D C Christiani

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Design and analysis issues in gene and environment studies
    Chen Yu Liu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 11:93. 2012
  2. pmc Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
    Paula Tejera
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Med Genet 49:671-80. 2012
  3. doi request reprint Invited commentary: the action in the interaction and exposure modification
    David C Christiani
    Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 175:606-8. 2012
  4. pmc In-home solid fuel use and cardiovascular disease: a cross-sectional analysis of the Shanghai Putuo study
    Mi Sun Lee
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 11:18. 2012
  5. doi request reprint Frontiers in occupational and environmental lung disease research
    Saeher A F Muzaffar
    Massachusetts General Hospital, Boston, MA 02115, USA
    Chest 141:772-81. 2012
  6. doi request reprint Genetic variants associated with severe pneumonia in A/H1N1 influenza infection
    J Zuniga
    Instituto Nacional deEnfermedades Respiratorias IsmaelCosio Villegas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Eur Respir J 39:604-10. 2012
  7. pmc Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 10:97. 2011
  8. pmc Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 9:78. 2010
  9. pmc GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study
    Carrie V Breton
    Harvard School of Public Health, Dept of Environmental Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Environ Health 6:39. 2007
  10. pmc Effect of Qigong on quality of life: a cross-sectional population-based comparison study in Taiwan
    Tsung Jung Ho
    School of Public Health, China Medical University, Taichung, Taiwan
    BMC Public Health 11:546. 2011

Collaborators

Detail Information

Publications68

  1. pmc Design and analysis issues in gene and environment studies
    Chen Yu Liu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 11:93. 2012
    ..Future research directions are also discussed...
  2. pmc Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
    Paula Tejera
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Med Genet 49:671-80. 2012
    ..The aim of this study was to identify genetic variants contributing to ALI/ARDS from pulmonary or extrapulmonary causes...
  3. doi request reprint Invited commentary: the action in the interaction and exposure modification
    David C Christiani
    Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 175:606-8. 2012
    ..More cross-talk between biologists and epidemiologists is needed to tackle key issues in chronic disease etiology, and the argument for the use of parsimonious joint models in epidemiology is convincing...
  4. pmc In-home solid fuel use and cardiovascular disease: a cross-sectional analysis of the Shanghai Putuo study
    Mi Sun Lee
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 11:18. 2012
    ..We explored the association between in-home solid fuel use and self-reported diagnoses of cardiovascular endpoints, such as hypertension, coronary heart disease (CHD), stroke, and diabetes...
  5. doi request reprint Frontiers in occupational and environmental lung disease research
    Saeher A F Muzaffar
    Massachusetts General Hospital, Boston, MA 02115, USA
    Chest 141:772-81. 2012
    ....
  6. doi request reprint Genetic variants associated with severe pneumonia in A/H1N1 influenza infection
    J Zuniga
    Instituto Nacional deEnfermedades Respiratorias IsmaelCosio Villegas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Eur Respir J 39:604-10. 2012
    ..Two of these SNPs are mapped within genes (FCGR2A, C1QBP) involved in the handling of immune complexes and complement activation, respectively, suggesting that these genes may confer risk due to increased activation of host immunity...
  7. pmc Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 10:97. 2011
    ..Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism...
  8. pmc Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 9:78. 2010
    ..One suggested pathway is that pollution causes oxidative stress. If so, oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure...
  9. pmc GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study
    Carrie V Breton
    Harvard School of Public Health, Dept of Environmental Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Environ Health 6:39. 2007
    ..Chronic arsenic exposure is associated with an increased risk of skin, bladder and lung cancers. Generation of oxidative stress may contribute to arsenic carcinogenesis...
  10. pmc Effect of Qigong on quality of life: a cross-sectional population-based comparison study in Taiwan
    Tsung Jung Ho
    School of Public Health, China Medical University, Taichung, Taiwan
    BMC Public Health 11:546. 2011
    ..In Taiwan, Waitankung, a type of Qigong, is as popular as Tai Chi Chuan. This population-based comparison study compares the health-related quality of life between people practicing Waitankung and their comparable community residents...
  11. pmc Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study
    Chen Yu Liu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    BMC Cancer 9:15. 2009
    ..This study investigated whether consumed cured/smoked meat and fish, the major dietary resource for exposure to nitrites and nitrosamines, is associated with childhood acute leukemia...
