Research Topics
Genomes and Genes | Laura C CollinsSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community settingLaurel A Habel
Division of Research, Kaiser Permanente, Northern California, 2000 Broadway, Oakland, CA 94612, USA
Breast Cancer Res 11:R85. 2009..The aims of this study were to examine the use and impact of these therapies on risk of recurrence among ductal carcinoma in situ patients diagnosed and treated in the community setting...
The influence of family history on breast cancer risk in women with biopsy-confirmed benign breast disease: results from the Nurses' Health StudyLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer 107:1240-7. 2006..However, the influence of a positive family history (FH) on breast cancer risk among women with biopsy-confirmed BBD is less certain...- Relationship between clinical and pathologic features of ductal carcinoma in situ and patient age: an analysis of 657 patientsLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue Boston, MA 02215, USA
Am J Surg Pathol 33:1802-8. 2009..Whether these features contribute to the higher local recurrence risk in young women with DCIS treated with the breast-conserving therapy requires further study... 
Comparison of estrogen receptor results from pathology reports with results from central laboratory testingLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
J Natl Cancer Inst 100:218-21. 2008..78, P < .001). Thus, ER assay results from pathology reports appear to be a reasonable alternative to central laboratory ER testing for large, population-based studies of patients with breast cancer...- Papillary lesions of the breast: selected diagnostic and management issuesL C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Histopathology 52:20-9. 2008..The role of immunohistochemistry in the evaluation of these lesions, particularly the role of myoepithelial cell markers, will be emphasized... - Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia: an analysis of 543 patientsLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Mod Pathol 20:1149-55. 2007.... - Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissueLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Appl Immunohistochem Mol Morphol 17:438-41. 2009..Whether or not TMAs may also be a potentially useful platform for assessing biomarkers in benign proliferative breast lesions (BPBL) and normal breast tissue has not been previously studied in detail... - Magnitude and laterality of breast cancer risk according to histologic type of atypical hyperplasia: results from the Nurses' Health StudyLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer 109:180-7. 2007..Atypical hyperplasia (AH) in a benign breast biopsy is associated with an increased breast cancer risk. However, the influence of the histologic type of AH on the magnitude and laterality of breast cancer risk is poorly defined... - Intracystic papillary carcinomas of the breast: a reevaluation using a panel of myoepithelial cell markersLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Am J Surg Pathol 30:1002-7. 2006.... - Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health StudyLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Mod Pathol 24:924-31. 2011..Our findings raise the possibility that targeting the androgen receptor pathway may represent a novel therapeutic approach to the management of patients with basal-like cancers... - HER2 protein overexpression in estrogen receptor-positive ductal carcinoma in situ of the breast: frequency and implications for tamoxifen therapyLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Mod Pathol 18:615-20. 2005..Whether or not HER2 overexpression is associated with a diminished response to tamoxifen in patients with ER-positive DCIS will require investigation in clinical outcome studies... - Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses' Health StudyLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer 103:1778-84. 2005..Studies of patients with ductal carcinoma in situ (DCIS) "treated" by diagnostic biopsy alone have been rare, but provide important opportunities to gain insights into the natural history of these lesions... - Basal cytokeratin and epidermal growth factor receptor expression are not predictive of BRCA1 mutation status in women with triple-negative breast cancersLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Am J Surg Pathol 33:1093-7. 2009..However, whether or not expression of biomarkers characteristic of basal-like breast cancers helps to define a subset of women with triple-negative breast cancers who are likely to harbor BRCA1 mutations is an unresolved issue... - Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancerL C Collins
Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, USA
Breast Cancer Res Treat 131:1061-6. 2012..These findings may have implications with regard to the etiology and prognosis of breast cancer in young women... - Ten-year risk of diagnostic mammograms and invasive breast procedures after breast-conserving surgery for DCISLarissa Nekhlyudov
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
