P Christmas

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Alternative splicing determines the function of CYP4F3 by switching substrate specificity
    P Christmas
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 276:38166-72. 2001
  2. ncbi Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter
    Peter Christmas
    Renal Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    J Biol Chem 278:25133-42. 2003
  3. ncbi Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase
    P Christmas
    Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 274:21191-9. 1999
  4. ncbi Differential localization of 5- and 15-lipoxygenases to the nuclear envelope in RAW macrophages
    P Christmas
    Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 274:25594-8. 1999
  5. ncbi Membrane localization and topology of leukotriene C4 synthase
    Peter Christmas
    Renal Unit and Program in Membrane Biology, Department of Medicine, Harvard Medical School and Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:28902-8. 2002
  6. ncbi The organization and consequences of eicosanoid signaling
    Roy J Soberman
    Renal Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 Navy Yard, Charlestown, MA 02129, USA
    J Clin Invest 111:1107-13. 2003
  7. ncbi Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4
    Peter Christmas
    Renal Unit and Department of Medicine, Massachusetts General Hospital East, Navy Yard Bldg 149, 13th Street, Charlestown, MA 02129, USA
    J Biol Chem 281:7189-96. 2006
  8. ncbi The membrane organization of leukotriene synthesis
    Asim K Mandal
    Department of Medicine, Massachusetts General Hospital, 149 The Navy Yard, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:6587-92. 2004

Research Grants

  1. The role of the CYP4F3 gene in inflammation
    Peter Christmas; Fiscal Year: 2003
  2. CYP4F3 in renal inflammation
    Peter Christmas; Fiscal Year: 2009
  3. CYP4F3 in renal inflammation
    Peter Christmas; Fiscal Year: 2010
  4. CYP4F3 in renal inflammation
    Peter Christmas; Fiscal Year: 2011
  5. CYP4F3 in renal inflammation
    Peter Christmas; Fiscal Year: 2010

Collaborators

Detail Information

Publications8

  1. ncbi Alternative splicing determines the function of CYP4F3 by switching substrate specificity
    P Christmas
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 276:38166-72. 2001
    ..The results establish that tissue-specific alternative splicing of pre-mRNA can be used as a mechanism for changing substrate specificity and increasing the functional diversity of cytochrome P450 genes...
  2. ncbi Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter
    Peter Christmas
    Renal Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    J Biol Chem 278:25133-42. 2003
    ..ZEB-2 interacts with C-terminal binding protein and Smads, and this would provide opportunities for integrating environmental signals in myelopoiesis and inflammation...
  3. ncbi Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase
    P Christmas
    Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 274:21191-9. 1999
    ..The data indicate that the tissue-specific expression of functionally distinct CYP4F3 isoforms is regulated by alternative promoter usage and mutually exclusive exon splicing...
  4. ncbi Differential localization of 5- and 15-lipoxygenases to the nuclear envelope in RAW macrophages
    P Christmas
    Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 274:25594-8. 1999
    ..Significantly, no discrete targeting domain could be identified in 5-LO, suggesting that sequences throughout the molecule are required for nuclear envelope localization...
  5. ncbi Membrane localization and topology of leukotriene C4 synthase
    Peter Christmas
    Renal Unit and Program in Membrane Biology, Department of Medicine, Harvard Medical School and Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:28902-8. 2002
    ..The differential localization of two very similar integral membrane proteins suggests that mechanisms other than size-dependent exclusion regulate their passage to the inner nuclear membrane...
  6. ncbi The organization and consequences of eicosanoid signaling
    Roy J Soberman
    Renal Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 Navy Yard, Charlestown, MA 02129, USA
    J Clin Invest 111:1107-13. 2003
  7. ncbi Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4
    Peter Christmas
    Renal Unit and Department of Medicine, Massachusetts General Hospital East, Navy Yard Bldg 149, 13th Street, Charlestown, MA 02129, USA
    J Biol Chem 281:7189-96. 2006
    ..The results identify CYP4F18 as a critical protein in the regulation of LTB(4) metabolism and functional responses in mouse PMN and identify it as the functional orthologue of human PMN CYP4F3A...
  8. ncbi The membrane organization of leukotriene synthesis
    Asim K Mandal
    Department of Medicine, Massachusetts General Hospital, 149 The Navy Yard, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:6587-92. 2004
    ..The results indicate that the formation of LTC(4) and LTB(4) may be determined by the compartmentalization of biosynthetic enzymes in discrete molecular complexes...

Research Grants6

  1. The role of the CYP4F3 gene in inflammation
    Peter Christmas; Fiscal Year: 2003
    ..The tissue localization of CYP4F3 gene products in the gastrointestinal tract and kidney will be analyzed by immunohistochemistry, in situ hybridization, and isoform-specific PCR. ..
  2. CYP4F3 in renal inflammation
    Peter Christmas; Fiscal Year: 2009
    ..The long-term objectives are to correlate changes in CYP4F3 activity with inflammatory disease states in humans, and to identify and manipulate the regulatory pathways that control CYP4F3 gene expression and activity. ..
  3. CYP4F3 in renal inflammation
    Peter Christmas; Fiscal Year: 2010
    ..The long-term objectives are to correlate changes in CYP4F3 activity with inflammatory disease states in humans, and to identify and manipulate the regulatory pathways that control CYP4F3 gene expression and activity. ..
  4. CYP4F3 in renal inflammation
    Peter Christmas; Fiscal Year: 2011
    ..The long-term objectives are to correlate changes in CYP4F3 activity with inflammatory disease states in humans, and to identify and manipulate the regulatory pathways that control CYP4F3 gene expression and activity. ..
  5. CYP4F3 in renal inflammation
    Peter Christmas; Fiscal Year: 2010
    ..Project Description Page 6 ..