  12. doi request reprint Genetic susceptibility to occupational exposures
    D C Christiani
    Environmental and Occupational Medicine and Epidemiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Occup Environ Med 65:430-6; quiz 436, 397. 2008
    ..Thus, large scale genetic screening in the workplace is not currently recommended...
  13. doi request reprint Lung cancer genetics: a family affair?
    David C Christiani
    Harvard School of Public Health, Department of Epidemiology, Boston, Massachusetts 02115, USA
    Clin Cancer Res 15:2581-2. 2009
    ..This report provides new insights into a mechanism that will help to guide preventive interventions in the future...
  14. pmc Patterns of pulmonary dysfunction in asbestos workers: a cross-sectional study
    Belayneh A Abejie
    Harvard School of Public Health, Boston, MA, USA
    J Occup Med Toxicol 5:12. 2010
    ..Studies are less consistent, however, regarding the association of asbestos inhalation with airway dysfunction and obstructive impairment...
  15. ncbi request reprint Differential association of the codon 72 p53 and GSTM1 polymorphisms on histological subtype of non-small cell lung carcinoma
    G Liu
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 61:8718-22. 2001
    ..1-2.8; case-only analysis) of having AC versus SCC if they also carried a p53 Pro allele. We conclude that different genotype combinations of p53 and GSTM1 increase the risk of developing specific histological subtypes of NSCLC...
  16. ncbi request reprint Longitudinal changes in pulmonary function and respiratory symptoms in cotton textile workers. A 15-yr follow-up study
    D C Christiani
    Department of Environmental Health Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 163:847-53. 2001
    ..Consistent reporting of respiratory symptoms, including byssinosis and chest tightness at work, is of value to predict the magnitude and severity of chronic impairments in textile workers...
  17. pmc Respiratory symptoms and cotton dust exposure; results of a 15 year follow up observation
    X R Wang
    Department of Environmental Health Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Occup Environ Med 60:935-41. 2003
    ..To determine chronic effects of long term exposure to cotton dust and endotoxin on incidence of respiratory symptoms and the effect of cessation of exposure...
  18. ncbi request reprint Pulmonary function among cotton textile workers. A study of variability in symptom reporting, across-shift drop in FEV1, and longitudinal change
    D C Christiani
    Department of Environmental Health, Harvard School of Public Health, Boston
    Chest 105:1713-21. 1994
    ..Among cotton workers, consistent responders to either symptom questionnaire or across-shift FEV1 decrements of > or = 5 percent appear to be at increased risk for lung function impairment...
  19. ncbi request reprint A 20-year follow-up study on chronic respiratory effects of exposure to cotton dust
    X R Wang
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Eur Respir J 26:881-6. 2005
    ..In conclusion, the current study suggests that long-term exposure to cotton dust, in which airborne endotoxin appears to play an important role, results in substantial adverse chronic respiratory effects...
  20. pmc Sex-specific association of epidermal growth factor gene polymorphisms with acute respiratory distress syndrome
    C C Sheu
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Eur Respir J 33:543-50. 2009
    ..The present study suggests that associations of epidermal growth factor gene variants with acute respiratory distress syndrome risk are modified by sex. The current findings should be replicated in other populations...
  21. ncbi request reprint Cotton dust exposure, across-shift drop in FEV1, and five-year change in lung function
    D C Christiani
    Department of Environmental Health Occupational Health Program, Harvard School of Public Health, Boston, MA 02115
    Am J Respir Crit Care Med 150:1250-5. 1994
    ..01). Silk workers with or without 5% across-shift drops had similar annual rates of decline (-33.8 ml and -36.1 ml, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi request reprint Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer
    D H Kim
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts, MA 02115, USA
    Oncogene 20:1765-70. 2001
    ..However, they strongly suggest that DAP-kinase may be important in the progression of non-small cell lung cancer from early to late stage disease...
  23. ncbi request reprint Tobacco smoke-induced DNA damage and an early age of smoking initiation induce chromosome loss at 3p21 in lung cancer
    T Hirao
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115-6021, USA
    Cancer Res 61:612-5. 2001
    ..Finally, LOH in 3p21 may be an early molecular event in NSCLC, because it is significantly associated with a tendency to start smoking at a young age...
