THEODORE H COHEN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The prevalence and drug sensitivity of tuberculosis among patients dying in hospital in KwaZulu-Natal, South Africa: a postmortem study
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000296. 2010
  2. pmc Use of spatial information to predict multidrug resistance in tuberculosis patients, Peru
    Hsien Ho Lin
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 18:811-3. 2012
  3. pmc Spontaneous emergence of multiple drug resistance in tuberculosis before and during therapy
    Caroline Colijn
    Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e18327. 2011
  4. pmc Mixed-strain mycobacterium tuberculosis infections and the implications for tuberculosis treatment and control
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Microbiol Rev 25:708-19. 2012
  5. pmc Linking surveillance with action against drug-resistant tuberculosis
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 186:399-401. 2012
  6. pmc Too little of a good thing: a paradox of moderate infection control
    Ted Cohen
    Division of Social Medicine and Health Inequalities Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Epidemiology 19:588-9. 2008
  7. pmc Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston MA 02115, USA
    Proc Natl Acad Sci U S A 105:16302-7. 2008
  8. pmc Estimating the magnitude and direction of bias in tuberculosis drug resistance surveys conducted only in the public sector: a simulation study
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, 641 Huntington Avenue, Boston 02115, USA
    BMC Public Health 10:355. 2010
  9. ncbi request reprint Mathematical models of the epidemiology and control of drug-resistant TB
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA, USA and Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Expert Rev Respir Med 3:67-79. 2009
  10. pmc Are survey-based estimates of the burden of drug resistant TB too low? Insight from a simulation study
    Ted Cohen
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2363. 2008

Detail Information

Publications29

  1. pmc The prevalence and drug sensitivity of tuberculosis among patients dying in hospital in KwaZulu-Natal, South Africa: a postmortem study
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000296. 2010
    ..We conducted limited autopsies on young adults dying in a single public hospital in the province of KwaZulu-Natal between October 2008 and August 2009 in order to estimate the magnitude of deaths attributable to tuberculosis...
  2. pmc Use of spatial information to predict multidrug resistance in tuberculosis patients, Peru
    Hsien Ho Lin
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 18:811-3. 2012
    ..We found that crude representation of spatial location at the level of the health center improved prediction of multidrug resistance...
  3. pmc Spontaneous emergence of multiple drug resistance in tuberculosis before and during therapy
    Caroline Colijn
    Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e18327. 2011
    ..This finding suggests that multidrug resistant M. tb may not be an entirely "man-made" phenomenon and may help explain how highly drug resistant forms of TB have independently emerged in many settings...
  4. pmc Mixed-strain mycobacterium tuberculosis infections and the implications for tuberculosis treatment and control
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Microbiol Rev 25:708-19. 2012
    ..We conclude by highlighting questions that should be resolved in order to improve our understanding of the importance of mixed-strain M. tuberculosis infections...
  5. pmc Linking surveillance with action against drug-resistant tuberculosis
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 186:399-401. 2012
    ..We describe methods for the analysis of routinely collected data and alternative surveys that can help tighten the link between surveillance activities and interventions...
  6. pmc Too little of a good thing: a paradox of moderate infection control
    Ted Cohen
    Division of Social Medicine and Health Inequalities Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Epidemiology 19:588-9. 2008
    ..For those pathogens that cause more severe disease among hosts of an older age, interventions that limit transmission can paradoxically increase the burden of disease in a population...
  7. pmc Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston MA 02115, USA
    Proc Natl Acad Sci U S A 105:16302-7. 2008
    ..tuberculosis within communities...
  8. pmc Estimating the magnitude and direction of bias in tuberculosis drug resistance surveys conducted only in the public sector: a simulation study
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, 641 Huntington Avenue, Boston 02115, USA
    BMC Public Health 10:355. 2010
    ..However, in locations where a substantial fraction of TB cases seek care with private providers, these surveys may not accurately measure resistance in the entire population...
  9. ncbi request reprint Mathematical models of the epidemiology and control of drug-resistant TB
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA, USA and Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Expert Rev Respir Med 3:67-79. 2009
    ..These models also highlight knowledge gaps for which new research will improve our ability to project trends of drug resistance and develop more effective policies for its control...
  10. pmc Are survey-based estimates of the burden of drug resistant TB too low? Insight from a simulation study
    Ted Cohen
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2363. 2008
    ....
  11. pmc Challenges in estimating the total burden of drug-resistant tuberculosis
    Ted Cohen
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 177:1302-6. 2008
    ....
  12. pmc Mixed-strain Mycobacterium tuberculosis infections among patients dying in a hospital in KwaZulu-Natal, South Africa
    Ted Cohen
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Microbiol 49:385-8. 2011
    ..Of 56 culture-positive samples genotyped, we detected mixed strains in five (9%) and clonal heterogeneity in an additional four (7%)...
  13. pmc Exogenous re-infection and the dynamics of tuberculosis epidemics: local effects in a network model of transmission
    Ted Cohen
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, One Brigham Circle, Boston, MA 02120, USA
    J R Soc Interface 4:523-31. 2007
    ..These results have important implications for the development of TB control strategies...
  14. pmc Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV-tuberculosis coinfected populations
    Ted Cohen
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, One Brigham Circle, 1620 Tremont Street, Boston, MA 02120, USA
    Proc Natl Acad Sci U S A 103:7042-7. 2006
    ....
  15. pmc Incident tuberculosis among recent US immigrants and exogenous reinfection
    Ted Cohen
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 11:725-8. 2005
    ..We offer additional data from tuberculosis cases among recent US immigrants which strengthen the claim that reinfection in areas of intense transmission is common...
  16. pmc Multiple introductions of multidrug-resistant tuberculosis into households, Lima, Peru
    Ted Cohen
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 17:969-75. 2011
    ..These findings suggest that community exposure to MDR TB in Lima occurs frequently. Rapid drug sensitivity testing of strains from household contacts of known MDR TB patients is needed to identify optimal treatment regimens...
  17. pmc Negative controls: a tool for detecting confounding and bias in observational studies
    Marc Lipsitch
    Department of Epidemiology, Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 21:383-8. 2010
    ....
  18. pmc The impact of realistic age structure in simple models of tuberculosis transmission
    Ellen Brooks-Pollock
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e8479. 2010
    ..While previous work has addressed the mathematical description of TB natural history, the impact of demography on the behaviour of TB models has not been assessed...
  19. pmc Antiviral resistance and the control of pandemic influenza
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e15. 2007
    ..Nonetheless, antiviral resistance has received little attention when evaluating these plans...
  20. ncbi request reprint The effect of drug resistance on the fitness of Mycobacterium tuberculosis
    Ted Cohen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Lancet Infect Dis 3:13-21. 2003
    ..On the basis of these diverse lines of evidence, we conclude that the fitness estimates of drug-resistant M tuberculosis are quite heterogeneous and that this variation may preclude our ability to predict future trends of this pathogen...
  21. pmc Emergent heterogeneity in declining tuberculosis epidemics
    Caroline Colijn
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Theor Biol 247:765-74. 2007
    ..We discuss the implications of this finding for tuberculosis control in low incidence settings...
  22. pmc Personal digital assistants to collect tuberculosis bacteriology data in Peru reduce delays, errors, and workload, and are acceptable to users: cluster randomized controlled trial
    Joaquin A Blaya
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    Int J Infect Dis 13:410-8. 2009
    ..The PDA- and paper-based systems were evaluated based on processing times, frequency of errors, and number of work-hours expended by data collectors...
  23. pmc No coexistence for free: neutral null models for multistrain pathogens
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemics 1:2-13. 2009
    ..Neutral models can be a parsimonious starting point for studying mechanisms of strain coexistence; implications for past and future studies are discussed...
  24. pmc Use of cumulative incidence of novel influenza A/H1N1 in foreign travelers to estimate lower bounds on cumulative incidence in Mexico
    Marc Lipsitch
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e6895. 2009
    ..Accordingly, the total number of cases will be underestimated and disease severity overestimated. This problem is manifest in the current epidemic of novel influenza A/H1N1...
  25. pmc Isoniazid resistance and the future of drug-resistant tuberculosis
    Ted Cohen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Microb Drug Resist 10:280-5. 2004
    ..Here we present ecological evidence to support the hypothesis that mutations at the 315 position of katG confer isoniazid resistance for Mycobacterium tuberculosis without diminishing virulence or transmissibility...
  26. pmc Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness
    Ted Cohen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nat Med 10:1117-21. 2004
    ....
  27. pmc Effects of smoking and solid-fuel use on COPD, lung cancer, and tuberculosis in China: a time-based, multiple risk factor, modelling study
    Hsien Ho Lin
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Lancet 372:1473-83. 2008
    ..We aimed to predict the effects of risk-factor trends on COPD, lung cancer, and tuberculosis...
  28. pmc Development of extensively drug-resistant tuberculosis during multidrug-resistant tuberculosis treatment
    Sonya S Shin
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 182:426-32. 2010
    ..Preventing this amplification of resistance will likely improve clinical outcomes and delay the secondary spread of XDR-TB...
  29. pmc Transmission dynamics and control of severe acute respiratory syndrome
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 300:1966-70. 2003
    ..Public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic...

Research Grants3

  1. Molecular approaches for understanding TB dynamics
    Theodore Cohen; Fiscal Year: 2007
    ..It is our hope that better analytic techniques will allow for more accurate assessments of treatment and prevention. ..
  2. Prevalence, risk factors and consequences of complex M. Tuberculosis infections
    Theodore Cohen; Fiscal Year: 2009
    ..The overall goal of this study is to learn more about the natural history of TB and to use this knowledge to improve the health of individuals and their communities. ..