Tucker Collins

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc All in the family: the BTB/POZ, KRAB, and SCAN domains
    T Collins
    Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:3609-15. 2001
  2. ncbi request reprint Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain
    Dmitri Ivanov
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 17:137-43. 2005
  3. ncbi request reprint Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 42:1301-8. 2003
  4. pmc Domain-swapped dimerization of the HIV-1 capsid C-terminal domain
    Dmitri Ivanov
    Department of Pathology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:4353-8. 2007
  5. ncbi request reprint The SCAN domain family of zinc finger transcription factors
    Leonard C Edelstein
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Gene 359:1-17. 2005
  6. ncbi request reprint Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1
    Nathaniel G dela Paz
    Molecular Pathology Graduate Program, School of Medicine, University of California, San Diego, La Jolla, California 92093 0673, and Department of Pathology, Children s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:8424-34. 2007
  7. ncbi request reprint The SCAN domain defines a large family of zinc finger transcription factors
    Tara L Sander
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Gene 310:29-38. 2003
  8. ncbi request reprint The role of hydrogen peroxide in endothelial proliferative responses
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endothelium 9:231-8. 2002
  9. pmc The SCAN domain of ZNF174 is a dimer
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:5448-52. 2002
  10. pmc Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling
    Monica L Calicchio
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Pathol 174:1638-49. 2009

Research Grants

  1. TRANSCRIPTIONAL REGULATION OF E-SELECTIN
    Tucker Collins; Fiscal Year: 2001
  2. The SCAN Family: Characterization of ZNF174
    Tucker Collins; Fiscal Year: 2005
  3. TRANSCRIPTIONAL REGULATION OF E-SELECTIN
    Tucker Collins; Fiscal Year: 2005
  4. ENDOTHELIAL-SPECIFIC GENE EXPRESSION
    Tucker Collins; Fiscal Year: 1993
  5. ENDOTHELIAL SPECIFIC GENE EXPRESSION
    Tucker Collins; Fiscal Year: 1992
  6. TRANSCRIPTIONAL REGULATION OF PDGF BY ENDOTHELIUM
    Mark Fleming; Fiscal Year: 2007

