Nancy Cook

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial
    Nancy R Cook
    Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Ann Intern Med 159:77-85. 2013
  2. pmc Clinical utility of lipoprotein-associated phospholipase A₂ for cardiovascular disease prediction in a multiethnic cohort of women
    Nancy R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 58:1352-63. 2012
  3. pmc Aspirin in the primary prevention of cardiovascular disease in the Women's Health Study: effect of noncompliance
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur J Epidemiol 27:431-8. 2012
  4. pmc Comparison of the Framingham and Reynolds Risk scores for global cardiovascular risk prediction in the multiethnic Women's Health Initiative
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circulation 125:1748-56, S1-11. 2012
  5. pmc Joint effects of sodium and potassium intake on subsequent cardiovascular disease: the Trials of Hypertension Prevention follow-up study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
    Arch Intern Med 169:32-40. 2009
  6. ncbi request reprint Tree and spline based association analysis of gene-gene interaction models for ischemic stroke
    Nancy R Cook
    Center for Cardiovascular Disease Prevention and the Leducq Center for Molecular and Genetic Epidemiology, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stat Med 23:1439-53. 2004
  7. ncbi request reprint Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:47-55. 2005
  8. ncbi request reprint Dose-response of sodium excretion and blood pressure change among overweight, nonhypertensive adults in a 3-year dietary intervention study
    N R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    J Hum Hypertens 19:47-54. 2005
  9. ncbi request reprint Using the area under the curve to reduce measurement error in predicting young adult blood pressure from childhood measures
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Stat Med 23:3421-35. 2004
  10. ncbi request reprint Use and misuse of the receiver operating characteristic curve in risk prediction
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circulation 115:928-35. 2007

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. pmc Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial
    Nancy R Cook
    Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Ann Intern Med 159:77-85. 2013
    ..Recent evidence suggests that daily aspirin use decreases cancer risk, particularly for colorectal cancer, but evidence for alternate-day use is scant...
  2. pmc Clinical utility of lipoprotein-associated phospholipase A₂ for cardiovascular disease prediction in a multiethnic cohort of women
    Nancy R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 58:1352-63. 2012
    ..Findings regarding the association of lipoprotein-associated phospholipase A₂ (Lp-PLA2) activity and mass with incident cardiovascular disease (CVD) have been inconsistent, and their role in risk prediction is uncertain...
  3. pmc Aspirin in the primary prevention of cardiovascular disease in the Women's Health Study: effect of noncompliance
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur J Epidemiol 27:431-8. 2012
    ..These results support a limited effect of low-dose aspirin on total CVD in women, but potential benefit for CVD mortality...
  4. pmc Comparison of the Framingham and Reynolds Risk scores for global cardiovascular risk prediction in the multiethnic Women's Health Initiative
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circulation 125:1748-56, S1-11. 2012
    ..Framingham-based and Reynolds Risk scores for cardiovascular disease (CVD) prediction have not been directly compared in an independent validation cohort...
  5. pmc Joint effects of sodium and potassium intake on subsequent cardiovascular disease: the Trials of Hypertension Prevention follow-up study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
    Arch Intern Med 169:32-40. 2009
    ..Previous studies of dose-response effects of usual sodium and potassium intake on subsequent cardiovascular disease (CVD) have largely relied on suboptimal measures of intake...
  6. ncbi request reprint Tree and spline based association analysis of gene-gene interaction models for ischemic stroke
    Nancy R Cook
    Center for Cardiovascular Disease Prevention and the Leducq Center for Molecular and Genetic Epidemiology, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stat Med 23:1439-53. 2004
    ..Although further external validation of these models is necessary, these methods may be valuable in exploring and identifying potential gene-gene as well as gene-environment interactions in association studies...
  7. ncbi request reprint Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:47-55. 2005
    ..Basic research and observational evidence as well as results from trials of colon polyp recurrence suggest a role for aspirin in the chemoprevention of cancer...