  24. ncbi request reprint The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer
    W Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:461-6. 2001
    ....
  25. ncbi request reprint Work area measurements as predictors of personal exposure to endotoxin and cotton dust in the cotton textile industry
    A J Mehta
    Department of Environmental Health, Environmental and Occupational Medicine and Epidemiology Program, Harvard School of Public Health, Boston, MA, USA
    Ann Occup Hyg 52:45-54. 2008
    ....
  26. ncbi request reprint Polymorphisms in GSTT1 and p53 and urinary transitional cell carcinoma in south-western Taiwan: a preliminary study
    Y C Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, MA 02115, Boston, USA
    Biomarkers 9:386-94. 2004
    ..However, the results were not statistically significant and larger confirmatory studies are needed to clarify the role of candidate gene polymorphisms and bladder cancer risk in arsenic exposed populations...
  27. ncbi request reprint Respiratory disease in a textile factory in Nicaragua
    A M Velazquez
    Takemi Program in International Health, Boston, MA
    Am J Ind Med 20:195-208. 1991
    ..Results are related to cotton dust exposure, as has been documented elsewhere. The poorer health status of the women in this study population deserves follow-up...
  28. pmc Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome
    M N Gong
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY, and Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston 02115, USA
    Eur Respir J 27:674-81. 2006
    ..Among those with acute respiratory distress syndrome, the -1082GG genotype is associated with lower mortality and organ failure. Further studies are needed to confirm these findings...
  29. ncbi request reprint Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib
    G Liu
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center and Hematology Oncology Division, Massachusetts General Hospital, Boston, MA, USA
    Pharmacogenomics J 8:129-38. 2008
    ..01) and a significantly higher risk of treatment-related rash/diarrhea (P=0.004, multivariate model). EGFR intron 1 and -216G/T polymorphisms influence clinical outcomes in gefitinib-treated non-small-cell lung cancer patients...
  30. ncbi request reprint Use of an asbestos exposure score and the presence of pleural and parenchymal abnormalities in a lung cancer case series
    E S Schaeffner
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Int J Occup Environ Health 7:14-8. 2001
    ..93; 95%CI 1.05-23.12). The results suggest that assessment of asbestos exposures by means of an algorithm-based index can classify the exposures accurately for epidemiologic studies...
  31. ncbi request reprint p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    D H Kim
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Cancer Res 61:3419-24. 2001
    ..These findings suggest that methylation of CpG islands in tobacco-associated cancers occurs in a gene- and tissue-specific manner and is induced directly or indirectly by exposure to tobacco smoke in NSCLC...
  32. pmc Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis
    R Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Thorax 64:784-90. 2009
    ..Elevated bilirubin may induce inflammation and apoptosis. It was hypothesised that increased serum bilirubin on Intensive Care Unit (ICU) admission contributes to sepsis-related acute respiratory distress syndrome (ARDS)...
  33. ncbi request reprint The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking behavior
    L L Xu
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:303-9. 2001
    ..Our results support the concept that differential susceptibility to lung cancer is a function of both an inheritable trait in NQO1 metabolism and individual smoking characteristics...
  34. ncbi request reprint Association of heart rate variability with occupational and environmental exposure to particulate air pollution
    S R Magari
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 104:986-91. 2001
    ..The clinical significance of these effects in a healthy working population is unclear...
  35. pmc Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS
    R Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Thorax 62:718-22. 2007
    ..Genetic variations of the VEGF gene have been associated with VEGF production. A study was undertaken to investigate the impact of VEGF gene polymorphisms on the clinical outcomes of ARDS...
  36. pmc Comparison of squamous cell carcinoma and adenocarcinoma of the lung by metabolomic analysis of tissue-serum pairs
    K W Jordan
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
    Lung Cancer 68:44-50. 2010
    ..Our results strongly indicate the potential of serum MR spectroscopy to achieve the task of differentiating between the tested human lung cancer types and from controls...
  37. ncbi request reprint Pulmonary function in long-term asbestos workers in China
    X R Wang
    Department of Environmental Health (Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Occup Environ Med 43:623-9. 2001
    ..These data indicate that asbestos-related functional defects manifested by lung restriction and mild airway obstruction correlate with exposure to asbestos and with parenchymal and pleural abnormalities, independent of smoking...
