Laura C Collins

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Risk factors for non-invasive and invasive local recurrence in patients with ductal carcinoma in situ
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Breast Cancer Res Treat 139:453-60. 2013
  2. pmc Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community setting
    Laurel A Habel
    Division of Research, Kaiser Permanente, Northern California, 2000 Broadway, Oakland, CA 94612, USA
    Breast Cancer Res 11:R85. 2009
  3. ncbi request reprint The influence of family history on breast cancer risk in women with biopsy-confirmed benign breast disease: results from the Nurses' Health Study
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer 107:1240-7. 2006
  4. ncbi request reprint Magnitude and laterality of breast cancer risk according to histologic type of atypical hyperplasia: results from the Nurses' Health Study
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer 109:180-7. 2007
  5. ncbi request reprint Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia: an analysis of 543 patients
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 20:1149-55. 2007
  6. doi request reprint Papillary lesions of the breast: selected diagnostic and management issues
    L C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Histopathology 52:20-9. 2008
  7. doi request reprint Comparison of estrogen receptor results from pathology reports with results from central laboratory testing
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Natl Cancer Inst 100:218-21. 2008
  8. pmc Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissue
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Appl Immunohistochem Mol Morphol 17:438-41. 2009
  9. doi request reprint Basal cytokeratin and epidermal growth factor receptor expression are not predictive of BRCA1 mutation status in women with triple-negative breast cancers
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Am J Surg Pathol 33:1093-7. 2009
  10. doi request reprint Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer
    L C Collins
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, USA
    Breast Cancer Res Treat 131:1061-6. 2012

Detail Information

Publications47

  1. doi request reprint Risk factors for non-invasive and invasive local recurrence in patients with ductal carcinoma in situ
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Breast Cancer Res Treat 139:453-60. 2013
    ..Future research efforts should focus on non-clinicopathologic factors to identify more powerful risk factors for LR...
  2. pmc Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community setting
    Laurel A Habel
    Division of Research, Kaiser Permanente, Northern California, 2000 Broadway, Oakland, CA 94612, USA
    Breast Cancer Res 11:R85. 2009
    ..The aims of this study were to examine the use and impact of these therapies on risk of recurrence among ductal carcinoma in situ patients diagnosed and treated in the community setting...
  3. ncbi request reprint The influence of family history on breast cancer risk in women with biopsy-confirmed benign breast disease: results from the Nurses' Health Study
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer 107:1240-7. 2006
    ..However, the influence of a positive family history (FH) on breast cancer risk among women with biopsy-confirmed BBD is less certain...
  4. ncbi request reprint Magnitude and laterality of breast cancer risk according to histologic type of atypical hyperplasia: results from the Nurses' Health Study
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer 109:180-7. 2007
    ..Atypical hyperplasia (AH) in a benign breast biopsy is associated with an increased breast cancer risk. However, the influence of the histologic type of AH on the magnitude and laterality of breast cancer risk is poorly defined...
  5. ncbi request reprint Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia: an analysis of 543 patients
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 20:1149-55. 2007
    ....
  6. doi request reprint Papillary lesions of the breast: selected diagnostic and management issues
    L C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Histopathology 52:20-9. 2008
    ..The role of immunohistochemistry in the evaluation of these lesions, particularly the role of myoepithelial cell markers, will be emphasized...
  7. doi request reprint Comparison of estrogen receptor results from pathology reports with results from central laboratory testing
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Natl Cancer Inst 100:218-21. 2008
    ..78, P < .001). Thus, ER assay results from pathology reports appear to be a reasonable alternative to central laboratory ER testing for large, population-based studies of patients with breast cancer...
  8. pmc Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissue
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Appl Immunohistochem Mol Morphol 17:438-41. 2009
    ..Whether or not TMAs may also be a potentially useful platform for assessing biomarkers in benign proliferative breast lesions (BPBL) and normal breast tissue has not been previously studied in detail...
  9. doi request reprint Basal cytokeratin and epidermal growth factor receptor expression are not predictive of BRCA1 mutation status in women with triple-negative breast cancers
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Am J Surg Pathol 33:1093-7. 2009
    ..However, whether or not expression of biomarkers characteristic of basal-like breast cancers helps to define a subset of women with triple-negative breast cancers who are likely to harbor BRCA1 mutations is an unresolved issue...
  10. doi request reprint Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer
    L C Collins
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, USA
    Breast Cancer Res Treat 131:1061-6. 2012
    ..These findings may have implications with regard to the etiology and prognosis of breast cancer in young women...
  11. ncbi request reprint Intracystic papillary carcinomas of the breast: a reevaluation using a panel of myoepithelial cell markers
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Am J Surg Pathol 30:1002-7. 2006
    ....
  12. pmc Relationship between clinical and pathologic features of ductal carcinoma in situ and patient age: an analysis of 657 patients
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue Boston, MA 02215, USA
    Am J Surg Pathol 33:1802-8. 2009
    ..Whether these features contribute to the higher local recurrence risk in young women with DCIS treated with the breast-conserving therapy requires further study...
  13. pmc Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health Study
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Mod Pathol 24:924-31. 2011
    ..Our findings raise the possibility that targeting the androgen receptor pathway may represent a novel therapeutic approach to the management of patients with basal-like cancers...
  14. ncbi request reprint Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses' Health Study
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer 103:1778-84. 2005
    ..Studies of patients with ductal carcinoma in situ (DCIS) "treated" by diagnostic biopsy alone have been rare, but provide important opportunities to gain insights into the natural history of these lesions...
  15. ncbi request reprint HER2 protein overexpression in estrogen receptor-positive ductal carcinoma in situ of the breast: frequency and implications for tamoxifen therapy
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 18:615-20. 2005
    ..Whether or not HER2 overexpression is associated with a diminished response to tamoxifen in patients with ER-positive DCIS will require investigation in clinical outcome studies...
  16. pmc Ten-year risk of diagnostic mammograms and invasive breast procedures after breast-conserving surgery for DCIS
    Larissa Nekhlyudov
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    J Natl Cancer Inst 104:614-21. 2012
    ..Breast-conserving surgery (BCS) is the most common treatment for ductal carcinoma in situ (DCIS); however, how often women experience subsequent diagnostic evaluations over time is not known...
  17. pmc Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res Treat 128:243-50. 2011
    ..Further studies to confirm these findings are necessary...
  18. pmc Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res Treat 131:159-67. 2012
    ..Identifying risk factors for less common subtypes such as luminal B, HER2-type and basal-like tumors has important implications for prevention of these more aggressive subtypes...
  19. pmc Columnar cell lesions and subsequent breast cancer risk: a nested case-control study
    Sarah A Aroner
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 12:R61. 2010
    ..However, the risk of subsequent breast cancer associated with the presence of CCL in a benign breast biopsy is poorly understood...
  20. pmc Lobule type and subsequent breast cancer risk: results from the Nurses' Health Studies
    Heather J Baer
    Division of General Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    Cancer 115:1404-11. 2009
    ..Lobules in normal breast tissue can be classified based on their degree of development, which may affect their susceptibility to carcinogenesis. However, few epidemiologic studies to date have addressed this...
  21. pmc Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health Study
    Jonathan D Marotti
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 23:197-204. 2010
    ..The role of ER-beta in the development and progression of breast cancers defined by lack of expression of ER-alpha merits further investigation...
  22. pmc Adherence to long-term surveillance mammography among women with ductal carcinoma in situ treated with breast-conserving surgery
    Larissa Nekhlyudov
    Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    J Clin Oncol 27:3211-6. 2009
    ..CONCLUSION Surveillance mammography after BCS among insured women with DCIS often did not occur yearly and declined over time after treatment. Patients and providers must remain vigilant about surveillance after BCS...
  23. doi request reprint Pathologic features and immunophenotype of estrogen receptor-positive breast cancers in BRCA1 mutation carriers
    Jennifer S Kaplan
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Surg Pathol 36:1483-8. 2012
    ..We conclude that ER+ BRCA1-related breast cancers show several morphologic and immunophenotypic differences from ER+ sporadic breast cancers as well as some similarities to ER- BRCA1-related cancers...
  24. pmc Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancer
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Breast Cancer Res 10:R67. 2008
    ..The purpose of this study was to compare the prevalence of these distinct molecular subtypes among cases of DCIS and invasive breast cancer...
  25. pmc Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers
    Nadine Tung
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Breast Cancer Res 12:R95. 2010
    ....
  26. pmc High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:18378-83. 2011
    ..The findings indicate that HSF1 should be evaluated prospectively as an independent prognostic indicator in ER-positive breast cancer. HSF1 may ultimately be a useful therapeutic target in cancer...
  27. pmc Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 21:1033-46. 2010
    ..We examined the association between adolescent fiber intake and proliferative BBD, a marker of increased breast cancer risk, in the Nurses' Health Study II...
  28. pmc Androgen receptor expression and breast cancer survival in postmenopausal women
    Rong Hu
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 17:1867-74. 2011
    ..However, the association between tumor AR status and breast cancer survival is uncertain. Hence, we examined the association between AR status and breast cancer survival in the Nurses' Health Study (NHS)...
  29. pmc Radial scars and subsequent breast cancer risk: results from the Nurses' Health Studies
    Sarah A Aroner
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Breast Cancer Res Treat 139:277-85. 2013
    ..Larger studies are needed to further evaluate whether risk is increased when multiple RS are present and whether associations vary by age at biopsy or by hormone receptor status of the breast tumor...
  30. ncbi request reprint Ductal carcinoma in situ with basal-like phenotype: a possible precursor to invasive basal-like breast cancer
    Bradley B Bryan
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 19:617-21. 2006
    ....
  31. pmc Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:180-90. 2010
    ..These results suggest that genetic variants and circulating levels of IGFBP-3 may play a role in the early stage of breast carcinogenesis...