  8. ncbi request reprint Dose-response of sodium excretion and blood pressure change among overweight, nonhypertensive adults in a 3-year dietary intervention study
    N R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    J Hum Hypertens 19:47-54. 2005
    ..DBP changes were smaller and nonsignificant at 36 months. In conclusion, incremental decreases in BP with lower sodium excretion were observed in these overweight nonhypertensive individuals...
  9. ncbi request reprint Using the area under the curve to reduce measurement error in predicting young adult blood pressure from childhood measures
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Stat Med 23:3421-35. 2004
    ....
  10. ncbi request reprint Use and misuse of the receiver operating characteristic curve in risk prediction
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circulation 115:928-35. 2007
    ..As novel risk factors are discovered, sole reliance on the c statistic to evaluate their utility as risk predictors thus seems ill-advised...
  11. pmc A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Intern Med 167:1610-8. 2007
    ..Few trials have examined interactions among antioxidants, and, to our knowledge, no previous trial has examined the individual effect of ascorbic acid (vitamin C) on CVD...
  12. ncbi request reprint Comments on 'Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond' by M. J. Pencina et al., Statistics in Medicine (DOI: 10.1002/sim.2929)
    Nancy R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stat Med 27:191-5. 2008
  13. ncbi request reprint The effect of including C-reactive protein in cardiovascular risk prediction models for women
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 145:21-9. 2006
    ..While high-sensitivity C-reactive protein (hsCRP) is an independent predictor of cardiovascular risk, global risk prediction models incorporating hsCRP have not been developed for clinical use...
  14. pmc Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)
    Nancy R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMJ 334:885-8. 2007
    ..To examine the effects of reduction in dietary sodium intake on cardiovascular events using data from two completed randomised trials, TOHP I and TOHP II...
  15. ncbi request reprint Imputation strategies for blood pressure data nonignorably missing due to medication use
    N R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Trials 3:411-20. 2006
    ..Untreated levels are not missing at random but would be higher among those on such medication. In such cases, standard methods of analysis may lead to bias...
  16. ncbi request reprint Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:17-23. 2008
    ..Diagnostic and prognostic or predictive models serve different purposes. Whereas diagnostic models are usually used for classification, prognostic models incorporate the dimension of time, adding a stochastic element...
  17. pmc Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures
    Nancy R Cook
    Donald W Reynolds Center for Cardiovascular Research and the Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Ann Intern Med 150:795-802. 2009
    ..These measures are targeted at evaluating the potential of new models and markers to change risk strata and alter treatment decisions...
  18. pmc Performance of reclassification statistics in comparing risk prediction models
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Biom J 53:237-58. 2011
    ..The relative power of the RC statistic, a test of calibration, and the NRI, a test of discrimination, varied depending on the model assumptions. These tools provide unique but complementary information...
  19. ncbi request reprint Self-selected posttrial aspirin use and subsequent cardiovascular disease and mortality in the physicians' health study
    N R Cook
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215 1204, USA
    Arch Intern Med 160:921-8. 2000
    ..00001) 44% reduction of first myocardial infarction (MI) among those assigned to aspirin. As a result, there were insufficient numbers of strokes or cardiovascular disease (CVD)-related deaths to evaluate these end points definitively...
  20. ncbi request reprint Use of a marginal structural model to determine the effect of aspirin on cardiovascular mortality in the Physicians' Health Study
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 155:1045-53. 2002
    ..65, 1.25). Although the numbers of cardiovascular deaths were insufficient to evaluate this endpoint definitively, use of such methods holds much potential for controlling time-varying confounders affected by previous exposure...
  21. ncbi request reprint Combining annual blood pressure measurements in childhood to improve prediction of young adult blood pressure
    N R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Stat Med 19:2625-40. 2000
    ..These results suggest that averaging BP over at least two years during childhood increases tracking correlations and improves the prediction of adult values from childhood levels...
  22. ncbi request reprint Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physicians' Health Study (United States)
    N R Cook
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Cancer Causes Control 11:617-26. 2000
    ..This report updates results for beta-carotene and examines effect modification by baseline characteristics...
