Jun Chung

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
  2. ncbi request reprint Contributions of the alpha6 integrins to breast carcinoma survival and progression
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cells 17:203-9. 2004
  3. ncbi request reprint Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 64:4711-6. 2004
  4. ncbi request reprint The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:32287-93. 2004
  5. ncbi request reprint Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Semin Cancer Biol 14:115-22. 2004
  6. ncbi request reprint Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine and Veterans Affairs Hospital, Atlanta, Georgia 30322, USA
    J Biol Chem 280:13936-43. 2005
  7. doi request reprint Integrin-dependent translational control: Implication in cancer progression
    Jun Chung
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Microsc Res Tech 71:380-6. 2008

Collaborators

Detail Information

Publications7

  1. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
    ..These findings reveal that integrin-mediated activation of PI-3K-Akt is amplified by integrin-stimulated VEGF expression and they provide a mechanism that substantiates the reported role of alpha 6 beta 4 in carcinoma progression...
  2. ncbi request reprint Contributions of the alpha6 integrins to breast carcinoma survival and progression
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cells 17:203-9. 2004
    ..VEGF produced by breast carcinoma cells in response to alpha6 integrin regulation can function in an autocrine manner to promote survival signaling...
  3. ncbi request reprint Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 64:4711-6. 2004
    ....
  4. ncbi request reprint The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:32287-93. 2004
    ..These data argue that the invasive function of Met can be independent of alpha(6)beta(4) and that alpha(6)beta(4) has a generic influence on the invasion of carcinoma cells that is not specific to Met...
  5. ncbi request reprint Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Semin Cancer Biol 14:115-22. 2004
    ....
  6. ncbi request reprint Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine and Veterans Affairs Hospital, Atlanta, Georgia 30322, USA
    J Biol Chem 280:13936-43. 2005
    ..Our model allows the assessment of epigenetic changes that occur during human carcinogenesis. In addition, these studies provide insight into the clinical failure of tyrosine kinase inhibitors as monotherapy for advanced malignancy...
  7. doi request reprint Integrin-dependent translational control: Implication in cancer progression
    Jun Chung
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Microsc Res Tech 71:380-6. 2008
    ..This review also examines the hypothesis that integrins contribute to various aspects of cancer progression such as proliferation, survival, angiogenesis, and invasion through translational control...