  32. pmc Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II
    Megan S Rice
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave 3rd Floor, Boston, MA, 02115 USA
    Breast Cancer Res 14:R44. 2012
    ..Studies in animal models suggest that insulin-like growth factor-1 (IGF-1) may inhibit involution of lobules in the breast; however, this has not been studied in humans...
  33. pmc Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features
    Nadine Tung
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Brookline Avenue, Boston, MA 02215, USA
    Breast Cancer Res 12:R12. 2010
    ..We undertook a study to assess the clinical factors that predict for an estrogen receptor positive (ER+) breast cancer in BRCA1 mutation carriers and to characterize the pathologic features of these tumors...
  34. doi request reprint DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer
    Brian M Alexander
    Dana Farber Brigham and Women s Cancer Center Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 16:5796-804. 2010
    ....
  35. doi request reprint Phenotypic alterations in myoepithelial cells associated with benign sclerosing lesions of the breast
    Justin B Hilson
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 34:896-900. 2010
    ..This needs to be taken into consideration when selecting myoepithelial markers to help distinguish benign sclerosing lesions from invasive breast cancer...
  36. doi request reprint Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: biologic and diagnostic implications
    Justin B Hilson
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Surg Pathol 33:227-32. 2009
    ..This observation should be taken into consideration when selecting MEC markers to help distinguish in situ from invasive breast carcinomas...
  37. doi request reprint Update on percutaneous needle biopsy of nonmalignant breast lesions
    Nicole B Johnson
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA02215, USA
    Adv Anat Pathol 16:183-95. 2009
    ....
  38. pmc Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidence
    Xuehong Zhang
    Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory at Landmark Center, 401 Park Dr, Boston, MA 02115, USA
    J Clin Oncol 30:3468-77. 2012
    ..We examined these associations with breast cancer, both overall and by molecular subtype...
  39. ncbi request reprint Carcinoid tumors in the breast
    J Nalinee Upalakalin
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Am J Surg 191:799-805. 2006
    ..Carcinoid tumors in the breast are rare. Most represent metastases from other primary sites, but commonly are mistaken for primary breast lesions...
  40. ncbi request reprint Diagnostic agreement in the evaluation of image-guided breast core needle biopsies: results from a randomized clinical trial
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Am J Surg Pathol 28:126-31. 2004
    ....
  41. pmc Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics
    Lusine Yaghjyan
    Department of Surgery, Division of Public Health Sciences, Washington University in St Louis School of Medicine, St Louis, MO, USA
    J Natl Cancer Inst 103:1179-89. 2011
    ..We aimed to determine whether the associations between breast density and subsequent breast cancer varied by tumor characteristics...
  42. ncbi request reprint Relative risk of high grade squamous intraepithelial lesion associated with prior abnormal Pap smears
    L C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Reprod Med 46:105-9. 2001
    ..Pap smear frequency remains controversial, especially for women with consecutive negative smears. We undertook the current study to ascertain the association of high grade squamous intraepithelial lesions (HSIL) and prior abnormal Paps...
  43. ncbi request reprint Atypical cytology in a persistent seroma following mastectomy for breast cancer: a case report and review of the literature
    Brian M Alexander
    Harvard Radiation Oncology Program, Boston, Massachusetts 02115, USA
    Breast J 13:196-9. 2007
    ..We report a case of a woman with atypical cells in a persistent seroma following mastectomy for node negative infiltrating ductal carcinoma...
  44. ncbi request reprint Bimodal frequency distribution of estrogen receptor immunohistochemical staining results in breast cancer: an analysis of 825 cases
    Laura C Collins
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Clin Pathol 123:16-20. 2005
    ..The overwhelming majority of breast cancers are either completely ER- or unambiguously ER+, and cases with weak ER immunostaining are rare...
  45. pmc Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression
    Celina G Kleer
    Department of Pathology, University of Michigan Cancer Center, Ann Arbor, Michigan, USA
    Clin Cancer Res 14:5357-67. 2008
    ..To evaluate the expression of cathepsin K (CTSK) and CXCL14 in stromal and epithelial cells in human breast tumor progression...
  46. ncbi request reprint Interobserver reproducibility in the diagnosis of flat epithelial atypia of the breast
    Frances P O'Malley
    Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
    Mod Pathol 19:172-9. 2006
    ..1-97.4%), than for determining its presence (90.4%: 95% CI, 79.9-96.7%). We conclude that the diagnosis of FEA and its distinction from CCLs without atypia is highly reproducible with the use of available diagnostic criteria...
  47. ncbi request reprint Ductal lavage of fluid-yielding and non-fluid-yielding ducts in BRCA1 and BRCA2 mutation carriers and other women at high inherited breast cancer risk
    Allison W Kurian
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 5820
    Cancer Epidemiol Biomarkers Prev 14:1082-9. 2005
    ..Most publications on ductal lavage for cell collection report cannulating fluid-yielding ducts only. We report lavage of fluid-yielding and non-fluid-yielding ducts in women at high inherited breast cancer risk...