  23. pmc Mammographic screening and risk factors for breast cancer
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Am J Epidemiol 170:1422-32. 2009
    ..Adjustment for screening had some impact on breast cancer prediction in this cohort, especially for hormone therapy and smoking...
  24. ncbi request reprint C-reactive protein is independently associated with fasting insulin in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, Mass 02215 1204, USA
    Arterioscler Thromb Vasc Biol 23:650-5. 2003
    ..Insulin resistance is associated with chronic subclinical inflammation, and both conditions are linked with increased risk for type 2 diabetes mellitus and atherothrombotic cardiovascular disease...
  25. ncbi request reprint Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
    ..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
  26. ncbi request reprint A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ..Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women...
  27. pmc A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Am J Clin Nutr 88:1602-10. 2008
    ..High homocysteine concentrations may be neurotoxic and contribute to cognitive decline in older persons...
  28. ncbi request reprint Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 23:859-63. 2003
    ..Because diabetes and atherothrombosis share common antecedents, we sought evidence that this polymorphism might also be associated with reduced risk of myocardial infarction...
  29. pmc Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms
    Samia Mora
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 116:2110-8. 2007
    ..Although the precise mechanisms underlying this inverse association are unclear, differences in several cardiovascular risk factors may mediate this effect...
  30. ncbi request reprint Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease
    Hylton V Joffe
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02215, USA
    Ann Epidemiol 16:105-12. 2006
    ..We hypothesized that high androgens, low estradiol, and low sex hormone-binding globulin (SHBG) would be associated with high CRP in postmenopausal women...
  31. pmc Low dose aspirin and cognitive function in the women's health study cognitive cohort
    Jae Hee Kang
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMJ 334:987. 2007
    ..To determine whether low dose aspirin protects women aged 65 or more against cognitive decline...
  32. pmc Common variants in cardiac ion channel genes are associated with sudden cardiac death
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Channing Laboratory, and Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 1204, USA
    Circ Arrhythm Electrophysiol 3:222-9. 2010
    ....
  33. ncbi request reprint Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS)
    Peter J Mason
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215 1204, USA
    Circulation 109:1623-9. 2004
    ..In apparently healthy people, the relation between blood pressure and risk of subsequent cardiovascular disease (CVD) is linear. In persons with CVD, the relation is uncertain...
  34. pmc Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
    ..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
  35. ncbi request reprint A randomized trial of vitamin E supplementation and cognitive function in women
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Arch Intern Med 166:2462-8. 2006
    ..Oxidative stress may play a key role in the development of cognitive impairment. Long-term supplementation with vitamin E, a strong antioxidant, may provide cognitive benefits...
  36. pmc Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 82:1185-92. 2008
    ....
  37. pmc C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 118:2243-51, 4p following 2251. 2008
    ....
  38. pmc Low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women
    Melissa E Weinberg
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Metabolism 55:1473-80. 2006
    ..7 kg/m2. An androgenic hormone profile is associated with both the individual components of the metabolic syndrome and clustering of metabolic abnormalities in postmenopausal women...
  39. pmc Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 56:1898-904. 2007
    ..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes...
  40. pmc The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (women's health study)
    Usha B Tedrow
    Center for Arrhythmia Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 55:2319-27. 2010
    ..The purpose of this study was to characterize the relationship between changes in body mass index (BMI) and incident atrial fibrillation (AF) in a large cohort of women...
  41. ncbi request reprint Estrogen-progestin replacement therapy and breast cancer risk: the Women's Health Study (United States)
    Juliet V Porch
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Cancer Causes Control 13:847-54. 2002
    ..We therefore examined estrogen-progestin replacement therapy and breast cancer risk in the Women's Health Study...
  42. pmc Blood pressure differences by ethnic group among United States children and adolescents
    Bernard Rosner
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Hypertension 54:502-8. 2009
    ..Ethnic differences in prevalence rates of pediatric BP elevation that are not explained by obesity are present, primarily in boys. Whether these differences are attributable to genetic or environmental factors is unknown...
