect in this relatively large sample suggests an oligogenetic architecture for 25(OH)D...
  16. pmc Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex diseases
    Hugues Aschard
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 90:962-72. 2012
    ..We show that the inclusion of G-G and G-E interaction effects in risk-prediction models is unlikely to dramatically improve the discrimination ability of these models...
  17. pmc Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the U.S
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 62:49-55. 2013
    ..69 (1.39-2.05) (P for heterogeneity = 0.45). These findings suggest that plasma fetuin-A levels were independently associated with higher risk of developing type 2 diabetes...
  18. pmc TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 89:1256-62. 2009
    ..Dietary factors that increase the insulin demand might enhance the risk of T2D associated with TCF7L2 variants...
  19. pmc Association of Urinary Concentrations of Bisphenol A and Phthalate Metabolites with Risk of Type 2 Diabetes: A Prospective Investigation in the Nurses' Health Study (NHS) and NHSII Cohorts
    Qi Sun
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Environ Health Perspect 122:616-23. 2014
    ..Environ Health Perspect 122:616-623; http://dx.doi.org/10.1289/ehp.1307201. ..
  20. pmc Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts
    Shun Chiao Chang
    Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, MA, United States Electronic address
    Psychoneuroendocrinology 39:257-68. 2014
    ..Further work considering genetic pathways in relation to social integration may be more fruitful if these additional factors can be more comprehensively evaluated. ..
  21. doi request reprint Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challenges
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts 02115, USA
    Annu Rev Nutr 32:245-59. 2012
    ..Nonetheless, continued investment in gene-environment interaction studies through large collaborative efforts holds promise in furthering our understanding of the interplay between genetic and environmental factors...
  22. pmc Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hum Mol Genet 21:5329-43. 2012
    ..The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general...
  23. pmc Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the Nurses' Health Study
    Mengmeng Du
    Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, United States of America
    PLoS ONE 8:e52240. 2013
    ..We therefore examined whether genetic predisposition to higher BMI or T2D was associated with shortened leukocyte telomere length (LTL)...
  24. doi request reprint Coffee intake
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Prog Mol Biol Transl Sci 108:293-322. 2012
    ..This chapter focuses on those factors that are genetically determined and briefly summarizes progress in applying this knowledge to epidemiological studies of coffee and disease...
  25. pmc Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Curr Psychiatry Rep 12:313-26. 2010
    ..Genome-wide association studies offer the best opportunity to identify novel "true" risk variants for the disorder that in turn has the potential to inform our understanding of PTSD etiology...