ADAM EZRA COHEN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Screening fluorescent voltage indicators with spontaneously spiking HEK cells
    Jeehae Park
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e85221. 2013
  2. pmc Euler buckling and nonlinear kinking of double-stranded DNA
    Alexander P Fields
    Biophysics Program, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA and Department of Physics, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Nucleic Acids Res 41:9881-90. 2013
  3. pmc Optical recording of action potentials in mammalian neurons using a microbial rhodopsin
    Joel M Kralj
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA
    Nat Methods 9:90-5. 2012
  4. doi request reprint The cat that caught the canary: what to do with single-molecule trapping
    Adam E Cohen
    Harvard University, Cambridge, Massachusetts 02138, USA
    ACS Nano 5:5296-9. 2011
  5. pmc Controlling Brownian motion of single protein molecules and single fluorophores in aqueous buffer
    Adam E Cohen
    Dept of Chemistry, Stanford University, Stanford, CA 94305, USA
    Opt Express 16:6941-56. 2008
  6. pmc Internal mechanical response of a polymer in solution
    Adam E Cohen
    Department of Physics, Stanford University, Stanford, California 94305, USA
    Phys Rev Lett 98:116001. 2007
  7. pmc Principal-components analysis of shape fluctuations of single DNA molecules
    Adam E Cohen
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:12622-7. 2007
  8. ncbi request reprint Force-extension curve of a polymer in a high-frequency electric field
    Adam E Cohen
    Department of Physics, 382 Via Pueblo Mall, Stanford University, Stanford, California 94305 4060, USA
    Phys Rev Lett 91:235506. 2003
  9. pmc Suppressing Brownian motion of individual biomolecules in solution
    Adam E Cohen
    Department of Physics, Stanford University, 381 Via Pueblo Mall, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:4362-5. 2006
  10. ncbi request reprint Resonant enhancement and dissipation in nonequilibrium van der Waals forces
    Adam E Cohen
    Department of Physics, 382 Via Pueblo Mall, Stanford University, Stanford, California 94305 4060, USA
    Phys Rev Lett 91:233202. 2003

Research Grants

Collaborators

  • Shaul Mukamel
  • W E Moerner
  • L Mahadevan
  • Joel M Kralj
  • Jeehae Park
  • Alexander P Fields
  • Christopher A Werley
  • Sulayman D Dib-Hajj
  • Elisabeth A Meyer
  • Veena Venkatachalam
  • Stephen G Waxman
  • Daniel R Hochbaum
  • Adam D Douglass
  • Dougal Maclaurin

Detail Information

Publications11

  1. pmc Screening fluorescent voltage indicators with spontaneously spiking HEK cells
    Jeehae Park
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e85221. 2013
    ..We screened a small library of mutants of archaerhodopsin 3 (Arch) in spiking HEK cells and identified two mutants with greater voltage-sensitivity than found in previously published Arch voltage indicators. ..
  2. pmc Euler buckling and nonlinear kinking of double-stranded DNA
    Alexander P Fields
    Biophysics Program, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA and Department of Physics, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Nucleic Acids Res 41:9881-90. 2013
    ..The molecular vise is exquisitely sensitive to the sequence-dependent linear and nonlinear elastic properties of dsDNA. ..
  3. pmc Optical recording of action potentials in mammalian neurons using a microbial rhodopsin
    Joel M Kralj
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA
    Nat Methods 9:90-5. 2012
    ..Microbial rhodopsin-based voltage indicators promise to enable optical interrogation of complex neural circuits and electrophysiology in systems for which electrode-based techniques are challenging...
  4. doi request reprint The cat that caught the canary: what to do with single-molecule trapping
    Adam E Cohen
    Harvard University, Cambridge, Massachusetts 02138, USA
    ACS Nano 5:5296-9. 2011
    ..We propose areas of investigation in which anti-Brownian electrokinetic (ABEL) trapping of single molecules is likely to lead to significant new insights into biomolecular dynamics...
  5. pmc Controlling Brownian motion of single protein molecules and single fluorophores in aqueous buffer
    Adam E Cohen
    Dept of Chemistry, Stanford University, Stanford, CA 94305, USA
    Opt Express 16:6941-56. 2008
    ..The feedback latency is set by the finite rate of arrival of photons. We demonstrate trapping of individual molecules of the protein GroEL in buffer, and we show confinement of single fluorophores of the dye Cy3 in water...
  6. pmc Internal mechanical response of a polymer in solution
    Adam E Cohen
    Department of Physics, Stanford University, Stanford, California 94305, USA
    Phys Rev Lett 98:116001. 2007
    ..We find a nonmonotonic radial dependence of the relaxation time. In contrast with earlier measurements on freely diffusing dsDNA, we observe clear signs of internal hydrodynamic interactions...
  7. pmc Principal-components analysis of shape fluctuations of single DNA molecules
    Adam E Cohen
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:12622-7. 2007
    ..The modes show strong signs of nonlinear hydrodynamics, a feature of the underlying equations of polymer dynamics that has not previously been reported and is neglected in the widely used Rouse and Zimm approximations...
  8. ncbi request reprint Force-extension curve of a polymer in a high-frequency electric field
    Adam E Cohen
    Department of Physics, 382 Via Pueblo Mall, Stanford University, Stanford, California 94305 4060, USA
    Phys Rev Lett 91:235506. 2003
    ..A sufficiently strong ac field causes the polymer to extend spontaneously to almost its full contour length. The theory is applied to recent experiments on dielectrophoretic stretching of DNA...
  9. pmc Suppressing Brownian motion of individual biomolecules in solution
    Adam E Cohen
    Department of Physics, Stanford University, 381 Via Pueblo Mall, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:4362-5. 2006
    ..We also demonstrate trapping and manipulation of single virus particles, lipid vesicles, and fluorescent semiconductor nanocrystals...
  10. ncbi request reprint Resonant enhancement and dissipation in nonequilibrium van der Waals forces
    Adam E Cohen
    Department of Physics, 382 Via Pueblo Mall, Stanford University, Stanford, California 94305 4060, USA
    Phys Rev Lett 91:233202. 2003
    ....
  11. pmc Kinks, rings, and rackets in filamentous structures
    Adam E Cohen
    Semiconductor Physics Group, Cavendish Laboratory, Wilberforce Road, Cambridge University, Cambridge CB3 0WA, United Kingdom
    Proc Natl Acad Sci U S A 100:12141-6. 2003
    ..Our mesoscopic continuum theory is capable of quantifying observations of these structures and is suggestive of their occurrence in other filamentous assemblies as well...

Research Grants1

  1. Engineering Microbial Rhodopsins as Optical Voltage Sensors
    ADAM EZRA COHEN; Fiscal Year: 2011
    ..This protein will facilitate studies on the electrophysiology of a wide range of cells implicated in human health and disease. ..