  43. ncbi request reprint Should age and time be eliminated from cardiovascular risk prediction models? Rationale for the creation of a new national risk detection program
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circulation 111:657-8. 2005
  44. pmc Relation of vigorous exercise to risk of atrial fibrillation
    Anthony Aizer
    Center for Arrhythmia Prevention, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 103:1572-7. 2009
    ..This risk decreased as the population aged and was offset by known beneficial effects of vigorous exercise on other AF risk factors...
  45. pmc Amino-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein as predictors of sudden cardiac death among women
    Ethan C Korngold
    Cardiovascular Division, Massachusetts General Hospital, Boston, MA, USA
    Circulation 119:2868-76. 2009
    ..However, there are no data on SCD risk prediction for either of these markers in a population of women unselected on the basis of cardiovascular disease...
  46. ncbi request reprint Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study
    Hillary H Hegener
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 52:2021-7. 2006
    ..No prospective data are available, however, on the risk of atherothrombotic disorders in persons with ADIPOQ variations who do not have diabetes...
  47. pmc The relation of education and income to cognitive function among professional women
    Sunmin Lee
    Department of Health and Behavioral Sciences, University of Colorado at Denver and Health Sciences Center, Denver, CO 80217 3364, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neuroepidemiology 26:93-101. 2006
    ..0001). Results were generally similar for cognitive decline over 2 years, although slightly weaker. Thus, in these well-educated, professional women, educational attainment and income both predicted cognitive function and decline...
  48. ncbi request reprint No effect of beta-carotene supplementation on risk of nonmelanoma skin cancer among men with low baseline plasma beta-carotene
    Debra A Schaumberg
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 13:1079-80. 2004
  49. ncbi request reprint Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Hum Mol Genet 13:389-96. 2004
    ..These population-based data demonstrate the ability of prospective, epidemiological studies to test candidate gene associations for athero-thrombotic disease...
  50. pmc A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II
    Francine Grodstein
    Channing Laboratory, School of Public Health, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Arch Intern Med 167:2184-90. 2007
    ..Oxidative stress contributes to brain aging. Antioxidant treatment, especially over the long term, might confer cognitive benefits...
  51. ncbi request reprint Dietary fat and fatty acids and risk of colorectal cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 160:1011-22. 2004
    ..However, intake of fried foods and/or other factors related to their intake may be associated with colorectal cancer development. This finding warrants further examination...
  52. pmc Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein
    Emily B Levitan
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 57:437-43. 2008
    ..24, and TG = 13 mg/dL). Differences in blood lipids and CRP between extreme quintiles of dietary GI and GL were small, but may translate into a clinically meaningful difference in cardiovascular risk...
  53. doi request reprint Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults
    Olivia I Okereke
    Division of Aging and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 56:1028-36. 2008
    ..To relate diabetes mellitus (DM) status and duration to late-life cognitive impairment and decline in men and women...
  54. ncbi request reprint Relationship of physical activity vs body mass index with type 2 diabetes in women
    Amy R Weinstein
    Boston VA Healthcare System, MA, USA
    JAMA 292:1188-94. 2004
    ..Physical inactivity and body mass index (BMI) are established independent risk factors in the development of type 2 diabetes; however, their comparative importance and joint relationship with diabetes are unclear...
  55. doi request reprint The joint effects of physical activity and body mass index on coronary heart disease risk in women
    Amy R Weinstein
    Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Shapiro 1, Atrium Suite, Boston, MA 02215, USA
    Arch Intern Med 168:884-90. 2008
    ..Our objective was to study the combined association of physical activity and body mass index on CHD...
  56. ncbi request reprint Body mass index and risk of colorectal cancer in women (United States)
    Jennifer Lin
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Cancer Causes Control 15:581-9. 2004
    ..We prospectively investigated the role of BMI in colorectal cancer risk along with the modifying effects of estrogen in a large cohort from the Women's Health Study...
  57. ncbi request reprint Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02115, USA
    Atherosclerosis 175:91-4. 2004
    ..If confirmed in other cohorts, these data support the emerging hypothesis that eotaxin participates in atherosclerosis...
  58. pmc Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 1:21-30. 2008
    ....
