Leo T Chylack

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract
    Leo T Chylack
    Center for Ophthalmic Research, Department of Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Ophthalmic Epidemiol 9:49-80. 2002
  2. doi request reprint NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity
    Leo T Chylack
    Center for Ophthalmic Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Radiat Res 172:10-20. 2009
  3. ncbi request reprint A randomized, controlled trial to investigate the effect of ciclesonide and beclomethasone dipropionate on eye lens opacity
    Leo T Chylack
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    J Asthma 45:893-902. 2008
  4. ncbi request reprint Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration
    Chung Jung Chiu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 83:880-6. 2006
  5. ncbi request reprint Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesions
    Martha Savaria Morris
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Ophthalmic Epidemiol 14:288-98. 2007
  6. ncbi request reprint Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities
    Chung Jung Chiu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 81:1411-6. 2005
  7. ncbi request reprint Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density
    Minyi Lu
    Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 26:133-40. 2007
  8. ncbi request reprint Long-term nutrient intake and 5-year change in nuclear lens opacities
    Paul F Jacques
    Jean Mayer USDA Human Nutrition Research Center on Aging, School of Nutrition Science and Policy, Tufts University, Boston, Mass, USA
    Arch Ophthalmol 123:517-26. 2005
  9. ncbi request reprint NASCA report 2: Longitudinal study of relationship of exposure to space radiation and risk of lens opacity
    Leo T Chylack
    a Center for Ophthalmic Research, Brigham and Women s Hospital, Boston, Massachusetts
    Radiat Res 178:25-32. 2012
  10. ncbi request reprint Dietary fat intake and early age-related lens opacities
    Minyi Lu
    Nutritional Epidemiology Program and the Center for Ophthalmic Research, Department of Ophthalmology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Nutr 81:773-9. 2005