Collaborators

Detail Information

Publications30

  1. pmc All in the family: the BTB/POZ, KRAB, and SCAN domains
    T Collins
    Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:3609-15. 2001
  2. ncbi request reprint Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain
    Dmitri Ivanov
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 17:137-43. 2005
    ..In the SCAN-like dimer, the MHR contributes the major part of the large intertwined dimer interface explaining its functional significance...
  3. ncbi request reprint Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 42:1301-8. 2003
    ....
  4. pmc Domain-swapped dimerization of the HIV-1 capsid C-terminal domain
    Dmitri Ivanov
    Department of Pathology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:4353-8. 2007
    ..Our observations suggest that swapping of the MHR segments of adjacent Gag molecules may be a critical intermediate in retroviral assembly...
  5. ncbi request reprint The SCAN domain family of zinc finger transcription factors
    Leonard C Edelstein
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Gene 359:1-17. 2005
    ....
  6. ncbi request reprint Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1
    Nathaniel G dela Paz
    Molecular Pathology Graduate Program, School of Medicine, University of California, San Diego, La Jolla, California 92093 0673, and Department of Pathology, Children s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:8424-34. 2007
    ..Finally, the cytokine interleukin-6 induces Oct-1 gene expression, providing a biologically relevant means by which NF-kappaB-dependent gene expression can be selectively reverted by Oct-1 to quiescent levels...
  7. ncbi request reprint The SCAN domain defines a large family of zinc finger transcription factors
    Tara L Sander
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Gene 310:29-38. 2003
    ..Collectively, these studies define a large family of vertebrate-specific transcriptional regulators that may have rapidly expanded during recent evolution...
  8. ncbi request reprint The role of hydrogen peroxide in endothelial proliferative responses
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endothelium 9:231-8. 2002
    ..Recently a functional proteomics approach has been utilized to identify proteins responsive to low concentrations of H2O2 in human endothelial cells...
  9. pmc The SCAN domain of ZNF174 is a dimer
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:5448-52. 2002
    ....
  10. pmc Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling
    Monica L Calicchio
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Pathol 174:1638-49. 2009
    ..The identification of genes differentially expressed in proliferating and involuting hemangiomas in vivo will contribute to our understanding of this vascular lesion, which remains a leading cause of morbidity in newborn children...
  11. pmc Chromatin modification and the endothelial-specific activation of the E-selectin gene
    Leonard C Edelstein
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:11192-202. 2005
    ..Collectively, these studies suggest a model for the selective induction of the E-selectin gene in which the core promoter chromatin architecture is specifically modified in endothelial cells...
  12. pmc Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression
    El Bachir Affar
    Harvard Medical School, Department of Pathology, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 26:3565-81. 2006
    ..These data not only shed new light on the molecular basis for YY1 developmental roles and cellular functions, but also provide insight into the general mechanisms controlling eukaryotic cell proliferation, apoptosis, and differentiation...
  13. ncbi request reprint Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cells
    James R Stone
    Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:15621-8. 2002
    ..The effects were observed with as little as 1 microm H(2)O(2) and were maximal with 5-8 microm H(2)O(2). The H(2)O(2)-stimulated phosphorylation was inhibited by catalase, but not by the transcriptional inhibitor actinomycin D...
  14. ncbi request reprint Isolation and characterization of a novel zinc-finger protein with transcription repressor activity
    A J Williams
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 270:22143-52. 1995
    ..This member of the C2H2-type zinc-finger family is a novel transcriptional repressor...
  15. pmc cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)
    E S Silverman
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biochem J 336:183-9. 1998
    ..These data suggest that CBP and p300 act as transcriptional co-activators for Egr-1-mediated gene expression and that variations between individuals in such co-activation could serve as a genetic basis for variability in gene expression...
  16. ncbi request reprint Extinguishing Egr-1-dependent inflammatory and thrombotic cascades after lung transplantation
    M Okada
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA; and, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 15:2757-9. 2001
    ..Blocking expression of a proximal transcription factor, which activates deleterious inflammatory and coagulant effector mechanisms, is an effective molecular strategy to improve organ preservation...
  17. pmc Pathways of Egr-1-mediated gene transcription in vascular biology
    E S Silverman
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 154:665-70. 1999
  18. pmc Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors
    J D Crispino
    Division of Hematology and Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genes Dev 15:839-44. 2001
    ..We also infer that GATA-4 function is dependent on interaction with FOG-2 and, very likely, an additional FOG protein for distinct aspects of heart formation...
  19. pmc High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis
    T A McCaffrey
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:653-62. 2000
    ..Thus, induction of Egr-1 by atherogenic factors may be a key step in coordinating the cellular events that result in vascular lesions...
  20. pmc The zinc finger-associated SCAN box is a conserved oligomerization domain
    A J Williams
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mol Cell Biol 19:8526-35. 1999
    ..These findings suggest that the SCAN domain plays an important role in the assembly and function of this newly defined subclass of transcriptional regulators...
  21. ncbi request reprint GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury
    L M Khachigian
    Centre for Thrombosis and Vascular Research, The University of New South Wales, Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Circ Res 84:1258-67. 1999
    ..These findings demonstrate negative regulation of PDGF-A expression by GCF2. This is the first report of the induction of an endogenous transcriptional repressor in the rat vessel wall...
  22. pmc Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene
    M I Cybulsky
    Department of Pathology, Brigham and Women s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 88:7859-63. 1991
    ..Structural analysis of the human VCAM1 gene provides the basis for alternative mRNA splicing and an initial approach to elucidating the regulation of VCAM-1 expression...
  23. pmc Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing
    D T Bonthron
    Division of Hematology Oncology, Children s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 85:1492-6. 1988
    ..This and other structural features of the A-chain gene suggest that PDGF expression may be modulated at transcriptional and post-transcriptional levels...
  24. ncbi request reprint Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1
    T Collins
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Biol Chem 266:2466-73. 1991
    ....
  25. ncbi request reprint Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis
    T Collins
    Nature 316:748-50. 1985
    ..Our results establish that normal human endothelial cells in culture express the B chain of PDGF, and that endothelial-derived PDGF B chain is synthesized as a predicted precursor polypeptide of Mr 27,281...
  26. ncbi request reprint Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice
    A M Reimold
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nature 379:262-5. 1996
    ....
  27. pmc CREB-binding protein/p300 are transcriptional coactivators of p65
    M E Gerritsen
    Bayer Corporation, West Haven, CT 06516, USA
    Proc Natl Acad Sci U S A 94:2927-32. 1997
    ..CBP and p300 act as coactivators of p65-driven gene activation and may play an important role in the cytokine-induced expression of various immune and inflammatory genes...
  28. ncbi request reprint I kappa B kinase is critical for TNF-alpha-induced VCAM1 gene expression in renal tubular epithelial cells
    Z Tu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 605 Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 166:6839-46. 2001
    ..Moreover, dominant negative versions of IKK inhibit TNF-alpha activation of a VCAM1 promoter reporter. We conclude that the IKK/NF-kappaB pathway is critical in the TNF-alpha-induced up-regulation of VCAM1 mRNA in renal TEC...
  29. ncbi request reprint PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
    N Marx
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division and the Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 99:3125-31. 1999
    ..The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1)...
  30. ncbi request reprint Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts
    R W Redline
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106
    Genomics 13:425-30. 1992
    ..Expression was particularly strong in the uterus. This suggests that aside from its effects during embryogenesis, the HOX4E gene may play a continuing role in adult genitourinary tract function...

Research Grants21

  1. TRANSCRIPTIONAL REGULATION OF E-SELECTIN
    Tucker Collins; Fiscal Year: 2001
    ..Such information may provide novel strategies for therapeutic approaches to the important problem of vascualr disease. ..
  2. The SCAN Family: Characterization of ZNF174
    Tucker Collins; Fiscal Year: 2005
    ..Collectively, these studies should define this transcription factor and provide mechanistic insights into the large number of C2H2 type zinc finger proteins defined by the SCAN domain. ..
  3. TRANSCRIPTIONAL REGULATION OF E-SELECTIN
    Tucker Collins; Fiscal Year: 2005
    ..Such information may provide novel strategies for therapeutic approaches to the important problem of vascular disease. ..
  4. ENDOTHELIAL-SPECIFIC GENE EXPRESSION
    Tucker Collins; Fiscal Year: 1993
    ..Furthermore, characterization of both the cis-elements and transacting factors responsible for endothelial-specific gene expression may permit the development of new strategies for identifying patients at risk of vascular disease...
  5. ENDOTHELIAL SPECIFIC GENE EXPRESSION
    Tucker Collins; Fiscal Year: 1992
    ..Furthermore, characterization of both the cis-elements and transacting factors responsible for endothelial-specific gene expression may permit the development of new strategies for identifying patients at risk of vascular disease...
  6. TRANSCRIPTIONAL REGULATION OF PDGF BY ENDOTHELIUM
    Mark Fleming; Fiscal Year: 2007
    ..Collectively, the studies should provide new strategies for the management of vascular disease. ..