  59. pmc Prediction of incident hypertension risk in women with currently normal blood pressure
    Nina P Paynter
    The Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Mass 02215, USA
    Am J Med 122:464-71. 2009
    ..We examined whether a hypertension risk prediction model based on clinical characteristics and blood biomarkers might improve on risk prediction based on current blood pressure alone...
  60. ncbi request reprint Body mass index and the risk of stroke in men
    Tobias Kurth
    Brigham and Women s Hospital, Division of Preventive Medicine, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
    Arch Intern Med 162:2557-62. 2002
    ..Although obesity is an established risk factor for coronary heart disease, its role as a risk factor for stroke remains controversial...
  61. ncbi request reprint Smoking and risk of hemorrhagic stroke in women
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Stroke 34:2792-5. 2003
    ..A recent study added smoking as a risk factor for intracerebral hemorrhage (ICH) in men. In contrast, the impact of smoking on ICH in women is less clear...
  62. ncbi request reprint The Women's Antioxidant Cardiovascular Study: design and baseline characteristics of participants
    Shari S Bassuk
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 13:99-117. 2004
    ..Large-scale randomized trials with clinical end points are necessary to minimize confounding and provide unbiased estimates of the balance of benefits and risks, yet data from such trials are scarce, especially among women...
  63. pmc Effects of vitamins C and E and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial
    Yiqing Song
    Division of Preventive Medicine and Cardiology Division, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 90:429-37. 2009
    ..Vitamin C, vitamin E, and beta-carotene are major antioxidants and as such may protect against the development of type 2 diabetes via reduction of oxidative stress...
  64. pmc Kidney function and risk of cardiovascular disease and mortality in women: a prospective cohort study
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    BMJ 338:b2392. 2009
    ..To evaluate the association of kidney function with cardiovascular disease and mortality among apparently healthy women...
  65. pmc Haplotype analysis of the beta2 adrenergic receptor gene and risk of myocardial infarction in humans
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, LeDucq Center for Molecular and Genetic Epidemiology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genetics 169:1583-7. 2005
    ..In conclusion, variation in haplotype frequencies for the beta2 adrenergic receptor gene was found to be associated with risk of myocardial infarction...
  66. pmc Association between a literature-based genetic risk score and cardiovascular events in women
    Nina P Paynter
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    JAMA 303:631-7. 2010
    ..While multiple genetic markers associated with cardiovascular disease have been identified by genome-wide association studies, their aggregate effect on risk beyond traditional factors is uncertain, particularly among women...
  67. pmc Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    J Natl Cancer Inst 101:14-23. 2009
    ..However, findings from randomized trials of the association between antioxidant use and cancer risk have been mostly negative...
  68. ncbi request reprint Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States)
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cancer Causes Control 16:225-33. 2005
    ..We prospectively examined the association between dietary intakes of fruit, vegetables, and fiber and colorectal cancer risk in a large female cohort from the Women's Health Study...
  69. ncbi request reprint Alcohol consumption and breast cancer risk in the Women's Health Study
    Shumin M Zhang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Am J Epidemiol 165:667-76. 2007
    ..The findings from this prospective study suggest that moderate alcohol consumption increases breast cancer risk...
  70. ncbi request reprint Dietary magnesium intake and risk of cardiovascular disease among women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:1135-41. 2005
    ..In conclusion, the results do not support the hypothesis that magnesium intake reduces the development of CHD, although a modest inverse association with stroke cannot be ruled out...
  71. ncbi request reprint Total magnesium intake and colorectal cancer incidence in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 15:2006-9. 2006
  72. ncbi request reprint Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Diabetes Care 28:1438-44. 2005
    ..The aim of this study was to examine whether and to what extent magnesium intake is related to systemic inflammation and the metabolic syndrome...
  73. ncbi request reprint Use of oral conjugated estrogen alone and risk of breast cancer
    Shumin M Zhang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 165:524-9. 2007
    ..These data, like those from the Women's Health Initiative, show no significant increase in breast cancer risk with use of oral conjugated estrogen alone (0.625 mg/day), but a small increase or decrease in risk cannot be excluded...
  74. ncbi request reprint Intakes of calcium and vitamin D and risk of colorectal cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 161:755-64. 2005
    ..Data provide little support for an association of calcium and vitamin D intake with colorectal cancer risk...
  75. ncbi request reprint Polymorphism in the beta2-adrenergic receptor and lipoprotein lipase genes as risk determinants for idiopathic venous thromboembolism: a multilocus, population-based, prospective genetic analysis
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 113:2193-200. 2006
    ..Candidate genes in inflammation, thrombosis, coagulation, and lipid metabolism pathways have been implicated in venous thromboembolism (VTE)...
  76. pmc Hemoglobin A1c concentrations and risk of colorectal cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 14:3010-2. 2005
  77. ncbi request reprint C-reactive protein and risk of breast cancer
    Shumin M Zhang
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    J Natl Cancer Inst 99:890-4. 2007
    ..71 to 1.16; P(trend) = .19; crude incidence rates: 273 versus 305 per 100,000 person-years). Our data suggest that baseline plasma CRP levels are not associated with the increased risk of breast cancer in apparently healthy women...
  78. ncbi request reprint Intakes of calcium and vitamin D and breast cancer risk in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 167:1050-9. 2007
    ..Animal data suggest the potential anticarcinogenic effects of calcium and vitamin D on breast cancer development. However, epidemiologic data relating calcium and vitamin D levels to breast cancer have been inconclusive...
  79. pmc Lipoprotein-associated phospholipase A2 activity improves risk discrimination of incident coronary heart disease among women
    Ida J Hatoum
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am Heart J 161:516-22. 2011
    ..This study sought to determine the relation between and discriminative capability of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and coronary heart disease (CHD) in a large population of disease-free women...
  80. pmc Effect of homocysteine-lowering treatment with folic Acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:1921-8. 2009
    ..We investigated whether homocysteine-lowering treatment by B vitamin supplementation prevents the risk of type 2 diabetes...
  81. ncbi request reprint Prospective evaluation of the alcohol dehydrogenase gamma1/gamma2 gene polymorphism and risk of stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stroke 35:e39-42. 2004
    ..Genetic polymorphism of the alcohol dehydrogenase type 3 gene (ADH1C) has recently been associated with reduced risk of myocardial infarction. However, data on risk of stroke are not available...
  82. ncbi request reprint Interaction between inflammation-related gene polymorphisms and cigarette smoking on the risk of myocardial infarction in the Physician's Health Study
    Sarah A Rosner
    Department of Epidemiology, Harvard School of Public Health Kresge 911, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Genet 118:287-94. 2005
    ..However, these results should be interpreted with caution due to the potential for false positive results that can arise from analyses with multiple comparisons...
  83. ncbi request reprint High-sensitivity C-reactive protein and cognitive function in older women
    Jennifer Weuve
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Epidemiology 17:183-9. 2006
    ..Inflammatory processes may be involved in the development of dementia, although findings from epidemiologic studies directly examining inflammatory markers and dementia or its precursor, impaired cognitive function, are inconsistent...
  84. ncbi request reprint Migraine and risk of cardiovascular disease in women
    Tobias Kurth
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215 1204, USA
    JAMA 296:283-91. 2006
    ..Although migraine with aura has been associated with increased risk of ischemic stroke, an association with cardiovascular disease (CVD) and, specifically, coronary events remains unclear...
  85. pmc Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 21:897-908. 2010
    ....
  86. pmc Plasma homocysteine and cysteine and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 70:2397-405. 2010
    ..The increased risk of breast cancer associated with high cysteine levels warrants further investigation...
  87. pmc Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women
    Shumin M Zhang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 163:108-15. 2006
    ..An alternative explanation is that other factors related to dietary intakes of folate and vitamin B(6) account for the inverse associations...
  88. ncbi request reprint Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:56-65. 2005
    ..Randomized trials do not generally support benefits of vitamin E, but there are few trials of long duration among initially healthy persons...