Detail Information

Publications24

  1. ncbi request reprint The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract
    Leo T Chylack
    Center for Ophthalmic Research, Department of Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Ophthalmic Epidemiol 9:49-80. 2002
    ..Funding surgery worldwide for age-related cataract (ARC), a leading cause of blindness, is a huge economic burden. Non-surgical means of slowing ARC progression could benefit patients and reduce this burden...
  2. doi request reprint NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity
    Leo T Chylack
    Center for Ophthalmic Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Radiat Res 172:10-20. 2009
    ..These results suggest increased cataract risks at smaller radiation doses than have been reported previously...
  3. ncbi request reprint A randomized, controlled trial to investigate the effect of ciclesonide and beclomethasone dipropionate on eye lens opacity
    Leo T Chylack
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    J Asthma 45:893-902. 2008
    ..However, reports from observational studies have suggested that the use of ICS may be associated with systemic adverse events, such as glaucoma and cataract (opacity of the lens) formation...
  4. ncbi request reprint Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration
    Chung Jung Chiu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 83:880-6. 2006
    ..Several dietary factors have been linked to age-related maculopathy (ARM), the early form of age-related macular degeneration, and there is reason to think that dietary carbohydrate may play a role in the development of ARM...
  5. ncbi request reprint Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesions
    Martha Savaria Morris
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Ophthalmic Epidemiol 14:288-98. 2007
    ..Results of observational and intervention studies have been inconsistent...
  6. ncbi request reprint Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities
    Chung Jung Chiu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 81:1411-6. 2005
    ..Animal studies suggest a role for dietary carbohydrate in cataractogenesis. However, few published human studies have evaluated associations between carbohydrate nutrition and lens opacification...
  7. ncbi request reprint Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density
    Minyi Lu
    Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 26:133-40. 2007
    ..The present study was designed to examine the associations between dietary fat and the change in nuclear lens opacification over five years...
  8. ncbi request reprint Long-term nutrient intake and 5-year change in nuclear lens opacities
    Paul F Jacques
    Jean Mayer USDA Human Nutrition Research Center on Aging, School of Nutrition Science and Policy, Tufts University, Boston, Mass, USA
    Arch Ophthalmol 123:517-26. 2005
    ..To determine if usual nutrient intake is related to a 5-year change in the amount of lens nuclear opacification assessed by computer-assisted image analysis...
  9. ncbi request reprint NASCA report 2: Longitudinal study of relationship of exposure to space radiation and risk of lens opacity
    Leo T Chylack
    a Center for Ophthalmic Research, Brigham and Women s Hospital, Boston, Massachusetts
    Radiat Res 178:25-32. 2012
    ..However, longer follow-up may be needed to further understand any impact of space radiation on progression rates for posterior subcapsular cataracts and nuclear cataracts, and to characterize changes to visual acuity...
  10. ncbi request reprint Dietary fat intake and early age-related lens opacities
    Minyi Lu
    Nutritional Epidemiology Program and the Center for Ophthalmic Research, Department of Ophthalmology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Nutr 81:773-9. 2005
    ..Dietary fat may affect lens cell membrane composition and function, which are related to age-related cataract...
  11. ncbi request reprint Overall adherence to the dietary guidelines for americans is associated with reduced prevalence of early age-related nuclear lens opacities in women
    Suzen M Moeller
    The Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging and the Gerald J and Dorothy R Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA, USA
    J Nutr 134:1812-9. 2004
    ..58; 95% CI: 0.32-1.05) and whole grains (OR = 0.64; 95% CI: 0.36-1.15). These results suggest that overall compliance with the Dietary Guidelines, as measured by the HEI, protects against nuclear opacities...
  12. ncbi request reprint Weight status, abdominal adiposity, diabetes, and early age-related lens opacities
    Paul F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging and Tufts University School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 78:400-5. 2003
    ..The association between weight status and the risk of lens opacities has received little attention...
  13. ncbi request reprint Moderate alcoholic beverage intake and early nuclear and cortical lens opacities
    Martha Savaria Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Channing Laboratory, Harvard School of Public Health, Boston, MA 02111, USA
    Ophthalmic Epidemiol 11:53-65. 2004
    ..To study the relationship between alcoholic beverage intake and early lens opacities...
  14. ncbi request reprint LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity
    Nigar Fatma
    Department of Ophthalmology, 985840 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5840, USA
    Am J Physiol Cell Physiol 287:C508-16. 2004
    ..The present findings indicate that LEDGF is one of the transcriptional activators of these genes that facilitates cellular protection against ethanol stress and plays a role in RA production...
  15. ncbi request reprint Cellular distribution of lens epithelium-derived growth factor (LEDGF) in the rat eye: loss of LEDGF from nuclei of differentiating cells
    Eri Kubo
    The Center for Ophthalmic Research, Brigham and Women s Hospital, Havard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Histochem Cell Biol 119:289-99. 2003
    ..The spatial and temporal distribution of LEDGF in the present study also provides a vision for further investigation as to how this protein is involved in cell fate determination...
  16. ncbi request reprint DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF
    Dhirendra P Singh
    Department of Ophthalmology, and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Mol Biol 355:379-94. 2006
    ..Collectively, our results demonstrate that LEDGF contains three DNA-binding domains, which regulate gene expression depending on cellular microenvironment and thus modify the physiology of cells to maintain cellular homeostasis...
  17. ncbi request reprint Postmenopausal hormone use and lens opacities
    June M Weintraub
    Department of Epidemiology, Harvard School of Public Health, Boston, MA
    Ophthalmic Epidemiol 9:179-90. 2002
    ..Women are at higher risk for age-related cataract than men, and it has been hypothesized that this difference is due in part to gender-related hormonal differences...
  18. ncbi request reprint Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities
    Allen Taylor
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 75:540-9. 2002
    ..Proper nutrition appears to protect against cataracts. Few studies have related nutrition to the odds of developing cortical or posterior subcapsular (PSC) cataracts...
  19. pmc Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleaching
    Shuhua Song
    Center for Ophthalmic Research Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Vis 14:1282-7. 2008
    ..We hypothesize that alteration of protein-protein interaction between R120G alphaB-crystallin and lens intermediate filament proteins is one of the mechanisms of congenital cataract...
  20. ncbi request reprint Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain
    Leo T Chylack
    Molecular Aging and Development Laboratory, Center for Ophthalmic Research, Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Exp Eye Res 79:941-8. 2004
    ..Moreover, the developmental and regional expression patterns of LEDGF/p75 suggest that this transcriptional co-activator may be involved in neuroepithelial stem cell differentiation and neurogenesis...
  21. ncbi request reprint Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells
    Preeti Sharma
    Center for Ophthalmic Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:20037-46. 2003
    ..Because overexpression of LEDGF was able to relieve TGF-beta1 and/or stress-induced changes, it would be a candidate molecule to postpone age-related degenerating disorders...
  22. ncbi request reprint Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease
    Lee E Goldstein
    Laboratory for Oxidation Biology, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Lancet 361:1258-65. 2003
    ..We aimed to investigate the hypothesis that molecular pathological findings associated with Alzheimer's disease overlap in the lens and brain...
  23. pmc Topical ocular hypotensive medication and lens opacification: evidence from the ocular hypertension treatment study
    David C Herman
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Ophthalmol 142:800-10. 2006
    ..To determine whether topical ocular hypotensive medication is associated with refractive changes, visual symptoms, decreased visual function, or increased lens opacification...
  24. ncbi request reprint Clinical application of the lens opacities classification system III in the performance of phacoemulsification
    James A Davison
    Wolfe Clinic, Marshalltown, Iowa, USA
    J Cataract Refract Surg 29:138-45. 2003
    ....