  38. ncbi request reprint Petrochemical exposure and menstrual disturbances
    S W Thurston
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Ind Med 38:555-64. 2000
    ..An exploratory, cross-sectional retrospective study was conducted to examine the effects of benzene exposure on menstrual problems...
  39. pmc Circulating adhesion molecules after short-term exposure to particulate matter among welders
    S C Fang
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, FXB 103, Boston, MA 02115, USA
    Occup Environ Med 67:11-6. 2010
    ....
  40. pmc Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy
    K T Kelsey
    Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115, USA
    Br J Cancer 76:852-4. 1997
    ..The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use...
  41. pmc Long driving time is associated with haematological markers of increased cardiovascular risk in taxi drivers
    J C Chen
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Occup Environ Med 62:890-4. 2005
    ..To examine the association between driving time and changes in haematological markers of increased risks for cardiovascular diseases (CVD)...
  42. ncbi request reprint Effects of exposure to organic solvents on menstrual cycle length
    S I Cho
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, FXB-101, Boston, MA 02115-6096, USA
    J Occup Environ Med 43:567-75. 2001
    ..53; 95% confidence interval, 1.00 to 2.34). We concluded that exposure to organic solvents is associated with a trend toward increased frequency of oligomenorrhea...
  43. pmc Occupational and personal factors associated with acquired lumbar spondylolisthesis of urban taxi drivers
    J C Chen
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Occup Environ Med 61:992-8. 2004
    ..To investigate the occupational and personal factors associated with lumbar spondylolisthesis in taxi drivers...
  44. ncbi request reprint Tofu consumption and blood lead levels in young Chinese adults
    C Chen
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 153:1206-12. 2001
    ..In conclusion, the authors found a significant inverse dose-response relation between tofu consumption and blood lead levels in this Chinese population...
  45. ncbi request reprint A prospective study of lung function among boilermaker construction workers exposed to combustion particulates
    R Hauser
    Department of Environmental Health Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Ind Med 39:454-62. 2001
    ....
  46. ncbi request reprint Ultrafine particles in human lung macrophages
    R Hauser
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Arch Environ Health 56:150-6. 2001
    ..The negative association between the number of ultrafine particles and ventilatory function demonstrates a need for further investigation into the pulmonary health effects of ultrafine particles...
  47. pmc Exposure to welding fumes is associated with acute systemic inflammatory responses
    J Y Kim
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Occup Environ Med 62:157-63. 2005
    ..To investigate the acute systemic inflammatory response to welding fume exposure...
  48. pmc Utilization of biomarker data for clinical and environmental intervention
    D C Christiani
    Occupational Medicine and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Environ Health Perspect 104:921-5. 1996
    ..This paper illustrates examples of these intervention strategies and reviews the current strengths and limitations of environmental molecular epidemiology in controlling disease caused by air toxics...
  49. ncbi request reprint A participatory workplace health and safety training program for ethylene oxide
    A D LaMontagne
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 9957
    Am J Ind Med 22:651-64. 1992
    ..This paper presents the challenges, benefits, and limitations of incorporating participatory and empowerment approaches in the design, implementation, and evaluation of EtO health and safety training...
  50. ncbi request reprint -308GA and TNFB polymorphisms in acute respiratory distress syndrome
    M N Gong
    Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Eur Respir J 26:382-9. 2005
    ....
  51. ncbi request reprint Smoking and the molecular epidemiology of lung cancer
    D C Christiani
    Department of Occupational Medicine and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Chest Med 21:87-93, viii. 2000
    ..This article discusses occupational carcinogen exposure and exposure from tobacco use, and the lung-cancer risk associated with these types of exposure...
  52. ncbi request reprint Applying genomic technologies in environmental health research: challenges and opportunities
    D C Christiani
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Occup Environ Med 43:526-33. 2001
    ..In this article, we describe a number of ELSI challenges in environmental genomic research and the opportunities and responsibilities that accompany this research...
  53. ncbi request reprint Hormesis: the new approach in risk assessment?
    D C Christiani
    Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Hum Exp Toxicol 21:399-400. 2002
    ..Even if hormesis were proven biologically, its assessment is limited due to difficulties of study design, biological markers selection, statistical power considerations, model and end point selection, and risk model approaches...