  89. pmc Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial
    Shumin M Zhang
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    JAMA 300:2012-21. 2008
    ..Folate, vitamin B(6), and vitamin B(12) are thought to play an important role in cancer prevention...
  90. ncbi request reprint Migraine and risk of cardiovascular disease in men
    Tobias Kurth
    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Arch Intern Med 167:795-801. 2007
    ..In women, migraine has been associated with increased risk of CVD, including coronary events. Compatible data in men are lacking...
  91. doi request reprint Alcohol consumption and the risk of hypertension in women and men
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston MA 02215 1204, USA
    Hypertension 51:1080-7. 2008
    ..The threshold above which alcohol became deleterious for hypertension risk emerged at >or=4 drinks per day in women versus a moderate level of >or=1 drink per day in men...
  92. pmc Weight status in childhood as a predictor of becoming overweight or hypertensive in early adulthood
    Alison E Field
    Children s Hospital Boston, Division of Adolescent Medicine, Department of Medicine, 300 Longwood Avenue, Boston, MA 02115, USA
    Obes Res 13:163-9. 2005
    ..To assess the extent to which weight status in childhood or adolescence predicts becoming overweight or hypertensive by young adulthood...
  93. ncbi request reprint Prospective study of body mass index and risk of stroke in apparently healthy women
    Tobias Kurth
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 111:1992-8. 2005
    ..Several studies have found positive associations between body mass index (BMI) and stroke in men, but the association with stroke and its subtypes is less clear in women...
  94. ncbi request reprint A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women
    Simin Liu
    Division of Preventive Medicine, Brigham Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Diabetes Care 27:2993-6. 2004
  95. ncbi request reprint Oral contraceptives, reproductive factors, and risk of colorectal cancer among women in a prospective cohort study
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 165:794-801. 2007
    ..09). No significant association was observed between reproductive factors and colorectal cancer risk. These findings provide some support for a potential role of OCs in reducing risk of colorectal cancer...
  96. ncbi request reprint Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 98:1616-21. 2006
    ..In conclusion, the results suggest that higher intake of dietary magnesium may have a modest effect on the development of hypertension in women...
  97. pmc Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular Study
    Jae Hee Kang
    Harvard School of Public Health, Boston, Mass, USA
    Circulation 119:2772-80. 2009
    ..Cardiovascular factors are associated with cognitive decline. Antioxidants may be beneficial...
  98. ncbi request reprint TP53 haplotype-based analysis and incidence of post-angioplasty restenosis
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Hum Genet 114:386-90. 2004
    ..Furthermore, our study demonstrates that a haplotype-based approach can be more informative than a single-marker or marker-by-marker analysis...
  99. ncbi request reprint Clinical usefulness of very high and very low levels of C-reactive protein across the full range of Framingham Risk Scores
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research and the Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 109:1955-9. 2004
    ..However, the positive predictive value of very low (<0.5 mg/L) and very high levels of hsCRP (>10.0 mg/L) is uncertain...
  100. ncbi request reprint Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 347:1557-65. 2002
    ..Both C-reactive protein and low-density lipoprotein (LDL) cholesterol levels are elevated in persons at risk for cardiovascular events. However, population-based data directly comparing these two biologic markers are not available...
  101. ncbi request reprint Postmenopausal hormone therapy and migraine headache
    Anastasia L Misakian
    University of California San Diego School of Medicine, San Diego, California, USA
    J Womens Health (Larchmt) 12:1027-36. 2003
    ..No population-based studies have examined the association between hormone therapy (HT) and migraine among postmenopausal women...

Research Grants7

  1. OBSERVATIONAL COHORT STUDY OF SODIUM, WEIGHT AND CVD
    Nancy Cook; Fiscal Year: 2003
    ..This cohort provides a unique resource to address the impact in a normotensive population of salt restriction and weight change on subsequent cardiovascular events. ..
  2. Causal Models for CVD Use by Aspirin and Vitamin E in the Women's Health Study
    Nancy Cook; Fiscal Year: 2007
    ..The findings of reduced risk of CVD mortality, however, as well as effects by age, should be explored further to clarify the public health message. ..