Research Topics
Genomes and Genes | Leo T ChylackSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataractLeo T Chylack
Center for Ophthalmic Research, Department of Surgery, Brigham and Women s Hospital, Boston, MA, USA
Ophthalmic Epidemiol 9:49-80. 2002..Funding surgery worldwide for age-related cataract (ARC), a leading cause of blindness, is a huge economic burden. Non-surgical means of slowing ARC progression could benefit patients and reduce this burden...
NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacityLeo T Chylack
Center for Ophthalmic Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Radiat Res 172:10-20. 2009..These results suggest increased cataract risks at smaller radiation doses than have been reported previously...- A randomized, controlled trial to investigate the effect of ciclesonide and beclomethasone dipropionate on eye lens opacityLeo T Chylack
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
J Asthma 45:893-902. 2008..However, reports from observational studies have suggested that the use of ICS may be associated with systemic adverse events, such as glaucoma and cataract (opacity of the lens) formation... - Dietary glycemic index and carbohydrate in relation to early age-related macular degenerationChung-Jung Chiu
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Am J Clin Nutr 83:880-6. 2006..6) was 2.71 (95% CI: 1.24, 5.93; P for trend = 0.01). Neither dietary GI nor total carbohydrate intake was related to drusen. CONCLUSION: Our results suggest that dietary GI may be an independent risk factor for ARM... - Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesionsMartha Savaria Morris
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Ophthalmic Epidemiol 14:288-98. 2007..Results of observational and intervention studies have been inconsistent... - Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacitiesChung-Jung Chiu
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 81:1411-6. 2005.... - Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear densityMinyi Lu
Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Am Coll Nutr 26:133-40. 2007..The present study was designed to examine the associations between dietary fat and the change in nuclear lens opacification over five years... - Long-term nutrient intake and 5-year change in nuclear lens opacitiesPaul F Jacques
Jean Mayer USDA Human Nutrition Research Center on Aging, School of Nutrition Science and Policy, Tufts University, Boston, Mass, USA
Arch Ophthalmol 123:517-26. 2005..006). CONCLUSION: Our results suggest that long-term use of vitamin E supplements and higher riboflavin and/or thiamin intake may reduce the progression of age-related lens opacification... - NASCA report 2: Longitudinal study of relationship of exposure to space radiation and risk of lens opacityLeo T Chylack
a Center for Ophthalmic Research, Brigham and Women s Hospital, Boston, Massachusetts
Radiat Res 178:25-32. 2012..However, longer follow-up may be needed to further understand any impact of space radiation on progression rates for posterior subcapsular cataracts and nuclear cataracts, and to characterize changes to visual acuity... - Dietary fat intake and early age-related lens opacitiesMinyi Lu
Nutritional Epidemiology Program and the Center for Ophthalmic Research, Department of Ophthalmology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA
Am J Clin Nutr 81:773-9. 2005..Further study is needed to clarify the relation between dietary fat and cataract risk... - Overall adherence to the dietary guidelines for americans is associated with reduced prevalence of early age-related nuclear lens opacities in womenSuzen M Moeller
The Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging and the Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA, USA
J Nutr 134:1812-9. 2004..58; 95% CI: 0.32-1.05) and whole grains (OR = 0.64; 95% CI: 0.36-1.15). These results suggest that overall compliance with the Dietary Guidelines, as measured by the HEI, protects against nuclear opacities... - Weight status, abdominal adiposity, diabetes, and early age-related lens opacitiesPaul F Jacques
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging and Tufts University School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 78:400-5. 2003..CONCLUSIONS: Diabetes is a strong risk factor for PSC opacities, and overweight and abdominal adiposity may be risk factors for PSC opacities... - Moderate alcoholic beverage intake and early nuclear and cortical lens opacitiesMartha Savaria Morris
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Channing Laboratory, Harvard School of Public Health, Boston, MA 02111, USA
Ophthalmic Epidemiol 11:53-65. 2004..CONCLUSIONS: Consumption of alcoholic beverages, particularly hard liquor and wine, was positively related to nuclear opacity. Wine drinking was inversely related to cortical opacity... - LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicityNigar Fatma
Department of Ophthalmology, 985840 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
Am J Physiol Cell Physiol 287:C508-16. 2004..The present findings indicate that LEDGF is one of the transcriptional activators of these genes that facilitates cellular protection against ethanol stress and plays a role in RA production... - Cellular distribution of lens epithelium-derived growth factor (LEDGF) in the rat eye: loss of LEDGF from nuclei of differentiating cellsEri Kubo
The Center for Ophthalmic Research, Brigham and Women s Hospital, Havard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
Histochem Cell Biol 119:289-99. 2003..The spatial and temporal distribution of LEDGF in the present study also provides a vision for further investigation as to how this protein is involved in cell fate determination... - DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGFDhirendra P Singh
Department of Ophthalmology, and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Mol Biol 355:379-94. 2006..Collectively, our results demonstrate that LEDGF contains three DNA-binding domains, which regulate gene expression depending on cellular microenvironment and thus modify the physiology of cells to maintain cellular homeostasis... - Postmenopausal hormone use and lens opacitiesJune M Weintraub
Department of Epidemiology, Harvard School of Public Health, Boston, MA
Ophthalmic Epidemiol 9:179-90. 2002..Women are at higher risk for age-related cataract than men, and it has been hypothesized that this difference is due in part to gender-related hormonal differences... - Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacitiesAllen Taylor
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 75:540-9. 2002..Proper nutrition appears to protect against cataracts. Few studies have related nutrition to the odds of developing cortical or posterior subcapsular (PSC) cataracts... 
Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleachingShuhua Song
Center for Ophthalmic Research Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
Mol Vis 14:1282-7. 2008..We hypothesize that alteration of protein-protein interaction between R120G alphaB-crystallin and lens intermediate filament proteins is one of the mechanisms of congenital cataract...- Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brainLeo T Chylack
Molecular Aging and Development Laboratory, Center for Ophthalmic Research, Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA
Exp Eye Res 79:941-8. 2004..Moreover, the developmental and regional expression patterns of LEDGF/p75 suggest that this transcriptional co-activator may be involved in neuroepithelial stem cell differentiation and neurogenesis... - Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cellsPreeti Sharma
Center for Ophthalmic Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:20037-46. 2003..Because overexpression of LEDGF was able to relieve TGF-beta1 and/or stress-induced changes, it would be a candidate molecule to postpone age-related degenerating disorders... - Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's diseaseLee E Goldstein
Laboratory for Oxidation Biology, Massachusetts General Hospital, Charlestown, MA 02129-4404, USA
Lancet 361:1258-65. 2003..INTERPRETATION: Abeta is present in the cytosol of lens fibre cells of people with Alzheimer's disease. Lens Abeta might promote regionally-specific lens protein aggregation, extracerebral amyloid formation, and supranuclear cataracts... - Topical ocular hypotensive medication and lens opacification: evidence from the ocular hypertension treatment studyDavid C Herman
Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Am J Ophthalmol 142:800-10. 2006..We found no evidence for a general effect of topical ocular hypotensive medication on lens opacification or visual function... - Clinical application of the lens opacities classification system III in the performance of phacoemulsificationJames A Davison
Wolfe Clinic, Marshalltown, Iowa, USA
J Cataract Refract Surg 29:138-45. 2003..Preoperative LOCS III cataract classification can help to create a more formally organized, integrated, customized operative plan...