  54. pmc Occupation and COPD
    D C Christiani
    Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Occup Environ Med 62:215. 2005
  55. ncbi request reprint The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population
    R Zhai
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Pharmacogenetics 11:699-701. 2001
    ..Only one GC heterozygous and no CC homozygous variants were found. Our results suggest that the frequency of the C allele in this Chinese population is lower than in Caucasian and east Indian populations...
  56. ncbi request reprint Urinalysis of atrazine exposure in farm pesticide applicators
    M J Perry
    Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Toxicol Ind Health 16:285-90. 2001
    ..The results indicate that single field applications of atrazine result in measurable pesticide doses to applicators and that the choice of field assay should depend on the exposure product to be evaluated...
  57. ncbi request reprint Firefighters' hearing: a comparison with population databases from the International Standards Organization
    S N Kales
    Cambridge Health Alliance, Cambridge, MA, USA
    J Occup Environ Med 43:650-6. 2001
    ..The results are consistent with accelerated hearing loss in excess of age-expected loss among the firefighters, especially at or above the 90th percentile...
  58. pmc A longitudinal observation of early pulmonary responses to cotton dust
    X R Wang
    Department of Environmental Health Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts, USA
    Occup Environ Med 60:115-21. 2003
    ..To examine early adverse pulmonary effects of exposure to cotton dust, and to identify potential risk factors, including atopy for pulmonary responses to cotton dust...
  59. ncbi request reprint Predictors of whole-body vibration levels among urban taxi drivers
    J C Chen
    Occupational Health Program, Department of Environmental Health Harvard School of Public Health, Boston, MA 02115, USA
    Ergonomics 46:1075-90. 2003
    ..03), and traffic period (p = 0.02). Our study suggests that a similar statistical approach could be employed in future studies to improve the quality and efficiency of WBV exposure assessment in professional drivers...
  60. ncbi request reprint Is air pollution a risk factor for low birth weight in Seoul?
    E H Ha
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 12:643-8. 2001
    ..Carbon monoxide, nitrogen dioxide, sulfur dioxide, and total suspended particle concentrations in the first trimester of pregnancy period are risk factors for low birth weight...
  61. ncbi request reprint The p53 codon 72 polymorphism and lung cancer risk
    R Fan
    Department of Environmental Health Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:1037-42. 2000
    ..The p53 gene may modulate the response to environment carcinogens and thereby affect the risk of developing lung adenocarcinoma...
  62. ncbi request reprint Atopic asthma: differential activation phenotypes among memory T helper cells
    M L Lara-Marquez
    Respiratory Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Clin Exp Allergy 31:1232-41. 2001
    ....
  63. ncbi request reprint Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells
    E J Duell
    Department of Cancer Cell Biology and Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 21:965-71. 2000
    ..The polymorphism in ERCC2 was unrelated to SCE frequency or DNA adduct level. Our results suggest that carriers of the polymorphic XRCC1 399Gln allele may be at greater risk for tobacco- and age-related DNA damage...
  64. ncbi request reprint Reliability of serial urine HCG as a biomarker to detect early pregnancy loss
    S I Cho
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Reprod 17:1060-6. 2002
    ....
  65. pmc Cardiac autonomic dysfunction from occupational exposure to polycyclic aromatic hydrocarbons
    Mi Sun Lee
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Occup Environ Med 68:474-8. 2011
    ..This study investigated the association between a biological marker of PAH exposure, assessed by urinary 1-hydroxypyrene (1-OHP), and heart-rate variability in an occupational cohort of boilermakers...
  66. ncbi request reprint Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interaction
    X Wang
    Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, MA 02118, USA
    Am J Epidemiol 152:693-700. 2000
    ..This study provides evidence of gene-environment interaction and supports further assessment of the role of genetic susceptibility in the evaluation of reproductive toxins...
  67. ncbi request reprint Health effects of occupational exposures to vehicle emissions in Shanghai
    W Zhou
    Department of Environmental Health, School of Public Health, Shanghai Medical University, China
    Int J Occup Environ Health 7:23-30. 2001
    ..Pulmonary function and blood lead levels were not significantly correlated with exposure status. The results suggest that occupational exposure to vehicle emissions may induce detectable adverse health effects...
  68. pmc Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma
    M Fruh
    Medical Oncology, Department of Medicine, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Br J Cancer 98:689-92. 2008
    ..In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship...