Sangmi Chung

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi ES cell-derived renewable and functional midbrain dopaminergic progenitors
    Sangmi Chung
    Molecular Neurobiology Laboratory and Department of Psychiatry and Program in Neuroscience, Harvard Stem Cell Institute, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 108:9703-8. 2011
  2. ncbi Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells
    Dong-Wook Kim
    Udall Parkinson's Disease Research Center of Excellence, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:557-67. 2006
  3. ncbi Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
    Sangmi Chung
    Department of Psychiatry and Program in Neuroscience, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Cell Stem Cell 5:646-58. 2009
  4. ncbi Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro
    Sangmi Chung
    Udall Parkinson's Disease Research Center of Excellence, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:1583-93. 2006
  5. ncbi Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
    Sangmi Chung
    Udall Parkinson's Disease Research Center of Excellence, Neuroregeneration Laboratory, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA
    Eur J Neurosci 16:1829-38. 2002
  6. ncbi Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines
    Sangmi Chung
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 20:139-45. 2002
  7. ncbi Transfection and promoter analysis in embryonic stem cells
    Sangmi Chung
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Methods Mol Biol 329:187-93. 2006
  8. ncbi Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner
    Kwang Soo Kim
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurochem 85:622-34. 2003
  9. ncbi Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson's Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002

Collaborators

Detail Information

Publications9

  1. ncbi ES cell-derived renewable and functional midbrain dopaminergic progenitors
    Sangmi Chung
    Molecular Neurobiology Laboratory and Department of Psychiatry and Program in Neuroscience, Harvard Stem Cell Institute, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 108:9703-8. 2011
    ..3 mm length in the entire striatum. We propose that functional and expandable mDA NPs can be efficiently isolated by this unique strategy and will serve as useful tools in regenerative medicine, bioassay, and drug screening...
  2. ncbi Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells
    Dong-Wook Kim
    Udall Parkinson's Disease Research Center of Excellence, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:557-67. 2006
    ....
  3. ncbi Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
    Sangmi Chung
    Department of Psychiatry and Program in Neuroscience, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Cell Stem Cell 5:646-58. 2009
    ..Together with previous works, this study shows that two regulatory loops (Wnt1-Lmx1a and SHH-FoxA2) critically link extrinsic signals to cell-intrinsic factors and cooperatively regulate mDA neuron development...
  4. ncbi Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro
    Sangmi Chung
    Udall Parkinson's Disease Research Center of Excellence, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:1583-93. 2006
    ..We conclude that ES NPs maintain their developmental potential during in vitro expansion, whereas mouse E12.5 VM NPs do not...
  5. ncbi Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
    Sangmi Chung
    Udall Parkinson's Disease Research Center of Excellence, Neuroregeneration Laboratory, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA
    Eur J Neurosci 16:1829-38. 2002
    ....
  6. ncbi Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines
    Sangmi Chung
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 20:139-45. 2002
    ..Our data show that individual promoters have different abilities to express reporter gene expression in the ES and other cell types tested...
  7. ncbi Transfection and promoter analysis in embryonic stem cells
    Sangmi Chung
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Methods Mol Biol 329:187-93. 2006
    ..The judicious selection of the optimum promoter system for specific genetic modification of ES cells will ensure the successful generation of transgenic ES cell lines...
  8. ncbi Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner
    Kwang Soo Kim
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurochem 85:622-34. 2003
    ..Our results suggest that Nurr1 may play a direct role for specification of DA neurotransmitter identity by activating TH gene transcription in a cell context-dependent manner...
  9. ncbi Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson's Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
    ..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...