J Natl Cancer Inst 104:614-21. 2012..Breast-conserving surgery (BCS) is the most common treatment for ductal carcinoma in situ (DCIS); however, how often women experience subsequent diagnostic evaluations over time is not known... - Expression of IGF1R in normal breast tissue and subsequent risk of breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Breast Cancer Res Treat 128:243-50. 2011..Further studies to confirm these findings are necessary... - Traditional breast cancer risk factors in relation to molecular subtypes of breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res Treat 131:159-67. 2012..Identifying risk factors for less common subtypes such as luminal B, HER2-type and basal-like tumors has important implications for prevention of these more aggressive subtypes... - Columnar cell lesions and subsequent breast cancer risk: a nested case-control studySarah A Aroner
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Breast Cancer Res 12:R61. 2010..However, the risk of subsequent breast cancer associated with the presence of CCL in a benign breast biopsy is poorly understood... - Lobule type and subsequent breast cancer risk: results from the Nurses' Health StudiesHeather J Baer
Division of General Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
Cancer 115:1404-11. 2009..Lobules in normal breast tissue can be classified based on their degree of development, which may affect their susceptibility to carcinogenesis. However, few epidemiologic studies to date have addressed this... - Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health StudyJonathan D Marotti
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Mod Pathol 23:197-204. 2010..The role of ER-beta in the development and progression of breast cancers defined by lack of expression of ER-alpha merits further investigation... - Pathologic features and immunophenotype of estrogen receptor-positive breast cancers in BRCA1 mutation carriersJennifer S Kaplan
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Surg Pathol 36:1483-8. 2012..We conclude that ER+ BRCA1-related breast cancers show several morphologic and immunophenotypic differences from ER+ sporadic breast cancers as well as some similarities to ER- BRCA1-related cancers... - Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancerRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
Breast Cancer Res 10:R67. 2008..The purpose of this study was to compare the prevalence of these distinct molecular subtypes among cases of DCIS and invasive breast cancer... - Adherence to long-term surveillance mammography among women with ductal carcinoma in situ treated with breast-conserving surgeryLarissa Nekhlyudov
Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
J Clin Oncol 27:3211-6. 2009..CONCLUSION Surveillance mammography after BCS among insured women with DCIS often did not occur yearly and declined over time after treatment. Patients and providers must remain vigilant about surveillance after BCS... - Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancersNadine Tung
Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Breast Cancer Res 12:R95. 2010.... - High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancerSandro Santagata
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:18378-83. 2011..The findings indicate that HSF1 should be evaluated prospectively as an independent prognostic indicator in ER-positive breast cancer. HSF1 may ultimately be a useful therapeutic target in cancer... - Intake of fiber and nuts during adolescence and incidence of proliferative benign breast diseaseXuefen Su
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
Cancer Causes Control 21:1033-46. 2010..We examined the association between adolescent fiber intake and proliferative BBD, a marker of increased breast cancer risk, in the Nurses' Health Study II... - Androgen receptor expression and breast cancer survival in postmenopausal womenRong Hu
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Clin Cancer Res 17:1867-74. 2011..However, the association between tumor AR status and breast cancer survival is uncertain. Hence, we examined the association between AR status and breast cancer survival in the Nurses' Health Study (NHS)... - Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast diseaseXuefen Su
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 126:180-90. 2010..These results suggest that genetic variants and circulating levels of IGFBP-3 may play a role in the early stage of breast carcinogenesis... - Ductal carcinoma in situ with basal-like phenotype: a possible precursor to invasive basal-like breast cancerBradley B Bryan
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Mod Pathol 19:617-21. 2006.... - Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic featuresNadine Tung
Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Brookline Avenue, Boston, MA 02215, USA
Breast Cancer Res 12:R12. 2010..We undertook a study to assess the clinical factors that predict for an estrogen receptor positive (ER+) breast cancer in BRCA1 mutation carriers and to characterize the pathologic features of these tumors... - Phenotypic alterations in myoepithelial cells associated with benign sclerosing lesions of the breastJustin B Hilson
