Research Topics
| Andrew J ColeSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Debate: Should antiepileptic drugs be stopped after successful epilepsy surgery?Andrew J Cole
Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Epilepsia 49:29-34. 2008..The goal is to provide physicians with the best available data, a context in which to consider it, and a full understanding of its limitations. This article also highlights an area that is ripe for further prospective study...
Advances in the application of technology to epilepsy: the CIMIT/NIO Epilepsy Innovation SummitSteven C Schachter
Center for Integration of Medicine and Innovative Technology, Boston, MA, USA
Epilepsy Behav 16:3-46. 2009..This article summarizes the discussions and demonstrates that cross-disciplinary interactions can catalyze collaborations between physicians and engineers to address and solve many of the pressing unmet needs in epilepsy...- Treatment of acute seizures and status epilepticusDaniel J Costello
Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Intensive Care Med 22:319-47. 2007.... - An intraoperative multimodal neurophysiologic approach to successful resection of precentral gyrus epileptogenic lesionsMirela V Simon
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02214, USA
Epilepsia 53:e75-9. 2012.... 
Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsyClaus Reinsberger
Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 52:1238-42. 2010..This finding may, in part, explain the unfavorable outcome in some MTLE patients after epilepsy surgery...- Cryptogenic New Onset Refractory Status Epilepticus (NORSE) in adults-Infectious or not?Daniel J Costello
Epilepsy Service, Department of Neurology, ACC 835, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Neurol Sci 277:26-31. 2009..They are usually presumed to be due to infectious encephalitis and typically have devastating consequences. We describe our experience with six adults who presented with NORSE and raise the possibility of non-infectious causes... - The utility of routine EEG in the diagnosis of sleep disordered breathingIoannis Karakis
Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Neurophysiol 29:333-8. 2012..Increased awareness is required by the EEG technologists, interpreting neurologists, and referring physicians, regarding reporting and using sleep apnea features on the EEG... - Absence of early epileptiform abnormalities predicts lack of seizures on continuous EEGMouhsin M Shafi
Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Neurology 79:1796-801. 2012..To determine whether the absence of early epileptiform abnormalities predicts absence of later seizures on continuous EEG monitoring of hospitalized patients... - Foramen ovale electrodes in the evaluation of epilepsy surgery: conventional and unconventional usesIoannis Karakis
Epilepsy Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Epilepsy Behav 22:247-54. 2011..We also summarize the pros and cons of FO electrodes implantation and attempt to reestablish their utility in presurgical evaluation... - Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsyNaoaki Tanaka
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Epilepsy Res 85:279-86. 2009..Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy... - Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: behavioral, physiological and histological studiesYi Zheng
Epilepsy Research Laboratory, Epilepsy Service and Neurology Service, Massachusetts General Hospital, Boston, MA 02114, USA
Neuropharmacology 58:793-8. 2010..We sought to determine the effect of LEV administered intravenously in a chemoconvulsant model of status epilepticus... - Propofol and the electroencephalogramDaniel San-Juan
Neurophysiology Service, Massachusetts General Hospital, MA 02114, USA
Clin Neurophysiol 121:998-1006. 2010..This paper presents a review of the effects of propofol in electroencephalograms and discusses proconvulsive, anticonvulsive proprieties and the EEG findings in different medical conditions... - Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticusDaniel J Costello
Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
Arch Neurol 63:895-901. 2006..There have been few published reports of successful surgical treatment of focal status epilepticus. Surgical intervention is considered a last resort after medical strategies have been exhausted... - Hyperacute neuropathological findings after proton beam radiosurgery of the rat hippocampusJonathan L Brisman
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Neurosurgery 56:1330-7; discussion 1337-8. 2005..Activated mitogen-activated protein kinase was incompletely colocalized with DNAF, suggesting that activation of this cascade is neither necessary nor sufficient to initiate acute cell death after irradiation... - Status epilepticus and periictal imagingAndrew J Cole
MGH Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Epilepsia 45:72-7. 2004..A framework is proposed for considering the relation between ictal duration and severity, the characteristics of imaging abnormalities, and the mechanism of their underlying pathophysiology... - Prognostic implications of periodic epileptiform dischargesDaniel San Juan Orta
Epilepsy Service, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Arch Neurol 66:985-91. 2009..Periodic epileptiform discharges (PEDs) are an abnormal finding on electroencephalograms (EEGs), the significance of which is uncertain... - Revising the "Rule of Three" for inferring seizure freedomM Brandon Westover
Neurology Department, Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Epilepsia 53:368-76. 2012..Therefore, we set out to determine whether an alternative approach to the Rule of Three might be possible, and under what conditions the rule may be expected to hold or would need to be extended... - Susceptibility to seizure-induced injury and acquired microencephaly following intraventricular injection of saporin-conjugated 192 IgG in developing rat brainSookyong Koh
MGH Epilepsy Service, Epilepsy Research Laboratory, Massachusetts General Hospital and Harvard Medical School, VBK 830, 55 Fruit Street, Boston, MA 02114, USA
Exp Neurol 194:457-66. 2005.... - Extrapyramidal epilepsyIoannis Karakis
Massachussets General Hospital, Harvard Medical School, Boston, MA, USA
Epileptic Disord 13:181-4. 2011..Familiarity and inclusion of the disease in the list of conditions that mimic epilepsy, as well as prolonged video-EEG recordings, may prevent diagnostic delays and unnecessary or belated treatments. [Published with video sequences]... - Multimodal longitudinal imaging of focal status epilepticusColin P Doherty
Epilepsy Service, Neurology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Can J Neurol Sci 31:276-81. 2004..Increased flow through large vessels appeared to be shunted and did not translate into increased microvascular perfusion... - Case records of the Massachusetts General Hospital. Case 24-2007. A 20-year-old pregnant woman with altered mental statusAndrew J Cole
Neurology Service, Massachusetts General Hospital, USA
N Engl J Med 357:589-600. 2007 - Initial individualized selection of long-term anticonvulsant drugs by neurologistsAndrew J Cole
Epilepsy Service, Massachusetts General Hospital, VBK 830, 55 Fruit Street, Boston, MA 02114, USA
Neurology 63:S1-2. 2004 - Guidelines for new epilepsy drugs. New epilepsy drugs are safer and cause fewer adverse effects than their predecessors. But they're not more effectiveAndrew J Cole
Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts, USA
Health News 10:6-7. 2004 - Journal Club: Randomized phase III study 306: Adjunctive perampanel for refractory partial-onset seizuresMathew J Pulicken
From the Massachusetts General Hospital, Epilepsy Service, Boston, MA
Neurology 80:e17-9. 2013..In this Journal Club, we evaluate a phase III study by Krauss et al.(1) that demonstrates efficacy and safety of adjunctive perampanel for refractory partial-onset seizures... - MRI changes in the rat hippocampus following proton radiosurgeryJames D Rabinov
Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Stereotact Funct Neurosurg 82:156-64. 2004..To define radiographic dose-response relationships for proton radiosurgery using a rat brain model... - Diffusion-weighted imaging abnormalities in the splenium after seizuresJoel Oster
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Epilepsia 44:852-4. 2003.... - Neuroprotection and antiepileptogenesis: overview, definitions, and contextAndrew J Cole
MGH Epilepsy Service, Massachusetts General Hospital, Harvard Medical School, Fruit Street, Boston, MA 02114, USA
Neurology 59:S1-2. 2002