Tucker Collins

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi All in the family: the BTB/POZ, KRAB, and SCAN domains
    T Collins
    Department of Pathology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:3609-15. 2001
  2. ncbi Extinguishing Egr-1-dependent inflammatory and thrombotic cascades after lung transplantation
    M Okada
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA; and, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 15:2757-9. 2001
  3. ncbi Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors
    J D Crispino
    Division of Hematology and Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genes Dev 15:839-44. 2001
  4. ncbi High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis
    T A McCaffrey
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:653-62. 2000
  5. ncbi The zinc finger-associated SCAN box is a conserved oligomerization domain
    A J Williams
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mol Cell Biol 19:8526-35. 1999
  6. ncbi GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury
    L M Khachigian
    Centre for Thrombosis and Vascular Research, The University of New South Wales, Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Circ Res 84:1258-67. 1999
  7. ncbi Pathways of Egr-1-mediated gene transcription in vascular biology
    E S Silverman
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 154:665-70. 1999
  8. ncbi cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)
    E S Silverman
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biochem J 336:183-9. 1998
  9. ncbi Isolation and characterization of a novel zinc-finger protein with transcription repressor activity
    A J Williams
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 270:22143-52. 1995
  10. ncbi CREB-binding protein/p300 are transcriptional coactivators of p65
    M E Gerritsen
    Bayer Corporation, West Haven, CT 06516, USA
    Proc Natl Acad Sci U S A 94:2927-32. 1997

Research Grants

  1. TRANSCRIPTIONAL REGULATION OF E-SELECTIN
    Tucker Collins; Fiscal Year: 2001
  2. The SCAN Family: Characterization of ZNF174
    Tucker Collins; Fiscal Year: 2005
  3. TRANSCRIPTIONAL REGULATION OF E-SELECTIN
    Tucker Collins; Fiscal Year: 2005
  4. ENDOTHELIAL-SPECIFIC GENE EXPRESSION
    Tucker Collins; Fiscal Year: 1993
  5. ENDOTHELIAL SPECIFIC GENE EXPRESSION
    Tucker Collins; Fiscal Year: 1992
  6. TRANSCRIPTIONAL REGULATION OF PDGF BY ENDOTHELIUM
    Mark Fleming; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi All in the family: the BTB/POZ, KRAB, and SCAN domains
    T Collins
    Department of Pathology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:3609-15. 2001
  2. ncbi Extinguishing Egr-1-dependent inflammatory and thrombotic cascades after lung transplantation
    M Okada
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA; and, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 15:2757-9. 2001
    ..Blocking expression of a proximal transcription factor, which activates deleterious inflammatory and coagulant effector mechanisms, is an effective molecular strategy to improve organ preservation...
  3. ncbi Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors
    J D Crispino
    Division of Hematology and Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genes Dev 15:839-44. 2001
    ..We also infer that GATA-4 function is dependent on interaction with FOG-2 and, very likely, an additional FOG protein for distinct aspects of heart formation...
  4. ncbi High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis
    T A McCaffrey
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:653-62. 2000
    ..Thus, induction of Egr-1 by atherogenic factors may be a key step in coordinating the cellular events that result in vascular lesions...
  5. ncbi The zinc finger-associated SCAN box is a conserved oligomerization domain
    A J Williams
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mol Cell Biol 19:8526-35. 1999
    ..These findings suggest that the SCAN domain plays an important role in the assembly and function of this newly defined subclass of transcriptional regulators...
  6. ncbi GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury
    L M Khachigian
    Centre for Thrombosis and Vascular Research, The University of New South Wales, Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Circ Res 84:1258-67. 1999
    ..These findings demonstrate negative regulation of PDGF-A expression by GCF2. This is the first report of the induction of an endogenous transcriptional repressor in the rat vessel wall...
  7. ncbi Pathways of Egr-1-mediated gene transcription in vascular biology
    E S Silverman
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 154:665-70. 1999
  8. ncbi cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)
    E S Silverman
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biochem J 336:183-9. 1998
    ..These data suggest that CBP and p300 act as transcriptional co-activators for Egr-1-mediated gene expression and that variations between individuals in such co-activation could serve as a genetic basis for variability in gene expression...
  9. ncbi Isolation and characterization of a novel zinc-finger protein with transcription repressor activity
    A J Williams
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 270:22143-52. 1995
    ..This member of the C2H2-type zinc-finger family is a novel transcriptional repressor...
  10. ncbi CREB-binding protein/p300 are transcriptional coactivators of p65
    M E Gerritsen
    Bayer Corporation, West Haven, CT 06516, USA
    Proc Natl Acad Sci U S A 94:2927-32. 1997
    ..CBP and p300 act as coactivators of p65-driven gene activation and may play an important role in the cytokine-induced expression of various immune and inflammatory genes...
  11. ncbi I kappa B kinase is critical for TNF-alpha-induced VCAM1 gene expression in renal tubular epithelial cells
    Z Tu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 605 Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 166:6839-46. 2001
    ..Moreover, dominant negative versions of IKK inhibit TNF-alpha activation of a VCAM1 promoter reporter. We conclude that the IKK/NF-kappaB pathway is critical in the TNF-alpha-induced up-regulation of VCAM1 mRNA in renal TEC...
  12. ncbi Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1
    T Collins
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Biol Chem 266:2466-73. 1991
    ....
  13. ncbi Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene
    M I Cybulsky
    Department of Pathology, Brigham and Women s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 88:7859-63. 1991
    ..Structural analysis of the human VCAM1 gene provides the basis for alternative mRNA splicing and an initial approach to elucidating the regulation of VCAM-1 expression...
  14. ncbi Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing
    D T Bonthron
    Division of Hematology Oncology, Children s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 85:1492-6. 1988
    ..This and other structural features of the A-chain gene suggest that PDGF expression may be modulated at transcriptional and post-transcriptional levels...
  15. ncbi Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis
    T Collins
    Nature 316:748-50. 1985
    ..Our results establish that normal human endothelial cells in culture express the B chain of PDGF, and that endothelial-derived PDGF B chain is synthesized as a predicted precursor polypeptide of Mr 27,281...
  16. ncbi PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
    N Marx
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division and the Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 99:3125-31. 1999
    ..The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1)...
  17. ncbi Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice
    A M Reimold
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nature 379:262-5. 1996
    ....
  18. ncbi Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts
    R W Redline
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106
    Genomics 13:425-30. 1992
    ..Expression was particularly strong in the uterus. This suggests that aside from its effects during embryogenesis, the HOX4E gene may play a continuing role in adult genitourinary tract function...