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 34:896-900. 2010..This needs to be taken into consideration when selecting myoepithelial markers to help distinguish benign sclerosing lesions from invasive breast cancer... - Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: biologic and diagnostic implicationsJustin B Hilson
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Am J Surg Pathol 33:227-32. 2009..This observation should be taken into consideration when selecting MEC markers to help distinguish in situ from invasive breast carcinomas... - Update on percutaneous needle biopsy of nonmalignant breast lesionsNicole B Johnson
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA02215, USA
Adv Anat Pathol 16:183-95. 2009.... - DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancerBrian M Alexander
Dana Farber Brigham and Women s Cancer Center Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts, USA
Clin Cancer Res 16:5796-804. 2010.... - Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidenceXuehong Zhang
Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory at Landmark Center, 401 Park Dr, Boston, MA 02115, USA
J Clin Oncol 30:3468-77. 2012..We examined these associations with breast cancer, both overall and by molecular subtype... - Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study IIMegan S Rice
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave 3rd Floor, Boston, MA, 02115 USA
Breast Cancer Res 14:R44. 2012..Studies in animal models suggest that insulin-like growth factor-1 (IGF-1) may inhibit involution of lobules in the breast; however, this has not been studied in humans... - Carcinoid tumors in the breastJ Nalinee Upalakalin
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Am J Surg 191:799-805. 2006..If there is no history of a prior carcinoid tumor, a thorough work-up to look for an occult primary tumor elsewhere should be performed... - Diagnostic agreement in the evaluation of image-guided breast core needle biopsies: results from a randomized clinical trialLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Am J Surg Pathol 28:126-31. 2004..89, 95% confidence interval 0.86-0.92). CONCLUSIONS: The level of diagnostic agreement in interpretation of breast CNB is extremely high among pathologists and is comparable to that seen for open surgical biopsy... - Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristicsLusine Yaghjyan
Department of Surgery, Division of Public Health Sciences, Washington University in St Louis School of Medicine, St Louis, MO, USA
J Natl Cancer Inst 103:1179-89. 2011..We aimed to determine whether the associations between breast density and subsequent breast cancer varied by tumor characteristics... - Relative risk of high grade squamous intraepithelial lesion associated with prior abnormal Pap smearsL C Collins
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
J Reprod Med 46:105-9. 2001..Pap smear frequency remains controversial, especially for women with consecutive negative smears. We undertook the current study to ascertain the association of high grade squamous intraepithelial lesions (HSIL) and prior abnormal Paps... - Atypical cytology in a persistent seroma following mastectomy for breast cancer: a case report and review of the literatureBrian M Alexander
Harvard Radiation Oncology Program, Boston, Massachusetts 02115, USA
Breast J 13:196-9. 2007..We report a case of a woman with atypical cells in a persistent seroma following mastectomy for node negative infiltrating ductal carcinoma... - Bimodal frequency distribution of estrogen receptor immunohistochemical staining results in breast cancer: an analysis of 825 casesLaura C Collins
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Clin Pathol 123:16-20. 2005..The overwhelming majority of breast cancers are either completely ER- or unambiguously ER+, and cases with weak ER immunostaining are rare... - Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progressionCelina G Kleer
Department of Pathology, University of Michigan Cancer Center, Ann Arbor, Michigan, USA
Clin Cancer Res 14:5357-67. 2008..To evaluate the expression of cathepsin K (CTSK) and CXCL14 in stromal and epithelial cells in human breast tumor progression... - Interobserver reproducibility in the diagnosis of flat epithelial atypia of the breastFrances P O'Malley
Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
Mod Pathol 19:172-9. 2006..1-97.4%), than for determining its presence (90.4%: 95% CI, 79.9-96.7%). We conclude that the diagnosis of FEA and its distinction from CCLs without atypia is highly reproducible with the use of available diagnostic criteria... - Ductal lavage of fluid-yielding and non-fluid-yielding ducts in BRCA1 and BRCA2 mutation carriers and other women at high inherited breast cancer riskAllison W Kurian
Division of Oncology, Department of Medicine, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 5820
Cancer Epidemiol Biomarkers Prev 14:1082-9. 2005..Most publications on ductal lavage for cell collection report cannulating fluid-yielding ducts only. We report lavage of fluid-yielding and non-fluid-yielding ducts in women at high inherited breast cancer risk...