Sangmi Chung

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development
    Sangmi Chung
    Molecular Neurobiology Laboratory, Department of Psychiatry and Program in Neuroscience Harvard Stem Cell Institute, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    J Neurochem 122:244-50. 2012
  2. pmc ES cell-derived renewable and functional midbrain dopaminergic progenitors
    Sangmi Chung
    Molecular Neurobiology Laboratory and Department of Psychiatry and Program in Neuroscience, Harvard Stem Cell Institute, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 108:9703-8. 2011
  3. pmc Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells
    Dong Wook Kim
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:557-67. 2006
  4. pmc Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
    Sangmi Chung
    Department of Psychiatry and Program in Neuroscience, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Cell Stem Cell 5:646-58. 2009
  5. pmc Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro
    Sangmi Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:1583-93. 2006
  6. pmc Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
    Sangmi Chung
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Eur J Neurosci 16:1829-38. 2002
  7. pmc Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson's disease, the aphakia (ak) mouse
    Jisook Moon
    Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02178, USA
    Cell Transplant 22:1263-79. 2013
  8. ncbi request reprint Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner
    Kwang Soo Kim
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurochem 85:622-34. 2003
  9. ncbi request reprint Transfection and promoter analysis in embryonic stem cells
    Sangmi Chung
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Methods Mol Biol 329:187-93. 2006
  10. pmc Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines
    Sangmi Chung
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 20:139-45. 2002

Collaborators

Detail Information

Publications12

  1. pmc Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development
    Sangmi Chung
    Molecular Neurobiology Laboratory, Department of Psychiatry and Program in Neuroscience Harvard Stem Cell Institute, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    J Neurochem 122:244-50. 2012
    ..Thus, this study demonstrates that dopamine transporter is a direct target of Lmx1a and emphasizes a novel role of Lmx1a as one of regulators of mature midbrain dopaminergic neurotransmitter phenotypes...
  2. pmc ES cell-derived renewable and functional midbrain dopaminergic progenitors
    Sangmi Chung
    Molecular Neurobiology Laboratory and Department of Psychiatry and Program in Neuroscience, Harvard Stem Cell Institute, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 108:9703-8. 2011
    ..3 mm length in the entire striatum. We propose that functional and expandable mDA NPs can be efficiently isolated by this unique strategy and will serve as useful tools in regenerative medicine, bioassay, and drug screening...
  3. pmc Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells
    Dong Wook Kim
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:557-67. 2006
    ....
  4. pmc Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
    Sangmi Chung
    Department of Psychiatry and Program in Neuroscience, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Cell Stem Cell 5:646-58. 2009
    ..Together with previous works, this study shows that two regulatory loops (Wnt1-Lmx1a and SHH-FoxA2) critically link extrinsic signals to cell-intrinsic factors and cooperatively regulate mDA neuron development...
  5. pmc Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro
    Sangmi Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:1583-93. 2006
    ..We conclude that ES NPs maintain their developmental potential during in vitro expansion, whereas mouse E12.5 VM NPs do not...
  6. pmc Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
    Sangmi Chung
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Eur J Neurosci 16:1829-38. 2002
    ....
  7. pmc Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson's disease, the aphakia (ak) mouse
    Jisook Moon
    Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02178, USA
    Cell Transplant 22:1263-79. 2013
    ....
  8. ncbi request reprint Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner
    Kwang Soo Kim
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurochem 85:622-34. 2003
    ..Our results suggest that Nurr1 may play a direct role for specification of DA neurotransmitter identity by activating TH gene transcription in a cell context-dependent manner...
  9. ncbi request reprint Transfection and promoter analysis in embryonic stem cells
    Sangmi Chung
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Methods Mol Biol 329:187-93. 2006
    ..The judicious selection of the optimum promoter system for specific genetic modification of ES cells will ensure the successful generation of transgenic ES cell lines...
  10. pmc Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines
    Sangmi Chung
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 20:139-45. 2002
    ..Our data show that individual promoters have different abilities to express reporter gene expression in the ES and other cell types tested...
  11. pmc Functional roles of Nurr1, Pitx3, and Lmx1a in neurogenesis and phenotype specification of dopamine neurons during in vitro differentiation of embryonic stem cells
    Sunghoi Hong
    1 Molecular Neurobiology Laboratory, Department of Psychiatry and Program in Neuroscience, McLean Hospital Harvard Medical School, Belmont, Massachusetts
    Stem Cells Dev 23:477-87. 2014
    ..Taken together, our data demonstrate that key mDA regulators (Nurr1, Pitx3, and Lmx1a) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons. ..
  12. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
    ..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...