Research Grants21

  1. TRANSCRIPTIONAL REGULATION OF E-SELECTIN
    Tucker Collins; Fiscal Year: 2001
    ..Such information may provide novel strategies for therapeutic approaches to the important problem of vascualr disease. ..
  2. The SCAN Family: Characterization of ZNF174
    Tucker Collins; Fiscal Year: 2005
    ..Collectively, these studies should define this transcription factor and provide mechanistic insights into the large number of C2H2 type zinc finger proteins defined by the SCAN domain. ..
  3. TRANSCRIPTIONAL REGULATION OF E-SELECTIN
    Tucker Collins; Fiscal Year: 2005
    ..Such information may provide novel strategies for therapeutic approaches to the important problem of vascular disease. ..
  4. ENDOTHELIAL-SPECIFIC GENE EXPRESSION
    Tucker Collins; Fiscal Year: 1993
    ..Furthermore, characterization of both the cis-elements and transacting factors responsible for endothelial-specific gene expression may permit the development of new strategies for identifying patients at risk of vascular disease...
  5. ENDOTHELIAL SPECIFIC GENE EXPRESSION
    Tucker Collins; Fiscal Year: 1992
    ..Furthermore, characterization of both the cis-elements and transacting factors responsible for endothelial-specific gene expression may permit the development of new strategies for identifying patients at risk of vascular disease...
  6. TRANSCRIPTIONAL REGULATION OF PDGF BY ENDOTHELIUM
    Mark Fleming; Fiscal Year: 2007
    ..Collectively, the studies should provide new strategies for the management of vascular disease. ..